Induction of protective immunity against Chlamydia muridarum intravaginal infection with the chlamydial immunodominant antigen macrophage infectivity potentiator

Microbes and Infection

Volumn 15, Issue 4, 2013, Pages 329-338

  Lu, Chunxue ^a   Peng, Bo ^a   Li, Zhihong ^b   Lei, Lei ^c   Li, Zhongyu ^a   Chen, Lili ^a   He, Qingzhi ^a   Zhong, Guangming ^a,c   Wu, Yimou ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Chlamydia muridarum; Macrophage infectivity potentiator; Protective immunity; Vaccine

Indexed keywords

BACTERIAL ANTIGEN; MACROPHAGE INFECTIVITY POTENTIATOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL SHEDDING; CHLAMYDIA; CHLAMYDIASIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNITY; IMMUNIZATION; INFECTION PREVENTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VAGINITIS;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL SHEDDING; BACTERIAL VACCINES; CHLAMYDIA INFECTIONS; CHLAMYDIA MURIDARUM; DISEASE MODELS, ANIMAL; FEMALE; IMMUNODOMINANT EPITOPES; MICE; REPRODUCTIVE TRACT INFECTIONS;

CHLAMYDIA MURIDARUM; CHLAMYDIA TRACHOMATIS; MUS;

EID: 84876074318     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2013.02.001     Document Type: Article

References (41)

1. Sherman K.J., Daling J.R., Stergachis A., Weiss N.S., Foy H.M., Wang S., Grayston J.T. Sexually transmitted diseases and tubal pregnancy. Sex. Transm. Dis. 1990, 17:115-121.
2. Kelly K.A. Cellular immunity and Chlamydia genital infection: induction, recruitment, and effector mechanisms. Int. Rev. Immunol. 2003, 22:3-41.
3. Rodgers A.K., Wang J., Zhang Y., Holden A., Berryhill B., Budrys N.M., Schenken R.S., Zhong G. Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P. Am. J. Obstet. Gynecol. 2010, 203. 494.e7--494.e14.
4. Rockey D.D., Wang J., Lei L., Zhong G. Chlamydia vaccine candidates and tools for chlamydial antigen discovery. Expert Rev. Vaccines 2009, 8:1365-1377.
5. Dhir S.P., Agarwal L.P., Gupta S.B., Detels R., Wang S.P., Grayston J.T. Trachoma vaccine trial in India: results of two-year follow-up. Indian J. Med. Res. 1968, 56:1289-1294.
6. Grayston J.T., Wang S.P., Woolridge R.L., Alexander E.R. Prevention of trachoma with vaccine. Arch. Environ. Health 1964, 8:518-526.
7. Morrison S.G., Su H., Caldwell H.D., Morrison R.P. Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4+ T cells but not CD8++ T cells. Infect. Immun. 2000, 68:6979-6987.
8. Zhong G., Smith G.P., Berry J., Brunham R.C. Conformational mimicry of a chlamydial neutralization epitope on filamentous phage. J. Biol. Chem. 1994, 269:24183-24188.
9. Su H., Messer R., Whitmire W., Hughes S., Caldwell H.D. Subclinical chlamydial infection of the female mouse genital tract generates a potent protective immune response: implications for development of live attenuated chlamydial vaccine strains. Infect. Immun. 2000, 68:192-196.
10. Cruz-Fisher M.I., Cheng C., Sun G., Pal S., Teng A., Molina D.M., Kayala M.A., Vigil A., Baldi P., Felgner P.L. Identification of immunodominant antigens by probing a whole Chlamydia trachomatis open reading frame proteome microarray using sera from immunized mice. Infect. Immun. 2011, 79:246-257.
11. Cotter T.W., Meng Q., Shen Z.L., Zhang Y.X., Su H., Caldwell H.D. Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection. Infect. Immun. 1995, 63:4704-4714.
12. Dong-Ji Z., Yang X., Shen C., Lu H., Murdin A., Brunham R.C. Priming with Chlamydia trachomatis major outer membrane protein (MOMP) DNA followed by MOMP ISCOM boosting enhances protection and is associated with increased immunoglobulin A and Th1 cellular immune responses. Infect. Immun. 2000, 68:3074-3078.
13. Eko F.O., He Q., Brown T., Mcmillan L., Ifere G.O., Ananaba G.A., Lyn D., Lubitz W., Kellar K.L., Black C.M. A novel recombinant multisubunit vaccine against Chlamydia. J. Immunol. 2004, 173:3375-3382.
14. Pal S., Barnhart K.M., Wei Q., Abai A.M., Peterson E.M., De La Maza L.M. Vaccination of mice with DNA plasmids coding for the Chlamydia trachomatis major outer membrane protein elicits an immune response but fails to protect against a genital challenge. Vaccine 1999, 17:459-465.
15. Pal S., Theodor I., Peterson E.M., De La Maza L.M. Monoclonal immunoglobulin A antibody to the major outer membrane protein of the Chlamydia trachomatis mouse pneumonitis biovar protects mice against a chlamydial genital challenge. Vaccine 1997, 15:575-582.
16. Su H., Parnell M., Caldwell H.D. Protective efficacy of a parenterally administered MOMP-derived synthetic oligopeptide vaccine in a murine model of Chlamydia trachomatis genital tract infection: serum neutralizing IgG antibodies do not protect against chlamydial genital tract infection. Vaccine 1995, 13:1023-1032.
17. Zhang D., Yang X., Berry J., Shen C., Mcclarty G., Brunham R.C. DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection. J. Infect. Dis. 1997, 176:1035-1040.
18. Murthy A.K., Chambers J.P., Meier P.A., Zhong G., Arulanandam B.P. Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production. Infect. Immun. 2007, 75:666-676.
19. Cong Y., Jupelli M., Guentzel M.N., Zhong G., Murthy A.K., Arulanandam B.P. Intranasal immunization with chlamydial protease-like activity factor and CpG deoxynucleotides enhances protective immunity against genital Chlamydia muridarum infection. Vaccine 2007, 25:3773-3780.
20. Li W., Murthy A.K., Guentzel M.N., Chambers J.P., Forsthuber T.G., Seshu J., Zhong G., Arulanandam B.P. Immunization with a combination of integral chlamydial antigens and a defined secreted protein induces robust immunity against genital chlamydial challenge. Infect. Immun. 2010, 78:3942-3949.
21. Wang J., Chen L., Chen F., Zhang X., Zhang Y., Baseman J., Perdue S., Yeh I., Shain R., Holland M. A chlamydial type III-secreted effector protein (Tarp) is predominantly recognized by antibodies from humans infected with Chlamydia trachomatis and induces protective immunity against upper genital tract pathologies in mice. Vaccine 2009, 27:2967-2980.
22. Olsen A.W., Theisen M., Christensen D., Follmann F., Andersen P. Protection against Chlamydia promoted by a subunit vaccine (CTH1) compared with a primary intranasal infection in a mouse genital challenge model. PLoS One 2010, 5:e10768.
23. Meoni E., Faenzi E., Frigimelica E., Zedda L., Skibinski D., Giovinazzi S., Bonci A., Petracca R., Bartolini E., Galli G. CT043, a protective antigen that induces a CD4+ Th1 response during Chlamydia trachomatis infection in mice and humans. Infect. Immun. 2009, 77:4168-4176.
24. Donati M., Sambri V., Comanducci M., Di Leo K., Storni E., Giacani L., Ratti G., Cevenini R. DNA immunization with pgp3 gene of Chlamydia trachomatis inhibits the spread of chlamydial infection from the lower to the upper genital tract in C3H/HeN mice. Vaccine 2003, 21:1089-1093.
25. Starnbach M.N., Loomis W.P., Ovendale P., Regan D., Hess B., Alderson M.R., Fling S.P. An inclusion membrane protein from Chlamydia trachomatis enters the MHC class I pathway and stimulates a CD8+ T cell response. J. Immunol. 2003, 171:4742-4749.
26. Finco O., Frigimelica E., Buricchi F., Petracca R., Galli G., Faenzi E., Meoni E., Bonci A., Agnusdei M., Nardelli F. Approach to discover T-and B-cell antigens of intracellular pathogens applied to the design of Chlamydia trachomatis vaccines. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:9969-9974.
27. Pal S., Peterson E.M., Luis M. New murine model for the study of Chlamydia trachomatis genitourinary tract infections in males. Infect. Immun. 2004, 72:4210-4216.
28. Swenson C.E., Schachter J. Infertility as a consequence of chlamydial infection of the upper genital tract in female mice. Sex. Transm. Dis. 1984, 11:64-67.
29. Wang J., Zhang Y., Lu C., Lei L., Yu P., Zhong G. A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans. J. Immunol. 2010, 185:1670-1680.
30. Zeng H., Hou S., Gong S., Dong X., Zou Q., Zhong G. Mapping immunodominant antigens and H-2-linked antibody responses in mice urogenitally infected with Chlamydia muridarum. Microbes Infect. 2012, 14:659-665.
31. Lu C., Zeng H., Li Z., Lei L., Yeh I., Wu Y., Zhong G. Protective immunity against mouse upper genital tract pathology correlates with high IFNγ? but low IL-17 T cell and anti-secretion protein antibody responses induced by replicating chlamydial organisms in the airway. Vaccine 2012, 30:475-485.
32. Li Z., Lu C., Peng B., Zeng H., Zhou Z., Wu Y., Zhong G. Induction of protective immunity against Chlamydia muridarum intravaginal infection with a chlamydial glycogen phosphorylase. PLoS One 2012, 7:e32997.
33. Chen L., Lei L., Chang X., Li Z., Lu C., Zhang X., Wu Y., Yeh I.T., Zhong G. Mice deficient in MyD88 develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection. J. Immunol. 2010, 184:2602-2610.
34. Peng B., Lu C., Tang L., Yeh I.T., He Z., Wu Y., Zhong G. Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum. BMC Infect. Dis. 2011, 11:347.
35. Shah A.A., Schripsema J.H., Imtiaz M.T., Sigar I.M., Kasimos J., Matos P.G., Inouye S., Ramsey K.H. Histopathologic changes related to fibrotic oviduct occlusion after genital tract infection of mice with Chlamydia muridarum. Sex. Transm. Dis. 2005, 32:49-56.
36. Imtiaz M.T., Schripsema J.H., Sigar I.M., Kasimos J.N., Ramsey K.H. Inhibition of matrix metalloproteinases protects mice from ascending infection and chronic disease manifestations resulting from urogenital Chlamydia muridarum infection. Infect. Immun. 2006, 74:5513-5521.
37. Soriani M., Petit P., Grifantini R., Petracca R., Gancitano G., Frigimelica E., Nardelli F., Garcia C., Spinelli S., Scarabelli G. Exploiting antigenic diversity for vaccine design. J. Biol. Chem. 2010, 285:30126-30138.
38. Fadel S., Eley A. Chlamydia trachomatis OmcB protein is a surface-exposed glycosaminoglycan-dependent adhesin. J. Med. Microbiol. 2007, 56:15-22.
39. Neff L., Daher S., Muzzin P., Spenato U., Gülaçar F., Gabay C., Bas S. Molecular characterization and subcellular localization of macrophage infectivity potentiator, a Chlamydia trachomatis lipoprotein. J. Bacteriol. 2007, 189:4739-4748.
40. Morrison R.P., Caldwell H.D. Immunity to murine chlamydial genital infection. Infect. Immun. 2002, 70:2741-2751.
41. Morrison S.G., Morrison R.P. A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection. J. Immunol. 2005, 175:7536-7542.