Glucocorticoid replacement therapy: Are patients over treated end does it matter?

Clinical Endocrinology

Volumn 46, Issue 3, 1997, Pages 255-261

  Peacey, Steven R ^a,b   Guo, Chun Yuan ^a   Robinson, Anthony M ^a   Price, Alun ^a   Giles, Martin A ^a   Eastell, Richard ^a   Weetman, Anthony P ^a  

^a NORTHERN GENERAL HOSPITAL   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGIPRESSIN; COLLAGEN DERIVATIVE; CORTISONE ACETATE; ESTROGEN; FLUDROCORTISONE; GLUCOCORTICOID; HYDROCORTISONE; OSTEOCALCIN; TESTOSTERONE; THYROXINE;

ADDISON DISEASE; AGED; ARTICLE; BLOOD ANALYSIS; BONE MINERAL; BONE TURNOVER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE URINE LEVEL; HYPOPITUITARISM; MALE; OSTEOLYSIS; PRIORITY JOURNAL; URINALYSIS;

EID: 0030956296     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1997.780907.x     Document Type: Article

References (29)

1. Adinoff, A.D. & Hollister, J.R. (1983) Steroid induced fractures and hone loss in patients with asthma. New England Journal of Medicine, 309, 265-268.
2. Al-Shoumer, K.A.S., Beshyah, S.A., Niththyananthan, R. & Johnston, D.G. (1995) Effect of glucocorticoid replacement therapy on glucose tolerance and intermediary metabolites in hypopituitary adults. Clinical Endocrinology, 42, 85-90.
3. Besser, G.M. & Jeffcoate, W.J. (1976) Adrenal diseases. British Medical Journal, 1, 448-451.
4. Bright, G.M. & Darmaun, D. (1995) Corticosteroid-binding globulin modulates cortisol concentration responses to a given production rate. Journal of Clinical Endocrinology and Metabolism, 80, 764-769.
5. Burke, C.W. & Beardwell, C.G. (1973) Cushings's syndrome. Quarterly Journal of Medicine, 42, 175-204.
6. Canalis, E. & Avioli, L. (1992) Effects of deflazacorton aspects of bone formation in cultures of intact calvariae and osteoblast enriched cells. Journal of Bone and Mineral Research, 7, 1085-1092.
7. Contreras, L.N., Satoshi, H. & Tyrell, J.B. (1986) Urinary cortisol in the assessment of pituitary - adrenal function: utility of 24 hour and spot determinations. Journal of Clinical Endocrinology and Metabolism, 62, 965-969.
8. Cushing, H. (1932) The basophil adenomas of the pituitary bodyand their clinical manifestations (pituitary basophilism). Bulletin of Johns Hopkins Hospital, 1, 137-192.
9. Dunne, F.P., Elliot, P. Gammage, M.D., Stallard, T., Ryan, T., Sheppard, M.C. & Stewart, P.M. (1995) Cardiovascular function and glucocorticoid replacement in patients with hypopituitarism. Clinical Endocrinology, 43, 623-629.
10. Esteban, N.V., Loughlin, T., Yergey, A.L., Zawadzki, J.K., Boothe, J.D., Winterer, J.C. & Loriaux, D.L. (1991) Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry. Journal of Clinical Endocrinology and Metabolism, 72, 39-45.
11. Feek, C.M., Ratcliffe, J.G., Seth, J., Gray, C.E., Toft, A.D. & Irvine, W.J. (1981) Patterns of plasma cortisol and ACTH concentrations in patients with Addison's disease treated with conventional cortisol replacement. Clinical Endocrinology, 14, 451-458.
12. Gennari, C., Imbimbo, B., Montagnani, M., Bernini, M., Nardi, P. & Avioli, L.V. (1984) Effects of prednisone and deflazacort on mineral metabolism and parathyroid hormone activity in humans. Calcified Tissue International, 36, 245-252.
13. Godschalk, M.F. & Downs, R.W. (1988) Effect of short-term glucocorticoids on serum osteocalcin in healthy young men. Journal of Bone and Mineral Research, 3, 113-115.
14. Groves, R.W., Toms, G.C., Houghton, B.J. & Monson, J.P. (1988) Corticosteroid replacement therapy: twice or thrice daily? Journal of The Royal Society of Medicine, 81, 514-516.
15. Hellman, L., Nakada, F., Curti, J., Weilzman, E.D., Kream, J., Roffwarg, H., Ellman, S., Fukushima, D.K. & Gallagher, T.F. (1970) Cortisol is secreted episodically by normal man. Journal of Clinical Endocrinology, 30, 411-422.
16. Hermus, A.D., Smals, A.G., Swinkels, L.M., Huysmans, D.A., Pieters, G.F., Sweep, C.F., Corstens, F.H. & Kloppenborg, P.W. (1995) Bone mineral density and bone turnover before and after surgical cure of Cushings's syndrome. Journal of Clinical Endocrinology and Metabolism, 80, 2859-2865.
17. Holmes, S.J., Economou, G., Whitehouse, R.W., Adams, J.E. & Shalet, S.M. (1994) Reduced bone mineral density in patients with adult onset growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism, 78, 669-674.
18. Kotowicz, M.A., Hall, S., Hunder, G.G., Cedel, S.L., Mann, K.G. & Riggs, B.L. (1990) Relationship of glucocorticoid dosage to serum bone Gla-protein concentration in patients with rheumatologic disorders. Arthritis and Rheumatism, 33, 1487-1492.
19. Larsen, K. (1972) Creatinine assay by a reaction kinetic principle. Acta Clinical Chemistry, 41, 209.
20. Martinus, J.A. & Klein, L.D. (1985) A flourescence polarisation immunoassay (FPIA) for the quantification of cortisol. Clinical Chemistry, 31, 956.
21. Osikowicz, G. & Irmen, J. (1986) A fluorescence polarisation immunoassay for the quantitation of urinary free cortisol. Clinical Chemistry, 32, 956.
22. Peacey, S.R., Pope, R.M., Naik, K.S., Hardern, R.D., Page, M.D. & Belchetz, P.E. (1993) Corticosteroid therapy and intercurrent illness: the need for continuing patient education. Postgraduate Medical Journal, 69, 282-284.
23. Salassa, R.M., Bennett, W.A., Keating, F.R. & Sprague, R.G. (1953) Postoperative adrenal cortical insufficiency: occurence in patients previously treated with cortisone. Journal of the American Medical Association, 152, 1509-1515.
24. Sampson, P.A., Brooke, B.N. & Winstone, N.E. (1961) Biochemical confirmation of collapse due to adrenal failure. Lancet, i, 1377.
25. Toogood, A.A., Beardwell, C.G. & Shalet, S.M. (1994) The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism. Clinical Endocrinology, 41, 511-516.
26. Trainer, P.J., Eastment, C., Grossman, A.B., Wheeler, M.J., Perry, L. & Besser, G.M. (1993a) The relationship between cortisol production rate and serum cortisol estimation in patients on medical therapy for Cushing's syndrome. Clinical Endocrinology, 39, 441-443.
27. Trainer, P.J., McHardy, K.C., Harvey, R.D. & Reid, I.W. (1993b) Urinary free cortisol in the assesment of hydrocortisone replacement therapy. Hormone and Metabolic Research, 24, 117-120.
28. Weitzman, E.D., Fukushima, D., Nogeire, C., Roffwarg, H., Gallagher, T.F. & Hellman, L. (1971) Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. Journal of Clinical Endocrinology, 33, 14-22.
29. Zelissen, P.M.J., Croughs, R.J.M., van Rijk, P.P. & Raymakers, J.A. (1994) Effect of glucocorticoid replacement therapy on bone mineral density in patients with Addison disease. Annals of Internal medicine, 120, 207-210.