Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice

Hepatology Research

Volumn 43, Issue 4, 2013, Pages 384-393

  Takemura, Takayo ^a   Yoshida, Yuichi ^a   Kiso, Shinichi ^a   Saji, Yukiko ^a   Ezaki, Hisao ^a   Hamano, Mina ^a   Kizu, Takashi ^a   Egawa, Mayumi ^a   Chatani, Norihiro ^a   Furuta, Kunimaro ^a   Kamada, Yoshihiro ^a   Iwamoto, Ryo ^b   Mekada, Eisuke ^b   Higashiyama, Shigeki ^c,d   Hayashi, Norio ^e   Takehara, Tetsuo ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d EHIME UNIVERSITY   (Japan)

^e KANSAI ROSAI HOSPITAL   (Japan)

Author keywords

Apoptosis; Growth factor; Heparin binding epidermal growth factor like growth factor; Liver injury; Mx1 cre

Indexed keywords

ALANINE AMINOTRANSFERASE; CARBON TETRACHLORIDE; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TUMOR NECROSIS FACTOR ALPHA;

ACUTE DISEASE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE INACTIVATION; LIVER CELL; LIVER INJURY; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; WOUND HEALING;

EID: 84876147909     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2012.01074.x     Document Type: Article

References (44)

1. Michalopoulos GK. Liver regeneration. J Cell Physiol 2007; 213: 286-300.
2. Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology 2006; 43: S45-53.
3. Taub R. Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol 2004; 5: 836-47.
4. Bansal MB, Kovalovich K, Gupta R etal. Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. J Hepatol 2005; 42: 548-56.
5. Kalinichenko VV, Bhattacharyya D, Zhou Y etal. Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury. Hepatology 2003; 37: 107-17.
6. Yamada Y, Fausto N. Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor. Am J Pathol 1998; 152: 1577-89.
7. Huh CG, Factor VM, Sanchez A, Uchida K, Conner EA, Thorgeirsson SS. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A 2004; 101: 4477-82.
8. Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 1991; 251: 936-9.
9. Iwamoto R, Higashiyama S, Mitamura T, Taniguchi N, Klagsbrun M, Mekada E. Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity. EMBO J 1994; 13: 2322-30.
10. Iwamoto R, Mekada E. ErbB and HB-EGF signaling in heart development and function. Cell Struct Funct 2006; 31: 1-14.
11. Higashiyama S, Iwabuki H, Morimoto C, Hieda M, Inoue H, Matsushita N. Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands. Cancer Sci 2008; 99: 214-20.
12. Elenius K, Paul S, Allison G, Sun J, Klagsbrun M. Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO J 1997; 16: 1268-78.
13. Goishi K, Higashiyama S, Klagsbrun M etal. Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell 1995; 6: 967-80.
14. Higashiyama S, Abraham JA, Klagsbrun M. Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate. J Cell Biol 1993; 122: 933-40.
15. Mathay C, Giltaire S, Minner F, Bera E, Herin M, Poumay Y. Heparin-binding EGF-like growth factor is induced by disruption of lipid rafts and oxidative stress in keratinocytes and participates in the epidermal response to cutaneous wounds. J Invest Dermatol 2008; 128: 717-27.
16. Ito N, Kawata S, Tamura S etal. Heparin-binding EGF-like growth factor is a potent mitogen for rat hepatocytes. Biochem Biophys Res Commun 1994; 198: 25-31.
17. Kiso S, Kawata S, Tamura S etal. Alteration in growth regulation of hepatocytes in primary culture obtained from cirrhotic rat: poor response to transforming growth factor-beta 1 and interferons. Hepatology 1994; 20: 1303-8.
18. Kiso S, Kawata S, Tamura S etal. Effects of exogenous human heparin-binding epidermal growth factor-like growth factor on DNA synthesis of hepatocytes in normal mouse liver. Biochem Biophys Res Commun 1999; 259: 683-7.
19. Kiso S, Kawata S, Tamura S etal. Expression of heparin-binding epidermal growth factor-like growth factor in the hepatocytes of fibrotic rat liver during hepatocarcinogenesis. J Gastroenterol Hepatol 1999; 14: 1203-9.
20. Kiso S, Kawata S, Tamura S etal. Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy. Gastroenterology 2003; 124: 701-7.
21. Iwamoto R, Yamazaki S, Asakura M etal. Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A 2003; 100: 3221-6.
22. Fukushima J, Kamada Y, Matsumoto H etal. Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization. Hepatol Res 2009; 39: 724-38.
23. Ezaki H, Yoshida Y, Saji Y etal. Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice. Biochem Biophys Res Commun 2009; 378: 68-72.
24. El-Assal ON, Besner GE. HB-EGF enhances restitution after intestinal ischemia/reperfusion via PI3K/Akt and MEK/ERK1/2 activation. Gastroenterology 2005; 129: 609-25.
25. Louis H, Van Laethem JL, Wu W etal. Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice. Hepatology 1998; 28: 1607-15.
26. Sakuda S, Tamura S, Yamada A etal. NF-kappaB activation in non-parenchymal liver cells after partial hepatectomy in rats: possible involvement in expression of heparin-binding epidermal growth factor-like growth factor. J Hepatol 2002; 36: 527-33.
27. Kiso S, Kawata S, Tamura S etal. Role of heparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy. Hepatology 1995; 22: 1584-90.
28. Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005; 121: 977-90.
29. Hayashi M, Kim SW, Imanaka-Yoshida K etal. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest 2004; 113: 1138-48.
30. Yu X, Radulescu A, Chen CL, James IO, Besner GE. Heparin-binding EGF-like growth factor protects pericytes from injury. J Surg Res 2012; 172: 165-76.
31. James IA, Chen CL, Huang G, Zhang HY, Velten M, Besner GE. HB-EGF protects the lungs after intestinal ischemia/reperfusion injury. J Surg Res 2010; 163: 86-95.
32. Zhang HY, Radulescu A, Besner GE. Heparin-binding epidermal growth factor-like growth factor is essential for preservation of gut barrier function after hemorrhagic shock and resuscitation in mice. Surgery 2009; 146: 334-9.
33. Miyoshi E, Higashiyama S, Nakagawa T, Hayashi N, Taniguchi N. Membrane-anchored heparin-binding epidermal growth factor-like growth factor acts as a tumor survival factor in a hepatoma cell line. J Biol Chem 1997; 272: 14349-55.
34. Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 2007; 117: 539-48.
35. Ramadori G, Saile B. Inflammation, damage repair, immune cells, and liver fibrosis: specific or nonspecific, this is the question. Gastroenterology 2004; 127: 997-1000.
36. Miyamoto S, Yagi H, Yotsumoto F, Kawarabayashi T, Mekada E. Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy. Cancer Sci 2006; 97: 341-7.
37. Mine N, Iwamoto R, Mekada E. HB-EGF promotes epithelial cell migration in eyelid development. Development 2005; 132: 4317-26.
38. Shirakata Y, Kimura R, Nanba D etal. Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing. J Cell Sci 2005; 118: 2363-70.
39. Carver RS, Stevenson MC, Scheving LA, Russell WE. Diverse expression of ErbB receptor proteins during rat liver development and regeneration. Gastroenterology 2002; 123: 2017-27.
40. Michalopoulos GK, Khan Z. Liver regeneration, growth factors, and amphiregulin. Gastroenterology 2005; 128: 503-6.
41. Berasain C, Garcia-Trevijano ER, Castillo J etal. Novel role for amphiregulin in protection from liver injury. J Biol Chem 2005; 280: 19012-20.
42. Berasain C, Garcia-Trevijano ER, Castillo J etal. Amphiregulin: an early trigger of liver regeneration in mice. Gastroenterology 2005; 128: 424-32.
43. Russell WE, Kaufmann WK, Sitaric S, Luetteke NC, Lee DC. Liver regeneration and hepatocarcinogenesis in transforming growth factor-alpha-targeted mice. Mol Carcinog 1996; 15: 183-9.
44. Natarajan A, Wagner B, Sibilia M. The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci U S A 2007; 104: 17081-6.