HIV prevalence and incidence among sexually active females in two districts of South Africa to determine microbicide trial feasibility

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Nel, Annaléne ^a   Louw, Cheryl ^b   Hellstrom, Elizabeth ^c   Braunstein, Sarah L ^d   Treadwell, Ina ^c   Marais, Melanie ^c   de Villiers, Martie ^b   Hugo, Jannie ^b   Paschke, Inge ^c   Andersen, Chrisna ^c   van de Wijgert, Janneke ^e  

^a INTERNATIONAL PARTNERSHIP FOR MICROBICIDES   (United States)

^b Madibeng Centre for Research   (South Africa)

^c Be Part Yoluntu Centre   (South Africa)

^d NEW YORK CITY DEPARTMENT OF HEALTH AND MENTAL HYGIENE   (United States)

^e ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MICROBICIDE; ANTIINFECTIVE AGENT;

ADULT; AGE DISTRIBUTION; ARTICLE; ATTITUDE TO AIDS; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DYSURIA; FEASIBILITY STUDY; FEMALE; GENITAL ULCER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; MAJOR CLINICAL STUDY; ODOR; PATIENT ATTITUDE; POPULATION RESEARCH; PREGNANCY; PREVALENCE; SEROCONVERSION; SOUTH AFRICA; SYMPTOMATOLOGY; VAGINA DISCHARGE; VAGINAL PRURITUS; ADOLESCENT; CLINICAL TRIAL (TOPIC); DEMOGRAPHY; PROSPECTIVE STUDY; SEXUAL BEHAVIOR;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS; CLINICAL TRIALS AS TOPIC; CROSS-SECTIONAL STUDIES; DEMOGRAPHY; FEASIBILITY STUDIES; FEMALE; HIV INFECTIONS; HUMANS; INCIDENCE; PREGNANCY; PREVALENCE; PROSPECTIVE STUDIES; SEXUAL BEHAVIOR; SOUTH AFRICA; YOUNG ADULT;

EID: 80051534139     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021528     Document Type: Article

References (15)

1. UNAIDS (2010) UNAIDS Report on the Global AIDS Epidemic 2010 Geneva UNAIDS Available: http://www.unaids.org/globalreport/global_report.htm. Accessed 2011 July 23.
2. Elias C, Coggins C, (1996) Female-controlled methods to prevent sexual transmission of HIV. AIDS 10 (Suppl 3): S43-S51.
3. Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, et al. (2010) Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 329: 1168-1174.
4. van de Wijgert J, Jones H, (2006) Commentary: Challenges in microbicide trial design and implementation. Stud Fam Plann 37: 123-129.
5. Braunstein S, van de Wijgert J, Nash D, (2009) HIV incidence in sub-Saharan Africa: a review of available data with implications for surveillance and prevention planning. AIDS Reviews 11: 140-156.
6. Parekh BS, Kennedy MS, Dobbs T, Pau CP, Byers R, et al. (2002) Quantitative detection of increasing HIV type 1 antibodies after seroconversion: a simple assay for detecting recent HIV infection and estimating incidence. AIDS Res Hum Retroviruses 18: 295-307.
7. WHO Department of Reproductive Health (2010) Medical Eligibility Criteria for Contraceptive Use, 4th edition Geneva WHO Available: http://www.who.int/reproductivehealth/publications/family_planning/9789241563888/en/Accessed 2011 July 23.
8. National Department of Health, South Africa (2008) First line comprehensive management and control of sexually transmitted infections (STIs): protocol for the management of a person with a sexually transmitted infection according to the Essential Drug List Pretoria National Department of Health.
9. McWalter TA, Welte A, (2009) Relating recent infection prevalence to incidence with a sub-population of assay non-progressors. J Math Biol 60: 687-710.
10. Formula spreadsheet available at: http://www.sacema.com/page/assay-based-incidence-estimation. Accessed 2011 July 23.
11. Hargrove JW, Humphrey JH, Mutasa K, Parekh BS, McDougal JS, et al. (2008) Improved HIV-1 incidence estimates using the BED capture enzyme immunoassay. AIDS 22: 511-518.
12. Braunstein S, Nash D, Kim A, Ford K, Mwamarangwe L, et al. (2011) Dual testing algorithm of BED-CEIA and AxSYM Avidity Index assays performs best in identifying recent HIV infection in a sample of Rwandan sex workers. PloS ONE 6: e18402.
13. Baldwin JI, Baldwin JD, (2000) Heterosexual anal intercourse: an understudied, high-risk sexual behavior. Arch Sex Behav 29: 357-373.
14. UNAIDS/WHO (2011) When and how to use assays for recent infection to estimate HIV incidence at a population level Geneva UNAIDS/WHO Available: http://www.who.int/diagnostics_laboratory/hiv_incidence_may13_final.pdf. Accessed 2011 July 23.
15. Raymond EG, Taylor D, Cates W, Tolley EE, Borasky D, et al. (2007) Pregnancy in effectiveness trials of HIV prevention agents. Sex Transm Dis 34: 1035-1039.