The proliferative effect of synthetic N-POMC1-28 peptides in rat adrenal cortex: A possible role for cyclin E

Molecular and Cellular Endocrinology

Volumn 336, Issue 1-2, 2011, Pages 156-161

  Mendonça, Pedro O R de ^a   Lotfi, Claudimara F P ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

ACTH; Adrenal cortex; Cyclin E; N POMC1 28; Proliferation

Indexed keywords

BROXURIDINE; CORTICOTROPIN; CYCLIN E; DEXAMETHASONE; DNA; PROOPIOMELANOCORTIN;

ADRENAL CORTEX; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE S PHASE; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DISULFIDE BOND; DNA SYNTHESIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ZONA GLOMERULOSA;

ADRENAL CORTEX; ADRENOCORTICOTROPIC HORMONE; ANIMALS; BROMODEOXYURIDINE; CELL NUCLEUS; CELL PROLIFERATION; CYCLIN E; DEXAMETHASONE; MALE; PEPTIDE FRAGMENTS; PEPTIDES; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; SUBCELLULAR FRACTIONS; ZONA FASCICULATA; ZONA GLOMERULOSA; ZONA RETICULARIS;

EID: 79952073051     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.12.012     Document Type: Article

References (14)

1. Baccaro R.B., Mendonca P.O., Torres T.E., Lotfi C.F. Immunohistochemical Jun/Fos protein localization and DNA synthesis in rat adrenal cortex after treatment with ACTH or FGF2. Cell Tissue Res. 2007, 328(1):7-18.
2. Coll A.P., Fassnacht M., Klammer S., Hahner S., Schulte D.M., Piper S., Tung Y.C., Challis B.G., Weinstein Y., Allolio B., O'Rahilly S., Beuschlein F. Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production. J. Endocrinol. 2006, 190:515-525.
3. Denef C., Roudbaraki M., Van Bael A. Growth and differentiation factors derived from the N-terminal domain of pro-opiomelanocortin. Clin. Exp. Pharmacol. Physiol. 2001, 28(3):239-243.
4. Estivariz F.E., Carino M., Lowry P.J., Jackson S. Further evidence that N-terminal pro-opiomelanocortin peptides are involved in adrenal mitogenesis. J. Endocrinol. 1988, 116(2):201-206.
5. Estivariz F.E., Iturriza F., McLean C., Hope J., Lowry P.J. Stimulation of adrenal mitogenesis by N-terminal proopiocortin peptides. Nature 1982, 297(5865):419-422.
6. Fassnacht M., Hahner S., Hansen I.A., Kreutzberger T., Zink M., Adermann K., Jakob F., Troppmair J., Allolio B. N-terminal proopiomelanocortin acts as a mitogen in adrenocortical tumor cells and decreases adrenal steroidogenesis. J. Clin. Endocrinol. Metab. 2003, 88:2171-2179.
7. Lowry P.J., Silas L., McLean C., Linton E.A., Estivariz F.E. Pro-gamma-melanocyte-stimulating hormone cleavage in adrenal gland undergoing compensatory growth. Nature 1983, 306(5938):70-73.
8. New M.I. Diagnosis and management of congenital adrenal hyperplasia. Annu. Rev. Med. 1998, 49:311-328.
9. Otis M., Campbell S., Payet M.D., Gallo-Payet N. Expression of extracellular matrix proteins and integrins in rat adrenal gland: importance for ACTH-associated functions. J. Endocrinol. 2007, 193(3):331-347.
10. Pestell R.G., Albanese C., Reutens A.T., Segall J.E., Lee R.J., Arnold A. The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocrine Rev. 1999, 20:501L 534.
11. Seger M.A., Bennett H.P. Structure and bioactivity of the amino-terminal fragment of pro-opiomelanocortin. J. Steroid Biochem. 1986, 25(5B):703-710.
12. Torres T.E., Lotfi C.F. Distribution of cells expressing Jun and Fos proteins and synthesizing DNA in the adrenal cortex of hypophysectomized rats: regulation by ACTH and FGF2. Cell Tissue Res. 2007, 329:443L 455.
13. Torres T.E., de Mendonca P.O., Lotfi C.F. Synthetic modified N-POMC(1-28) controls in vivo proliferation and blocks apoptosis in rat adrenal cortex. Cell Tissue Res. 2010, 341(2):239-250.
14. Usategui R., Oliver C., Vaudry H., Lombardi G., Rozenberg I., Mourre A.M. Immunoreactive α-MSH and ACTH levels in rat plasma and pituitary. Endocrinology 1976, 98(1):189-196.