The effect of Korean red ginseng on allergic inflammation in a murine model of allergic rhinitis

Journal of Ginseng Research

Volumn 37, Issue 2, 2013, Pages 167-175

  Jung, Joo Hyun ^a   Kang, Il Gyu ^a   Kim, Dae Young ^a   Hwang, You Jin ^a   Kim, Seon Tae ^a  

^a Gachon University   (South Korea)

Author keywords

Allergic rhinitis; Korean red ginseng; Mice; Panax ginseng

Indexed keywords

MURINAE; MUS; PANAX GINSENG;

EID: 84876037556     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2013.37.167     Document Type: Article

References (38)

1. Nathan RA. The burden of allergic rhinitis. Allergy Asthma Proc 2007;28:3-9.
2. Ciprandi G, Klersy C, Cirillo I, Marseglia GL. Quality of life in allergic rhinitis: relationship with clinical, immunological, and functional aspects. Clin Exp Allergy 2007;37:1528-1535.
3. Pratt EL, Craig TJ. Assessing outcomes from the sleep disturbance associated with rhinitis. Curr Opin Allergy Clin Immunol 2007;7:249-256.
4. Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol 2001;108(1 Suppl):S2-S8.
5. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 1998;351:1225-1232.
6. Cho SH, Kim YK, Sohn JW, Kim WK, Lee SR, Park JK, Min KU, Ha MN, Ahn YO, Jee YK et al. Prevalence of chronic rhinitis in Korean children and adolescents. Korean J Asthma Allergy Clin Immunol 1999;19:452-458.
7. Suh M, Kim HH, Sohn MH, Kim KE, Kim C, Shin DC. Prevalence of allergic diseases among Korean schoolage children: a nationwide cross-sectional questionnaire study. J Korean Med Sci 2011;26:332-338.
8. Park HS, Choi GS, Cho JS, Kim YY. Epidemiology and current status of allergic rhinitis, asthma, and associated allergic diseases in Korea: ARIA Asia-Pacific workshop report. Asian Pac J Allergy Immunol 2009;27:167-171.
9. Blanc PD, Trupin L, Earnest G, Katz PP, Yelin EH, Eisner MD. Alternative therapies among adults with a reported diagnosis of asthma or rhinosinusitis: data from a popula tion-based survey. Chest 2001;120:1461-1467.
10. Tindle HA, Davis RB, Phillips RS, Eisenberg DM. Trends in use of complementary and alternative medicine by US adults: 1997-2002. Altern Ther Health Med 2005;11:42-49.
11. Ernst E. Panax ginseng: an overview of the clinical evidence. J Ginseng Res 2010;34:259-263.
12. Ro JY, Ahn YS, Kim KH. Inhibitory effect of ginsenoside on the mediator release in the guinea pig lung mast cells activated by specific antigen-antibody reactions. Int J Immunopharmacol 1998;20:625-641.
13. Bae EA, Han MJ, Shin YW, Kim DH. Antiallergic and antipsoriatic effects of Korean red ginseng.J Ginseng Res 2005;29:80-85.
14. Wakabayashi C, Hasegawa H, Murata J, Saiki I. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol Res 1997;9:411-417.
15. Kim SN, Ha YW, Shin H, Son SH, Wu SJ, Kim YS. Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control.J Pharm Biomed Anal 2007;45:164-170.
16. Park EK, Choo MK, Han MJ, Kim DH. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int Arch Allergy Immunol 2004;133:113-120.
17. Park EK, Choo MK, Kim EJ, Han MJ, Kim DH. Antiallergic activity of ginsenoside Rh2. Biol Pharm Bull 2003;26:1581-1584.
18. Lim YJ, Na HS, Yun YS, Choi IS, Oh JS, Rhee JH, Cho BH, Lee HC. Suppressive effects of ginsan on the development of allergic reaction in murine asthmatic model. Int Arch Allergy Immunol 2009;150:32-42.
19. Kim HS, Kim DH, Kim BK, Yoon SK, Kim MH, Lee JY, Kim HO, Park YM. Effects of topically applied Korean red ginseng and its genuine constituents on atopic dermatitis-like skin lesions in NC/Nga mice. Int Immunopharmacol 2011;11:280-285.
20. Bae EA, Han MJ, Shin YW, Kim DH. Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. Biol Pharm Bull 2006;29:1862-1867.
21. Babayigit A, Olmez D, Karaman O, Bagriyanik HA, Yilmaz O, Kivcak B, Erbil G, Uzuner N. Ginseng ameliorates chronic histopathologic changes in a murine model of asthma. Allergy Asthma Proc 2008;29:493-498.
22. Sumiyoshi M, Sakanaka M, Kimura Y. Effects of red ginseng extract on allergic reactions to food in Balb/c mice. J Ethnopharmacol 2010;132:206-212.
23. Yang Z, Chen A, Sun H, Ye Y, Fang W. Ginsenoside Rd elicits Th1 and Th2 immune responses to ovalbumin in mice. Vaccine 2007;25:161-169.
24. Park HJ, Byeon HE, Choi KW, Rhee DK, Lee KR, Pyo S. Inhibitory effects of ginsenoside Rb1 on atopic dermatitis-like skin lesions in mice. J Ginseng Res 2010;34:363-368.
25. Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol 2008;8:205-217.
26. Naclerio RM. Allergic rhinitis. N Engl J Med 1991;325:860-869.
27. Ahmad N, Zacharek MA. Allergic rhinitis and rhinosinusitis. Otolaryngol Clin North Am 2008;41:267-281.
28. Eliashar R, Levi-Schaffer F. The role of the eosinophil in nasal diseases. Curr Opin Otolaryngol Head Neck Surg 2005;13:171-175.
29. Rosenberg HF, Phipps S, Foster PS. Eosinophil trafficking in allergy and asthma. J Allergy Clin Immunol 2007;119:1303-1310.
30. Jung HW, Seo UK, Kim JH, Leem KH, Park YK. Flower extract of Panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of NFkappaB signaling pathway in murine macrophages. J Ethnopharmacol 2009;122:313-319.
31. Kim BH, Lee YG, Park TY, Kim HB, Rhee MH, Cho JY. Ginsenoside Rp1, a ginsenoside derivative, blocks lipopolysaccharide-induced interleukin-1beta production via suppression of the NF-kappaB pathway. Planta Med 2009;75:321-326.
32. Ichikawa T, Li J, Nagarkatti P, Nagarkatti M, Hofseth LJ, Windust A, Cui T. American ginseng preferentially suppresses STAT/iNOS signaling in activated macrophages. J Ethnopharmacol 2009;125:145-150.
33. Evans CM, Kim K, Tuvim MJ, Dickey BF. Mucus hypersecretion in asthma: causes and effects. Curr Opin Pulm Med 2009;15:4-11.
34. Kim S, Nadel JA. Role of neutrophils in mucus hypersecretion in COPD and implications for therapy. Treat Respir Med 2004;3:147-159.
35. Ali MS, Wilson JA, Bennett M, Pearson JP. Mucin gene expression in nasal polyps. Acta Otolaryngol 2005;125:618-624.
36. Chung E, Lee KY, Lee YJ, Lee YH, Lee SK. Ginsenoside Rg1 down-regulates glucocorticoid receptor and displays synergistic effects with cAMP. Steroids 1998;63:421-424.
37. Lee YJ, Chung E, Lee KY, Lee YH, Huh B, Lee SK. Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor. Mol Cell Endocrinol 1997;133:135-140.
38. Sun J, Song X, Hu S. Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice. Clin Vaccine Immunol 2008;15:303-307.