1,25-dihydroxyvitamin D3 and its nuclear receptor repress human α1(I) collagen expression and type I collagen formation

Liver International

Volumn 33, Issue 5, 2013, Pages 677-686

  Potter, James J ^a   Liu, Xiaopu ^a   Koteish, Ayman ^a   Mezey, Esteban ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

1(I) collagen; 1,25 dihydroxyvitamin D3; Sp1; Stellate cells; Transforming growth factor 1; Vitamin D receptor

Indexed keywords

CALCITRIOL; CALCITRIOL RECEPTOR; CASPASE 3; COLLAGEN TYPE 1; GELATINASE B; RETINOID X RECEPTOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA1; TRICHOSTATIN A; VITAMIN D RECEPTOR;

APOPTOSIS; ARTICLE; BINDING SITE; CHROMATIN STRUCTURE; COLLAGEN DEGRADATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DNA FRAGMENTATION; EXPRESSION VECTOR; GENETIC TRANSFECTION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; STELLATE CELL; VITAMIN D RESPONSIVE ELEMENT;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCITRIOL; CASPASE 3; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; COLLAGEN TYPE I; DROSOPHILA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HUMANS; LUCIFERASES; OLIGONUCLEOTIDES; PLASMIDS; PROMOTER REGIONS, GENETIC; RECEPTORS, CALCITRIOL; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84876087225     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12122     Document Type: Article

References (34)

1. Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Endocrinol Metab Clin N Am 2010; 39: 243-53.
2. Arteh J, Narra S, Nair S. Prevalence of vitamin D deficiency in chronic liver disease. Dig Dis Sci 2010; 55: 2624-8.
3. Targher G, Bertolini L, Scala L, et al. Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 2007; 17: 517-24.
4. Petta S, Camma C, Scazzone C, et al. Low vitamin D serum level is related to severe fibrosis and low responsiveness to INF-based therapy in genotype 1 chronic hepatitis C. Hepatology 2010; 51: 1158-67.
5. 2 collagen mRNA and their use in studying the regulation of Type I collagen synthesis by 1, 25-dihydroxyvitamin D. Biochemistry 1984; 23: 6210-16.
6. 1(I) collagen promoter. Regulation by 1, 25-hydroxyvitamin D. J Biol Chem 1989; 264: 3072-7.
7. Ramirez AM, Wongtrakool C, Welch T, et al. Vitamin D inhibition of pro-fibrotic effects of transforming growth factor β1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol 2010; 118: 142-50.
8. Abramovitch S, Dahan-Bachar L, Sharvit E, et al. Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thiocetamide-induced fibrosis in rats. Gut 2011; 60: 1728-39.
9. Haussler MR, Haussler CA, Jurutka PW, et al. The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol 1997; 154: S57-73.
10. Jimenez-Lara A, Aranda A. Interaction of vitamin D and retinoic receptors on regulation of gene expression. Horm Res 2000; 54: 301-5.
11. Carlberg C. Mechanisms of nuclear signaling by vitamin D3. Interplay with retinoid and thyroid hormone signaling. Eur J Biochem 1995; 231: 517-27.
12. 3 in the transcriptional control of type I collagen synthesis in MC3T3-E1 osteoblastic cells. J Cell Physiol 1995; 164: 459-64.
13. kip1 expression of vitamin D3. Oncogene 2004; 23: 4856-61.
14. 1(I) procollagen gene promoter. Differential activity in collagen-producing and-nonproducing cells and response to transforming growth factor β 1. J Biol Chem 1994; 269: 12684-91.
15. 1(I) collagen is mediated by Sp1 and Smad2 transacting factors. DNA Cell Biol 2009; 28: 425-34.
16. 2(I) collagen promoter by leptin in not mediated by transforming growth factor β responsive elements. Biochem Biophys Res Commun 2003; 312: 629-33.
17. Potter JJ, Mezey E, Christy RJ, et al. CCAAT/enhancer binding protein binds and activates the promoter to the rat class I alcohol dehydrogenase gene. Arch Biochem Biophys 1991; 285: 246-51.
18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
19. Feinberg AP, Vogelstein B. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1983; 132: 6-13.
20. Di Nocera PP, Dawid IB. Transient expression of genes introduced into cultured cells in Drosophila. Proc Natl Acad Sci U.S.A. 1983; 80: 7095-8.
21. Nowak DE, Tian B, Brasier AR. Two-step crosslinking method for identification of NF-KappaB gene network by chromatin immunoprecipitation. Biotechniques 2005; 39: 715-24.
22. Evans PM, Zhang W, Chen X, Yang J, Bhakat KK, Liu C. Kruppel-like factor 4 is acetylated by P300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem 2007; 282: 33994-4002.
23. Aparicio O, Geisberg JV, Sekinger E, et al. Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo. Curr Protoc Mol Biol 2005; 21; 21.3.1-3.33.
24. Schubeler D, MacAlpine DM, Scalzo D, et al. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev 2004; 18: 1263-71.
25. Sorg BL, Klan N, Seuter S, et al. Analysis of the 5-lipoxygenase promoter and characterization of the vitamin D receptor binding site. Biochim Biophys Acta 2006; 1761: 686-97.
26. skp2 expression via Sp1 sites in human prostate cancer cells. J Cell Physiol 2006; 209: 363-9.
27. Klan N, Seuter S, Schnur N, Jung M, Steinhilber D. Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. Biol Chem 2003; 384: 777-85.
28. Schnur N, Seuter S, Katryniok C, Radmark O, Steinhilber D. The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC boxes. Biochim Biophys Acta 2007; 1771: 1271-82.
29. Iredale JP, Benyon RC, Pickering J, et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998; 102: 538-49.
30. De Blesser PJ, Xu G, Rombouts K, Rogiers V, Geerts A. Glutathione levels discriminate between oxidative stress and transforming growth factor-β signaling activated rat hepatic stellate cells. J Biol Chem 1999; 274: 33881-7.
31. Herrera B, Murillo MM, Alvarez-Barrientos A, et al. Source of early reactive species in the apoptosis induced by transforming growth factor-β in fetal rat hepatocytes. Free Radic Biol Med 2004; 36: 16-26.
32. Issa R, Williams E, Trim N, et al. Apoptosis of hepatic stellate cells involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut 2001; 48: 548-57.
33. Diker-Cohen T, Koren R, Liberman A, Ravid A. Vitamin D protects keratinocytes from apoptosis induced by osmotic shock, oxidative stress, and tumor necrosis factor. Ann NY Acad Sci 2003; 1010: 350-3.
34. 3 and its low calcemic analogues on staurosporin-induced apoptosis. Pharmacol Rev 2007; 59: 393-401.