Resistance to antiretroviral drugs in newly diagnosed, young treatment-naïve HIV-positive pregnant women in the province of KwaZulu-Natal, South Africa

Journal of Medical Virology

Volumn 83, Issue 9, 2011, Pages 1508-1513

  Parboosing, R ^a   Naidoo, A ^a   Gordon, M ^b   Taylor, M ^b   Vella, V ^c  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

^c KwaZulu Natal Department of Health   (South Africa)

Author keywords

HIV drug resistance; South africa; Surveillance; Transmitted resistance

Indexed keywords

ANTIRETROVIRUS AGENT;

ADOLESCENT; ADULT; ANTIVIRAL RESISTANCE; ARTICLE; FEMALE; FOLLOW UP; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN IMMUNODEFICIENCY VIRUS PREVALENCE; MAJOR CLINICAL STUDY; PREGNANT WOMAN; PRENATAL CARE; SOUTH AFRICA; STRUCTURAL GENE; VIRUS MUTATION;

ADOLESCENT; ANTI-HIV AGENTS; BASE SEQUENCE; DRUG RESISTANCE, VIRAL; FEMALE; GENES, POL; GENOTYPE; HIV; HIV INFECTIONS; HIV SEROPOSITIVITY; HUMANS; MALE; MUTATION; POL GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SOUTH AFRICA; YOUNG ADULT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79960137971     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.22143     Document Type: Article

References (30)

1. Abegaz W, Grossman Z, Wolday D, Ram D, Kaplan J, Sibide K, Wuhib T, Ismael S, Nkengasong J, Mekonen T. 2008. Threshold survey evaluating transmitted HIV drug resistance among public antenatal clinic clients in Addis Ababa, Ethiopia. Antivir Ther 13: 89.
2. Adam M, Johnson L. 2009. Estimation of adult antiretroviral treatment coverage in South Africa. South Afr Med J 99: 661.
3. Aghokeng A, Vergne L, Mpoudi-Ngole E, Mbangue M, Deoudje N, Mokondji E, Nambei W, Peyou-Ndi M, Moka J, Delaporte E. 2009. Evaluation of transmitted HIV drug resistance among recently-infected antenatal clinic attendees in four Central African countries. Antivir Ther 14: 401.
4. Anonymous. 2000. Ethical considerations for HIV and AIDS clinical and epidemiological research. National Department of Health, South Africa.
5. Anonymous. 2003. Operational plan for comprehensive HIV and AIDS care, management and treatment for South Africa. National Department of Health, South Africa
6. Anonymous. 2004. National ARV rollout statistics. Treatment action campaign.
7. Barth R, Wensing A, Tempelman H, Moraba R, Schuurman R, Hoepelman A. 2008. Rapid accumulation of nonnucleoside reverse transcriptase inhibitor-associated resistance: Evidence of transmitted resistance in rural South Africa. AIDS 22: 2210.
8. Bennett D, Bertagnolio S, Sutherland D, Gilks C. 2008a. The World Health Organization's global strategy for prevention and assessment of HIV drug resistance. Antivir Ther 13: 1.
9. Bennett D, Myatt M, Bertagnolio S, Sutherland D, Gilks C. 2008b. Recommendations for surveillance of transmitted HIV drug resistance in countries scaling up antiretroviral treatment. Antivir Ther 13: 25.
10. Blower S, Ma L, Farmer P, Koenig S. 2003. Predicting the impact of antiretrovirals in resource-poor settings: Preventing HIV infections whilst controlling drug resistance. Curr Drug Targets Infect Disord 3: 345-353.
11. Food and Drug Administration (US). ViroSeq HIV-1 Genotyping System with the 3100 Genetic Analyzer.
12. Govender T, Vella V, Tarin M, Parboosing R. 2007. Poster: A baseline antiretroviral resistance threshold survey in KwaZulu Natal. 3rd South African AIDS Conference Durban 5-8 June 2007.
13. Guindon S, Gascuel O. 2003. A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52: 696-704.
14. Hoffmann C, Charalambous S, Sim J, Ledwaba J, Schwikkard G, Chaisson R, Fielding K, Churchyard G, Morris L, Grant A. 2009. Viremia, resuppression, and time to resistance in Human Immunodeficiency Virus (HIV) subtype C during first line antiretroviral therapy in South Africa. Clin Infect Dis 49: 1928-1935.
15. Jacobs G, Laten A, van Rensburg E, Bodem J, Weissbrich B, Rethwilm A, Preiser W, Engelbrecht S. 2008. Phylogenetic diversity and low level antiretroviral resistance mutations in HIV type 1 treatment-naive patients from Cape Town, South Africa. AIDS Res Hum Retroviruses 24: 1009-1012.
16. Kapoor A, Jones M, Shafer RW, Rhee SY, Kazanjian P, Delwart EL. 2004. Sequencing-based detection of low-frequency human immunodeficiency virus type 1 drug-resistant mutants by an RNA/DNA heteroduplex generator-tracking assay. J Virol 78: 7112-7123.
17. Karim S, Churchyard G, Karim Q, Lawn S. 2009. HIV infection and tuberculosis in South Africa: An urgent need to escalate the public health response. The Lancet 374: 921-933.
18. KwaZulu-Natal Department of Health. Annual Performance Plan - KwaZulu-Natal Department of Health 2008/9 to 2010/11. Pietermaritzburg, South Africa.
19. Marconi V, Sunpath H, Lu Z, Gordon M, Koranteng-Apeagyei K, Hampton J, Carpenter S, Giddy J, Ross D, Holst H. 2008. Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa. Clin Infect Dis 46: 1589-1597.
20. Motsoaledi A. 2009. HIV and AIDS: Business as Usual?
21. Myatt M, Bennett DE. 2008. A novel sequential sampling technique for the surveillance of transmitted HIV drug resistance by cross-sectional survey for use in low resource settings. Antivir Ther 13: 37-48.
22. National Department of Health, South Africa, 2009. National HIV and Syphilis Antenatal Sero-prevalence Survey, 2008. Pretoria, South Africa.
23. Nguyen HT, Duc NB, Shrivastava R, Tran TH, Nguyen TA, Thang PH, McNicholl JM, Leelawiwat W, Chonwattana W, Sidibe K, Fujita M, Luu CM, Kakkar R, Bennett DE, Kaplan J, Cosimi L, Wolfe MI. 2008. HIV drug resistance threshold survey using specimens from voluntary counselling and testing sites in Hanoi. Vietnam, Antivir Ther (Suppl) 2: 115-121.
24. Pillay V, Ledwaba J, Hunt G, Rakgotho M, Singh B, Makubalo L, Bennett DE, Puren A, Morris L. 2008a. Antiretroviral drug resistance surveillance among drug-naive HIV-1-infected individuals in Gauteng Province, South Africa in 2002 and 2004. Antivir Ther 13: 101-107.
25. Pillay V, Pillay C, Kantor R, Venter F, Levin L, Morris L. 2008b. HIV type 1 subtype C drug resistance among pediatric and adult South African patients failing antiretroviral therapy. AIDS Res Hum Retroviruses 24: 1449-1454.
26. Rambaut A. 2008. FigTree v1.1.1: Tree figure drawing tool.
27. Sunpath H, Kamihara J, Chelin N. 2008. Prospective analysis of HIV-1 drug resistance after virologic failure on Antiretroviral Therapy (ART): Initial results from a paediatric cohort study from KZN, South Africa.
28. Thompson JD, Higgins DG, Gibson TJ. 1994. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680.
29. WHO. 2003. Draft Guidelines for Surveillance of HIV Drug Resistance. World Health Organisation.
30. Zuma J. 2009. Address by President Jacob Zuma on the occasion of World AIDS Day.