N-POMC1-28 increases cyclin D expression and inhibits P27kip1 in the adrenal cortex

Molecular and Cellular Endocrinology

Volumn 371, Issue 1-2, 2013, Pages 166-173

  de Mendonca, Pedro O R ^a   Liria, Cleber W ^a   Machini, Maria Teresa ^a   Lotfi, Claudimara F P ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

ACTH; Adrenal cortex; Cyclin D; N POMC1 28; P27kip; Proliferation

Indexed keywords

CORTICOTROPIN; CYCLIN D; CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYSTEINE; DISULFIDE; METHIONINE; PROOPIOMELANOCORTIN; PROOPIOMELANOCORTIN 1-28 AMINO TERMINAL PEPTIDE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CCND1 PROTEIN, RAT; CCND2 PROTEIN, RAT; CCND3 PROTEIN, RAT; CDKN1B PROTEIN, RAT; CELL CYCLE PROTEIN; N POMC (1 28); N-POMC (1-28); PEPTIDE FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CHEMICAL BOND; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; GROWTH REGULATION; MALE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT; UPREGULATION; ZONA GLOMERULOSA; ADRENAL CORTEX; ANIMAL; BIOSYNTHESIS; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; DRUG EFFECT; METABOLISM; SPRAGUE DAWLEY RAT;

ADRENAL CORTEX; ADRENOCORTICOTROPIC HORMONE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CYCLIN D; CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOWN-REGULATION; MALE; PEPTIDE FRAGMENTS; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION; ZONA GLOMERULOSA;

EID: 84876075170     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.11.017     Document Type: Article

References (25)

1. Baccaro R.B., Mendonca P.O., Torres T.E., Lotfi C.F. Immunohistochemical Jun/Fos protein localization and DNA synthesis in rat adrenal cortex after treatment with ACTH or FGF2. Cell Tissue Res. 2007, 328:7-18.
2. Boyle B., Butz H., Liko I., Zalatnai A., Toth M., Feldman K., Horanyi J., Igaz P., Racz K., Patocs A. Expression of glucocorticoid receptor isoforms in human adrenocortical adenomas. Steroids 2010, 75:695-700.
3. Ciemerych M.A., Kenney A.M., Sicinska E., Kalaszczynska I., Bronson R.T., Rowitch D.H., Gardner H., Sicinski P. Development of mice expressing a single D-type cyclin. Genes Develop. 2002, 16:3277-3289.
4. Coulter C.L., Pestell R.G., Ross J.T., Salkeld M.D., James S., Bennett H.P., McMillen I.C. Effect of N-proopiomelanocortin (1-77) and (1-49) infusions on adrenal expression of cyclin D1 in the fetal sheep. Endocr. Res. 2002, 28:625-629.
5. Dumitrescu A., Aberdeen G.W., Pepe G.J., Albrecht E.D. Developmental expression of cell cycle regulators in the baboon fetal adrenal gland. J. Endocrinol. 2007, 192:237-247.
6. Estivariz F.E., Iturriza F., McLean C., Hope J., Lowry P.J. Stimulation of adrenal mitogenesis by N-terminal proopiocortin peptides. Nature 1982, 297:419-422.
7. Estivariz F.E., Carino M., Lowry P.J., Jackson S. Further evidence that N-terminal pro-opiomelanocortin peptides are involved in adrenal mitogenesis. J. Endocrinol. 1988, 116:201-206.
8. Inaba T., Matsushime H., Valentine M., Roussel M.F., Sherr C.J., Look A.T. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics 1992, 13:565-574.
9. King P., Paul A., Laufer E. Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. PNAS 2009, 106:21185-21190.
10. Kitagawa K., Kotake Y., Kitagawa M. Ubiquitin-mediated control of oncogene and tumor suppressor gene products. Cancer Sci. 2009, 100:1374-1381.
11. Kobayashi H., Kambe F., Imai T., Hibi Y., Kikumori T., Ohmori S., Nakao A., Seo H. Differential expression of cyclin-dependent kinase inhibitors, p27Kip1 and p57Kip2, by corticotropin in rat adrenal cortex. J. Endocrinol. 2006, 189:671-679.
12. Lotfi C.F., Lepique A.P., Forti F.L., Schwindt T.T., Eichler C.B., Santos M.O., Rebustini I.T., Hajj G.N., Juliano L., Armelin H.A. Proliferative signaling initiated in ACTH receptors. Brazil. J. Med. Biol. Res. 2000, 33:1133-1140.
13. Lowry P.J., Silas L., McLean C., Linton E.A., Estivariz F.E. Pro-gamma-melanocyte-stimulating hormone cleavage in adrenal gland undergoing compensatory growth. Nature 1983, 306:70-73.
14. Mattos G., Jacysyn J., Amarante-Mendes G., Lotfi C. Comparative effect of FGF2, synthetic peptides 1-28 N-POMC and ACTH on proliferation in rat adrenal cell primary cultures. Cell Tissue Res. 2011, 345:343-356.
15. McLean C., Hope J., Salacinski P., Estivariz F., Lowry P.J. Purification and characterization of amino-terminal pro-opiocortin peptides from human pituitary glands. Biosci. Rep. 1981, 1:843-849.
16. 1-28 peptides in rat adrenal cortex: a possible role for cyclin E. Mol. Cell. Endocrinol. 2011, 336:156-161.
17. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996, 85:707-720.
18. Pepper D.J., Bicknell A.B. The stimulation of mitogenic signaling pathways by N-POMC peptides. Mol. Cell. Endocrinol. 2009, 300:77-82.
19. Pestell R.G., Albanese C., Reutens A.T., Segall J.E., Lee R.J., Arnold A. The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr. Rev. 1999, 20:501-534.
20. Kip1 inhibits cyclin D-Cyclin-dependent kinase 4 by two independent modes. Mol. Cell. Biol. 2009, 29:986-999.
21. Schwindt T.T., Forti F.L., Juliano M.A., Juliano L., Armelin H.A. Arginine vasopressin inhibition of cyclin D1 gene expression blocks the cell cycle and cell proliferation in the mouse Y1 adrenocortical tumor cell line. Biochemistry 2003, 42:2116-2121.
22. Torres T.E., Lotfi C.F. Distribution of cells expressing Jun and Fos proteins and synthesizing DNA in the adrenal cortex of hypophysectomized rats: regulation by ACTH and FGF2. Cell Tissue Res. 2007, 329:443-455.
23. Torres T.E., de Mendonca P.O., Lotfi C.F. Synthetic modified N-POMC(1-28) controls in vivo proliferation and blocks apoptosis in rat adrenal cortex. Cell Tissue Res. 2010, 341:239-250.
24. Watanabe G., Lee R.J., Albanese C., Rainey W.E., Batlle D., Pestell R.G. Angiotensin II activation of cyclin D1-dependent kinase activity. J. Biol. Chem. 1996, 271:22570-22577.
25. Xiong Y., Connolly T., Futcher B., Beach D. Human D-type cyclin. Cell 1991, 65:691-699.