Anti- and proconvulsive actions of levcromakalim, an opener of ATP-sensitive K+ channel, in the model of hippocampus-generating partial seizures in rats

European Journal of Pharmacology

Volumn 311, Issue 1, 1996, Pages 37-44

  Katsumori, Hiroshi ^a,b   Ito, Yuji ^c   Higashida, Haruhiro ^a,c   Hashii, Minako ^a,c   Minabe, Yoshio ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Ca2+ channel; Hippocampus; K+ channel; Levcromakalim; Patch clamp; Seizure

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; GLIBENCLAMIDE; LEMAKALIM; NIMODIPINE; POTASSIUM CHANNEL STIMULATING AGENT; TETRYLAMMONIUM;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVULSION; HIPPOCAMPUS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

EID: 0030571029     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00400-1     Document Type: Article

References (29)

1. Abele, A.E. and R.J. Miller, 1990, Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons, Neurosci. Lett. 115, 195.
2. Alzheimer, C. and G. Ten Bruggencate, 1988, Actions of BRL 34915 (cromakalim) upon convulsive discharges in guinea pig hippocampal slices, Naunyn-Schmiedeberg's Arch. Pharmacol. 337, 429.
3. Ashford, M.L.J., N.C. Sturgress, N.J. Trout, N.J. Gardner and C.N. Hales, 1988, Adenocine-5′-triphosphate-sensitive ion channels in neonatal rat cultured central neurons, Pflüger Arch. 412, 297.
4. Babb, T.L. and W.J. Brown, 1987, Pathological findings in epilepsy, in: Surgical Treatment of the Epilepsies, ed. J. Engel, Jr. (Raven, New York) p. 511.
5. Brown, D.A. and H. Higashida, 1988a, Voltage-and calcium activated potassium currents in mouse neuroblastoma × rat glioma hybrid cells, J. Physiol. 397, 149.
6. Brown, D.A. and H. Higashida, 1988b, Membrane current responses of NG108-15 mouse neuroblastoma × rat glioma hybrid cells to bradykinin, J. Physiol. 397, 185.
7. De Sarro, G.B., B.S. Meldrum and G. Nisticó, 1988, Anticonvulsant effects of some calcium entry blockers in DBA/2 mice, Br. J. Pharmacol. 93, 247.
8. Dolin, S.J., A.B. Hunter, M.J. Halsey and H.J. Little, 1988, Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine, Eur. J. Pharmacol. 152, 19.
9. Emori, K. and Y. Minabe, 1990, Effects of anticonvulsants on hippocampus-generating seizures, Brain Res. 511, 217.
10. + channels openers prevent epilepsy induced by the bee venom peptide MCD, Eur. J. Pharmacol. 159, 329.
11. + channel openers decrease seizures in genetically epileptic rats, Eur. J. Pharmacol. 167, 181.
12. Gilbert, M.E., 1988, The NMDA-receptors antagonist, MK-801, suppresses limbic kindling and kindled seizures, Brain Res. 463, 90.
13. Grace, G.M., M.E. Corcoran and R.W. Skelton, 1990, Kindling with stimulation of dentate gyrus. I. Characterization of electrographic and behavioral events, Brain Res. 509, 249.
14. 2+ currents in NG108-15 neuroblastoma × glioma hybrid cells, FEBS Lett. 262, 313.
15. Jones, R.S.G. and U.H. Heinemann, 1987, Differential effects of calcium entry blockers on pre-and postsynaptic influx of calcium in the rat hippocampus in vitro, Brain Res. 416, 25.
16. Löscher, W. and D. Schmidt, 1994, Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?, Epilepsy Res. 17, 95.
17. Mattia, D., T. Nagao, M.A. Rogawski and M. Avoli, 1994, Potassium channel activators counteract anoxic hyperexcitability but not 4-aminopyridine-induced epileptiform activity in the rat hippocampal slice, Neuropharmacology 33, 1515.
18. Minabe, Y. and K. Emori, 1992, Two types of neuroplasticities in the kindling phenomenon, effects chronic MK-801 and methamphetamine, Brain Res. 585, 237.
19. Minabe, Y., K. Emori, R. Shibata and M. Kurachi, 1992, Antiepileptic effect of MK-801, a noncompetitive NMDA receptor antagonist, in the low frequency kindling model of epilepsy, Jpn. J. Psychiatr. Neurol. 46, 755.
20. Minabe, Y., K. Emori and T. Uehara, 1993, Effects of long-stimulus intervals and scopolamine administration on hippocampal kindling, Brain Res. 600, 322.
21. Mourre, C., Y. Ben-Ari, H. Bernardi, M. Fosset and M. Lazdunski, 1989, Antidiabetic sulfonylureas: localization of binding sites in the brain and effects on the hyperpolarization induced by anoxia in hippocampal slices, Brain Res. 486, 159.
22. Okabe, K., S. Kajioka, K. Nakano, K. Kitamura, H. Kuriyama and A.H. Weston, 1990, Actions of cromakalim on ionic currents recorded from single smooth muscle cells of the rat portal vein, J. Pharmacol. Exp. Ther. 252, 832.
23. Popoli, P., A. Pezzola, S. Sagratella, Y.C. Zeng and A. Scotti de Carolis, 1991, Cromakalim (BRL 34915) counteracts the epileptiform activity elicited by diltiazem and verapamil in rats, Br. J. Pharmacol. 104, 907.
24. Porter, R.J., M.A. Rogawski, 1992, New antiepileptic drugs: from serendipity to rational discovery, Epilepsia 33 (Suppl. 1), S1.
25. Racine, R.J., 1972, Modification of seizure activity by electrical stimulation. II. Motor seizure, Electroenceph. Clin. Neurophysiol. 32, 281.
26. Sato, K., K. Morimoto and M. Okamoto, 1988, Anticonvulsant action of a non-competetive antagonist of NMDA receptors (MK-801) in the kindling model of epilepsy, Brain Res. 463, 12.
27. 3H] glibenclamide binding sites in the rat hippocampus, Neurosci. Lett. 127, 21.
28. Van Luijtelaar, E.L.J.M., N. Ates and A.M.L. Coenen, 1995, Role of L-type calcium channel modulation in nonconvulsive epilepsy in rats, Epilepsia 36, 86.
29. Yamada, N. and D.K. Bilkey, 1991, Nifedipine has paradoxical effects on the development of kindling but not on kindled seizures in amygdalakindled rats, Neuropharmacology 30, 501.