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Volumn 4, Issue 2, 2013, Pages

Pluripotent stem cells for Parkinson's disease: Progress and challenges

Author keywords

[No Author keywords available]

Indexed keywords

AADC PROTEIN; CELL PROTEIN; DOPAMINE; DOPAMINE TRANSPORTER; FIBROBLAST GROWTH FACTOR 8; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HEPATOCYTE NUCLEAR FACTOR 3BETA; NERVE CELL ADHESION MOLECULE; NUCLEAR RECEPTOR RELATED FACTOR 1; PROTEIN GIRK2; PROTEIN LMX1A; PROTEIN LMX1B; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR PITX3; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER;

EID: 84876102476     PISSN: None     EISSN: 17576512     Source Type: Journal    
DOI: 10.1186/scrt173     Document Type: Review
Times cited : (13)

References (53)
  • 1
    • 0025023096 scopus 로고
    • The nigrostriatal system in Parkinson's disease
    • 1978514
    • The nigrostriatal system in Parkinson's disease. Graybiel AM, Hirsch EC, Agid Y, Adv Neurol 1990 53 17 29 1978514
    • (1990) Adv Neurol , vol.53 , pp. 17-29
    • Graybiel, A.M.1    Hirsch, E.C.2    Agid, Y.3
  • 2
    • 65349181409 scopus 로고    scopus 로고
    • Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease
    • 10.1016/j.tips.2009.03.001 19362379
    • Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease. Lindvall O, Kokaia Z, Trends Pharmacol Sci 2009 30 260 267 10.1016/j.tips.2009.03.001 19362379
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 260-267
    • Lindvall, O.1    Kokaia, Z.2
  • 3
    • 78649534741 scopus 로고    scopus 로고
    • Dyskinesias after neural transplantation in Parkinson's disease: What do we know and what is next?
    • 10.1186/1741-7015-8-80 21126348
    • Dyskinesias after neural transplantation in Parkinson's disease: what do we know and what is next? Politis M, BMC Med 2010 8 80 10.1186/1741-7015-8-80 21126348
    • (2010) BMC Med , vol.8 , pp. 80
    • Politis, M.1
  • 4
    • 0018778418 scopus 로고
    • Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system
    • Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Perlow MJ, Freed WJ, Hoffer BJ, Seiger A, Olson L, Wyatt RJ, Science 1979 204 643 647 10.1126/science.571147 571147 (Pubitemid 9221523)
    • (1979) Science , vol.204 , Issue.4393 , pp. 643-647
    • Perlow, M.J.1    Freed, W.J.2    Hoffer, B.J.3
  • 5
    • 0018825573 scopus 로고
    • Reinnervation of the denervated striatum by substantia nigra transplants: Functional consequences as revealed by pharmacological and sensorimotor testing
    • DOI 10.1016/0006-8993(80)90692-7
    • Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing. Björklund A, Dunnett SB, Stenevi U, Lewis ME, Iversen SD, Brain Res 1980 199 307 333 10.1016/0006-8993(80)90692-7 7417786 (Pubitemid 10055937)
    • (1980) Brain Research , vol.199 , Issue.2 , pp. 307-333
    • Bjorklund, A.1    Dunnett, S.B.2    Stenevi, U.3
  • 6
    • 0019124289 scopus 로고
    • Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: Long-term behavioral, biochemical, and histochemical studies
    • DOI 10.1002/ana.410080508
    • Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: long-term behavioral, biochemical, and histochemical studies. Freed WJ, Perlow MJ, Karoum F, Seiger A, Olson L, Hoffer BJ, Wyatt RJ, Ann Neurol 1980 8 510 519 10.1002/ana.410080508 7436393 (Pubitemid 11209236)
    • (1980) Annals of Neurology , vol.8 , Issue.5 , pp. 510-519
    • Freed, W.J.1    Perlow, M.J.2    Karoum, F.3
  • 7
    • 33644684826 scopus 로고    scopus 로고
    • Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats
    • 10.1038/1105 10195162
    • Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Studer L, Tabar V, McKay RD, Nat Neurosci 1998 1 290 295 10.1038/1105 10195162
    • (1998) Nat Neurosci , vol.1 , pp. 290-295
    • Studer, L.1    Tabar, V.2    McKay, R.D.3
  • 12
    • 0028911848 scopus 로고
    • Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease
    • 10.1056/NEJM199504273321702 7700284
    • Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. Kordower JH, Freeman TB, Snow BJ, Vingerhoets FJG, Mufson EJ, Sanberg PR, Hauser RA, Smith DA, Nauert GM, Perl DP, Olanow CW, N Engl J Med 1995 332 1118 1124 10.1056/NEJM199504273321702 7700284
    • (1995) N Engl J Med , vol.332 , pp. 1118-1124
    • Kordower, J.H.1    Freeman, T.B.2    Snow, B.J.3    Vingerhoets, F.J.G.4    Mufson, E.J.5    Sanberg, P.R.6    Hauser, R.A.7    Smith, D.A.8    Nauert, G.M.9    Perl, D.P.10    Olanow, C.W.11
  • 13
    • 75149140104 scopus 로고    scopus 로고
    • Dopamine cell implantation in Parkinson's disease: Long-term clinical and (18)F-FDOPA PET outcomes
    • 10.2967/jnumed.109.066811 20008998
    • Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomes. Ma Y, Tang C, Chaly T, Greene P, Breeze R, Fahn S, Freed C, Dhawan V, Eidelberg D, J Nucl Med 2010 51 7 15 10.2967/jnumed.109. 066811 20008998
    • (2010) J Nucl Med , vol.51 , pp. 7-15
    • Ma, Y.1    Tang, C.2    Chaly, T.3    Greene, P.4    Breeze, R.5    Fahn, S.6    Freed, C.7    Dhawan, V.8    Eidelberg, D.9
  • 15
    • 58349096894 scopus 로고    scopus 로고
    • Future of cell and gene therapies for Parkinson's disease
    • 19127583
    • Future of cell and gene therapies for Parkinson's disease. Isacson O, Kordower JH, Ann Neurol 2008 64 Suppl 2 122 138 19127583
    • (2008) Ann Neurol , vol.64 , Issue.SUPPL. 2 , pp. 19122-19138
    • Isacson, O.1    Kordower, J.H.2
  • 17
    • 43249090937 scopus 로고    scopus 로고
    • Assessing fetal nerve cell grafts in Parkinson's disease
    • DOI 10.1038/nm0508-483, PII NM0508483
    • Assessing fetal nerve cell grafts in Parkinson's disease. Braak H, Del Tredici K, Nat Med 2008 14 483 485 10.1038/nm0508-483 18463652 (Pubitemid 351655198)
    • (2008) Nature Medicine , vol.14 , Issue.5 , pp. 483-485
    • Braak, H.1    Del Tredici, K.2
  • 18
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • Embryonic stem cell lines derived from human blastocysts. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM, Science 1998 282 1145 1147 9804556 (Pubitemid 28516247)
    • (1998) Science , vol.282 , Issue.5391 , pp. 1145-1147
    • Thomson, J.A.1
  • 23
    • 10444252732 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in parkinsonian rats
    • DOI 10.1634/stemcells.2004-0094
    • Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Ben-Hur T, Idelson M, Khaner H, Pera M, Reinhartz E, Itzik A, Reubinoff BE, Stem Cells 2004 22 1246 1255 10.1634/stemcells.2004-0094 15579643 (Pubitemid 39636402)
    • (2004) Stem Cells , vol.22 , Issue.7 , pp. 1246-1255
    • Ben-Hur, T.1    Idelson, M.2    Khaner, H.3    Pera, M.4    Reinhartz, E.5    Itzik, A.6    Reubinoff, B.E.7
  • 24
    • 38349004470 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats
    • 10.1634/stemcells.2007-0494 17951220
    • Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Yang D, Zhang ZJ, Oldenburg M, Ayala M, Zhang SC, Stem Cells 2008 26 55 63 10.1634/stemcells.2007-0494 17951220
    • (2008) Stem Cells , vol.26 , pp. 55-63
    • Yang, D.1    Zhang, Z.J.2    Oldenburg, M.3    Ayala, M.4    Zhang, S.C.5
  • 25
    • 56249145671 scopus 로고    scopus 로고
    • Noggin enhances dopamine neuron production from human embryonic stem cells and improves behavioral outcome after transplantation into Parkinsonian rats
    • 10.1634/stemcells.2008-0085 18772316
    • Noggin enhances dopamine neuron production from human embryonic stem cells and improves behavioral outcome after transplantation into Parkinsonian rats. Chiba S, Lee YM, Zhou W, Freed CR, Stem Cells 2008 26 2810 2820 10.1634/stemcells.2008-0085 18772316
    • (2008) Stem Cells , vol.26 , pp. 2810-2820
    • Chiba, S.1    Lee, Y.M.2    Zhou, W.3    Freed, C.R.4
  • 26
    • 67650562117 scopus 로고    scopus 로고
    • Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them
    • 10.1371/journal.pone.0006233 19597550
    • Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them. Swistowski A, Peng J, Han Y, Swistowska AM, Rao MS, Zeng X, PLoS One 2009 4 6233 10.1371/journal.pone.0006233 19597550
    • (2009) PLoS One , vol.4 , pp. 56233
    • Swistowski, A.1    Peng, J.2    Han, Y.3    Swistowska, A.M.4    Rao, M.S.5    Zeng, X.6
  • 27
    • 33750706917 scopus 로고    scopus 로고
    • Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
    • DOI 10.1038/nm1495, PII NM1495
    • Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA, Nat Med 2006 12 1259 1268 10.1038/nm1495 17057709 (Pubitemid 44706928)
    • (2006) Nature Medicine , vol.12 , Issue.11 , pp. 1259-1268
    • Roy, N.S.1    Cleren, C.2    Singh, S.K.3    Yang, L.4    Beal, M.F.5    Goldman, S.A.6
  • 29
    • 11144354441 scopus 로고    scopus 로고
    • Generation of dopaminergic neurons in vitro from human embryonic stem cells treated with neurotrophic factors
    • DOI 10.1016/j.neulet.2004.01.073, PII S0304394004001429
    • Generation of dopaminergic neurons in vitro from human embryonic stem cells treated with neurotrophic factors. Park S, Lee KS, Lee YJ, Shin HA, Cho HY, Wang KC, Kim YS, Lee HT, Chung KS, Kim EY, Lim J, Neurosci Lett 2004 359 99 103 10.1016/j.neulet.2004.01.073 15050721 (Pubitemid 38446648)
    • (2004) Neuroscience Letters , vol.359 , Issue.1-2 , pp. 99-103
    • Park, S.1    Lee, K.S.2    Lee, Y.J.3    Shin, H.A.4    Cho, H.Y.5    Wang, K.C.6    Kim, Y.S.7    Lee, H.T.8    Chung, K.S.9    Kim, E.Y.10    Lim, J.11
  • 30
    • 4444308824 scopus 로고    scopus 로고
    • Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF
    • Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF. Buytaert-Hoefen KA, Alvarez E, Freed CR, Stem Cells 2004 22 669 674 10.1634/stemcells.22-5-669 15342931 (Pubitemid 39166925)
    • (2004) Stem Cells , vol.22 , Issue.5 , pp. 669-674
    • Buytaert-Hoefen, K.A.1    Alvarez, E.2    Freed, C.R.3
  • 32
    • 20344368813 scopus 로고    scopus 로고
    • Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells
    • DOI 10.1634/stemcells.2004-0365
    • Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Yan Y, Yang D, Zarnowska ED, Du Z, Werbel B, Valliere C, Pearce RA, Thomson JA, Zhang SC, Stem Cells 2005 23 781 790 10.1634/stemcells. 2004-0365 15917474 (Pubitemid 40791793)
    • (2005) Stem Cells , vol.23 , Issue.6 , pp. 781-790
    • Yan, Y.1    Yang, D.2    Zarnowska, E.D.3    Du, Z.4    Werbel, B.5    Valliere, C.6    Pearce, R.A.7    Thomson, J.A.8    Zhang, S.-C.9
  • 33
    • 75749103824 scopus 로고    scopus 로고
    • Stage-specific role for shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells
    • 10.1089/scd.2009.0107 19788370
    • Stage-specific role for shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells. Swistowska AM, da Cruz AB, Han Y, Swistowski A, Liu Y, Shin S, Zhan M, Rao MS, Zeng X, Stem Cells Dev 2010 19 71 82 10.1089/scd.2009.0107 19788370
    • (2010) Stem Cells Dev , vol.19 , pp. 71-82
    • Swistowska, A.M.1    Da Cruz, A.B.2    Han, Y.3    Swistowski, A.4    Liu, Y.5    Shin, S.6    Zhan, M.7    Rao, M.S.8    Zeng, X.9
  • 34
    • 0034044317 scopus 로고    scopus 로고
    • Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
    • DOI 10.1038/76536
    • Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Lee SH, Lumelsky N, Studer L, Auerbach JM, McKay RD, Nat Biotechnol 2000 18 675 679 10.1038/76536 10835609 (Pubitemid 30415305)
    • (2000) Nature Biotechnology , vol.18 , Issue.6 , pp. 675-679
    • Lee, S.-H.1    Lumelsky, N.2    Studer, L.3    Auerbach, J.M.4    McKay, R.D.5
  • 36
    • 0035200623 scopus 로고    scopus 로고
    • In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    • DOI 10.1038/nbt1201-1129
    • In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Zhang SC, Wernig M, Duncan ID, Brüstle O, Thomson JA, Nat Biotechnol 2001 19 1129 1133 10.1038/nbt1201-1129 11731781 (Pubitemid 33115698)
    • (2001) Nature Biotechnology , vol.19 , Issue.12 , pp. 1129-1133
    • Zhang, S.-C.1    Wernig, M.2    Duncan, I.D.3    Brustle, O.4    Thomson, J.A.5
  • 37
    • 0033638174 scopus 로고    scopus 로고
    • Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity
    • 10.1016/S0896-6273(00)00083-0 11086981
    • Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, Nakanishi S, Nishikawa SI, Sasai Y, Neuron 2000 28 31 40 10.1016/S0896-6273(00)00083-0 11086981
    • (2000) Neuron , vol.28 , pp. 31-40
    • Kawasaki, H.1    Mizuseki, K.2    Nishikawa, S.3    Kaneko, S.4    Kuwana, Y.5    Nakanishi, S.6    Nishikawa, S.I.7    Sasai, Y.8
  • 39
    • 68949130137 scopus 로고    scopus 로고
    • A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells
    • 10.1371/journal.pone.0006606 19672298
    • A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells. Vazin T, Becker KG, Chen J, Spivak CE, Lupica CR, Zhang Y, Worden L, Freed WJ, PLoS One 2009 4 6606 10.1371/journal.pone.0006606 19672298
    • (2009) PLoS One , vol.4 , pp. 56606
    • Vazin, T.1    Becker, K.G.2    Chen, J.3    Spivak, C.E.4    Lupica, C.R.5    Zhang, Y.6    Worden, L.7    Freed, W.J.8
  • 40
    • 77949892562 scopus 로고    scopus 로고
    • Efficient derivation of functional floor plate tissue from human embryonic stem cells
    • 10.1016/j.stem.2010.03.001 20362538
    • Efficient derivation of functional floor plate tissue from human embryonic stem cells. Fasano CA, Chambers SM, Lee G, Tomishima MJ, Studer L, Cell Stem Cell 2010 6 336 347 10.1016/j.stem.2010.03.001 20362538
    • (2010) Cell Stem Cell , vol.6 , pp. 336-347
    • Fasano, C.A.1    Chambers, S.M.2    Lee, G.3    Tomishima, M.J.4    Studer, L.5
  • 41
    • 77956613688 scopus 로고    scopus 로고
    • Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid
    • 10.1016/j.mcn.2010.06.017 20603216
    • Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Cooper O, Hargus G, Deleidi M, Blak A, Osborn T, Marlow E, Lee K, Levy A, Perez-Torres E, Yow A, Isacson O, Mol Cell Neurosci 2010 45 258 266 10.1016/j.mcn.2010.06.017 20603216
    • (2010) Mol Cell Neurosci , vol.45 , pp. 258-266
    • Cooper, O.1    Hargus, G.2    Deleidi, M.3    Blak, A.4    Osborn, T.5    Marlow, E.6    Lee, K.7    Levy, A.8    Perez-Torres, E.9    Yow, A.10    Isacson, O.11
  • 42
    • 77954932494 scopus 로고    scopus 로고
    • Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats
    • 10.1089/scd.2009.0319 19824823
    • Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats. Cai J, Yang M, Poremsky E, Kidd S, Schneider JS, Iacovitti L, Stem Cells Dev 2010 19 1017 1023 10.1089/scd.2009.0319 19824823
    • (2010) Stem Cells Dev , vol.19 , pp. 1017-1023
    • Cai, J.1    Yang, M.2    Poremsky, E.3    Kidd, S.4    Schneider, J.S.5    Iacovitti, L.6
  • 45
    • 34247590317 scopus 로고    scopus 로고
    • Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations
    • DOI 10.1634/stemcells.2006-0540
    • Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations. Hedlund E, Pruszak J, Ferree A, Viñuela A, Hong S, Isacson O, Kim KS, Stem Cells 2007 25 1126 1135 10.1634/stemcells.2006-0540 17234989 (Pubitemid 46684872)
    • (2007) Stem Cells , vol.25 , Issue.5 , pp. 1126-1135
    • Hedlund, E.1    Pruszak, J.2    Ferree, A.3    Vinuela, A.4    Hong, S.5    Isacson, O.6    Kim, K.-S.7
  • 46
    • 0032535637 scopus 로고    scopus 로고
    • Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver
    • DOI 10.1006/dbio.1998.9076
    • Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver. Schein JC, Hunter DD, Roffler-Tarlov S, Dev Biol 1998 204 432 450 10.1006/dbio.1998.9076 9882481 (Pubitemid 29024490)
    • (1998) Developmental Biology , vol.204 , Issue.2 , pp. 432-450
    • Schein, J.C.1    Hunter, D.D.2    Roffler-Tarlov, S.3
  • 48
    • 79959992876 scopus 로고    scopus 로고
    • Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet Beta cells
    • 10.1016/j.stem.2011.06.007 21726830
    • Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet Beta cells. Bar-Nur O, Russ HA, Efrat S, Benvenisty N, Cell Stem Cell 2011 9 17 23 10.1016/j.stem.2011.06.007 21726830
    • (2011) Cell Stem Cell , vol.9 , pp. 17-23
    • Bar-Nur, O.1    Russ, H.A.2    Efrat, S.3    Benvenisty, N.4
  • 49
    • 78149302874 scopus 로고    scopus 로고
    • Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions
    • 10.1002/stem.499 20715183
    • Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions. Swistowski A, Peng J, Liu Q, Mali P, Rao MS, Cheng L, Zeng X, Stem Cells 2010 28 1893 1904 10.1002/stem.499 20715183
    • (2010) Stem Cells , vol.28 , pp. 1893-1904
    • Swistowski, A.1    Peng, J.2    Liu, Q.3    Mali, P.4    Rao, M.S.5    Cheng, L.6    Zeng, X.7
  • 50
    • 80054757204 scopus 로고    scopus 로고
    • Directed differentiation of dopamine neurons from human pluripotent stem cells
    • 10.1007/978-1-61779-201-4-30 21822892
    • Directed differentiation of dopamine neurons from human pluripotent stem cells. Ma L, Liu Y, Zhang SC, Methods Mol Biol 2011 767 411 418 10.1007/978-1-61779-201-4-30 21822892
    • (2011) Methods Mol Biol , vol.767 , pp. 411-418
    • Ma, L.1    Liu, Y.2    Zhang, S.C.3
  • 53
    • 81155158882 scopus 로고    scopus 로고
    • Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells
    • 10.1186/1471-2202-12-82 21831300
    • Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells. Koehler KR, Tropel P, Theile JW, Kondo T, Cummins TR, Viville S, Hashino E, BMC Neurosci 2011 12 82 10.1186/1471-2202-12- 82 21831300
    • (2011) BMC Neurosci , vol.12 , pp. 82
    • Koehler, K.R.1    Tropel, P.2    Theile, J.W.3    Kondo, T.4    Cummins, T.R.5    Viville, S.6    Hashino, E.7


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