Efficacy of different mouthrinse formulations in reducing oral malodour: A randomized clinical trial

Journal of Clinical Periodontology

Volumn 40, Issue 5, 2013, Pages 505-513

  Dadamio, Jesica ^a,b   Van Tournout, Marie ^a   Teughels, Wim ^a,b   Dekeyser, Christel ^a   Coucke, Wim ^c   Quirynen, Marc ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b CATHOLIC UNIVERSITY OF LEUVEN   (Belgium)

^c SCIENTIFIC INSTITUTE OF PUBLIC HEALTH   (Belgium)

Author keywords

bad breath; biofilm; halitosis; mouthrinses; oral malodour; RCT; zinc

Indexed keywords

AMINE; ANTIINFECTIVE AGENT; CETYLPYRIDINIUM SALT; CHLORHEXIDINE; CHLORHEXIDINE GLUCONATE; DRUG DERIVATIVE; HYDROGEN SULFIDE; LACTIC ACID DERIVATIVE; MERIDOL; METHANETHIOL; MOUTHWASH; OXIDIZING AGENT; THIOL DERIVATIVE; TIN FLUORIDE; TOPICAL ANTIINFECTIVE AGENT; VOLATILE ORGANIC COMPOUND; ZINC DERIVATIVE;

ARTICLE; BACTERIAL LOAD; CHEMISTRY; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; DRUG EFFECT; EQUIPMENT; FEMALE; GAS CHROMATOGRAPHY; HALITOSIS; HUMAN; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; SALIVA; TONGUE; TREATMENT OUTCOME;

AMINES; ANTI-INFECTIVE AGENTS; ANTI-INFECTIVE AGENTS, LOCAL; BACTERIAL LOAD; CETYLPYRIDINIUM; CHEMISTRY, PHARMACEUTICAL; CHLORHEXIDINE; CHROMATOGRAPHY, GAS; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; HALITOSIS; HUMANS; HYDROGEN SULFIDE; LACTATES; MALE; MIDDLE AGED; MOUTHWASHES; OXIDANTS; SALIVA; SULFHYDRYL COMPOUNDS; TIN FLUORIDES; TONGUE; TREATMENT OUTCOME; VOLATILE ORGANIC COMPOUNDS; ZINC COMPOUNDS;

EID: 84876019079     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/jcpe.12090     Document Type: Article

References (46)

1. Auschill, T. M., Hein, N., Hellwig, E., Follo, M., Sculean, A., &, Arweiler, N. B., (2005) Effect of two antimicrobial agents on early in situ biofilm formation. Journal of Clinical Periodontology 32, 147-152.
2. Berchier, C. E., Slot, D. E., &, Van der Weijden, G. A., (2010) The efficacy of 0.12% chlorhexidine mouthrinse compared with 0.2% on plaque accumulation and periodontal parameters: a systematic review. Journal of Clinical Periodontology 37, 829-839.
3. Brecx, M., Macdonald, L. L., Legary, K., Cheang, M., &, Forgay, M. G., (1993) Long-term effects of Meridol and chlorhexidine mouthrinses on plaque, gingivitis, staining, and bacterial vitality. Journal of Dental Research 72, 1194-1197.
4. Coil, J. M., Yaegaki, K., Matsuo, T., &, Miyazaki, H., (2002) Treatment needs (TN) and practical remedies for halitosis. International Dental Journal 52 (Suppl 3), 187-191.
5. Dadamio, J., Van Tornout, M., Van den Velde, S., Federico, R., Dekeyser, C., &, Quirynen, M., (2011) A novel and visual test for oral malodour: first observations. Journal of Breath Research 5, 046003.
6. Doty, R. L., Shaman, P., Applebaum, S. L., Giberson, R., Siksorski, L., &, Rosenberg, L., (1984) Smell identification ability: changes with age. Science 226, 1441-1443.
7. Fedorowicz, Z., Aljufairi, H., Nasser, M., Outhouse, T. L., &, Pedrazzi, V., (2008) Mouthrinses for the treatment of halitosis. Cochrane Database of Systematic Reviews, CD006701.
8. Goldberg, S., Kozlovsky, A., Gordon, D., Gelernter, I., Sintov, A., &, Rosenberg, M., (1994) Cadaverine as a putative component of oral malodor. Journal of Dental Research 73, 1168-1172.
9. Greenman, J., Duffield, J., Spencer, P., Rosenberg, M., Corry, D., Saad, S., Lenton, P., Majerus, G., Nachnani, S., &, El-Maaytah, M., (2004) Study on the organoleptic intensity scale for measuring oral malodor. Journal of Dental Research 83, 81-85.
10. Hoshi, K., &, van Steenberghe, D., (1996) The effect of tongue brushing or toothpaste application on oral malodour reduction. In, van Steenberghe, D., &, Rosenberg, M., (eds). Bad Breath: A Multidisciplinary Approach, pp. 255-264. Leuven: Leuven University Press.
11. Kleinberg, I., &, Codipilly, D. M., (2002) Cysteine challenge testing: a powerful tool for examining oral malodour processes and treatments in vivo. International Dental Journal 52 (Suppl 3), 221-228.
12. Loesche, W. J., &, Kazor, C., (2002) Microbiology and treatment of halitosis. Periodontology 2000 28, 256-279.
13. Nakano, Y., Yoshimura, M., &, Koga, T., (2002) Correlation between oral malodor and periodontal bacteria. Microbes and Infectio/Institut Pasteur 4, 679-683.
14. Navada, R., Kumari, H., Le, S., &, Zhang, J., (2008) Oral malodor reduction from a zinc-containing toothpaste. The Journal of Clinical Dentistry 19, 69-73.
15. Newby, E. E., Hickling, J. M., Hughes, F. J., Proskin, H. M., &, Bosma, M. P., (2008) Control of oral malodour by dentifrices measured by gas chromatography. Archives of Oral Biology 53 (Suppl 1), S19-S25.
16. Øgaard, B., Alm, A. A., Larsson, E., &, Adolfsson, U., (2006) A prospective, randomized clinical study on the effects of an amine fluoride/stannous fluoride toothpaste/mouthrinse on plaque, gingivitis and initial caries lesion development in orthodontic patients. European Journal of Orthodontics 28, 8-12.
17. Pauling, L., (1988) General chemistry, 3rd edition. San Francisco: W.H. Freeman.
18. Peruzzo, D. C., Salvador, S. L., Sallum, A. W., da Nogueira-Filho, G. R., (2008) Flavoring agents present in a dentifrice can modify volatile sulphur compounds (VSCs) formation in morning bad breath. Brazilian Oral Research 22, 252-257.
19. Porter, S. R., &, Scully, C., (2006) Oral malodour (halitosis). BMJ (Clinical Research Ed.) 333, 632-635.
20. Quirynen, M., Avontroodt, P., Soers, C., Zhao, H., Pauwels, M., Coucke, W., &, van Steenberghe, D., (2002a) The efficacy of amine fluoride/stannous fluoride in the suppression of morning breath odour. Journal of Clinical Periodontology 29, 944-954.
21. Quirynen, M., Dadamio, J., Van den Velde, S., De Smit, M., Dekeyser, C., Van Tornout, M., &, Vandekerckhove, B., (2009) Characteristics of 2000 patients who visited a halitosis clinic. Journal of Clinical Periodontology 36, 970-975.
22. Quirynen, M., Van den Velde, S., Vandekerckhove, B., &, Dadamio, J., (2011) Oral Malodour. In, Newman, M. G., Takei, H. H., &, Klokkevold, P.R., (eds). Carranza's Clinical Periodontology, pp. 331-338, Philadelphia: Elsevier Health Sciences.
23. Quirynen, M., Van Eldere, J., Pauwels, M., Bollen, C. M., &, van Steenberghe, D., (1999) In vitro volatile sulfur compound production of oral bacteria in different culture media. Quintessence International 30, 351-356.
24. Quirynen, M., Zhao, H., &, van Steenberghe, D., (2002b) Review of the treatment strategies for oral malodour. Clinical Oral Investigations 6, 1-10.
25. Reingewirtz, Y., Girault, O., Reingewirtz, N., Senger, B., &, Tenenbaum, H., (1999) Mechanical effects and volatile sulfur compound-reducing effects of chewing gums: comparison between test and base gums and a control group. Quintessence International 30, 319-323.
26. Roldán, S., Herrera, D., Santa-Cruz, I., O'Connor, A., González, I., &, Sanz, M., (2004) Comparative effects of different chlorhexidine mouth-rinse formulations on volatile sulphur compounds and salivary bacterial counts. Journal of Clinical Periodontology 31, 1128-1134.
27. Roldán, S., Winkel, E. G., Herrera, D., Sanz, M., &, Van Winkelhoff, A. J., (2003) The effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc lactate on the microflora of oral halitosis patients: a dual-centre, double-blind placebo-controlled study. Journal of Clinical Periodontology 30, 427-434.
28. Rölla, G., Jonski, G., &, Young, A., (2002) The significance of the source of zinc and its anti-VSC effect. International Dental Journal 52 (Suppl 3), 233-235.
29. Rosenberg, M., (1996) Clinical assessment of bad breath: current concepts. Journal of the American Dental Association 127, 475-482.
30. van Steenberghe, D., Avontroodt, P., Peeters, W., Pauwels, M., Coucke, W., Lijnen, A., &, Quirynen, M., (2001) Effect of different mouthrinses on morning breath. Journal of Periodontology 72, 1183-1191.
31. Suarez, F. L., Furne, J. K., Springfield, J., &, Levitt, M. D., (2000) Morning breath odor: influence of treatments on sulfur gases. Journal of Dental Research 79, 1773-1777.
32. Tangerman, A., (2002) Halitosis in medicine: a review. International Dental Journal 52 (Suppl 3), 201-206.
33. Tangerman, A., (2009) Measurement and biological significance of the volatile sulfur compounds hydrogen sulfide, methanethiol and dimethyl sulfide in various biological matrices. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 877, 3366-3377.
34. Tonzetich, J., (1977) Production and origin of oral malodor: a review of mechanisms and methods of analysis. Journal of Periodontology 48, 13-20.
35. Tonzetich, J., (1978) Oral malodour: an indicator of health status and oral cleanliness. International Dental Journal 28, 309-319.
36. Vandekerckhove, B., Van den Velde, S., De Smit, M., Dadamio, J., Teughels, W., Van Tornout, M., &, Quirynen, M., (2009) Clinical reliability of non-organoleptic oral malodour measurements. Journal of Clinical Periodontology 36, 964-969.
37. Wåler, S. M., (1997) The effect of some metal ions on volatile sulfur-containing compounds originating from the oral cavity. Acta Odontologica Scandinavica 55, 261-264.
38. Watts, A., &, Addy, M., (2001) Tooth discolouration and staining: a review of the literature. British Dental Journal 190, 309-316.
39. Wichmann, B. A., &, Hill, I. D., (1982) Algorithm AS 183: An Efficient and Portable Pseudo-Random Number Generator. Journal of the Royal Statistical Society. Series C (Applied Statistics) 31, 188-190.
40. Wigger-Alberti, W., Gysen, K., Axmann, E.-M., &, Wilhelm, K.-P., (2009) Efficacy of a new mouthrinse formulation on the reduction of oral malodour in vivo. A randomized, double-blind, placebo-controlled, 3 week clinical study. Journal of Breath Research 4, 017102.
41. Wilhelm, D., Gysen, K., Himmelmann, A., Krause, C., &, Wilhelm, K.-P., (2010) Short-term effect of a new mouthrinse formulation on oral malodour after single use in vivo: a comparative, randomized, single-blind, parallel-group clinical study. Journal of Breath Research 4, 036002.
42. Yaegaki, K., Coil, J. M., Kamemizu, T., &, Miyazaki, H., (2002) Tongue brushing and mouth rinsing as basic treatment measures for halitosis. International Dental Journal 52 (Suppl 3), 192-196.
43. Yaegaki, K., &, Sanada, K., (1992) Volatile sulfur compounds in mouth air from clinically healthy subjects and patients with periodontal disease. Journal of Periodontal Research 27, 233-238.
44. Young, A., &, Jonski, G., (2011) Effect of a single brushing with two Zn-containing toothpastes on VSC in morning breath: a 12 h, randomized, double-blind, cross-over clinical study. Journal of Breath Research 5, 046012.
45. Young, A., Jonski, G., &, Rölla, G., (2003) Inhibition of orally produced volatile sulfur compounds by zinc, chlorhexidine or cetylpyridinium chloride-effect of concentration. European Journal of Oral Sciences 111, 400-404.
46. Young, A., Jonski, G., Rölla, G., &, Wåler, S. M., (2001) Effects of metal salts on the oral production of volatile sulfur-containing compounds (VSC). Journal of Clinical Periodontology 28, 776-781.