Iodine-catalyzed aza-prins cyclization: Metal-free synthesis and antiproliferative activity of hexahydrobenzo[f]isoquinolines

Synthesis (Germany)

Volumn 45, Issue 8, 2013, Pages 1076-1082

  Figueiredo, Carlos A M ^a   Reddy, K R Kishore K ^a   Monteiro, Paula A ^b   De Carvalho, João E ^b   Ruiz, Ana L T G ^b   Silva Jr , Luiz F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

aldehydes; amines; antitumor agents; catalysis; cyclizations; heterocycles; iodine

Indexed keywords

ANTI-PROLIFERATIVE ACTIVITIES; ANTI-TUMOR ACTIVITIES; ANTI-TUMOR AGENTS; AZA-PRINS CYCLIZATION; CYCLIZATIONS; HETEROCYCLES; METAL-FREE CONDITIONS; SOLVENT FREE CONDITIONS;

ALDEHYDES; AMINES; CATALYSIS; IODINE; SYNTHESIS (CHEMICAL);

CYCLIZATION;

1 METHYL 4 (4 NITROPHENYL) 3 TOSYL 1,2,3,4,5,6 HEXAHYDROBENZO[F]ISOQUINOLINE; 1 METHYL 4 PHENYL 3 TOSYL 1,2,3,4,5,6 HEXAHYDROBENZO[F]ISOQUINOLINE; 1 METHYL 4 PROPYL 3 TOSYL 1,2,3,4,5,6 HEXAHYDROBENZO[F]ISOQUINOLINE; 4 (4 METHOXYPHENYL) 1 METHYL 3 TOSYL 1,2,3,4,5,6 HEXAHYDROBENZO[F]ISOQUINOLINE; 4 ISOPROPYL 1 METHYL 3 TOSYL 1,2,3,4,5,6 HEXAHYDROBENZO[F]ISOQUINOLINE; ALDEHYDE; BENZ[F]ISOQUINOLINE DERIVATIVE; DOXORUBICIN; HEXAHYDROBENZO[F]ISOQUINOLINE DERIVATIVE; IODINE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AZA PRINS CYCLIZATION; CANCER INHIBITION; CATALYSIS; CONTROLLED STUDY; CYCLIZATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; TUMOR CELL;

EID: 84876013769     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0032-1318478     Document Type: Article

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