Prevalence of HIV-1 Drug Resistance among Women Screening for HIV Prevention Trials in KwaZulu-Natal, South Africa (MTN-009)

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Parikh, Urvi M ^a   Kiepiela, Photini ^b   Ganesh, Shayhana ^b   Gomez, Kailazarid ^c   Horn, Stephanie ^c   Eskay, Krista ^a   Kelly, Cliff ^d   Mensch, Barbara ^e   Gorbach, Pamina ^f   Soto Torres, Lydia ^g   Ramjee, Gita ^b   Mellors, John W ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^c FAMILY HEALTH INTERNATIONAL   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

^e POPULATION COUNCIL   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARAGINE; EMTRICITABINE; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR; TENOFOVIR DISOPROXIL; VALINE; VIRUS RNA;

ADULT; ANTIVIRAL RESISTANCE; ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL EVALUATION; CROSS-SECTIONAL STUDY; FEMALE; GENE MUTATION; GENE SEQUENCE; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MASS SCREENING; MULTICENTER STUDY; PHASE 2 CLINICAL TRIAL; PREVENTION STUDY; PRIMARY HEALTH CARE; PROTEINASE GENE; RNA DIRECTED DNA POLYMERASE GENE; RNA SEQUENCE; SOUTH AFRICA; WOMEN'S HEALTH;

ADULT; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE, VIRAL; FEMALE; HIV INFECTIONS; HIV PROTEASE; HIV REVERSE TRANSCRIPTASE; HIV SEROPOSITIVITY; HIV-1; HUMANS; MASS SCREENING; MUTATION; PREVALENCE; RNA, VIRAL; SOUTH AFRICA; VIRAL LOAD;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84876043815     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059787     Document Type: Article

References (33)

1. Voelker R, (2005) Women shoulder growing HIV/AIDS burden. JAMA 293: 281-282.
2. WHO/UNAIDS (2010) Global Report: UNAIDS Report on the Global AIDS Epidemic 2010. Joint United Nations Programme on HIV/AIDS.
3. Celum C, Baeten JM, (2012) Tenofovir-based pre-exposure prophylaxis for HIV prevention: evolving evidence. Curr Opin Infect Dis 25: 51-57.
4. Woodsong C, Alleman P, Musara P, Chandipwisa A, Chirenje M, et al. (2012) Preventive Misconception as a Motivation for Participation and Adherence in Microbicide Trials: Evidence from Female Participants and Male Partners in Malawi and Zimbabwe. AIDS Behav 16: 785-790.
5. Tabana H, Doherty T, Swanevelder S, Lombard C, Jackson D, et al. (2012) Knowledge of HIV status prior to a community HIV counseling and testing intervention in a rural district of south Africa: results of a community based survey. BMC Infect Dis 12: 73.
6. Abbas UL, Hood G, Wetzel AW, Mellors JW, (2011) Factors influencing the emergence and spread of HIV drug resistance arising from rollout of antiretroviral pre-exposure prophylaxis (PrEP). PLoS ONE 6: e18165.
7. Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, et al. (2010) Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women. Science 329: 1168-1174.
8. Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, et al. (2010) Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 363: 2587-2599.
9. Thigpen MC, Kebaabetswe PM, Paxton LA, Smith DK, Rose CE, et al. (2012) Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana. N Engl J Med 367: 423-434.
10. Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, et al. (2012) Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women. N Engl J Med 367: 399-410.
11. Bennett DE, (2006) The requirement for surveillance of HIV drug resistance within antiretroviral rollout in the developing world. Curr Opin Infec Dis 19: 607-614.
12. Little SJ, Holte S, Routy J-P, Daar ES, Markowitz M, et al. (2002) Antiretroviral-drug resistance among patients recently infected with HIV. N Engl J Med 347: 385-394.
13. Hamers RL, Wallis CL, Kityo C, Siwale M, Mandaliya K, et al. (2011) HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study. Lancet Infect Dis 11: 750-759.
14. Nwobegahay JM, Bessong PO, Masebe TM, Mavhandu LG, Iweriebor BC, et al. (2011) Prevalence of antiretroviral drug resistance mutations and HIV-I subtypes among newly-diagnosed drug-naive persons visiting a voluntary testing and counselling centre in northeastern South Africa. J Health Popul Nutr 29: 303-309.
15. Manasa J, Katzenstein D, Cassol S, Newell ML, de Oliveira T, et al. (2012) Primary Drug Resistance in South Africa: Data from 10 Years of Surveys. AIDS Res Hum Retroviruses 28: 558-565.
16. Parboosing R, Naidoo A, Gordon M, Taylor M, Vella V, (2011) Resistance to antiretroviral drugs in newly diagnosed, young treatment-naive HIV-positive pregnant women in the province of KwaZulu-Natal, South Africa. J Med Virol 83: 1508-1513.
17. Hunt GM, Ledwaba J, Basson AE, Moyes J, Cohen C, et al. (2012) Surveillance of Transmitted HIV-1 Drug Resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009. Clinical Infectious Diseases 54: S334-S338.
18. Liu TF, Shafer RW, (2006) Web resources for HIV type 1 genotypic-resistance test interpretation. Clin Infect Dis 42: 1608-1618.
19. Bennett DE, Camacho RJ, Otelea D, Kuritzkes DR, Fleury H, et al. (2009) Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update. PLoS ONE 4: e4724.
20. Motsoaledi A (2010) Clinical Guidelines for the Management of HIV & AIDS in Adults and Adolescents. South Africa: National Department of Health, South African National AIDS Council.
21. Castro KG, Ward JW, Slutsker L, Buehler JW, Jaffe HW, et al. (1992) 1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults. Morbidity and Mortality Weekly Report (MMWR) 4.
22. Nel A, Mabude Z, Smit J, Kotze P, Arbuckle D, et al. (2012) HIV Incidence Remains High in KwaZulu-Natal, South Africa: Evidence from Three Districts. PLoS ONE 7: e35278.
23. Nel A, Louw C, Hellstrom E, Braunstein SL, Treadwell I, et al. (2011) HIV prevalence and incidence among sexually active females in two districts of South Africa to determine microbicide trial feasibility. PLoS ONE 6: e21528.
24. Karim QA, Kharsany AB, Frohlich JA, Werner L, Mashego M, et al. (2011) Stabilizing HIV prevalence masks high HIV incidence rates amongst rural and urban women in KwaZulu-Natal, South Africa. Int J Epidemiol 40: 922-930.
25. Okulicz JF, Lambotte O, (2011) Epidemiology and clinical characteristics of elite controllers. Curr Opin HIV AIDS 6: 163-168.
26. Jordan MR, Bennett DE, Bertagnolio S, Gilks CF, Sutherland D, (2008) World Health Organization surveys to monitor HIV drug resistance prevention and associated factors in sentinel antiretroviral treatment sites. Antivir Ther 13Suppl 2: 15-23.
27. Jordan MR, Bennett DE, Wainberg MA, Havlir D, Hammer S, et al. (2012) Update on World Health Organization HIV Drug Resistance Prevention and Assessment Strategy: 2004-2011. Clinical Infectious Diseases 54: S245-S249.
28. Lockman S, Hughes MD, McIntyre J, Zheng Y, Chipato T, et al. (2010) Antiretroviral therapies in women after single-dose nevirapine exposure. N Engl J Med 363: 1499-1509.
29. Horwood C, Haskins L, Vermaak K, Phakathi S, Subbaye R, et al. (2010) Prevention of mother to child transmission of HIV (PMTCT) programme in KwaZulu-Natal, South Africa: an evaluation of PMTCT implementation and integration into routine maternal, child and women's health services. Trop Med Int Health.
30. Castro H, Pillay D, Sabin C, Dunn DT, (2012) Effect of misclassification of antiretroviral treatment status on the prevalence of transmitted HIV-1 drug resistance. BMC Med Res Methodol 12: 30.
31. Gorbach PM, Mensch BS, Husnik M, Coly A, Masse B, et al. (2012) Effect of Computer-Assisted Interviewing on Self-Reported Sexual Behavior Data in a Microbicide Clinical Trial. AIDS Behav.
32. Mensch BS, Hewett PC, Abbott S, Rankin J, Littlefield S, et al. (2011) Assessing the reporting of adherence and sexual activity in a simulated microbicide trial in South Africa: an interview mode experiment using a placebo gel. AIDS Behav 15: 407-421.
33. Li JF, Lipscomb JT, Wei X, Martinson NA, Morris L, et al. (2011) Detection of low-level K65R variants in nucleoside reverse transcriptase inhibitor-naive chronic and acute HIV-1 subtype C infections. J Infect Dis 203: 798-802.