메뉴 건너뛰기




Volumn 14, Issue 7, 2013, Pages 957-966

Ziconotide: A clinical update and pharmacologic review

Author keywords

Chronic pain; Intrathecal drug delivery systems; Neuropathic pain; Prialt; Ziconotide

Indexed keywords

BACLOFEN; BUPIVACAINE; CLONIDINE; DIHYDROMORPHINE; FENTANYL; HYDROMORPHONE; MORPHINE; OMEGA CONOTOXIN MVIIA; OPIATE; SUFENTANIL;

EID: 84876044991     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2013.784269     Document Type: Review
Times cited : (118)

References (57)
  • 1
    • 84885475133 scopus 로고    scopus 로고
    • Available from: http://www. washingtontimes.com/news/2013/jan/11/ny- mayor-bloomberg-limit-painmedication-hospitals/
  • 2
    • 70349696391 scopus 로고    scopus 로고
    • Mortality associated with implantation and management of intrathecal opioid drug infusion systems to treat noncancer pain
    • Coffey RJ, Owens ML, Broste SK, et al. Mortality associated with implantation and management of intrathecal opioid drug infusion systems to treat noncancer pain. Anesthesiology 2009;111:881-91
    • (2009) Anesthesiology , vol.111 , pp. 881-891
    • Coffey, R.J.1    Owens, M.L.2    Broste, S.K.3
  • 3
    • 84867576279 scopus 로고    scopus 로고
    • Polyanalgesic consensus conference 2012: Recommendations for the management of pain by intrathecal (intraspinal) drug delivery: Report of an interdisciplinary expert panel
    • Deer TR, Prager J, Levy R, et al. Polyanalgesic consensus conference 2012: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation 2012;15(5):436-64
    • (2012) Neuromodulation , vol.15 , Issue.5 , pp. 436-464
    • Deer, T.R.1    Prager, J.2    Levy, R.3
  • 5
    • 67650799129 scopus 로고    scopus 로고
    • Cost effectiveness of ziconotide in intrathecal pain management for severe chronic pain patients in the UK
    • Dewilde S, Verdian L, MacLaine GDH. Cost effectiveness of ziconotide in intrathecal pain management for severe chronic pain patients in the UK. Curr Med Res Opin 2009;25(8):2007-19
    • (2009) Curr Med Res Opin , vol.25 , Issue.8 , pp. 2007-2019
    • Dewilde, S.1    Verdian, L.2    Maclaine, G.D.H.3
  • 6
    • 84885475160 scopus 로고    scopus 로고
    • Available from: http://navigatorprogram. com/
  • 7
    • 0032528631 scopus 로고    scopus 로고
    • Localization of Ca 2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals
    • Westenbroek RE, Hoslins L, Cattarall WA. Localization of Ca 2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals. J Neurosci 1998;18(16):6319-30
    • (1998) J Neurosci , vol.18 , Issue.16 , pp. 6319-6330
    • Westenbroek, R.E.1    Hoslins, L.2    Cattarall, W.A.3
  • 8
    • 0023879251 scopus 로고
    • Autoradiographic localization of calcium challes with [125I] omega-conotoxin in rat brain
    • Kerr LM, Filloux F, Olivera BM, et al. Autoradiographic localization of calcium challes with [125I] omega-conotoxin in rat brain. Eur J Pharmacol 1988;146:181-3
    • (1988) Eur J Pharmacol , vol.146 , pp. 181-183
    • Kerr, L.M.1    Filloux, F.2    Olivera, B.M.3
  • 9
    • 77951652246 scopus 로고    scopus 로고
    • Ziconotide for treatment of severe chronic pain
    • Schmidtko A, Lotsch J, Freynhagen R, et al. Ziconotide for treatment of severe chronic pain. Lancet 2010;375(9725):1569-77
    • (2010) Lancet , vol.375 , Issue.9725 , pp. 1569-1577
    • Schmidtko, A.1    Lotsch, J.2    Freynhagen, R.3
  • 10
    • 0028105906 scopus 로고
    • Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium channel antagonist, SNX-230 (omega-conopeptide MVIIC)
    • Gohil K, Bell JR, Ramachandran J, et al. Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium channel antagonist, SNX-230 (omega-conopeptide MVIIC). Brain Res 1994;653(1-2):258-66
    • (1994) Brain Res , vol.653 , Issue.1-2 , pp. 258-266
    • Gohil, K.1    Bell, J.R.2    Ramachandran, J.3
  • 11
    • 60349128880 scopus 로고    scopus 로고
    • PRIALT (ziconotide Intrathecal Infusion) Azur Pharma Inc. Philadelphia PA
    • PRIALT (ziconotide intrathecal infusion). Prescribing information. Azur Pharma, Inc., Philadelphia, PA; 2010
    • (2010) Prescribing Information
  • 12
    • 9144230737 scopus 로고    scopus 로고
    • Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: A randomized controlled trial
    • Staats PS, Yearwood T, Charapata SG, et al. Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial. JAMA 2004;291:63-70
    • (2004) JAMA , vol.291 , pp. 63-70
    • Staats, P.S.1    Yearwood, T.2    Charapata, S.G.3
  • 13
    • 33746516663 scopus 로고    scopus 로고
    • A randomized, double-blind, placebocontrolled study of intrathecal ziconotide in adults with severe chronic pain
    • Rauck RL, Wallace MS, Leong MS, et al. A randomized, double-blind, placebocontrolled study of intrathecal ziconotide in adults with severe chronic pain. J Pain Symptom Manage 2006;31:393-406
    • (2006) J Pain Symptom Manage , vol.31 , pp. 393-406
    • Rauck, R.L.1    Wallace, M.S.2    Leong, M.S.3
  • 14
    • 33645794750 scopus 로고    scopus 로고
    • Intrathecal ziconotide in the treatment of chronic nonmalignant pain: A randomized, double-blind, placebo-controlled clinical trial
    • Wallace MS, Charapata SG, Fisher R, et al. Intrathecal ziconotide in the treatment of chronic nonmalignant pain: a randomized, double-blind, placebo-controlled clinical trial. Neuromodulation 2006;9:75-86
    • (2006) Neuromodulation , vol.9 , pp. 75-86
    • Wallace, M.S.1    Charapata, S.G.2    Fisher, R.3
  • 15
    • 61349140138 scopus 로고    scopus 로고
    • Long-term intrathecal ziconotide for chronic pain: An open labeled study
    • Webster LR, Fisher R, Chrpata S, Wallace MS. Long-term intrathecal ziconotide for chronic pain: an open labeled study. J Pain Symptom Manage 2009;37(3):363-72
    • (2009) J Pain Symptom Manage , vol.37 , Issue.3 , pp. 363-372
    • Webster, L.R.1    Fisher, R.2    Chrpata, S.3    Wallace, M.S.4
  • 16
    • 38549174565 scopus 로고    scopus 로고
    • Intrathecal ziconotide for severe chronic pain: Safety and tolerability results of an open-label, long-term trial
    • Wallace MS, Rauck R, Fisher R, et al. Intrathecal ziconotide for severe chronic pain: safety and tolerability results of an open-label, long-term trial. Anesth Analg 2008;106(2):628e637
    • (2008) Anesth Analg , vol.106 , Issue.2
    • Wallace, M.S.1    Rauck, R.2    Fisher, R.3
  • 17
    • 37549018110 scopus 로고    scopus 로고
    • Continuous intrathecal infusion of ziconotide for treatment of chronic malignant and nonmalignant pain over 12 months: A prospective, open-label study
    • Ellis DJ, Dissanayake S, McGuire D, et al. Continuous intrathecal infusion of ziconotide for treatment of chronic malignant and nonmalignant pain over 12 months: a prospective, open-label study. Neuromodulation 2008;11(1):40-9
    • (2008) Neuromodulation , vol.11 , Issue.1 , pp. 40-49
    • Ellis, D.J.1    Dissanayake, S.2    McGuire, D.3
  • 18
    • 62949187356 scopus 로고    scopus 로고
    • Convection-enhanced delivery in the treatment of epilepsy
    • Rogawski MA. Convection-enhanced delivery in the treatment of epilepsy. Neurotherapeutics 2009;6(2):344-51
    • (2009) Neurotherapeutics , vol.6 , Issue.2 , pp. 344-351
    • Rogawski, M.A.1
  • 19
    • 84885478618 scopus 로고    scopus 로고
    • Available from: http://www. chemicalbook.com/ChemicalProduct Property-EN-CB3190092.htm
  • 20
    • 34249017949 scopus 로고    scopus 로고
    • Ziconotide: A review of its pharmacology and use in the treatment of pain
    • McGivern JG. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat 2007;3(1):69-85
    • (2007) Neuropsychiatr Dis Treat , vol.3 , Issue.1 , pp. 69-85
    • McGivern, J.G.1
  • 21
    • 23244431760 scopus 로고    scopus 로고
    • Ziconotide, an intrathecally administered N-type calcium channel antagonist for the treatment of chronic pain
    • Wermeling DP. Ziconotide, an intrathecally administered N-type calcium channel antagonist for the treatment of chronic pain. Pharmacotherapy 2005;25:1084-94
    • (2005) Pharmacotherapy , vol.25 , pp. 1084-1094
    • Wermeling, D.P.1
  • 22
    • 84870527944 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of ziconotide (SNX-111), an intrathecal N-type calcium channel blocking analgesic, delivered by bolus and infusion in dog
    • Yaksh TL, De Kater A, Dean R, et al. Pharmacokinetic analysis of ziconotide (SNX-111), an intrathecal N-type calcium channel blocking analgesic, delivered by bolus and infusion in dog. Neuromodulation 2012;15:508-19
    • (2012) Neuromodulation , vol.15 , pp. 508-519
    • Yaksh, T.L.1    De Kater, A.2    Dean, R.3
  • 23
    • 0026693754 scopus 로고
    • Cardiovascular effects of omega-conotoxins MVIIA and CVID in conscious rats: Mechanisms of action
    • Bowersox SS, Singh T, Nadasdi L, et al. Cardiovascular effects of omega-conotoxins MVIIA and CVID in conscious rats: mechanisms of action. J Cardiovasc Pharmacol 1992;20:756-64
    • (1992) J Cardiovasc Pharmacol , vol.20 , pp. 756-764
    • Bowersox, S.S.1    Singh, T.2    Nadasdi, L.3
  • 24
    • 79960530506 scopus 로고    scopus 로고
    • Cerebrospinal Fluid Flow imaging by using phase-contrast MR technique
    • Battal B, Kocaoglu M, Bulanski N, et al. Cerebrospinal Fluid Flow imaging by using phase-contrast MR technique. Br J Radiol 2011;84(1004):758-65
    • (2011) Br J Radiol , vol.84 , Issue.1004 , pp. 758-765
    • Battal, B.1    Kocaoglu, M.2    Bulanski, N.3
  • 25
    • 78649903759 scopus 로고    scopus 로고
    • Recent insights into the hydrodynamics of the cerebrospinal fluid
    • Bulat M, Klarica M. Recent insights into the hydrodynamics of the cerebrospinal fluid. Brain Res Rev 2011;65:99-112
    • (2011) Brain Res Rev , vol.65 , pp. 99-112
    • Bulat, M.1    Klarica, M.2
  • 26
    • 0034105538 scopus 로고    scopus 로고
    • Origin of Subarachnoid cerebrospinal fluid pulsations: A phase-contrast MR analysis
    • Henry-Feugeas MC, Idy-Peretti I, Baledent O, et al. Origin of Subarachnoid cerebrospinal fluid pulsations: a phase-contrast MR analysis. Magn Reson Imaging 2000;18(4):387-95
    • (2000) Magn Reson Imaging , vol.18 , Issue.4 , pp. 387-395
    • Henry-Feugeas, M.C.1    Idy-Peretti, I.2    Baledent, O.3
  • 27
    • 0942298132 scopus 로고    scopus 로고
    • The influence of pulse and respiration on spinal cerebrospinal fluid pulsation
    • Friese S, Hamhaber U, Erb M, et al. The influence of pulse and respiration on spinal cerebrospinal fluid pulsation. Invest Radiol 2004;39:120-30
    • (2004) Invest Radiol , vol.39 , pp. 120-130
    • Friese, S.1    Hamhaber, U.2    Erb, M.3
  • 28
    • 33645717591 scopus 로고    scopus 로고
    • Effect of anatomic fine structure on the flow of cerebrospinal fluid in the spinal subarachnoid space
    • Stockman HW. Effect of anatomic fine structure on the flow of cerebrospinal fluid in the spinal subarachnoid space. J Biochem Eng 2006;128:106-14
    • (2006) J Biochem Eng , vol.128 , pp. 106-114
    • Stockman, H.W.1
  • 29
    • 0025217621 scopus 로고
    • Concentration gradients for HVA, 5-HIAA, ascorbic acid, and uric acid in cerebrospinal fluid
    • Degrell I, Nagy E. Concentration gradients for HVA, 5-HIAA, ascorbic acid, and uric acid in cerebrospinal fluid. Biol Psychiatry 1990;27:891-6
    • (1990) Biol Psychiatry , vol.27 , pp. 891-896
    • Degrell, I.1    Nagy, E.2
  • 30
    • 33746908188 scopus 로고    scopus 로고
    • Cerebrospinal fluid and spinal cord distribution of baclofen and bupivacaine during slow intrathecal infusion in pigs
    • Bernards CM. Cerebrospinal fluid and spinal cord distribution of baclofen and bupivacaine during slow intrathecal infusion in pigs. Anesthesiology 2006;105:169-78
    • (2006) Anesthesiology , vol.105 , pp. 169-178
    • Bernards, C.M.1
  • 31
    • 74049147804 scopus 로고    scopus 로고
    • Cerebrospinal fluid and spinal cord distribution of hyperbaric bupivacaine and baclofen during slow intrathecal infusion in pigs
    • Flack SH, Bernards CM. Cerebrospinal fluid and spinal cord distribution of hyperbaric bupivacaine and baclofen during slow intrathecal infusion in pigs. Anesthesiology 2010;112:165-75
    • (2010) Anesthesiology , vol.112 , pp. 165-175
    • Flack, S.H.1    Bernards, C.M.2
  • 32
    • 79251613727 scopus 로고    scopus 로고
    • Morphine distribution in the spinal cord after chronic infusion in pigs
    • Flack SH, Anderson CM, Bernards CM. Morphine distribution in the spinal cord after chronic infusion in pigs. Anesth Analg 2011;112(2):460-4
    • (2011) Anesth Analg , vol.112 , Issue.2 , pp. 460-464
    • Flack, S.H.1    Anderson, C.M.2    Bernards, C.M.3
  • 33
    • 78650811690 scopus 로고    scopus 로고
    • Measured density and calculated baricity of custom-compounded drugs for chronic intrathecal infusion
    • Hejtmanek MR, Harvey TD, Bernards CM. Measured density and calculated baricity of custom-compounded drugs for chronic intrathecal infusion. Reg Anesth Pain Med 2011;36(1):7-11
    • (2011) Reg Anesth Pain Med , vol.36 , Issue.1 , pp. 7-11
    • Hejtmanek, M.R.1    Harvey, T.D.2    Bernards, C.M.3
  • 34
    • 0037566977 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intrathecal ziconotide in chronic pain patients
    • Wermeling D, Drass M, Ellis D, et al. Pharmacokinetics and pharmacodynamics of intrathecal ziconotide in chronic pain patients. J Clin Pharmacol 2003;43:624-36
    • (2003) J Clin Pharmacol , vol.43 , pp. 624-636
    • Wermeling, D.1    Drass, M.2    Ellis, D.3
  • 35
    • 0027268233 scopus 로고
    • A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia
    • Valentino K, Newcomb R, Gadbois T, et al. A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia. Proc Natl Acad Sci USA 1993;90:7894-7
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7894-7897
    • Valentino, K.1    Newcomb, R.2    Gadbois, T.3
  • 36
    • 77949433165 scopus 로고    scopus 로고
    • Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain
    • Smith H, Deer T. Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain. Ther Clin Risk Manag 2009;5:521-34
    • (2009) Ther Clin Risk Manag , vol.5 , pp. 521-534
    • Smith, H.1    Deer, T.2
  • 37
    • 0030829127 scopus 로고    scopus 로고
    • Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain
    • Brose WG, Gutlove DP, Luther RR, et al. Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain. Clin J Pain 1997;13:256-9
    • (1997) Clin J Pain , vol.13 , pp. 256-259
    • Brose, W.G.1    Gutlove, D.P.2    Luther, R.R.3
  • 38
    • 12944332083 scopus 로고    scopus 로고
    • Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain
    • Atanassoff PG, Hartmannsgruber MW, Thrasher J, et al. Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain. Reg Anesth Pain Med 2000;25:274-8
    • (2000) Reg Anesth Pain Med , vol.25 , pp. 274-278
    • Atanassoff, P.G.1    Hartmannsgruber, M.W.2    Thrasher, J.3
  • 39
    • 70349803503 scopus 로고    scopus 로고
    • Intrathecal ziconotide for neuropathic pain: A review
    • Rauck RL, Wallace MS, Burton AW, et al. Intrathecal ziconotide for neuropathic pain: a review. Pain Pract 2009;9:327-37
    • (2009) Pain Pract , vol.9 , pp. 327-337
    • Rauck, R.L.1    Wallace, M.S.2    Burton, A.W.3
  • 40
    • 0033955464 scopus 로고    scopus 로고
    • Ziconotide for the treatment of severe spasticity after spinal cord injury
    • Ridgeway B, Wallace M, Gerayli A. Ziconotide for the treatment of severe spasticity after spinal cord injury. Pain 2000;85:287-9
    • (2000) Pain , vol.85 , pp. 287-289
    • Ridgeway, B.1    Wallace, M.2    Gerayli, A.3
  • 41
    • 77950985797 scopus 로고    scopus 로고
    • Successful treatment of a patient with trigeminal neuropathy using Ziconotide
    • Lux EA. Successful treatment of a patient with trigeminal neuropathy using Ziconotide. Anesth Analg 2010;110:1195-7
    • (2010) Anesth Analg , vol.110 , pp. 1195-1197
    • Lux, E.A.1
  • 42
    • 77955985526 scopus 로고    scopus 로고
    • Ziconotide combination intrathecal therapy: Rationale and evidence
    • Wallace MS, Rauck RL, Deer T. Ziconotide combination intrathecal therapy: rationale and evidence. Clin J Pain 2010;26:635-44
    • (2010) Clin J Pain , vol.26 , pp. 635-644
    • Wallace, M.S.1    Rauck, R.L.2    Deer, T.3
  • 43
    • 0033972437 scopus 로고    scopus 로고
    • Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats
    • Wang YX, Gao D, Pettus M, et al. Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. Pain 2000;84:271-81
    • (2000) Pain , vol.84 , pp. 271-281
    • Wang, Y.X.1    Gao, D.2    Pettus, M.3
  • 44
    • 0034083915 scopus 로고    scopus 로고
    • Analgesic properties of ziconotide, a selective blocker of N-type neuronal calcium channels
    • Wang YX, Bowersox SS. Analgesic properties of ziconotide, a selective blocker of N-type neuronal calcium channels. CNS Drug Rev 2000;6:1-20
    • (2000) CNS Drug Rev , vol.6 , pp. 1-20
    • Wang, Y.X.1    Bowersox, S.S.2
  • 45
    • 70350441859 scopus 로고    scopus 로고
    • Intrathecal Ziconotide and opioid combination therapy for noncancer pain: An observational study
    • Deer T, Kim C, Bowman R, et al. Intrathecal Ziconotide and opioid combination therapy for noncancer pain: an observational study. Pain Physician 2009;12:E291-6
    • (2009) Pain Physician , vol.12
    • Deer, T.1    Kim, C.2    Bowman, R.3
  • 46
    • 84155172552 scopus 로고    scopus 로고
    • Intrathecal combination of ziconotide and morphine for refractory cancer pain: A rapidly acting and effective choice
    • Alicino I, Giglio M, Manca F, et al. Intrathecal combination of ziconotide and morphine for refractory cancer pain: a rapidly acting and effective choice. Pain 2012;153:245-9
    • (2012) Pain , vol.153 , pp. 245-249
    • Alicino, I.1    Giglio, M.2    Manca, F.3
  • 47
    • 84867002720 scopus 로고    scopus 로고
    • Ziconotide adverse events in patients with cancer pain: A multicenter observational study of a slow titration, multidrug protocol
    • Dupoiron D, Bore F, Lefebvre-Kuntz D, et al. Ziconotide adverse events in patients with cancer pain: a multicenter observational study of a slow titration, multidrug protocol. Pain Physician 2012;15:395-403
    • (2012) Pain Physician , vol.15 , pp. 395-403
    • Dupoiron, D.1    Bore, F.2    Lefebvre-Kuntz, D.3
  • 48
    • 70449680360 scopus 로고    scopus 로고
    • Chemical stability of admixtures containing 25 mug/mL ziconotide and 10 mg/mL or 20 mg/mL morphine sulfate during simulated intrathecal administration
    • Shields DE, Aclan J, Szatkowski A. Chemical stability of admixtures containing 25 mug/mL ziconotide and 10 mg/mL or 20 mg/mL morphine sulfate during simulated intrathecal administration. Int J Pharm Compounding 2008;12:552-7
    • (2008) Int J Pharm Compounding , vol.12 , pp. 552-557
    • Shields, D.E.1    Aclan, J.2    Szatkowski, A.3
  • 49
    • 33745358754 scopus 로고    scopus 로고
    • Chemical stability of admixtures combining ziconotide with morphine or hydromorphone during simulated intrathecal administration
    • Shields D, Montenegro R, Ragusa M. Chemical stability of admixtures combining ziconotide with morphine or hydromorphone during simulated intrathecal administration. Neuromodulation 2005;8:257-63
    • (2005) Neuromodulation , vol.8 , pp. 257-263
    • Shields, D.1    Montenegro, R.2    Ragusa, M.3
  • 50
    • 34748848613 scopus 로고    scopus 로고
    • Chemical stability of admixtures combining ziconotide with baclofen during simulated intrathecal administration
    • Shields D, Montenegro R, Aclan J. Chemical stability of admixtures combining ziconotide with baclofen during simulated intrathecal administration. Neuromodulation 2007;10(Suppl 1):12-17
    • (2007) Neuromodulation , vol.10 , Issue.SUPPL. 1 , pp. 12-17
    • Shields, D.1    Montenegro, R.2    Aclan, J.3
  • 51
    • 34748868999 scopus 로고    scopus 로고
    • Chemical stability of ziconotide-clonidine hydrochloride admixtures with and without morphine sulfate during simulated intrathecal administration
    • Shields D, Montenegro R. Chemical stability of ziconotide-clonidine hydrochloride admixtures with and without morphine sulfate during simulated intrathecal administration. Neuromodulation 2007;10(Suppl 1):6-11
    • (2007) Neuromodulation , vol.10 , Issue.SUPPL. 1 , pp. 6-11
    • Shields, D.1    Montenegro, R.2
  • 52
    • 34748913607 scopus 로고    scopus 로고
    • Chemical stability of an admixture combining ziconotide and bupivacaine during simulated intrathecal administration
    • Shields D, Montenegro R, Aclan J. Chemical stability of an admixture combining ziconotide and bupivacaine during simulated intrathecal administration. Neuromodulation 2007;10(Suppl 1):1-5
    • (2007) Neuromodulation , vol.10 , Issue.SUPPL. 1 , pp. 1-5
    • Shields, D.1    Montenegro, R.2    Aclan, J.3
  • 53
    • 70449656199 scopus 로고    scopus 로고
    • Chemical stability of admixtures combining ziconotide with fentanyl or sufentanil during simulated intrathecal administration
    • Shields DE, Aclan J, Szatkowski A. Chemical stability of admixtures combining ziconotide with fentanyl or sufentanil during simulated intrathecal administration. Int J Pharm Compounding 2008;12:463-6
    • (2008) Int J Pharm Compounding , vol.12 , pp. 463-466
    • Shields, D.E.1    Aclan, J.2    Szatkowski, A.3
  • 54
    • 76149110115 scopus 로고    scopus 로고
    • Considerations and methodology for trialing Ziconotide
    • Burton AW, Deer T, Wallace MS, et al. Considerations and methodology for trialing Ziconotide. Pain Physician 2010;13:23-33
    • (2010) Pain Physician , vol.13 , pp. 23-33
    • Burton, A.W.1    Deer, T.2    Wallace, M.S.3
  • 55
    • 84892580988 scopus 로고    scopus 로고
    • Bolus Intrathecal Injection of Ziconotide (Prialt) to evaluate the Option of Continuous Administration via an Implanted Intrathecal Drug Delivery System: A pilot study
    • Epub ahead of print
    • Mohammed SI, Eldabe S, Simpson KH, et al. Bolus Intrathecal Injection of Ziconotide (Prialt) to evaluate the Option of Continuous Administration via an Implanted Intrathecal Drug Delivery System: a pilot study. Neuromodulation 2012; Epub ahead of print
    • (2012) Neuromodulation
    • Mohammed, S.I.1    Eldabe, S.2    Simpson, K.H.3
  • 56
    • 78650415529 scopus 로고    scopus 로고
    • Increased risk of suicide under intrathecal ziconotide treatment?-A warning
    • Maier C, Gockel HH, Gruhn K, et al. Increased risk of suicide under intrathecal ziconotide treatment?-A warning. Pain 2011;152:235-7
    • (2011) Pain , vol.152 , pp. 235-237
    • Maier, C.1    Gockel, H.H.2    Gruhn, K.3
  • 57
    • 80255132674 scopus 로고    scopus 로고
    • Combination of intrathecal opioids with bupivacaine attenuates opioid dose escalation in chronic noncancer pain patients
    • Veixi IE, Hayek SM, Narouze S, et al. Combination of intrathecal opioids with bupivacaine attenuates opioid dose escalation in chronic noncancer pain patients. Pain Med 2011;12(10):1481-9
    • (2011) Pain Med , vol.12 , Issue.10 , pp. 1481-1489
    • Veixi, I.E.1    Hayek, S.M.2    Narouze, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.