메뉴 건너뛰기




Volumn 50, Issue 1, 2013, Pages 1-6

Mice deficient in cystathionine beta synthase display increased Dyrk1A and SAHH activities in brain

Author keywords

Brain; Cystathionine beta synthase; DYRK1A; Hyperhomocysteinemia; Mice; S Adenosylhomocysteine hydrolase

Indexed keywords

ADENOSYLHOMOCYSTEINASE; CYSTATHIONINE BETA SYNTHASE; DUAL SPECIFICITY TYROSINE (Y) PHOSPHORYLATION REGULATED KINASE 1A; MESSENGER RNA; PRESENILIN 1; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

EID: 84876044654     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9835-0     Document Type: Article
Times cited : (15)

References (27)
  • 1
    • 67649506317 scopus 로고    scopus 로고
    • Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
    • 19458618 10.1038/nature08062 1:CAS:528:DC%2BD1MXmtFChsL8%3D
    • Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ et al (2009) Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 459:1126-1130
    • (2009) Nature , vol.459 , pp. 1126-1130
    • Baek, K.H.1    Zaslavsky, A.2    Lynch, R.C.3    Britt, C.4    Okada, Y.5    Siarey, R.J.6
  • 2
    • 78651070244 scopus 로고    scopus 로고
    • Activation, regulation, and inhibition of DYRK1A
    • 21126318 10.1111/j.1742-4658.2010.07956.x 1:CAS:528:DC%2BC3MXhtFGru7s%3D
    • Becker W, Sippl W (2011) Activation, regulation, and inhibition of DYRK1A. FEBS J 278:246-256
    • (2011) FEBS J , vol.278 , pp. 246-256
    • Becker, W.1    Sippl, W.2
  • 4
    • 26944433068 scopus 로고    scopus 로고
    • Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models
    • DOI 10.1016/j.nbd.2005.03.020, PII S0969996105000835
    • Ferrer I, Barrachina M, Puig B, Martínez de Lagrán M, Martí E, Avila J, Dierssen M (2005) Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Neurobiol Dis 20:392-400 (Pubitemid 41476265)
    • (2005) Neurobiology of Disease , vol.20 , Issue.2 , pp. 392-400
    • Ferrer, I.1    Barrachina, M.2    Puig, B.3    Martinez De Lagran, M.4    Marti, E.5    Avila, J.6    Dierssen, M.7
  • 5
    • 0036724569 scopus 로고    scopus 로고
    • Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice
    • 12192061 10.1128/MCB.22.18.6636-6647.2002 1:CAS:528:DC%2BD38XmsF2iur4%3D
    • Fotaki V, Dierssen M, Alcántara S, Martínez S, Martí E, Casas C et al (2002) Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. Mol Cell Biol 22:6636-6647
    • (2002) Mol Cell Biol , vol.22 , pp. 6636-6647
    • Fotaki, V.1    Dierssen, M.2    Alcántara, S.3    Martínez, S.4    Martí, E.5    Casas, C.6
  • 6
    • 84858156775 scopus 로고    scopus 로고
    • DYRK1A: A master regulatory protein controlling brain growth
    • 22293606 10.1016/j.nbd.2012.01.007 1:CAS:528:DC%2BC38Xjs1Ontb8%3D
    • Guedj F, Pereira PL, Najas S, Barallobre MJ, Chabert C, Souchet B et al (2012) DYRK1A: a master regulatory protein controlling brain growth. Neurobiol Dis 46:190-203
    • (2012) Neurobiol Dis , vol.46 , pp. 190-203
    • Guedj, F.1    Pereira, P.L.2    Najas, S.3    Barallobre, M.J.4    Chabert, C.5    Souchet, B.6
  • 7
    • 57749175510 scopus 로고    scopus 로고
    • Effect of hyperhomocysteinemia on the protein DYRK1A in liver of mice
    • 19059382 10.1016/j.bbrc.2008.11.126 1:CAS:528:DC%2BD1cXhsFClsrnE
    • Hamelet J, Noll C, Ripoll C, Paul JL, Janel N, Delabar JM (2009) Effect of hyperhomocysteinemia on the protein DYRK1A in liver of mice. Biochem Biophys Res Commun 378:673-677
    • (2009) Biochem Biophys Res Commun , vol.378 , pp. 673-677
    • Hamelet, J.1    Noll, C.2    Ripoll, C.3    Paul, J.L.4    Janel, N.5    Delabar, J.M.6
  • 9
    • 0022359847 scopus 로고
    • S-Adenosylhomocysteine hydrolase from human placenta. Affinity purification and characterization
    • Hershfield MS, Aiyar VN, Premakumar R, Small WC (1985) S-Adenosylhomocysteine hydrolase from human placenta. Affinity purification and characterization. Biochem J 230:43-52 (Pubitemid 16247268)
    • (1985) Biochemical Journal , vol.230 , Issue.1 , pp. 43-52
    • Hershfield, M.S.1    Aiyar, V.N.2    Premakumar, R.3    Small, W.C.4
  • 10
    • 30744450012 scopus 로고    scopus 로고
    • Elevated levels of homocysteine compromise blood-brain barrier integrity in mice
    • DOI 10.1182/blood-2005-06-2506
    • Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE et al (2006) Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood 107:591-593 (Pubitemid 43090794)
    • (2006) Blood , vol.107 , Issue.2 , pp. 591-593
    • Kamath, A.F.1    Chauhan, A.K.2    Kisucka, J.3    Dole, V.S.4    Loscalzo, J.5    Handy, D.E.6    Wagner, D.D.7
  • 11
    • 56049114215 scopus 로고    scopus 로고
    • S-Adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis
    • 18713839 10.1093/carcin/bgn198 1:CAS:528:DC%2BD1cXhtlalsLbP
    • Leal JF, Ferrer I, Blanco-Aparicio C, Hernández-Losa J, Ramón Y, Cajal S et al (2008) S-Adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis. Carcinogenesis 29:2089-2095
    • (2008) Carcinogenesis , vol.29 , pp. 2089-2095
    • Leal, J.F.1    Ferrer, I.2    Blanco-Aparicio, C.3    Hernández-Losa, J.4    Ramón, Y.5    Cajal, S.6
  • 12
    • 0037364417 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    • DOI 10.1016/S0166-2236(03)00032-8
    • Mattson MP, Shea TB (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26:137-146 (Pubitemid 36183675)
    • (2003) Trends in Neurosciences , vol.26 , Issue.3 , pp. 137-146
    • Mattson, M.P.1    Shea, T.B.2
  • 13
    • 0021894152 scopus 로고
    • The natural history of homocystinura due to cystathionine β-synthase deficiency
    • Mudd SH, Skovby F, Levy HL, Pettigrew KD, Wilcken B, Pyeritz RE (1985) The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 37:1-31 (Pubitemid 15138674)
    • (1985) American Journal of Human Genetics , vol.37 , Issue.1 , pp. 1-31
    • Mudd, S.H.1    Skovby, F.2    Levy, H.L.3
  • 14
    • 79951701209 scopus 로고    scopus 로고
    • Hypermethioninemias of genetic and non-genetic origin: A review
    • 10.1002/ajmg.c.30293 1:CAS:528:DC%2BC3MXjvFOgtrw%3D
    • Mudd SH (2011) Hypermethioninemias of genetic and non-genetic origin: a review. Am J Med Genet C 157:3-32
    • (2011) Am J Med Genet C , vol.157 , pp. 3-32
    • Mudd, S.H.1
  • 15
    • 70449555110 scopus 로고    scopus 로고
    • DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase
    • 19844572 10.1371/journal.pone.0007540
    • Noll C, Planque C, Ripoll C, Guedj F, Diez A, Ducros V et al (2009) DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. PLoS One 4:e7540
    • (2009) PLoS One , vol.4 , pp. 7540
    • Noll, C.1    Planque, C.2    Ripoll, C.3    Guedj, F.4    Diez, A.5    Ducros, V.6
  • 16
    • 33646747001 scopus 로고    scopus 로고
    • Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia
    • DOI 10.1016/j.febslet.2006.04.088, PII S001457930600545X
    • Obeid R, Herrmann W (2006) Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia. FEBS Lett 580:2994-3005 (Pubitemid 43744523)
    • (2006) FEBS Letters , vol.580 , Issue.13 , pp. 2994-3005
    • Obeid, R.1    Herrmann, W.2
  • 17
    • 78650035589 scopus 로고    scopus 로고
    • Hyperhomocysteinemia induced Dyrk1a downregulation results in cardiomyocyte hypertrophy rats
    • 19906449 10.1016/j.ijcard.2009.10.043
    • Raaf L, Noll C, Cherifi M, Benazzoug Y, Delabar JM, Janel N (2010) Hyperhomocysteinemia induced Dyrk1a downregulation results in cardiomyocyte hypertrophy rats. Int J Cardiol 145:306-307
    • (2010) Int J Cardiol , vol.145 , pp. 306-307
    • Raaf, L.1    Noll, C.2    Cherifi, M.3    Benazzoug, Y.4    Delabar, J.M.5    Janel, N.6
  • 19
    • 20444487720 scopus 로고    scopus 로고
    • Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus
    • DOI 10.1016/j.neuroscience.2005.03.034, PII S0306452205003489
    • Robert K, Pages C, Ledru A, Delabar J, Caboche J, Janel N (2005) Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus. Neuroscience 133:925-935 (Pubitemid 40814601)
    • (2005) Neuroscience , vol.133 , Issue.4 , pp. 925-935
    • Robert, K.1    Pages, C.2    Ledru, A.3    Delabar, J.4    Caboche, J.5    Janel, N.6
  • 20
    • 34447343104 scopus 로고    scopus 로고
    • Familial 4.3 Mb duplication of 21q22 sheds new light on the Down syndrome critical region
    • DOI 10.1136/jmg.2006.047373
    • Ronan A, Fagan K, Christie L, Conroy J, Nowak NJ, Turner G (2007) Familial 4.3 Mb duplication of 21q22 sheds new light on the Down syndrome critical region. J Med Genet 44:448-451 (Pubitemid 47056871)
    • (2007) Journal of Medical Genetics , vol.44 , Issue.7 , pp. 448-451
    • Ronan, A.1    Fagan, K.2    Christie, L.3    Conroy, J.4    Nowak, N.J.5    Turner, G.6
  • 21
    • 39749196069 scopus 로고    scopus 로고
    • Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: Evidence for a functional link between Down syndrome and Alzheimer's disease
    • DOI 10.1111/j.1471-4159.2007.05075.x
    • Ryoo SR, Cho HJ, Lee HW, Jeong HK, Radnaabazar C, Kim YS et al (2008) Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease. J Neurochem 104:1333-1344 (Pubitemid 351293338)
    • (2008) Journal of Neurochemistry , vol.104 , Issue.5 , pp. 1333-1344
    • Ryoo, S.-R.1    Cho, H.-J.2    Lee, H.-W.3    Jeong, H.K.4    Radnaabazar, C.5    Kim, Y.-S.6    Kim, M.-J.7    Son, M.-Y.8    Seo, H.9    Chung, S.-H.10    Song, W.-J.11
  • 22
    • 78651063834 scopus 로고    scopus 로고
    • Dyrk1A-mediated phosphorylation of Presilin 1: A functional link between Down syndrome and Alzheimer's disease
    • 20456003 10.1111/j.1471-4159.2010.06769.x 1:CAS:528:DC%2BC3cXhtlGlsb%2FJ
    • Ryu YS, Park SY, Jung MS, Yoon SH, Kwen MY, Lee SY et al (2010) Dyrk1A-mediated phosphorylation of Presilin 1: a functional link between Down syndrome and Alzheimer's disease. J Neurochem 115:574-584
    • (2010) J Neurochem , vol.115 , pp. 574-584
    • Ryu, Y.S.1    Park, S.Y.2    Jung, M.S.3    Yoon, S.H.4    Kwen, M.Y.5    Lee, S.Y.6
  • 23
    • 0037188423 scopus 로고    scopus 로고
    • Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals
    • Sachdev PS, Valenzuela M, Wang XL, Looi JC, Brodaty H (2002) Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals. Neurology 58:1539-1541 (Pubitemid 34552965)
    • (2002) Neurology , vol.58 , Issue.10 , pp. 1539-1541
    • Sachdev, P.S.1    Valenzuela, M.2    Wang, X.L.3    Looi, J.C.L.4    Brodaty, H.5
  • 24
    • 0032771346 scopus 로고    scopus 로고
    • Homocysteine metabolism
    • DOI 10.1146/annurev.nutr.19.1.217
    • Selhub J (1999) Homocysteine metabolism. Annu Rev Nutr 19:217-246 (Pubitemid 29380603)
    • (1999) Annual Review of Nutrition , vol.19 , pp. 217-246
    • Selhub, J.1
  • 25
    • 0028937163 scopus 로고
    • Mice deficient in cystathionine beta-synthase: Animal models for mild and severe homocyst(e)inemia
    • 7878023 10.1073/pnas.92.5.1585 1:CAS:528:DyaK2MXktFWku78%3D
    • Watanabe M, Osada J, Aratani Y, Kluckman K, Reddick R, Malinow MR, Maeda N (1995) Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci USA 92:1585-1589
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1585-1589
    • Watanabe, M.1    Osada, J.2    Aratani, Y.3    Kluckman, K.4    Reddick, R.5    Malinow, M.R.6    Maeda, N.7
  • 26
    • 77649163840 scopus 로고    scopus 로고
    • Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice
    • 20062804 10.1371/journal.pone.0008579
    • Yu S, Khor TO, Cheung KL, Li W, Wu TY, Huang Y et al (2010) Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. PloS ONE 5:e8579
    • (2010) PloS ONE , vol.5 , pp. 8579
    • Yu, S.1    Khor, T.O.2    Cheung, K.L.3    Li, W.4    Wu, T.Y.5    Huang, Y.6
  • 27
    • 65349162724 scopus 로고    scopus 로고
    • Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain
    • 19264913 10.2353/ajpath.2009.081036 1:CAS:528:DC%2BD1MXksVOku7w%3D
    • Zhang CE, Wei W, Liu YH, Peng JH, Tian Q, Liu GP et al (2009) Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain. Am J Pathol 174:1481-1491
    • (2009) Am J Pathol , vol.174 , pp. 1481-1491
    • Zhang, C.E.1    Wei, W.2    Liu, Y.H.3    Peng, J.H.4    Tian, Q.5    Liu, G.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.