Zinc deficiency regulates hippocampal gene expression and impairs neuronal differentiation

Nutritional Neuroscience

Volumn 16, Issue 4, 2013, Pages 174-182

  Gower Winter, Shannon D ^a   Corniola, Rikki S ^a,b   Morgan, Thomas J ^a   Levenson, Cathy W ^a,b  

^a FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Hippocampus; Neurogenesis; NT2; RXR; TGF

Indexed keywords

BETA TUBULIN; BETA TUBULIN TYPE III; DOUBLECORTIN; ISOPROTEIN; MESSENGER RNA; RETINOID X RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOUBLECORTIN GENE; DOWN REGULATION; GENE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MALE; MICROARRAY ANALYSIS; NERVE CELL DIFFERENTIATION; NERVE STIMULATION; NEUROLOGIC DISEASE; NONHUMAN; NUCLEAR RETINOIC ACID RECEPTOR GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; RAT; RETINOID X RECEPTOR GENE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA GENE; WEIGHT REDUCTION; WESTERN BLOTTING; ZINC DEFICIENCY;

EID: 84876088554     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830512Y.0000000043     Document Type: Article

References (36)

1. Mendoza-Torreblanca JG, Martinez-Martinez E, Tapia-Rodriguez M, Ramirez-Hernandez R, Gutierrez-Ospina G. The rostral migratory stream is a neurogenic niche that predomi-nantly engenders periglomerular cells: in vivo evidence in the adult rat brain. Neurosci Res 2008;60(3):289-99.
2. Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, et al. Neurogenesis in the adult human hippocampus. Nat Med 1998;4:1313-17.
3. Van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH. Functional neurogenesis in the adult hippocampus. Nature 2002;415(6875):1030-4.
4. Wang FD, Bian W, Kong LW, Zhao FJ, Guo JS, Jing NH. Maternal zinc deficiency impairs brain nestin expression in prenatal and postnatal mice. Cell Res 2001;11:135-41.
5. Corniola RS, Tassabehji NM, Hare J, Sharma G, Levenson CW. Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms. Brain Res 2008;1237:52-61.
6. Gao HL, Zheng W, Xin N, Chi ZH, Wang ZY, Chen J, et al. Zinc deficiency reduces neurogenesis accompanied by neuronal apoptosis through caspase-dependent and-independent signaling pathways. Neurotox Res 2009;16:416-25.
7. Andrews PW. Human teratocarcinomas. Biochem Biophys 1988; 948:17-36.
8. VanLandingham JW, Levenson CW. Effect of retinoic acid on ferritin H expression during brain development and neuronal differentiation. Nutr Neurosci 2003;6(1):39-45.
9. Ho E, Courtemanche C, Ames B. Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. J Nutr 2003;133(8):2543-8.
10. Suh SW, Won SJ, Hamby AM, Yoo BH, Fan Y, Sheline CT, et al. Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J Cerebr Blood Flow Metab 2009;29: 1579-88.
11. Enchev RI, Schreiber A, Beuron F, Morris EP. Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3. Structure 2010;18(4):518-27
12. Von Bohlen, Halbach O. Immunohistological markers for staging neurogenesis in adult hippocampus. Cell Tissue Res 2007;329(3):409-20.
13. Pleasure SJ, Page C, Lee VM. Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J Neurosci 1992;12(5):1802-15.
14. Takeda A, Minami A, Takefuta S, Tochigi M, Oku N. Zinc homeostasis in the brain of adult rats fed zinc-deficient diet. J Neurosci Res 2001;63:447-52.
15. Politis PK, Makri G, Thomaidou D, Geissen M, Rohrer H, Matsas R. BM88/CEND1 coordinates cell cycle exit and differentiation of neuronal precursors. Proc Natl Acad Sci 2007; 104(45):17861-66.
16. Katsimpardi L, Gaitanou M, Malnou CE, Lledo PM, Charneua P, Mastas R, et al. BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells. Stem Cells 2008;26(7): 1796-807.
17. Maden M. Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat Rev Neurosci 2007; 8(10):755-65.
18. Wang TW, Zhang H, Parent JM. Retinoic acid regulates postnatal neurogenesis in the murine subventricular zone-olfactory bulb pathway. Development 2005;132:2721-32.
19. Tozuka Y, Fukuda S, Namba T, Seki T, Hisatsune T. GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells. Neuron 2005;47(6):803-15
20. Jagasia R, Steib K, Englberger E, Herold S, Faus-Kessler T, Saxe M, et al. GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci 2009;29(25): 7966-77.
21. Hsieh J, Eisch AJ. Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind. Neurobiol Dis 2010;39(1):73-84.
22. Kohyama J, Kojima T, Takatsuka E, Yamashita T, Namiki J, Hsieh J, et al. Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain. Proc Natl Acad Sci 2008;105(46):18012-17.
23. Tsujimura K, Abematsu M, Kohyama J, Namihira M, Nakashima K. Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2. Exp Neurol 2009;219(1):104-11.
24. Lim DA, Huang Y, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, et al. Chromatin remodeling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature 2009; 458(7237):529-33.
25. Rifkin DB. Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability. J Biol Chem 2005;280(9):7409-12.
26. Bottner M, Krieglstein K, Unsicker K. The transforming growth factor-betas: structure, signaling, and roles in nervous system development and functions. J Neurochem 2000;75(6):2227-40
27. Wrana JL, Attisano L, Cárcamo J, Zantella A, Doody J, Laiho M, et al. TGF beta signals through a heteromeric protein kinase receptor complex. Cell 1992;71(6):1003-14.
28. Gomes FC, Sousa Vde O, Romão L. Emerging roles for TGF-beta1 in nervous system development. Int J Dev Neurosci 2005;23(5):413-24.
29. Kitisin K, Saha T, Blake T, Golestaneh N, Deng M, Kim C, et al. TGF-beta signaling in development. Sci STKE 2007; 2007(399):cm1.
30. Lu J, Wu Y, Sousa N, Almeida OF. SMAD pathway mediation of BDNF and TGF beta 2 regulation of proliferation and differentiation of hippocampal granule neurons. Development 2005; 132(14):3231-42.
31. Batista D, Ferrari CC, Gage FH, Pitossi FJ. Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Eur J Neurosci 2006;23(1):83-93.
32. Ren RF, Hawver DB, Kim RS, Flanders KC. Transforming growth factor-β protects human hNT cells from degeneration induced by β-amylpid peptide: involvement of the TGF-β type II receptor. Brain Res Mol Brain Res 1997;48:315-22.
33. Misumi S, Kim T, Jung C, Masuda T, Urakawa S, Isobe Y, et al. Enhanced neurogenesis from neural progenitor cells with G1/S-phase cell cycle arrest is mediated by transforming growth factor β1. Eur J Neurosci 2008;28(6):1049-59.
34. Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, et al. Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest 2006;116(11):3060-9.
35. Brown KH, Wuehler SE, Peerson JM. The importance of zinc in human nutrition and estimation of the global prevalence of zinc deficiency. Food Nutr Bull 2001;22(2):113-25.
36. Cope EC, Levenson CW. Role of zinc in the development and treatment of mood disorders. Curr Opin Clin Nutr Metab Care 2010;13(6):685-9.