Biologically-optimised IMRT based on molecular imaging of tumour hypoxia-the impact of the tracer used

IFMBE Proceedings

Volumn 39 IFMBE, Issue , 2013, Pages 1742-1745

  Toma Dasu, I ^a   Dasu, A ^b,c  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b Department of Clinical Immunology and Transfusion Medicine   (Sweden)

^c LINKÖPING UNIVERSITY   (Sweden)

Author keywords

oxygenation; PET imaging; treatment optimisation; tumour oxygenation; vasculature

Indexed keywords

DOSE DISTRIBUTIONS; FUNCTIONAL ASPECTS; FUNCTIONAL IMAGING; OPTIMISATIONS; PET IMAGING; RADIATION SENSITIVITY; TREATMENT DURATION; VASCULATURE;

BINDING ENERGY; BIOMEDICAL ENGINEERING; MOLECULAR IMAGING; OPTIMIZATION; OXYGENATION; PATIENT TREATMENT; PHYSICAL THERAPY;

TUMORS;

EID: 84876068279     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-642-29305-4_458     Document Type: Conference Paper

References (16)

1. Höckel M, Knoop C, Schlenger K et al. (1993) Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol 26:45-50 (Pubitemid 23063609)
2. Brizel DM, Dodge RK, Clough RW et al. (1999) Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol 53:113-117
3. Apisarnthanarax S, Chao KS (2005) Current imaging paradigms in radiation oncology. Radiat Res 163:1-25 (Pubitemid 40039940)
4. Thorwarth D, Alber M (2010) Implementation of hypoxia imaging into treatment planning and delivery. Radiother Oncol 97:172-175
5. Eschmann SM, Paulsen F, Bedeshem C et al. (2007) Hypoxia-imaging with (18)F-Misonidazole and PET: changes of kinetics during radiotherapy of head-and-neck cancer. Radiother Oncol 83:406-410 (Pubitemid 46915551)
6. Busk M, Horsman MR, Overgaard J (2008) Resolution in PET hypoxia imaging: voxel size matters. Acta Oncol 47:1201-1210
7. Toma-Dasu I, Dasu A, Brahme A (2009) Dose prescription and optimisation based on tumour hypoxia. Acta Oncol 48:1181-1192
8. Toma-Dasu I, Uhrdin J, Antonovic L et al. (2011) Dose prescription and treatment planning based on FMISO-PET hypoxia. Acta Oncol
9. Toma-Dasu I, Uhrdin J, Dasu A et al. (2009) Therapy optimization based on non-linear uptake of PET tracers versus "linear dose painting". in: WC 2009, IFMBE Proceedings 25/I, edited by Dössel O, Schlegel WC. Springer, 221-224
10. Lewis JS, McCarthy DW, McCarthy TJ et al. (1999) Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model. J Nucl Med 40:177-183 (Pubitemid 29044189)
11. Rasey JS, Hofstrand PD, Chin LK et al. (1999) Characterization of [18F]fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia. J Nucl Med 40:1072-1079 (Pubitemid 29269230)
12. Alper T, Howard-Flanders P (1956) Role of oxygen in modifying the radiosensitivity of E. Coli B. Nature 178:978-979
13. Dasu A, Toma-Dasu I, Karlsson M (2003) Theoretical simulation of tumour oxygenation and results from acute and chronic hypoxia. Phys Med Biol 48:2829-2842 (Pubitemid 37121463)
14. Dasu A, Toma-Dasu I (2008) Vascular oxygen content and the tissue oxygenation - a theoretical analysis. Med Phys 35:539-545 (Pubitemid 351190874)
15. Chaplin DJ, Olive PL, Durand RE (1987) Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res 47:597-601 (Pubitemid 17009632)
16. Gagel B, Reinartz P, Dimartino E et al. (2004) pO(2) Polarography versus positron emission tomography ([(18)F] fluoromisonidazole, [(18)F]-2-fluoro- 2′-deoxyglucose). An appraisal of radiotherapeutically relevant hypoxia. Strahlenther Onkol 180:616-622 (Pubitemid 39361958)