-
1
-
-
84859571797
-
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor- initiating cells via activation of key transcription factors and a positive feedback signaling loop
-
Aceto, N., Sausgruber, N., Brinkhaus, H., Gaidatzis, D., Martiny-Baron, G., Mazzarol, G., Confalonieri, S., Quarto, M., Hu, G., Balwierz, P. J. et al. (2012). Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor- initiating cells via activation of key transcription factors and a positive feedback signaling loop. Nat. Med. 18, 529-537.
-
(2012)
Nat. Med.
, vol.18
, pp. 529-537
-
-
Aceto, N.1
Sausgruber, N.2
Brinkhaus, H.3
Gaidatzis, D.4
Martiny-Baron, G.5
Mazzarol, G.6
Confalonieri, S.7
Quarto, M.8
Hu, G.9
Balwierz, P.J.10
-
2
-
-
39449101205
-
Paxillin phosphorylation controls invadopodia/podosomes spatiotemporal organization
-
Badowski, C., Pawlak, G., Grichine, A., Chabadel, A., Oddou, C., Jurdic, P., Pfaff, M., Albigès-Rizo, C. and Block, M. R. (2008). Paxillin phosphorylation controls invadopodia/podosomes spatiotemporal organization. Mol. Biol. Cell 19, 633-645.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 633-645
-
-
Badowski, C.1
Pawlak, G.2
Grichine, A.3
Chabadel, A.4
Oddou, C.5
Jurdic, P.6
Pfaff, M.7
Albigès-Rizo, C.8
Block, M.R.9
-
3
-
-
79955979289
-
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis
-
Bard-Chapeau, E. A., Li, S., Ding, J., Zhang, S. S., Zhu, H. H., Princen, F., Fang, D. D., Han, T., Bailly-Maitre, B., Poli, V. et al. (2011). Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell 19, 629-639.
-
(2011)
Cancer Cell
, vol.19
, pp. 629-639
-
-
Bard-Chapeau, E.A.1
Li, S.2
Ding, J.3
Zhang, S.S.4
Zhu, H.H.5
Princen, F.6
Fang, D.D.7
Han, T.8
Bailly-Maitre, B.9
Poli, V.10
-
4
-
-
0037673945
-
Osteoclast differentiation and activation
-
Boyle, W. J., Simonet, W. S. and Lacey, D. L. (2003). Osteoclast differentiation and activation. Nature 423, 337-342.
-
(2003)
Nature
, vol.423
, pp. 337-342
-
-
Boyle, W.J.1
Simonet, W.S.2
Lacey, D.L.3
-
5
-
-
33745468872
-
Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion
-
Chen, S. Y. and Chen, H. C. (2006). Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol. Cell. Biol. 26, 5155-5167.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 5155-5167
-
-
Chen, S.Y.1
Chen, H.C.2
-
6
-
-
0037072731
-
Roles of Rho- associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells
-
Chen, B. H., Tzen, J. T. C., Bresnick, A. R. and Chen, H. C. (2002). Roles of Rho- associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells. J. Biol. Chem. 277, 33857-33863.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 33857-33863
-
-
Chen, B.H.1
Tzen, J.T.C.2
Bresnick, A.R.3
Chen, H.C.4
-
7
-
-
9144223721
-
Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo
-
Chiusaroli, R., Knobler, H., Luxenburg, C., Sanjay, A., Granot-Attas, S., Tiran, Z., Miyazaki, T., Harmelin, A., Baron, R. and Elson, A. (2004). Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo. Mol. Biol. Cell 15, 234-244.
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 234-244
-
-
Chiusaroli, R.1
Knobler, H.2
Luxenburg, C.3
Sanjay, A.4
Granot-Attas, S.5
Tiran, Z.6
Miyazaki, T.7
Harmelin, A.8
Baron, R.9
Elson, A.10
-
8
-
-
40849120593
-
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion
-
Cortesio, C. L., Chan, K. T., Perrin, B. J., Burton, N. O., Zhang, S., Zhang, Z. Y. and Huttenlocher, A. (2008). Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. J. Cell Biol. 180, 957-971.
-
(2008)
J. Cell Biol.
, vol.180
, pp. 957-971
-
-
Cortesio, C.L.1
Chan, K.T.2
Perrin, B.J.3
Burton, N.O.4
Zhang, S.5
Zhang, Z.Y.6
Huttenlocher, A.7
-
9
-
-
38749128376
-
The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts
-
Destaing, O., Sanjay, A., Itzstein, C., Horne, W. C., Toomre, D., De Camilli, P. and Baron, R. (2008). The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts. Mol. Biol. Cell 19, 394-404.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 394-404
-
-
Destaing, O.1
Sanjay, A.2
Itzstein, C.3
Horne, W.C.4
Toomre, D.5
De Camilli, P.6
Baron, R.7
-
10
-
-
45349107819
-
Regulation of RhoA-dependent ROCKII activation by Shp2
-
Lee, H. H. and Chang, Z. F. (2008). Regulation of RhoA-dependent ROCKII activation by Shp2. J. Cell Biol. 181, 999-1012.
-
(2008)
J. Cell Biol.
, vol.181
, pp. 999-1012
-
-
Lee, H.H.1
Chang, Z.F.2
-
11
-
-
77956915812
-
Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics
-
Lee, H. H., Tien, S. C., Jou, T. S., Chang, Y. C., Jhong, J. G. and Chang, Z. F. (2010). Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics. J. Cell Sci. 123, 3368-3377.
-
(2010)
J. Cell Sci.
, vol.123
, pp. 3368-3377
-
-
Lee, H.H.1
Tien, S.C.2
Jou, T.S.3
Chang, Y.C.4
Jhong, J.G.5
Chang, Z.F.6
-
12
-
-
33847343034
-
The matrix corroded: podosomes and invadopodia in extracellular matrix degradation
-
Linder, S. (2007). The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol. 17, 107-117.
-
(2007)
Trends Cell Biol.
, vol.17
, pp. 107-117
-
-
Linder, S.1
-
13
-
-
0038433238
-
Podosomes: adhesion hot-spots of invasive cells
-
Linder, S. and Aepfelbacher, M. (2003). Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol. 13, 376-385.
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 376-385
-
-
Linder, S.1
Aepfelbacher, M.2
-
14
-
-
0039441744
-
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility
-
Mañes, S., Mira, E., Gómez-Mouton, C., Zhao, Z. J., Lacalle, R. A. and Martínez-A, C. (1999). Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol. Cell. Biol. 19, 3125-3135.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3125-3135
-
-
Mañes, S.1
Mira, E.2
Gómez-Mouton, C.3
Zhao, Z.J.4
Lacalle, R.A.5
Martínez-A, C.6
-
15
-
-
70349602267
-
Protein tyrosine phosphatase SHP-2: a proto-oncogene product that promotes Ras activation
-
Matozaki, T., Murata, Y., Saito, Y., Okazawa, H. and Ohnishi, H. (2009). Protein tyrosine phosphatase SHP-2: a proto-oncogene product that promotes Ras activation. Cancer Sci. 100, 1786-1793.
-
(2009)
Cancer Sci.
, vol.100
, pp. 1786-1793
-
-
Matozaki, T.1
Murata, Y.2
Saito, Y.3
Okazawa, H.4
Ohnishi, H.5
-
16
-
-
14044272770
-
A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
-
Montagner, A., Yart, A., Dance, M., Perret, B., Salles, J. P. and Raynal, P. (2005). A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. J. Biol. Chem. 280, 5350-5360.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 5350-5360
-
-
Montagner, A.1
Yart, A.2
Dance, M.3
Perret, B.4
Salles, J.P.5
Raynal, P.6
-
17
-
-
0141669167
-
Actin can reorganize into podosomes in aortic endothelial cells, a process controlled by Cdc42 and RhoA
-
Moreau, V., Tatin, F., Varon, C. and Génot, E. (2003). Actin can reorganize into podosomes in aortic endothelial cells, a process controlled by Cdc42 and RhoA. Mol. Cell. Biol. 23, 6809-6822.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 6809-6822
-
-
Moreau, V.1
Tatin, F.2
Varon, C.3
Génot, E.4
-
18
-
-
84862627339
-
Tks5-dependent formation of circumferential podosomes/ invadopodia mediates cell-cell fusion
-
Oikawa, T., Oyama, M., Kozuka-Hata, H., Uehara, S., Udagawa, N., Saya, H. and Matsuo, K. (2012). Tks5-dependent formation of circumferential podosomes/ invadopodia mediates cell-cell fusion. J. Cell Biol. 197, 553-568.
-
(2012)
J. Cell Biol.
, vol.197
, pp. 553-568
-
-
Oikawa, T.1
Oyama, M.2
Kozuka-Hata, H.3
Uehara, S.4
Udagawa, N.5
Saya, H.6
Matsuo, K.7
-
19
-
-
69449096397
-
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation
-
Oser, M., Yamaguchi, H., Mader, C. C., Bravo-Cordero, J. J., Arias, M., Chen, X., Desmarais, V., van Rheenen, J., Koleske, A. J. and Condeelis, J. (2009). Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J. Cell Biol. 186, 571-587.
-
(2009)
J. Cell Biol.
, vol.186
, pp. 571-587
-
-
Oser, M.1
Yamaguchi, H.2
Mader, C.C.3
Bravo-Cordero, J.J.4
Arias, M.5
Chen, X.6
Desmarais, V.7
van Rheenen, J.8
Koleske, A.J.9
Condeelis, J.10
-
20
-
-
80053944532
-
FAK is required for the assembly of podosome rosettes
-
Pan, Y. R., Chen, C. L. and Chen, H. C. (2011). FAK is required for the assembly of podosome rosettes. J. Cell Biol. 195, 113-129.
-
(2011)
J. Cell Biol.
, vol.195
, pp. 113-129
-
-
Pan, Y.R.1
Chen, C.L.2
Chen, H.C.3
-
21
-
-
0028837693
-
Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association
-
Peng, Z. Y. and Cartwright, C. A. (1995). Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association. Oncogene 11, 1955-1962.
-
(1995)
Oncogene
, vol.11
, pp. 1955-1962
-
-
Peng, Z.Y.1
Cartwright, C.A.2
-
22
-
-
0032581273
-
Shp-2 has a positive regulatory role in ES cell differentiation and proliferation
-
Qu, C. K. and Feng, G. S. (1998). Shp-2 has a positive regulatory role in ES cell differentiation and proliferation. Oncogene 17, 433-439.
-
(1998)
Oncogene
, vol.17
, pp. 433-439
-
-
Qu, C.K.1
Feng, G.S.2
-
23
-
-
1542289021
-
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor
-
Ren, Y., Meng, S., Mei, L., Zhao, Z. J., Jove, R. and Wu, J. (2004). Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J. Biol. Chem. 279, 8497-8505.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 8497-8505
-
-
Ren, Y.1
Meng, S.2
Mei, L.3
Zhao, Z.J.4
Jove, R.5
Wu, J.6
-
24
-
-
13844264301
-
The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells
-
Seals, D. F., Azucena, E. F., Jr, Pass, I., Jr, Tesfay, L., Gordon, R., Woodrow, M., Resau, J. H. and Courtneidge, S. A. (2005). The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell 7, 155-165.
-
(2005)
Cancer Cell
, vol.7
, pp. 155-165
-
-
Seals, D.F.1
Azucena, E.F.Jr.2
Pass Jr., I.3
Tesfay, L.4
Gordon, R.5
Woodrow, M.6
Resau, J.H.7
Courtneidge, S.A.8
-
25
-
-
69549122682
-
Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation
-
Stylli, S. S., Stacey, T. T., Verhagen, A. M., Xu, S. S., Pass, I., Courtneidge, S. A. and Lock, P. (2009). Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation. J. Cell Sci. 122, 2727-2740.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 2727-2740
-
-
Stylli, S.S.1
Stacey, T.T.2
Verhagen, A.M.3
Xu, S.S.4
Pass, I.5
Courtneidge, S.A.6
Lock, P.7
-
26
-
-
33645214468
-
Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA
-
Tsutsumi, R., Takahashi, A., Azuma, T., Higashi, H. and Hatakeyama, M. (2006). Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. Mol. Cell. Biol. 26, 261-276.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 261-276
-
-
Tsutsumi, R.1
Takahashi, A.2
Azuma, T.3
Higashi, H.4
Hatakeyama, M.5
-
27
-
-
33646270213
-
Transforming growth factor beta induces rosettes of podosomes in primary aortic endothelial cells
-
Varon, C., Tatin, F., Moreau, V., Van Obberghen-Schilling, E., Fernandez-Sauze, S., Reuzeau, E., Kramer, I. and Génot, E. (2006). Transforming growth factor beta induces rosettes of podosomes in primary aortic endothelial cells. Mol. Cell. Biol. 26, 3582-3594. Xu, R. (2007). Shp2, a novel oncogenic tyrosine phosphatase and potential therapeutic target for human leukemia. Cell Res. 17, 295-297.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3582-3594
-
-
Varon, C.1
Tatin, F.2
Moreau, V.3
Van Obberghen-Schilling, E.4
Fernandez-Sauze, S.5
Reuzeau, E.6
Kramer, I.7
Génot, E.8
-
28
-
-
34247379423
-
Shp2, a novel oncogenic tyrosine phosphatase and potential therapeutic target for human leukemia
-
Xu, R. (2007). Shp2, a novel oncogenic tyrosine phosphatase and potential therapeutic target for human leukemia. Cell Res. 17, 295-297.
-
(2007)
Cell Res.
, vol.17
, pp. 295-297
-
-
Xu, R.1
-
29
-
-
33644547703
-
An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival
-
Yang, W., Klaman, L. D., Chen, B., Araki, T., Harada, H., Thomas, S. M., George, E. L. and Neel, B. G. (2006). An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. Dev. Cell 10, 317-327.
-
(2006)
Dev. Cell
, vol.10
, pp. 317-327
-
-
Yang, W.1
Klaman, L.D.2
Chen, B.3
Araki, T.4
Harada, H.5
Thomas, S.M.6
George, E.L.7
Neel, B.G.8
-
30
-
-
3543036342
-
Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion
-
Yu, D. H., Qu, C. K., Henegariu, O., Lu, X. and Feng, G. S. (1998). Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J. Biol. Chem. 273, 21125-21131.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21125-21131
-
-
Yu, D.H.1
Qu, C.K.2
Henegariu, O.3
Lu, X.4
Feng, G.S.5
-
31
-
-
10744223870
-
Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment
-
Zhang, S. Q., Yang, W., Kontaridis, M. I., Bivona, T. G., Wen, G., Araki, T., Luo, J., Thompson, J. A., Schraven, B. L., Philips, M. R. et al. (2004). Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol. Cell 13, 341-355.
-
(2004)
Mol. Cell
, vol.13
, pp. 341-355
-
-
Zhang, S.Q.1
Yang, W.2
Kontaridis, M.I.3
Bivona, T.G.4
Wen, G.5
Araki, T.6
Luo, J.7
Thompson, J.A.8
Schraven, B.L.9
Philips, M.R.10
|