메뉴 건너뛰기




Volumn 13, Issue 6, 2010, Pages 685-689

Role of zinc in the development and treatment of mood disorders

Author keywords

anhedonia; anxiety; depression; hippocampus; zinc

Indexed keywords

ZINC CHLORIDE; ZINC SULFATE;

EID: 78149283354     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e32833df61a     Document Type: Review
Times cited : (63)

References (41)
  • 1
    • 70449627047 scopus 로고    scopus 로고
    • Insight into zinc signaling from dietary zinc deficiency
    • Takeda A, Tamano H. Insight into zinc signaling from dietary zinc deficiency. Brain Res Rev 2009;62:33-44.
    • (2009) Brain Res. Rev. , vol.62 , pp. 33-44
    • Takeda, A.1    Tamano, H.2
  • 2
    • 0030880731 scopus 로고    scopus 로고
    • Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness
    • Maes M, Vandoolaeghe E, Neels H, et al. Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness. Biol Psychiatry 1997;42:349-358.
    • (1997) Biol. Psychiatry , vol.42 , pp. 349-358
    • Maes, M.1    Vandoolaeghe, E.2    Neels, H.3
  • 4
    • 84866920835 scopus 로고    scopus 로고
    • Correlation between dietary zinc intakes and its serum levels with depression scales in young female students
    • Epub ahead of print
    • Amani R, Saeidi S, Nazari Z, Nematpour S. Correlation between dietary zinc intakes and its serum levels with depression scales in young female students. Biol Trace Elem Res 2009 [Epub ahead of print].
    • (2009) Biol. Trace Elem Res.
    • Amani, R.1    Saeidi, S.2    Nazari, Z.3    Nematpour, S.4
  • 5
    • 72949095445 scopus 로고    scopus 로고
    • Zinc-specific food frequency questionnaire to assess college women's eating habits
    • Lacey JM, Zotter DU. Zinc-specific Food Frequency Questionnaire to assess college women's eating habits. Can J Diet Pract Res 2009;70:204-208.
    • (2009) Can. J. Diet. Pract. Res. , vol.70 , pp. 204-208
    • Lacey, J.M.1    Zotter, D.U.2
  • 6
    • 33750064543 scopus 로고    scopus 로고
    • Realistic expectations and a disease management model for depressed patients with persistent symptoms
    • Keitner GI, Ryan CE, Solomon DA. Realistic expectations and a disease management model for depressed patients with persistent symptoms. J Clin Psychiatry 2006;67:1412-1421.
    • (2006) J. Clin. Psychiatry , vol.67 , pp. 1412-1421
    • Keitner, G.I.1    Ryan, C.E.2    Solomon, D.A.3
  • 7
    • 77949267046 scopus 로고    scopus 로고
    • Effect of zinc supplementation on mood states in young • women: A pilot study
    • This pilot study supports the use of supplemental zinc 7 mg once daily for 10 weeks in women between 18 and 21 years of age to significantly improve anger and depression scores measured by the Profile of Moods State POMS questionnaire
    • Sawada T, Yokoi K. Effect of zinc supplementation on mood states in young • women: a pilot study. Eur J Clin Nutr 2010;64:331-333. This pilot study supports the use of supplemental zinc (7 mg) once daily for 10 weeks in women between 18 and 21 years of age to significantly improve anger and depression scores measured by the Profile of Moods State (POMS) questionnaire.
    • (2010) Eur. J. Clin. Nutr. , vol.64 , pp. 331-333
    • Sawada, T.1    Yokoi, K.2
  • 8
    • 69949143152 scopus 로고    scopus 로고
    • Zinc supplementation augments efficacy of •• imipramine in treatment resistant patients: A double blind, placebo-controlled study
    • This study showed the effective use of 140mg imipramine in addition to 25 mg of zinc once daily for 12 weeks in treatment-resistant patients with major depression between 18 and 55 years of age. Supplemental zinc decreased depression scores and improved treatment outcomes in patients who were previously nonresponsive to antidepressant therapy
    • Siwek M, Dudek D, Paul IA, et al. Zinc supplementation augments efficacy of •• imipramine in treatment resistant patients: a double blind, placebo-controlled study. J Affect Disord 2009;118:187-195. This study showed the effective use of 140mg imipramine in addition to 25 mg of zinc once daily for 12 weeks in treatment-resistant patients with major depression between 18 and 55 years of age. Supplemental zinc decreased depression scores and improved treatment outcomes in patients who were previously nonresponsive to antidepressant therapy.
    • (2009) J. Affect. Disord. , vol.118 , pp. 187-195
    • Siwek, M.1    Dudek, D.2    Paul, I.A.3
  • 10
    • 69349102311 scopus 로고    scopus 로고
    • Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation
    • Tamano H, Kan F, Kawamura M, et al. Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation. Neurochem Int 2009;55:536-541.
    • (2009) Neurochem. Int. , vol.55 , pp. 536-541
    • Tamano, H.1    Kan, F.2    Kawamura, M.3
  • 11
    • 77049125930 scopus 로고    scopus 로고
    • Susceptibility to stress in young • rats after 2-week zinc deprivation
    • Rats fed a zinc-deficient diet for 2 weeks had increased levels of corticosterone following exposure to stress. Increased depressive-like behavior under zinc deficiency was restored to normal following 14 days of eating a control diet
    • Watanabe M, Tamano H, Kikuchi T, Takeda A. Susceptibility to stress in young • rats after 2-week zinc deprivation. Neurochem Int 2010;56:410-416. Rats fed a zinc-deficient diet for 2 weeks had increased levels of corticosterone following exposure to stress. Increased depressive-like behavior under zinc deficiency was restored to normal following 14 days of eating a control diet.
    • (2010) Neurochem. Int. , vol.56 , pp. 410-416
    • Watanabe, M.1    Tamano, H.2    Kikuchi, T.3    Takeda, A.4
  • 12
    • 0028875833 scopus 로고
    • Zinc status specifically changes preferences for carbohydrate and protein in rats selecting from separate carbohydrate-, protein-, and fat-containing diets
    • Rains TM, Shay NF. Zinc status specifically changes preferences for carbohydrate and protein in rats selecting from separate carbohydrate-, protein-, and fat-containing diets. J Nutr 1995;125:2874-2879.
    • (1995) J. Nutr. , vol.125 , pp. 2874-2879
    • Rains, T.M.1    Shay, N.F.2
  • 13
    • 55549135376 scopus 로고    scopus 로고
    • The effect of peripheral administration of zinc on food intake in rats fed Zn-adequate or Zn-deficient diets
    • Jing MY, Sun JY, Wang JF. The effect of peripheral administration of zinc on food intake in rats fed Zn-adequate or Zn-deficient diets. Biol Trace Elem Res 2008;124:144-156.
    • (2008) Biol. Trace Elem Res. , vol.124 , pp. 144-156
    • Jing, M.Y.1    Sun, J.Y.2    Wang, J.F.3
  • 14
    • 62749132933 scopus 로고    scopus 로고
    • Orally administered zinc • increases food intake via vagal stimulation in rats
    • Oral zinc administration of 19 μmol/kg but not i.p. zinc increases food intake in rats fed a zinc-deficient diet for 3 days. Additionally, neuropeptide Y and orexin significantly increased in the hypothalamus following oral zinc administration. Stimulation of food intake was abolished by vagatomy. Taken together, these data indicate that oral zinc administration stimulates food intake via orexigenic peptides and vagal stimulation
    • Ohinata K, Takemoto M, Kawanago M, et al. Orally administered zinc • increases food intake via vagal stimulation in rats. J Nutr 2009;139:611-616. Oral zinc administration of 19 μmol/kg but not i.p. zinc increases food intake in rats fed a zinc-deficient diet for 3 days. Additionally, neuropeptide Y and orexin significantly increased in the hypothalamus following oral zinc administration. Stimulation of food intake was abolished by vagatomy. Taken together, these data indicate that oral zinc administration stimulates food intake via orexigenic peptides and vagal stimulation.
    • (2009) J. Nutr. , vol.139 , pp. 611-616
    • Ohinata, K.1    Takemoto, M.2    Kawanago, M.3
  • 15
    • 0030434199 scopus 로고    scopus 로고
    • Comorbid depression and anxiety spectrum disorders
    • Gorman JM. Comorbid depression and anxiety spectrum disorders. Depress Anxiety 1996;4:160-168.
    • (1996) Depress Anxiety , vol.4 , pp. 160-168
    • Gorman, J.M.1
  • 16
    • 33846027889 scopus 로고    scopus 로고
    • Anxiety-like behavior of young rats after 2-week zinc deprivation
    • Takeda A, Tamano H, Kan F, et al. Anxiety-like behavior of young rats after 2-week zinc deprivation. Behav Brain Res 2007;177:1-6.
    • (2007) Behav. Brain Res. , vol.177 , pp. 1-6
    • Takeda, A.1    Tamano, H.2    Kan, F.3
  • 17
    • 41749122370 scopus 로고    scopus 로고
    • Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency
    • Takeda A, Tamano H, Kan F, et al. Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency. Life Sci 2008;82:909-914.
    • (2008) Life Sci. , vol.82 , pp. 909-914
    • Takeda, A.1    Tamano, H.2    Kan, F.3
  • 18
    • 44949103515 scopus 로고    scopus 로고
    • Effects of restraint stress on iron, zinc, calcium, and magnesium whole blood levels in mice
    • Teng WF, Sun WM, Shi LF, et al. Effects of restraint stress on iron, zinc, calcium, and magnesium whole blood levels in mice. Biol Trace Elem Res 2008;121:243-248.
    • (2008) Biol. Trace Elem Res. , vol.121 , pp. 243-248
    • Teng, W.F.1    Sun, W.M.2    Shi, L.F.3
  • 19
    • 42949093099 scopus 로고    scopus 로고
    • Involvement of the adenosine A1 and A2 receptors in the antidepressant-like effect of zinc in the forced swimming test
    • Lobato KR, Binfare RW, Budni J, et al. Involvement of the adenosine A1 and A2 receptors in the antidepressant-like effect of zinc in the forced swimming test. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:994-999.
    • (2008) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.32 , pp. 994-999
    • Lobato, K.R.1    Binfare, R.W.2    Budni, J.3
  • 21
    • 39149105610 scopus 로고    scopus 로고
    • Involvement of glutathione, ERK1/2 phosphorylation and BDNF expression in the antidepressant-like effect of zinc in rats
    • Franco JL, Posser T, Brocardo PS, et al. Involvement of glutathione, ERK1/2 phosphorylation and BDNF expression in the antidepressant-like effect of zinc in rats. Behav Brain Res 2008;188:316-323.
    • (2008) Behav. Brain Res. , vol.188 , pp. 316-323
    • Franco, J.L.1    Posser, T.2    Brocardo, P.S.3
  • 22
    • 0037707701 scopus 로고    scopus 로고
    • Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats
    • Nowak G, Szewczyk B, Wieronska JM, et al. Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats. Brain Res Bull 2003;61:159-164.
    • (2003) Brain Res. Bull. , vol.61 , pp. 159-164
    • Nowak, G.1    Szewczyk, B.2    Wieronska, J.M.3
  • 23
    • 57049188838 scopus 로고    scopus 로고
    • Antidepressant-like activity of zinc: Further behavioral and molecular evidence
    • Sowa-Kucma M, Legutko B, Szewczyk B, et al. Antidepressant-like activity of zinc: further behavioral and molecular evidence. J Neural Transm 2008;115:1621-1628.
    • (2008) J. Neural. Transm. , vol.115 , pp. 1621-1628
    • Sowa-Kucma, M.1    Legutko, B.2    Szewczyk, B.3
  • 24
    • 0032914382 scopus 로고    scopus 로고
    • Alterations in serum and brain trace element levels after antidepressant treatment: Part I. Zinc
    • Nowak G, Schlegel-Zawadzka M. Alterations in serum and brain trace element levels after antidepressant treatment: Part I. Zinc. Biol Trace Elem Res 1999;67:85-92.
    • (1999) Biol. Trace Elem Res. , vol.67 , pp. 85-92
    • Nowak, G.1    Schlegel-Zawadzka, M.2
  • 25
    • 34047132847 scopus 로고    scopus 로고
    • Influence of zinc supplementation on imipramine effect in a chronic unpredictable stress (CUS) model in rats
    • Cieslik K, Klenk-Majewska B, Danilczuk Z, et al. Influence of zinc supplementation on imipramine effect in a chronic unpredictable stress (CUS) model in rats. Pharmacol Rep 2007;59:46-52.
    • (2007) Pharmacol. Rep. , vol.59 , pp. 46-52
    • Cieslik, K.1    Klenk-Majewska, B.2    Danilczuk, Z.3
  • 26
    • 60049095030 scopus 로고    scopus 로고
    • The involvement of serotonergic •• system in the antidepressant effect of zinc in the forced swim test
    • Inhibition of the serotonergic system by the use of serotonin synthesis blockers or receptor antagonist abolishes the antidepressant effects of zinc as demonstrated in the forced swim test in rats
    • Szewczyk B, Poleszak E, Wlaz P, et al. The involvement of serotonergic •• system in the antidepressant effect of zinc in the forced swim test. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:323-329. Inhibition of the serotonergic system by the use of serotonin synthesis blockers or receptor antagonist abolishes the antidepressant effects of zinc as demonstrated in the forced swim test in rats.
    • (2009) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.33 , pp. 323-329
    • Szewczyk, B.1    Poleszak, E.2    Wlaz, P.3
  • 27
    • 76049120012 scopus 로고    scopus 로고
    • Zinc-induced adaptive changes in • NMDA/glutamatergic and serotonergic receptors
    • Antidepressant-effective doses of zinc alter the affinity of glycine to NMDA receptors and increase the density of the serotonin receptors in both the hippocampus and prefrontal cortex. These results are similar to the known action of antidepressant drugs
    • Cichy A, Sowa-Kucma M, Legutko B, et al. Zinc-induced adaptive changes in • NMDA/glutamatergic and serotonergic receptors. Pharmacol Rep 2009;61:1184-1191. Antidepressant-effective doses of zinc alter the affinity of glycine to NMDA receptors and increase the density of the serotonin receptors in both the hippocampus and prefrontal cortex. These results are similar to the known action of antidepressant drugs.
    • (2009) Pharmacol. Rep. , vol.61 , pp. 1184-1191
    • Cichy, A.1    Sowa-Kucma, M.2    Legutko, B.3
  • 28
    • 77953619227 scopus 로고    scopus 로고
    • The involvement of NMDA and AMPA receptors in the mechanism of antidepressant-like action of zinc in the forced swim test
    • Szewczyk B, Poleszak E, Sowa-Kucma M, et al. The involvement of NMDA and AMPA receptors in the mechanism of antidepressant-like action of zinc in the forced swim test. Amino Acids 2010;39:205-217.
    • (2010) Amino Acids , vol.39 , pp. 205-217
    • Szewczyk, B.1    Poleszak, E.2    Sowa-Kucma, M.3
  • 29
    • 60049088686 scopus 로고    scopus 로고
    • D-serine, a selective glycine/N-methyl-D-aspartate receptor agonist, antagonizes the antidepressant-like effects of magnesium and zinc in mice
    • Poleszak E, Szewczyk B, Wlaz A, et al. D-serine, a selective glycine/N-methyl-D-aspartate receptor agonist, antagonizes the antidepressant-like effects of magnesium and zinc in mice. Pharmacol Rep 2008;60:996-1000.
    • (2008) Pharmacol. Rep. , vol.60 , pp. 996-1000
    • Poleszak, E.1    Szewczyk, B.2    Wlaz, A.3
  • 30
    • 67650082421 scopus 로고    scopus 로고
    • Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus
    • Takeda A, Sakurada N, Ando M, et al. Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus. Neurochem Int 2009;55:376-382.
    • (2009) Neurochem. Int. , vol.55 , pp. 376-382
    • Takeda, A.1    Sakurada, N.2    Ando, M.3
  • 31
    • 67650960834 scopus 로고    scopus 로고
    • Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber longterm potentiation
    • Takeda A, Ando M, Kanno S, et al. Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber longterm potentiation. Neurotoxicology 2009;30:712-717.
    • (2009) Neurotoxicology , vol.30 , pp. 712-717
    • Takeda, A.1    Ando, M.2    Kanno, S.3
  • 32
    • 67349131573 scopus 로고    scopus 로고
    • Antiapoptotic and neurotrophic effects of antidepressants: A review of clinical and experimental studies
    • Drzyzga LR, Marcinowska A, Obuchowicz E. Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies. Brain Res Bull 2009;79:248-257.
    • (2009) Brain Res. Bull. , vol.79 , pp. 248-257
    • Drzyzga, L.R.1    Marcinowska, A.2    Obuchowicz, E.3
  • 33
    • 53149083386 scopus 로고    scopus 로고
    • Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms
    • Corniola RS, Tassabehji NM, Hare J, et al. Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms. Brain Res 2008;1237:52-61.
    • (2008) Brain Res. , vol.1237 , pp. 52-61
    • Corniola, R.S.1    Tassabehji, N.M.2    Hare, J.3
  • 34
    • 0042154427 scopus 로고    scopus 로고
    • Altered gene expression of brainderived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    • Dwivedi Y, Rizavi HS, Conley RR, et al. Altered gene expression of brainderived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 2003;60:804-815.
    • (2003) Arch. Gen. Psychiatry , vol.60 , pp. 804-815
    • Dwivedi, Y.1    Rizavi, H.S.2    Conley, R.R.3
  • 35
    • 49749101642 scopus 로고    scopus 로고
    • Serum brain-derived neurotrophic factor, depression, and antidepressant medications: Meta-analyses and implications
    • Sen S, Duman R, Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 2008;64:527-532.
    • (2008) Biol. Psychiatry , vol.64 , pp. 527-532
    • Sen, S.1    Duman, R.2    Sanacora, G.3
  • 36
    • 53649106504 scopus 로고    scopus 로고
    • Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action
    • Szewczyk B, Poleszak E, Sowa-Kucma M, et al. Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action. Pharmacol Rep 2008;60:588-589.
    • (2008) Pharmacol. Rep. , vol.60 , pp. 588-589
    • Szewczyk, B.1    Poleszak, E.2    Sowa-Kucma, M.3
  • 37
    • 39449119803 scopus 로고    scopus 로고
    • Ama 'zinc' link between TrkB transactivation and synaptic plasticity
    • Nagappan G, Woo NH, Lu B. Ama 'zinc' link between TrkB transactivation and synaptic plasticity. Neuron 2008;57:477-479.
    • (2008) Neuron , vol.57 , pp. 477-479
    • Nagappan, G.1    Woo, N.H.2    Lu, B.3
  • 38
    • 39449099067 scopus 로고    scopus 로고
    • Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse
    • Huang YZ, Pan E, Xiong ZQ, McNamara JO. Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse. Neuron 2008;57:546-558.
    • (2008) Neuron , vol.57 , pp. 546-558
    • Huang, Y.Z.1    Pan, E.2    Xiong, Z.Q.3    McNamara, J.O.4
  • 39
    • 77955844873 scopus 로고    scopus 로고
    • Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway
    • Xu H, Gao HL, Zheng W, et al. Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway. Hippocampus 2010.
    • (2010) Hippocampus
    • Xu, H.1    Gao, H.L.2    Zheng, W.3
  • 40
    • 0034671366 scopus 로고    scopus 로고
    • Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
    • Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000;20:9104-9110.
    • (2000) J. Neurosci. , vol.20 , pp. 9104-9110
    • Malberg, J.E.1    Eisch, A.J.2    Nestler, E.J.3    Duman, R.S.4
  • 41
    • 74949117713 scopus 로고    scopus 로고
    • Zinc deficiency reduces neurogenesis • accompanied by neuronal apoptosis through caspase-dependent and-independent signaling pathways
    • Dietary zinc deficiency reduces the number of proliferating cells and the amount of neuronal differentiation in the dentate gyrus of weanling mice. Fas-medicated and caspase-dependent mechanisms were attenuated by zinc deficiency, leading to an increase in hippocampal TUNEL labeling
    • Gao HL, Zheng W, Xin N, et al. Zinc deficiency reduces neurogenesis • accompanied by neuronal apoptosis through caspase-dependent and-independent signaling pathways. Neurotox Res 2009;16:416-425. Dietary zinc deficiency reduces the number of proliferating cells and the amount of neuronal differentiation in the dentate gyrus of weanling mice. Fas-medicated and caspase-dependent mechanisms were attenuated by zinc deficiency, leading to an increase in hippocampal TUNEL labeling.
    • (2009) Neurotox Res. , vol.16 , pp. 416-425
    • Gao, H.L.1    Zheng, W.2    Xin, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.