Neuroprotective effects of the immunomodulatory drug Setarud on cerebral ischemia in male rats

Neural Regeneration Research

Volumn 7, Issue 27, 2012, Pages 2085-2091

  Vafaee, Farzaneh ^a   Zangiabadi, Nasser ^b   Pour, Fatemeh Mehdi ^c   Dehghanian, Farzaneh ^c   Asadi Shekaari, Majid ^b  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antioxidant; Brain injury; Cerebral infarct; Cortex; Immunomodulatory drug; Inclined plate test; Neural regeneration; Neuroprotection; Prehensile test; Stroke

Indexed keywords

EID: 84876136497     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2012.27.001     Document Type: Article

References (30)

1. [1] Khairandish P, Mohraz M, Farzamfar B, et al. Preclinical and phase 1 clinical safety of Setarud (IMOD™), a novel immunomodulator. DARU. 2009;17(3):148-156.
2. [2] Khorram-Khorshid HR, Abdollahi M, Novitsky YA, et al. Studies on potential mutagenic and genotoxic activity of Setarud. DARU. 2008;16(4):223-228.
3. [3] Baghaei A, Esmaily H, Bdolghaffari AH, et al. Efficacy of Setarud (IMOD), a novel drug with potent anti-toxic stress potential in rat inflammatory bowel disease and comparison with dexamethasone and infliximab. Indian J Biochem Biophys. 2010;47:219-226.
4. [4] Khorram-Khorshid HR, Azonov JA, Novitsky YA, et al. Hepatoprotective effects of setarud against carbon tetrachloride-induced liver injury in rats. Indian J Gastroenterol. 2008;27:110-112.
5. [5] Khorram-Khorshid HR, Azonov JA, Novitsky YA, et al. Protective effects of setarud (IMODTM) on development of diet-induced hypercholesterolemia in rabbits. DARU. 2008;16(4):218-222.
6. [6] Gemma C, Mesches MH, Sepesi B, et al. Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar-adrenergic function and increases in proinflammatory cytokines. J Neurosci. 2002;22: 6114-6120.
7. [7] Caplan LR. Treatment of acute stroke: still struggling. JAMA. 2004;292:1883-1885.
8. [8] Durukan A, Tatlisumak T. Acute ischemic stroke: Overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol Biochem Behave. 2007;87:179-197.
9. [9] Sweeney MI, Kalt W, MacKinnon SL, et al. Feeding rats diets enriched in lowbush bluberries for six weeks decreases ischemia-induced brain damage. Nutr Neurosci. 2002;5:427-431.
10. [10] Panahi M, Asadi-Shekaari M, Kalantaripour TP, et al. Aqueous extract of date fruit protects CA1 neurons against oxidative injury: an ultrastructural Study. Curr Topics Nutraceutical Res. 2008;6(3):125-130.
11. [11] Zhao J, Zhao Y, Zheng W, et al. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res. 2008;6:969-985.
12. [12] Masada T, Hua Y, Xi G, et al. Attenuation of ischemic brain edema and cerebrovascular injury after ischemic preconditioning in the rat. J Cerebral Blood Flow Metabol. 2001;21:22-33.
13. [13] Caplan L, Babikian V, Helgason C, et al. Occlusive disease of the middle cerebral artery. Neurology. 1985;35: 975-982.
14. [14] Bolay H, Dalkara T. Mechanisms of motor dysfunction after transient MCA occlusion: persistent transmission failure in cortical synapses is a major determinant. Stroke. 1998;29:1988-1993.
15. [15] Aggarwal A, Gaur V, Kumar A. Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice. Life Sci. 2010;86:928-935.
16. [16] Gupta YK, Briyal S, Sharma U, et al. Effect of endothelin antagonist (TAK-044) on cerebral ischemic volume, oxidative stress markers and neurobehavioral parameters in the middle cerebral artery occlusion model of stroke in rats. Life Sci. 2005;77:15-27.
17. [17] Seyed Jafari SS, Ali Aghaei A, Asadi-Shekaari M, et al. Investigating the effects of adult neural stem cell transplantation by lumbar puncture in transient cerebral ischemia. Neurosci Lett. 2011;495:1-5.
18. [18] Maheshwari A, Badgujar L, Phukan B, et al. Protective effect of Etoricoxib against middle cerebral artery occlusion induced transient focal cerebral ischemia in rats. Eur J Pharmacol. 2011;667(1-3):230-237.
19. [19] Huang Y, McNamara JO. Ischemic stroke: “acidotoxicity” is a perpetrator. Cell. 2004;118:665-666.
20. [20] Biller J, Betsy B, Love B, et al. Ischemic cerebrovascular disease. In: Bradley WG, Darrof RB, Fenichel GM, Jakovic J, eds. Neurology in Clinical Practice. 5th ed. Philadelphia, Pa: Butterworth-Heinemann. 2008.
21. [21] Wang J, Tsirka E. Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage. Brain. 2005;128:1622-1633.
22. [22] Golubouff B, Shenkin HA, Haft H. The effects of Manitol and Urea on cerebral hemodynamics and cerebrospinal fluid pressure. Neurology. 1964;14:891-899.
23. [23] Yousuf S, Atif F, Ahmad M, et al. Selenium plays a modulatory role against cerebral ischemia-induced neuronal damage in rat hippocampus. Brain Res. 2007; 1174:218-225.
24. [24] Atif F, Yousuf S, Agrwal SK. Restraint stress-induced oxidative damage and its amelioration with selenium. Eur J Pharmacol. 2008;600:59-63.
25. [25] Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniotomy in rats. Stroke. 1989;20:84-91.
26. [26] Garcia JH, Wagner S, Liu KF, et al. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats statistical validation. Stroke. 1995;26:627-635.
27. [27] Longo UG, Franceschi F, Ruzzini L, et al. Characteristics at haematoxylin and eosin staining of ruptures of the long head of the biceps tendon. Br J Sports Med. 2009;43: 603-607.
28. [28] Yamashita K, Kataoka Y, Nakashima MN, et al. Neuroprotective effect of TTC-909, an isocarbacyclin methyl ester incorporated in lipid microspheres, on hippocampal delayed neuronal death of stroke-prone spontaneously hypertensive rats. Jpn J Pharmacol. 1996; 71(4):351-355.
29. [29] Kazushige M, Ryuji I, Hirotaka S, et al. Suppression of glucocorticoid secretion induces a behaviorally depressive state in rotarod performance in rat. Pharmacol Biochem Behav. 2008;90:730-734.
30. [30] Petullo D, Masonic K, Lincoln C, et al. Model development and behavioural assessment of focal cerebral ischemia in rats. Life Sci. 1999;64(13):1099-1198.