Ro52- and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjögren's syndrome

Clinical and Experimental Immunology

Volumn 172, Issue 2, 2013, Pages 228-237

  Aqrawi, L A ^a   Skarstein, K ^a   Oijordsbakken G ^a   Brokstad, K A ^a  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Autoimmunity; B cells; Ro SSA; Salivary glands; Sj gren's syndrome

Indexed keywords

CD19 ANTIGEN; CD20 ANTIGEN; CD27 ANTIGEN; CD5 ANTIGEN;

ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MEMORY CELL; PATHOGENESIS; PLASMA CELL; PRIORITY JOURNAL; SALIVARY GLAND; SJOEGREN SYNDROME;

ANTIBODIES, ANTINUCLEAR; ANTIGENS, CD19; ANTIGENS, CD20; ANTIGENS, CD27; ANTIGENS, CD5; AUTOANTIBODIES; AUTOANTIGENS; B-LYMPHOCYTES; HUMANS; IMMUNOLOGIC MEMORY; PLASMA CELLS; RIBONUCLEOPROTEINS; SALIVARY GLANDS; SJOGREN'S SYNDROME;

EID: 84876094337     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12058     Document Type: Article

References (47)

1. Jonsson R, Bolstad AI, Brokstad KA, Brun JG. Sjogren's syndrome-a plethora of clinical and immunological phenotypes with a complex genetic background. Ann NY Acad Sci 2007; 1108:433-447.
2. Jonsson R, Vogelsang P, Volchenkov R, Espinosa A, Wahren-Herlenius M, Appel S. The complexity of Sjogren's syndrome: novel aspects on pathogenesis. Immunol Lett 2011; 141:1-9.
3. Ramos-Casals M, Brito-Zeron P, Siso-Almirall A, Bosch X, Tzioufas AG. Topical and systemic medications for the treatment of primary Sjogren's syndrome. Nat Rev Rheumatol 2012; 8:399-411.
4. Garberg H, Jonsson R, Brokstad KA. The serological pattern of autoantibodies to the Ro52, Ro60, and La48 autoantigens in primary Sjogren's syndrome patients and healthy controls. Scand J Rheumatol 2005; 34:49-55.
5. Gordon TP, Bolstad AI, Rischmueller M, Jonsson R, Waterman SA. Autoantibodies in primary Sjogren's syndrome: new insights into mechanisms of autoantibody diversification and disease pathogenesis. Autoimmunity 2001; 34:123-132.
6. Volchenkov R, Jonsson R, Appel S. Anti-Ro and anti-La autoantibody profiling in Norwegian patients with primary Sjogren's syndrome using luciferase immunoprecipitation systems (LIPS). Scand J Rheumatol 2012; 41:314-315.
7. Halse A, Harley JB, Kroneld U, Jonsson R. Ro/SS-A-reactive B lymphocytes in salivary glands and peripheral blood of patients with Sjogren's syndrome. Clin Exp Immunol 1999; 115:203-207.
8. Salomonsson S, Wahren-Herlenius M. Local production of Ro/SSA and La/SSB autoantibodies in the target organ coincides with high levels of circulating antibodies in sera of patients with Sjogren's syndrome. Scand J Rheumatol 2003; 32:79-82.
9. Wahren-Herlenius M, Salomonsson S. Detection of antigen specific B-cells in tissues. Methods Mol Med 2007; 136:19-24.
10. Komai K, Shiozawa K, Tanaka Y etal. Sjogren's syndrome patients presenting with hypergammaglobulinemia are relatively unresponsive to cevimeline treatment. Mod Rheumatol 2009; 19:416-419.
11. Bohnhorst JO, Bjorgan MB, Thoen JE, Jonsson R, Natvig JB, Thompson KM. Abnormal B cell differentiation in primary Sjogren's syndrome results in a depressed percentage of circulating memory B cells and elevated levels of soluble CD27 that correlate with serum IgG concentration. Clin Immunol 2002; 103:79-88.
12. Bohnhorst JO, Thoen JE, Natvig JB, Thompson KM. Significantly depressed percentage of CD27+ (memory) B cells among peripheral blood B cells in patients with primary Sjogren's syndrome. Scand J Immunol 2001; 54:421-427.
13. Hansen A, Gosemann M, Pruss A etal. Abnormalities in peripheral B cell memory of patients with primary Sjogren's syndrome. Arthritis Rheum 2004; 50:1897-1908.
14. Hansen A, Odendahl M, Reiter K etal. Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjogren's syndrome. Arthritis Rheum 2002; 46:2160-2171.
15. Aqrawi LA, Brokstad KA, Jakobsen K, Jonsson R, Skarstein K. Low number of memory B cells in the salivary glands of patients with primary Sjogren's syndrome. Autoimmunity 2012; 45:547-555.
16. Szyszko EA, Brokstad KA, Oijordsbakken G, Jonsson MV, Jonsson R, Skarstein K. Salivary glands of primary Sjogren's syndrome patients express factors vital for plasma cell survival. Arthritis Res Ther 2011; 13:R2.
17. Hansen A, Lipsky PE, Dorner T. B cells in Sjogren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue. Arthritis Res Ther 2007; 9:218-229.
18. Jonsson R, Nginamau E, Szyszko E, Brokstad KA. Role of B cells in Sjogren's syndrome-from benign lymphoproliferation to overt malignancy. Front Biosci 2007; 12:2159-2170.
19. Jonsson MV, Skarstein K, Jonsson R, Brun JG. Serological implications of germinal center-like structures in primary Sjogren's syndrome. J Rheumatol 2007; 34:2044-2049.
20. Hamel KM, Liarski VM, Clark MR. Germinal center B-cells. Autoimmunity 2012; 45:333-347.
21. Salomonsson S, Jonsson MV, Skarstein K etal. Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren's syndrome. Arthritis Rheum 2003; 48:3187-3201.
22. Jung J, Choe J, Li L, Choi YS. Regulation of CD27 expression in the course of germinal center B cell differentiation: the pivotal role of IL-10. Eur J Immunol 2000; 30:2437-2443.
23. Cornec D, Devauchelle-Pensec V, Tobon GJ, Pers JO, Jousse-Joulin S, Saraux A. B cells in Sjogren's syndrome: from pathophysiology to diagnosis and treatment. J Autoimmun 2012; 39:161-167.
24. Herzenberg LA. B-1 cells: the lineage question revisited. Immunol Rev 2000; 175:9-22.
25. Youinou P, Hillion S, Jamin C, Pers JO, Saraux A, Renaudineau Y. B lymphocytes on the front line of autoimmunity. Autoimmun Rev 2006; 5:215-221.
26. Sims GP, Lipsky PE. Isolation of human B cell populations. Curr Protoc Immunol 2006; Chapter 7:Unit 7 5.
27. Agematsu K, Hokibara S, Nagumo H, Komiyama A. CD27: a memory B-cell marker. Immunol Today 2000; 21:204-206.
28. Klein U, Rajewsky K, Kuppers R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998; 188:1679-1689.
29. Szyszko EA, Skarstein K, Jonsson R, Brokstad KA. Distinct phenotypes of plasma cells in spleen and bone marrow of autoimmune NOD.B10.H2b mice. Autoimmunity 2011; 44:415-426.
30. Klein U, Kuppers R, Rajewsky K. Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life. Eur J Immunol 1993; 23:3272-3277.
31. Bohnhorst JO, Bjorgan MB, Thoen JE, Natvig JB, Thompson KM. Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjogren's syndrome. J Immunol 2001; 167:3610-3618.
32. Pascual V, Liu YJ, Magalski A, de Bouteiller O, Banchereau J, Capra JD. Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med 1994; 180:329-339.
33. Cambridge G, Leandro MJ, Teodorescu M etal. B cell depletion therapy in systemic lupus erythematosus: effect on autoantibody and antimicrobial antibody profiles. Arthritis Rheum 2006; 54:3612-3622.
34. Isaksen K, Jonsson R, Omdal R. Anti-CD20 treatment in primary Sjogren's syndrome. Scand J Immunol 2008; 68:554-564.
35. Vallerskog T, Gunnarsson I, Widhe M etal. Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE. Clin Immunol 2007; 122:62-74.
36. Aqrawi LA, Skarstein K, Bredholt G, Brun JG, Brokstad KA. Autoantigen-specific memory B cells in primary Sjogren's syndrome. Scand J Immunol 2012; 75:61-68.
37. Vitali C, Bombardieri S, Jonsson R etal. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61:554-558.
38. Al-Hashimi I, Wright JM, Cooley CA, Nunn ME. Reproducibility of biopsy grade in Sjogren's syndrome. J Oral Pathol Med 2001; 30:408-412.
39. Vivino FB, Gala I, Hermann GA. Change in final diagnosis on second evaluation of labial minor salivary gland biopsies. J Rheumatol 2002; 29:938-944.
40. Barcellos KS, Nonogaki S, Enokihara MM, Teixeira MS, Andrade LE. Differential expression of Ro/SSA 60kDa and La/SSB, but not Ro/SSA 52kDa, mRNA and protein in minor salivary glands from patients with primary Sjogren's syndrome. J Rheumatol 2007; 34:1283-1292.
41. Kunkel EJ, Butcher EC. Chemokines and the tissue-specific migration of lymphocytes. Immunity 2002; 16:1-4.
42. Szyszko EA, Brun JG, Skarstein K, Peck AB, Jonsson R, Brokstad KA. Phenotypic diversity of peripheral blood plasma cells in primary Sjogren's syndrome. Scand J Immunol 2011; 73:18-28.
43. Rasmussen T, Lodahl M, Hancke S, Johnsen HE. In multiple myeloma clonotypic CD38/CD19+/CD27+ memory B cells recirculate through bone marrow, peripheral blood and lymph nodes. Leuk Lymph 2004; 45:1413-1417.
44. Nakou M, Katsikas G, Sidiropoulos P etal. Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response. Arthritis Res Ther 2009; 11:R131.
45. Schittek B, Rajewsky K. Maintenance of B-cell memory by long-lived cells generated from proliferating precursors. Nature 1990; 346:749-751.
46. Slifka MK, Antia R, Whitmire JK, Ahmed R. Humoral immunity due to long-lived plasma cells. Immunity 1998; 8:363-372.
47. Slifka MK, Matloubian M, Ahmed R. Bone marrow is a major site of long-term antibody production after acute viral infection. J Virol 1995; 69:1895-1902.