Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex

Nucleic Acids Research

Volumn 33, Issue 20, 2005, Pages 6555-6565

  Han, Chunyu ^a,b   Liu, Hao ^c   Liu, Jin ^a,b   Yin, Kang ^d   Xie, Yi ^d   Shen, Xiao ^a,b   Wang, Yong ^a,b   Yuan, Jiangang ^a,b   Qiang, Boqing ^a,b   Liu, Yong Jian ^c   Peng, Xiaozhong ^a,b  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; BRAIN PROTEIN; DNA BINDING PROTEIN; LIM PROTEIN; PROTEIN BEX1; PROTEIN BEX2; PROTEIN BHLH; PROTEIN LDB1; PROTEIN LMO2; PROTEIN NSCL2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; DNA BINDING; E BOX ELEMENT; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE; CELL NUCLEUS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; METALLOPROTEINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; SEQUENCE ALIGNMENT; TRANS-ACTIVATION (GENETICS); TWO-HYBRID SYSTEM TECHNIQUES;

ANIMALIA; MAMMALIA;

EID: 29144468923     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki964     Document Type: Article

References (39)

1. Pan,M., Yuan,J., Chen,B., Zhou,Y. and Qiang,B. (1997) [Differential display analysis of human fetal brain mRNAs and isolation of brain-specific novel ESTs]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 19, 93-99.
2. Brown,A.L. and Kay,G.F. (1999) Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome. Hum. Mol. Genet., 8, 611-619.
3. Rapp,G., Freudenstein,J., Klaudiny,J., Mucha,J., Wempe,F., Zimmer,M. and Scheit,K.H. (1990) Characterization of three abundant mRNAs from human ovarian granulosa cells. DNA Cell Biol., 9, 479-485.
4. Faria,T.N., LaRosa,G.J., Wilen,E., Liao,J. and Gudas,L.J. (1998) Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest. Mol. Cell. Endocrinol., 143, 155-166.
5. Mukai,J., Hachiya,T., Shoji-Hoshino,S., Kimura,M.T., Nadano,D., Suvanto,P., Hanaoka,T., Li,Y., Irie,S., Greene,L.A. et al. (2000) NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J. Biol. Chem., 275, 17566-17570.
6. Koo,J.H., Saraswati,M. and Margolis,F.L. (2005) Immunolocalization of Bex protein in the mouse brain and olfactory system. J. Comp. Neurol., 487, 1-14.
7. Mukai,J., Suvant,P. and Sato,T.A. (2003) Nerve growth factor-dependent regulation of NADE-induced apoptosis. Vitam. Horm., 66, 385-402.
8. Alvarez,E., Zhou,W., Witta,S.E. and Freed,C.R. (2005) Characterization of the Bex gene family in humans, mice, and rats. Gene, 357, 18-28.
9. Williams,J.W., Hawes,S.M., Patel,B. and Latham,K.E. (2002) Trophectoderm-specific expression of the X-linked Bex1/Rex3 gene in preimplantation stage mouse embryos. Mol. Reprod. Dev., 61, 281-287.
10. Lee,N.H., Weinstock,K.G., Kirkness,E.F., Earle-Hughes,J.A., Fuldner,R.A., Marmaros,S., Glodek,A., Gocayne,J.D., Adams,M.D., Kerlavage,A.R. et al. (1995) Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment. Proc. Natl Acad. Sci. USA, 92, 8303-8307.
11. Behrens,M., Margolis,J.W. and Margolis,F.L. (2003) Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners. J. Neurochem., 86, 1289-1296.
12. Koo,J.H., Gill,S., Pannell,L.K., Menco,B.P., Margolis,J.W. and Margolis,F.L. (2004) The interaction of Bex and OMP reveals a dimer of OMP with a short half-life. J. Neurochem., 90, 102-116.
13. Yang,Q.S., Xia,F., Gu,S.H., Yuan,H.L., Chen,J.Z., Ying,K., Xie,Y. and Mao,Y.M. (2002) Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. Biochem. Genet., 40, 1-12.
14. McGuire,E.A., Hockett,R.D., Pollock,K.M., Bartholdi,M.F., O'Brien,S.J. and Korsmeyer,S.J. (1989) The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol. Cell. Biol., 9, 2124-2132.
15. Boehm,T., Foroni,L., Kaneko,Y., Perutz,M.F. and Rabbitts,T.H. (1991) The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc. Natl Acad. Sci. USA, 88, 4367-4371.
16. Zeng,C., Justice,N.J., Abdelilah,S., Chan,Y.M., Jan,L.Y. and Jan,Y.N. (1998) The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development. Proc. Natl Acad. Sci. USA, 95, 10637-10642.
17. Tsai,L.T., Bainton,R.J., Blau,J. and Heberlein,U. (2004) Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol., 2, e408.
18. Leuba,G., Vernay,A., Vu,D., Walzer,C., Belloir,B., Kraftsik,R., Bouras,C. and Savioz,A. (2004) Differential expression of LMO4 protein in Alzheimer's disease. Neuropathol. Appl. Neurobiol., 30, 57-69.
19. Vu,D., Marin,P., Walzer,C., Cathieni,M.M., Bianchi,E.N., Saidji,F., Leuba,G., Bouras,C. and Savioz,A. (2003)Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells. Brain Res. Mol. Brain Res., 115, 93-103.
20. Hermanson,O., Sugihara,T.M. and Andersen,B. (1999) Expression of LMO-4 in the central nervous system of the embryonic and adult mouse. Cell Mol. Biol. (Noisy-le-grand), 45, 677-686.
21. Boehm,T., Spillantini,M.G., Sofroniew,M.V., Surani,M.A. and Rabbitts,T.H. (1991) Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. Oncogene, 6, 695-703.
22. Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P., Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and Rabbitts,T.H. (1992) The rhombotin gene family encode related LEVI-domain proteins whose differing expression suggests multiple roles in mouse development. J. Mol. Biol., 226, 747-761.
23. Bulchand,S., Subramanian,L. and Tole,S. (2003) Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex. Dev. Dyn., 226, 460-469.
24. Hinks,G.L., Shah,B., French,S.J., Campos,L.S., Staley,K., Hughes,J. and Sofroniew,M.V. (1997) Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity. J. Neurosci., 17, 5549-5559.
25. Manetopoulos,C., Hansson,A., Karlsson,J., Jonsson,J.I. and Axelson,H. (2003) The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. Biochem. Biophys. Res. Commun., 307, 891-899.
26. Wadman,J.A., Osada,H., Grutz,G.G., Agulnick,A.D., Westphal,H., Forster,A. and Rabbitts,T.H. (1997) The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J., 16, 3145-3157.
27. Retaux,S. and Bachy,I. (2002) A short history of LIM domains (1993-2002): from protein interaction to degradation. Mol. Neurobiol., 26, 269-281.
28. Zhou,H.J., Wong,C.M., Chen,J.H., Qiang,B.Q., Yuan,J.G. and Jin,D.Y. (2001) Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. J. Biol. Chem., 276, 28933-28938.
29. Grutz,G.G., Bucher,K., Lavenir,I., Larson,T., Larson,R. and Rabbitts,T.H. (1998) The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. EMBO J., 17, 4594-4605.
30. Bao,J., Talmage,D.A., Role,L.W. and Gautier,J. (2000) Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. Development, 127, 425-435.
31. Ono,Y., Fukuhara,N. and Yoshie,O. (1997) Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. J. Biol. Chem., 272, 4576-4581.
32. Vitelli,L., Condorelli,G., Lulli,V., Hoang,T., Luchetti,L., Croce,C.M. and Peschle,C. (2000) A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts. Mol. Cell. Biol., 20, 5330-5342.
33. Mao,S., Neale,G.A. and Goorha,R.M. (1997) T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. Oncogene, 14, 1531-1539.
34. Lipkowitz,S., Gobel,V., Varterasian,M.L., Nakahara,K., Tchorz,K. and Kirsch,I.R. (1992) A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system. J. Biol. Chem., 267, 21065-21071.
35. Brown,L., Espinosa,R.III, Le Beau,M.M., Siciliano,M.J. and Baer,R. (1992) HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. Proc. Natl Acad. Sci. USA, 89, 8492-8496.
36. Matthews,J.M. and Visvader,J.E. (2003) LIM-domain-bindingprotein 1: a multifunctional cofactor that interacts with diverse proteins. EMBO Rep., 4, 1132-1137.
37. Wadman,I., Li,J., Bash,R.O., Forster,A., Osada,H., Rabbitts,T.H. and Baer,R. (1994) Specific in vivo association between the bHLH and LEVI proteins implicated in human T cell leukemia. EMBO J., 13, 4831-4839.
38. Begley,C.G., Lipkowitz,S., Gobel,V., Mahon,K.A., Bertness,V., Green,A.R., Gough,N.M. and Kirsch,J.R. (1992) Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system. Proc. Natl Acad. Sci. USA, 89, 38-42.
39. Gobel,V., Lipkowitz,S., Kozak,C.A. and Kirsch,J.R. (1992) NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis. Cell Growth Differ., 3, 143-148.