Identification of miR-27b as a Novel Signature from the mRNA Profiles of Adipose-Derived Mesenchymal Stem Cells Involved in the Tolerogenic Response

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Chen, Kuang Den ^a   Goto, Shigeru ^a,b   Hsu, Li Wen ^a,c   Lin, Tzu Yang ^a   Nakano, Toshiaki ^a   Lai, Chia Yun ^a   Chang, Yen Chen ^a   Weng, Wei Teng ^a   Kuo, Yur Ren ^a   Wang, Chih Chi ^a   Cheng, Yu Fan ^a   Ma, Yen Ying ^a   Lin, Chih Che ^a   Chen, Chao Long ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b Iwao Hospital   (Japan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 27B; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ARTICLE; BINDING SITE; CD4+ T LYMPHOCYTE; CELL ACTIVITY; CELL FUNCTION; COCULTURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; MESENCHYMAL STEM CELL; MITOSIS INHIBITION; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RNA ANALYSIS; RNA TRANSCRIPTION;

ADIPOSE TISSUE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FEMALE; MESENCHYMAL STROMAL CELLS; MICRORNAS; OLIGONUCLEOTIDES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING;

RATTUS;

EID: 84876170205     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060492     Document Type: Article

References (44)

1. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, et al. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147.
2. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, et al. (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7: 211-228.
3. Beyth S, Borovsky Z, Mevorach D, Liebergall M, Gazit Z, et al. (2005) Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 105: 2214-2219.
4. Augello A, Tasso R, Negrini SM, Cancedda R, Pennesi G, (2007) Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis Rheum 56: 1175-1186.
5. Yanez R, Lamana ML, Garcia-Castro J, Colmenero I, Ramirez M, et al. (2006) Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease. Stem Cells 24: 2582-2591.
6. McIntosh K, Zvonic S, Garrett S, Mitchell JB, Floyd ZE, et al. (2006) The immunogenicity of human adipose-derived cells: temporal changes in vitro. Stem Cells 24: 1246-1253.
7. Kloosterman WP, Plasterk RH, (2006) The diverse functions of microRNAs in animal development and disease. Dev Cell 11: 441-450.
8. Gangaraju VK, Lin H, (2009) MicroRNAs: key regulators of stem cells. Nat Rev Mol Cell Biol 10: 116-125.
9. Bushati N, Cohen SM, (2007) microRNA functions. Annu Rev Cell Dev Biol 23: 175-205.
10. Rusca N, Monticelli S, (2011) MiR-146a in Immunity and Disease. Mol Biol Int 2011: 437301.
11. Taganov KD, Boldin MP, Chang KJ, Baltimore D, (2006) NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 103: 12481-12486.
12. Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, et al. (2007) Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 179: 5082-5089.
13. Elkon R, Linhart C, Sharan R, Shamir R, Shiloh Y, (2003) Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells. Genome Res 13: 773-780.
14. Keating A, (2008) How do mesenchymal stromal cells suppress T cells? Cell Stem Cell 2: 106-108.
15. Burger JA, Kipps TJ, (2002) Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B cells. Leuk Lymphoma 43: 461-466.
16. Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, et al. (2006) Human mesenchymal stem cells modulate B-cell functions. Blood 107: 367-372.
17. Nauta AJ, Kruisselbrink AB, Lurvink E, Willemze R, Fibbe WE, (2006) Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J Immunol 177: 2080-2087.
18. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, et al. (2006) Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells 24: 1030-1041.
19. Ghannam S, Bouffi C, Djouad F, Jorgensen C, Noel D, (2010) Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications. Stem Cell Res Ther 1: 2.
20. Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, et al. (2002) G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 3: 687-694.
21. Saxena A, Fish JE, White MD, Yu S, Smyth JW, et al. (2008) Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation 117: 2224-2231.
22. Ghadge SK, Muhlstedt S, Ozcelik C, Bader M, (2011) SDF-1alpha as a therapeutic stem cell homing factor in myocardial infarction. Pharmacol Ther 129: 97-108.
23. Elmadbouh I, Haider H, Jiang S, Idris NM, Lu G, et al. (2007) Ex vivo delivered stromal cell-derived factor-1alpha promotes stem cell homing and induces angiomyogenesis in the infarcted myocardium. J Mol Cell Cardiol 42: 792-803.
24. Schuh A, Liehn EA, Sasse A, Hristov M, Sobota R, et al. (2008) Transplantation of endothelial progenitor cells improves neovascularization and left ventricular function after myocardial infarction in a rat model. Basic Res Cardiol 103: 69-77.
25. Tang J, Wang J, Yang J, Kong X, (2008) Adenovirus-mediated stromal cell-derived- factor-1alpha gene transfer induces cardiac preservation after infarction via angiogenesis of CD133+ stem cells and anti-apoptosis. Interact Cardiovasc Thorac Surg 7: 767-770.
26. Yamaguchi J, Kusano KF, Masuo O, Kawamoto A, Silver M, et al. (2003) Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 107: 1322-1328.
27. Zhang M, Mal N, Kiedrowski M, Chacko M, Askari AT, et al. (2007) SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB J 21: 3197-3207.
28. Tang J, Wang J, Yang J, Kong X, Zheng F, et al. (2009) Mesenchymal stem cells over-expressing SDF-1 promote angiogenesis and improve heart function in experimental myocardial infarction in rats. Eur J Cardiothorac Surg 36: 644-650.
29. Li Y, Yu X, Lin S, Li X, Zhang S, et al. (2007) Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells. Biochem Biophys Res Commun 356: 780-784.
30. Tang J, Wang J, Zheng F, Kong X, Guo L, et al. (2010) Combination of chemokine and angiogenic factor genes and mesenchymal stem cells could enhance angiogenesis and improve cardiac function after acute myocardial infarction in rats. Mol Cell Biochem 339: 107-118.
31. Lau TT, Wang DA, (2011) Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine. Expert Opin Biol Ther 11: 189-197.
32. Jin SZ, Meng XW, Han MZ, Sun X, Sun LY, et al. (2009) Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure. World J Gastroenterol 15: 2657-2664.
33. Swenson ES, Kuwahara R, Krause DS, Theise ND, (2008) Physiological variations of stem cell factor and stromal-derived factor-1 in murine models of liver injury and regeneration. Liver Int 28: 308-318.
34. Jung YJ, Ryu KH, Cho SJ, Woo SY, Seoh JY, et al. (2006) Syngenic bone marrow cells restore hepatic function in carbon tetrachloride-induced mouse liver injury. Stem Cells Dev 15: 687-695.
35. Hannoush EJ, Sifri ZC, Elhassan IO, Mohr AM, Alzate WD, et al. (2011) Impact of enhanced mobilization of bone marrow derived cells to site of injury. J Trauma 71: 283-289; discussion 289-291.
36. Zernecke A, Bot I, Djalali-Talab Y, Shagdarsuren E, Bidzhekov K, et al. (2008) Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res 102: 209-217.
37. Wang F, Yasuhara T, Shingo T, Kameda M, Tajiri N, et al. (2010) Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: focusing on neuroprotective effects of stromal cell-derived factor-1alpha. BMC Neurosci 11: 52.
38. Huang C, Gu H, Zhang W, Manukyan MC, Shou W, et al. (2011) SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol 301: H1496-1505.
39. Lu MH, Li CZ, Hu CJ, Fan YH, Wang SM, et al. (2012) microRNA-27b suppresses mouse MSC migration to the liver by targeting SDF-1alphain vitro. Biochem Biophys Res Commun 421: 389-395.
40. Liu Y, Jiang X, Zhang X, Chen R, Sun T, et al. (2011) Dedifferentiation-reprogrammed mesenchymal stem cells with improved therapeutic potential. Stem Cells 29: 2077-2089.
41. Martin D, Brun C, Remy E, Mouren P, Thieffry D, et al. (2004) GOToolBox: functional analysis of gene datasets based on Gene Ontology. Genome Biol 5: R101.
42. Shamir R, Maron-Katz A, Tanay A, Linhart C, Steinfeld I, et al. (2005) EXPANDER - an integrative program suite for microarray data analysis. BMC Bioinformatics 6: 232.
43. Flicek P, Aken BL, Beal K, Ballester B, Caccamo M, et al. (2008) Ensembl 2008. Nucleic Acids Res 36: D707-714.
44. Ulitsky I, Laurent LC, Shamir R, (2010) Towards computational prediction of microRNA function and activity. Nucleic Acids Res 38: e160.