Autoantigen-specific memory B cells in primary Sjögren's syndrome

Scandinavian Journal of Immunology

Volumn 75, Issue 1, 2012, Pages 61-68

  Aqrawi, L A ^a   Skarstein, K ^a   Bredholt, G ^a   Brun, J G ^a   Brokstad, K A ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; IMMUNOGLOBULIN G ANTIBODY; LA ANTIBODY; RO ANTIBODY;

ADULT; AGED; ANTIBODY BLOOD LEVEL; ANTIGEN SPECIFICITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LEUKOCYTE COUNT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MALE; MEMORY CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMA CELL; PRIORITY JOURNAL; SJOEGREN SYNDROME; SUPERNATANT;

ADULT; AGED; AUTOANTIBODIES; AUTOANTIGENS; B-LYMPHOCYTES; COHORT STUDIES; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOLOGIC MEMORY; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RIBONUCLEOPROTEINS; SJOGREN'S SYNDROME;

EID: 83455224582     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2011.02625.x     Document Type: Article

References (38)

1. Jonsson R, Bolstad AI, Brokstad KA, Brun JG. Sjogren's syndrome - a plethora of clinical and immunological phenotypes with a complex genetic background. Ann N Y Acad Sci 2007;1108:433-47.
2. Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjogren syndrome. Arch Intern Med 2004;164:1275-84.
3. Lerner MR, Boyle JA, Hardin JA, Steitz JA. Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus. Science 1981;211:400-2.
4. Hendrick JP, Wolin SL, Rinke J, Lerner MR, Steitz JA. Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells. Mol Cell Biol 1981;1:1138-49.
5. Mavragani CP, Tzioufas AG, Moutsopoulos HM. Sjogren's syndrome: autoantibodies to cellular antigens. Clinical and molecular aspects. Int Arch Allergy Immunol 2000;123:46-57.
6. Garberg H, Jonsson R, Brokstad KA. The serological pattern of autoantibodies to the Ro52, Ro60, and La48 autoantigens in primary Sjogren's syndrome patients and healthy controls. Scand J Rheumatol 2005;34:49-55.
7. Hansen A, Lipsky PE, Dorner T. B cells in Sjogren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue. Arthritis Res Ther 2007;9:218.
8. Jonsson R, Vogelsang P, Volchenkov R, Espinosa A, Wahren-Herlenius M, Appel S. The complexity of Sjogren's syndrome: novel aspects on pathogenesis. Immunol Lett 2011;July 12 [Epub ahead of print].
9. Halse A, Harley JB, Kroneld U, Jonsson R. Ro/SS-A-reactive B lymphocytes in salivary glands and peripheral blood of patients with Sjogren's syndrome. Clin Exp Immunol 1999;115:203-7.
10. Crotty S, Ahmed R. Immunological memory in humans. Semin Immunol 2004;16:197-203.
11. Hansen A, Daridon C, Dorner T. What do we know about memory B cells in primary Sjogren's syndrome? Autoimmun Rev 2010;9:600-3.
12. Klein U, Kuppers R, Rajewsky K. Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life. Eur J Immunol 1993;23:3272-7.
13. Bohnhorst JO, Bjorgan MB, Thoen JE, Natvig JB, Thompson KM. Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjogren's syndrome. J Immunol 2001;167:3610-8.
14. Pascual V, Liu YJ, Magalski A, de Bouteiller O, Banchereau J, Capra JD. Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med. 1994;180:329-39.
15. Hansen A, Odendahl M, Reiter K et al. Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjogren's syndrome. Arthritis Rheum 2002;46:2160-71.
16. Jonsson R, Nginamau E, Szyszko E, Brokstad KA. Role of B cells in Sjogren's syndrome - from benign lymphoproliferation to overt malignancy. Front Biosci 2007;12:2159-70.
17. Larsson A, Bredberg A, Henriksson G, Manthorpe R, Sallmyr A. Immunohistochemistry of the B-cell component in lower lip salivary glands of Sjogren's syndrome and healthy subjects. Scand J Immunol 2005;61:98-107.
18. Bohnhorst JO, Bjorgan MB, Thoen JE, Jonsson R, Natvig JB, Thompson KM. Abnormal B cell differentiation in primary Sjogren's syndrome results in a depressed percentage of circulating memory B cells and elevated levels of soluble CD27 that correlate with Serum IgG concentration. Clin Immunol 2002;103:79-88.
19. Czerkinsky CC, Nilsson LA, Nygren H, Ouchterlony O, Tarkowski A. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J Immunol Methods 1983;65:109-21.
20. Wahren M, Ruden U, Andersson B, Ringertz NR, Pettersson I. Identification of antigenic regions of the human Ro 60kDa protein using recombinant antigen and synthetic peptides. J Autoimmun 1992;5:319-32.
21. Halse A, Wahren-Herlenius M, Jonsson R. Ro/SS-A- and La/SS-B-reactive B lymphocytes in peripheral blood of patients with Sjogren's syndrome. Clin Exp Immunol 1999;115:208-13.
22. Crotty S, Aubert RD, Glidewell J, Ahmed R. Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system. J Immunol Methods 2004;286:111-22.
23. Farnes P, Barker BE, Brownhill LE, Fanger H. Mitogenic activity in Phytolacca Americana (Pokeweed). Lancet 1964;2:1100-1.
24. Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002;20:709-60.
25. Hartmann G, Weeratna RD, Ballas ZK et al. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. J Immunol 2000;164:1617-24.
26. Jonsson S, Kronvall G. The use of protein A-containing Staphylococcus aureus as a solid phase anti-IgG reagent in radioimmunoassays as exemplified in the quantitation of alpha-fetoprotein in normal human adult serum. Eur J Immunol 1974;4:29-33.
27. Langone JJ. Use of labeled protein A in quantitative immunochemical analysis of antigens and antibodies. J Immunol Methods 1982;51:3-22.
28. Tuaillon E, Tabaa YA, Petitjean G et al. Detection of memory B lymphocytes specific to hepatitis B virus (HBV) surface antigen (HBsAg) from HBsAg-vaccinated or HBV-immunized subjects by ELISPOT assay. J Immunol Methods 2006;315:144-52.
29. Buisman AM, de Rond CG, Ozturk K, Ten Hulscher HI, van Binnendijk RS. Long-term presence of memory B-cells specific for different vaccine components. Vaccine 2009;28:179-86.
30. Cruz SC, Silva GP, Sampaio FJ, Souza SL, Dias AA, Milagres LG. Comparison of long-term humoral memory development after immunisation against Neisseria meningitidis B or diphtheria toxoid. Vaccine 2010;28:6841-6.
31. Sundling C, Forsell MN, O'Dell S et al. Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates. J Exp Med 2010;207:2003-17.
32. Sasaki S, Jaimes MC, Holmes TH et al. Comparison of the influenza virus-specific effector and memory B-cell responses to immunization of children and adults with live attenuated or inactivated influenza virus vaccines. J Virol 2007;81:215-28.
33. Vitali C, Bombardieri S, Jonsson R et al. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554-8.
34. Blange I, Ringertz NR, Pettersson I. Identification of antigenic regions of the human 52kD Ro/SS-A protein recognized by patient sera. J Autoimmun 1994;7:263-74.
35. Nyman U, Ringertz NR, Pettersson I. Demonstration of an amino terminal La epitope recognized by human anti-La sera. Immunol Lett 1989;22:65-71.
36. Wahren M, Skarstein K, Blange I, Pettersson I, Jonsson R. MRL/lpr mice produce anti-Ro 52, 000MW antibodies: detection, analysis of specificity and site of production. Immunology 1994;83:9-15.
37. Szyszko EA, Brun JG, Skarstein K, Peck AB, Jonsson R, Brokstad KA. Phenotypic diversity of peripheral blood plasma cells in primary Sjogren's syndrome. Scand J Immunol 2011;73:18-28.
38. Alonso R, Buors C, Le Dantec C et al. Aberrant expression of CD6 on B-cell subsets from patients with Sjogren's syndrome. J Autoimmun 2010;35:336-41.