Role of JAK2-STAT3 in TLR2-mediated tissue factor expression

Journal of Cellular Biochemistry

Volumn 114, Issue 6, 2013, Pages 1315-1321

  Park, Dae Weon ^a   Lyu, Ji Hyo ^a   Kim, Jin Sik ^a   Chin, Haemin ^a   Bae, Yoe Sik ^b   Baek, Suk Hwan ^a  

^a Yeungnam University College of Medicine   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

JAK2; PAM3CSK4; RGS2; STAT3; TF; TLR2

Indexed keywords

JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; SMALL INTERFERING RNA; STAT3 PROTEIN; THROMBOPLASTIN; TOLL LIKE RECEPTOR 2;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE SILENCING; INHIBITION KINETICS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ATHEROSCLEROSIS; CELL LINE; JANUS KINASE 2; LIPOPEPTIDES; MACROPHAGES; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RGS PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; THROMBOPLASTIN; TOLL-LIKE RECEPTOR 2; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

MUS;

EID: 84876204166     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24472     Document Type: Article

References (28)

1. Akira S, Uematsu S, Takeuchi O,. 2006. Pathogen recognition and innate immunity. Cell 124: 783-801.
2. Batra A, Pietsch J, Fedke I, Glauben R, Okur B, Stroh T, Zeitz M, Siegmund B,. 2007. Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes. Am J Pathol 170: 1931-1941.
3. Butterbach K, Beckmann L, de Sanjose S, Benavente Y, Becker N, Foretova L, Maynadie M, Cocco P, Staines A, Boffetta P, Brennan P, Nieters A,. 2011. Association of JAK-STAT pathway related genes with lymphoma risk: Results of a European case-control study (EpiLymph). Br J Haematol 153: 318-333.
4. Cermak J, Key NS, Bach RR, Balla J, Jacob HS, Vercellotti GM,. 1993. C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor. Blood 82: 513-520.
5. Cole JE, Georgiou E, Monaco C,. 2010. The expression and functions of toll-like receptors in atherosclerosis. Mediators Inflamm 2010: 393946.
6. Edgington TS, Mackman N, Brand K, Ruf W,. 1991. The structural biology of expression and function of tissue factor. Thromb Haemost 66: 67-79.
7. Guha M, Mackman N,. 2002. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 277: 32124-32132.
8. He M, He X, Xie Q, Chen F, He S,. 2006. Angiotensin II induces the expression of tissue factor and its mechanism in human monocytes. Thromb Res 117: 579-590.
9. Katsoulidis E, Sassano A, Majchrzak-Kita B, Carayol N, Yoon P, Jordan A, Druker BJ, Fish EN, Platanias LC,. 2008. Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells. J Biol Chem 283: 10793-10803.
10. Kehrl JH, Sinnarajah S,. 2002. RG S2: A multifunctional regulator of G-protein signaling. Int J Biochem Cell Biol 34: 432-438.
11. Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP,. 2009. Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). J Biol Chem 284: 19402-19411.
12. Langer I, Tikhonova IG, Boulegue C, Esteve JP, Vatinel S, Ferrand A, Moroder L, Robberecht P, Fourmy D,. 2009. Evidence for a direct and functional interaction between the regulators of G protein signaling-2 and phosphorylated C terminus of cholecystokinin-2 receptor. Mol Pharmacol 75: 502-513.
13. Lee HK, Park DW, Bae JH, Kim HJ, Shin DG, Park JS, Lee JG, Lee SJ, Bae YS, Baek SH,. 2012. RGS2 is a negative regulator of STAT3-mediated Nox1 expression. Cell Signal 24: 803-809.
14. Mach F, Schonbeck U, Bonnefoy JY, Pober JS, Libby P,. 1997. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of C D40: Induction of collagenase, stromelysin, and tissue factor. Circulation 96: 396-399.
15. Manzur M, Ganss R,. 2009. Regulator of G protein signaling 5: A new player in vascular remodeling. Trends Cardiovasc Med 19: 26-30.
16. Moons AH, Levi M, Peters RJ,. 2002. Tissue factor and coronary artery disease. Cardiovasc Res 53: 313-325.
17. Newton K, Dixit VM,. 2012. Signaling in innate immunity and inflammation. Cold Spring Harb Perspect Biol 4: a006049.
18. Oeth P, Parry GC, Mackman N,. 1997. Regulation of the tissue factor gene in human monocytic cells. Role of AP-1, NF-kappa B/Rel, and Sp1 proteins in uninduced and lipopolysaccharide-induced expression. Arterioscler Thromb Vasc Biol 17: 365-374.
19. Osei-Owusu P, Sabharwal R, Kaltenbronn KM, Rhee MH, Chapleau MW, Dietrich HH, Blumer KJ,. 2012. Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling. J Biol Chem 287: 12541-12549.
20. Ott I, Fischer EG, Miyagi Y, Mueller BM, Ruf W,. 1998. A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280. J Cell Biol 140: 1241-1253.
21. Park DW, Kim JS, Chin BR, Baek SH,. 2012a. Resveratrol inhibits inflammation induced by heat-killed listeria monocytogenes. J Med Food 15: 788-794.
22. Park DW, Lee HK, Jeong TW, Kim JS, Bae YS, Chin BR, Baek SH,. 2012b. The JAK2-Akt-glycogen synthase kinase-3beta signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation. Mol Med Rep 5: 1063-1067.
23. Rane SG, Reddy EP,. 2000. Janus kinases: Components of multiple signaling pathways. Oncogene 19: 5662-5679.
24. Steffel J, Luscher TF, Tanner FC,. 2006. Tissue factor in cardiovascular diseases: Molecular mechanisms and clinical implications. Circulation 113: 722-731.
25. Sun X, Kaltenbronn KM, Steinberg TH, Blumer KJ,. 2005. RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling. Mol Pharmacol 67: 631-639.
26. ten Cate H,. 2012. Tissue factor-driven thrombin generation and inflammation in atherosclerosis. Thromb Res 129 (Suppl 2): S38-S40.
27. Wada H, Kaneko T, Wakita Y, Minamikawa K, Nagaya S, Tamaki S, Deguchi K, Shirakawa S,. 1994. Effect of lipoproteins on tissue factor activity and PAI-II antigen in human monocytes and macrophages. Int J Cardiol 47: S21-S25.
28. Wilcox JN, Smith KM, Schwartz SM, Gordon D,. 1989. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA 86: 2839-2843.