What is the best approach to tailoring hydrocortisone dose to meet patient needs in 2012?

Clinical Endocrinology

Volumn 78, Issue 5, 2013, Pages 659-664

  Debono, Miguel ^a   Ross, Richard J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONOCORT; CORTICOTROPIN; HYDROCORTISONE; OSTEOCALCIN; UNCLASSIFIED DRUG;

ADRENAL INSUFFICIENCY; AREA UNDER THE CURVE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DEPRESSION; DOSAGE SCHEDULE COMPARISON; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG METABOLISM; DRUG MONITORING; DRUG SALIVA LEVEL; EVENING DOSAGE; FATIGUE; FIRST PASS EFFECT; HORMONE ACTION; HORMONE SENSITIVITY; HORMONE SUBSTITUTION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE URINE LEVEL; INSULIN RESISTANCE; LIVER METABOLISM; MORBIDITY; MORNING DOSAGE; PATIENT COMPLIANCE; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; WEIGHT GAIN;

ADRENAL INSUFFICIENCY; CIRCADIAN RHYTHM; HUMANS; HYDROCORTISONE;

EID: 84876129484     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12117     Document Type: Article

References (33)

1. So, A.Y., Bernal, T.U., Pillsbury, M.L., et al,. (2009) Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proceedings of the National Academy of Sciences, USA, 106, 17582-17587.
2. Van Cauter, E., Polonsky, K.S., &, Scheen, A.J., (1997) Roles of circadian rhythmicity and sleep in human glucose regulation. Endocrine Reviews, 18, 716-738.
3. Spiegel, K., Knutson, K., Leproult, R., et al,. (2005) Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. Journal of Applied Physiology, 99, 2008-2019.
4. Bleicken, B., Hahner, S., Loeffler, M., et al,. (2010) Influence of hydrocortisone dosage scheme on health-related quality of life in patients with adrenal insufficiency. Clinical Endocrinology, 72, 297-304.
5. Elbelt, U., Hahner, S., &, Allolio, B., (2009) Altered insulin requirement in patients with type 1 diabetes and primary adrenal insufficiency receiving standard glucocorticoid replacement therapy. European Journal of Endocrinology, 160, 919-924.
6. Plat, L., Leproult, R., L'Hermite-Baleriaux, M., et al,. (1999) Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning. Journal of Clinical Endocrinology and Metabolism, 84, 3082-3092.
7. Langenheim, J., Ventz, M., Hinz, A., et al,. (2012) Modified-Release Prednisone Decreases Complaints and Fatigue Compared to Standard Prednisolone in Patients With Adrenal Insufficiency. Horm Metab Res.
8. Van Cauter, E., Leproult, R., &, Kupfer, D.J., (1996) Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. Journal of Clinical Endocrinology and Metabolism, 81, 2468-2473.
9. Purnell, J.Q., Brandon, D.D., Isabelle, L.M., et al,. (2004) Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women. Journal of Clinical Endocrinology and Metabolism, 89, 281-287.
10. Debono, M., Ghobadi, C., Rostami-Hodjegan, A., et al,. (2009) Modified-release hydrocortisone to provide circadian cortisol profiles. The Journal of Clinical Endocrinology and Metabolism, 94, 1548-1554.
11. Esteban, N.V., Loughlin, T., Yergey, A.L., et al,. (1991) Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry. The Journal of Clinical Endocrinology and Metabolism, 72, 39-45.
12. Kerrigan, J.R., Veldhuis, J.D., Leyo, S.A., et al,. (1993) Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis. The Journal of Clinical Endocrinology and Metabolism, 76, 1505-1510.
13. Arlt, W., &, Allolio, B., (2003) Adrenal insufficiency. Lancet, 361, 1881-1893.
14. Thomson, A.H., Devers, M.C., Wallace, A.M., et al,. (2007) Variability in hydrocortisone plasma and saliva pharmacokinetics following intravenous and oral administration to patients with adrenal insufficiency. Clinical Endocrinology, 66, 789-796.
15. Simon, N., Castinetti, F., Ouliac, F., et al,. (2010) Pharmacokinetic evidence for suboptimal treatment of adrenal insufficiency with currently available hydrocortisone tablets. Clinical Pharmacokinetics, 49, 455-463.
16. Selmaoui, B., &, Touitou, Y., (2003) Reproducibility of the circadian rhythms of serum cortisol and melatonin in healthy subjects: a study of three different 24-h cycles over six weeks. Life Sciences, 73, 3339-3349.
17. Westerbacka, J., Yki-Jarvinen, H., Vehkavaara, S., et al,. (2003) Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. The Journal of Clinical Endocrinology and Metabolism, 88, 4924-4931.
18. Stewart, P.M., Boulton, A., Kumar, S., et al,. (1999) Cortisol metabolism in human obesity: impaired cortisone->cortisol conversion in subjects with central adiposity. The Journal of Clinical Endocrinology and Metabolism, 84, 1022-1027.
19. Cardinal, J., Pretorius, C.J., &, Ungerer, J.P., (2010) Biological and diurnal variation in glucocorticoid sensitivity detected with a sensitive in vitro dexamethasone suppression of cytokine production assay. The Journal of Clinical Endocrinology and Metabolism, 95, 3657-3663.
20. Huizenga, N.A., Koper, J.W., De Lange, P., et al,. (1998) A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. The Journal of Clinical Endocrinology and Metabolism, 83, 144-151.
21. Bright, G.M., &, Darmaun, D., (1995) Corticosteroid-binding globulin modulates cortisol concentration responses to a given production rate. The Journal of Clinical Endocrinology and Metabolism, 80, 764-769.
22. Henley, D.E., &, Lightman, S.L., (2011) New insights into corticosteroid-binding globulin and glucocorticoid delivery. Neuroscience, 180, 1-8.
23. Cooper, M.S., Blumsohn, A., Goddard, P.E., et al,. (2003) 11beta-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone. The Journal of Clinical Endocrinology and Metabolism, 88, 3874-3877.
24. Mah, P.M., Jenkins, R.C., Rostami-Hodjegan, A., et al,. (2004) Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency. Clinical Endocrinology, 61, 367-375.
25. Rodriguez-Arnao, J., Perry, L., Besser, G.M., et al,. (1996) Growth hormone treatment in hypopituitary GH deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy. Clinical Endocrinology, 45, 33-37.
26. Howlett, T.A., (1997) An assessment of optimal hydrocortisone replacement therapy. Clinical Endocrinology, 46, 263-268.
27. Peacey, S.R., Guo, C.Y., Robinson, A.M., et al,. (1997) Glucocorticoid replacement therapy: are patients over treated and does it matter? Clinical Endocrinology, 46, 255-261.
28. Arlt, W., Rosenthal, C., Hahner, S., et al,. (2006) Quality of glucocorticoid replacement in adrenal insufficiency: clinical assessment vs. timed serum cortisol measurements. Clinical Endocrinology, 64, 384-389.
29. Johannsson, G., Nilsson, A.G., Bergthorsdottir, R., et al,. (2012) Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation. The Journal of Clinical Endocrinology and Metabolism, 97, 473-481.
30. Johannsson, G., Bergthorsdottir, R., Nilsson, A.G., et al,. (2009) Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study. European Journal of Endocrinology, 161, 119-130.
31. Merza, Z., Rostami-Hodjegan, A., Memmott, A., et al,. (2006) Circadian hydrocortisone infusions in patients with adrenal insufficiency and congenital adrenal hyperplasia. Clinical Endocrinology, 65, 45-50.
32. Lovas, K., &, Husebye, E.S., (2007) Continuous subcutaneous hydrocortisone infusion in Addison's disease. European Journal of Endocrinology, 157, 109-112.
33. Newell-Price, J., Whiteman, M., Rostami-Hodjegan, A., et al,. (2008) Modified-release hydrocortisone for circadian therapy: a proof-of-principle study in dexamethasone-suppressed normal volunteers. Clinical Endocrinology, 68, 130-135.