Mutual Antagonism between Circadian Protein Period 2 and Hepatitis C Virus Replication in Hepatocytes

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Benegiamo, Giorgia ^a,g   Mazzoccoli, Gianluigi ^a   Cappello, Francesco ^b,c   Rappa, Francesca ^c   Scibetta, Nunzia ^d   Oben, Jude ^e   Greco, Azzura ^f   Williams, Roger ^f   Andriulli, Angelo ^a   Vinciguerra, Manlio ^b,e   Pazienza, Valerio ^a  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b Euro Mediterranean Institute of Science and Technology   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

^d Civic Hospital   (Italy)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f INSTITUTE OF HEPATOLOGY   (United Kingdom)

^g UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOCHROME 1; CRYPTOCHROME 2; PER1 PROTEIN; PER2 PROTEIN; RETINOID RELATED ORPHAN RECEPTOR ALPHA; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTION FACTOR CLOCK;

ADULT; AGED; ARNTL GENE; ARNTL2 GENE; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CLOCK GENE; CONTROLLED STUDY; CRY1 GENE; CRY2 GENE; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CELL; MALE; NONHUMAN; PER1 GENE; PER2 GENE; PER3 GENE; REPLICON; REV ERB ALPHA GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ROR ALPHA GENE; VIRUS REPLICATION;

ADULT; AGED; CELL LINE; CELL LINE, TUMOR; FEMALE; GENOME, VIRAL; GENOTYPE; HEPACIVIRUS; HEPATITIS C; HEPATOCYTES; HUMANS; LIVER; MALE; MIDDLE AGED; PERIOD CIRCADIAN PROTEINS; RNA, VIRAL; VIRAL CORE PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 84875991864     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060527     Document Type: Article

References (38)

1. Bass J, (2012) Circadian topology of metabolism. Nature 491: 348-356.
2. Edery I, (2000) Circadian rhythms in a nutshell. Physiol Genomics 3: 59-74.
3. Nagoshi E, Saini C, Bauer C, Laroche T, Naef F, et al. (2004) Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell 119: 693-705.
4. Sahar S, Sassone-Corsi P, (2012) Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol Metab 23: 1-8.
5. Ohdo S, (2010) Chrono-drug-delivery focused on biological clock: intra- and inter-individual variability of molecular clock. Adv Drug Deliv Rev 62: 857-858.
6. Tevy MF, Giebultowicz J, Pincus Z, Mazzoccoli G, Vinciguerra M (2013) Aging signaling pathways and circadian clock-dependent metabolic derangements. Trends Endocrinol Metab.
7. Shadan FF, (2007) A circadian model for viral persistence. Med Hypotheses 68: 546-553.
8. Kalamvoki M, Roizman B, (2011) Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression. Proc Natl Acad Sci U S A 107: 17721-17726.
9. Collaco AM, Rahman S, Dougherty EJ, Williams BB, Geusz ME, (2005) Circadian regulation of a viral gene promoter in live transgenic mice expressing firefly luciferase. Mol Imaging Biol 7: 342-350.
10. El-Serag HB (2012) Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 142: 1264-1273 e1261.
11. Ripoli M, Pazienza V, (2011) Impact of HCV genetic differences on pathobiology of disease. Expert Rev Anti Infect Ther 9: 747-759.
12. Yoshida T, Hanada T, Tokuhisa T, Kosai K, Sata M, et al. (2002) Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med 196: 641-653.
13. Moriya K, Fujie H, Shintani Y, Yotsuyanagi H, Tsutsumi T, et al. (1998) The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 4: 1065-1067.
14. Pazienza V, Clement S, Pugnale P, Conzelman S, Foti M, et al. (2007) The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms. Hepatology 45: 1164-1171.
15. Rappa F, Greco A, Podrini C, Cappello F, Foti M, et al. (2013) Immunopositivity for Histone MacroH2A1 Isoforms Marks Steatosis-Associated Hepatocellular Carcinoma. PLoS ONE 8: e54458.
16. Ikeda M, Abe K, Dansako H, Nakamura T, Naka K, et al. (2005) Efficient replication of a full-length hepatitis C virus genome, strain O, in cell culture, and development of a luciferase reporter system. Biochem Biophys Res Commun 329: 1350-1359.
17. Abid K, Pazienza V, de Gottardi A, Rubbia-Brandt L, Conne B, et al. (2005) An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation. J Hepatol 42: 744-751.
18. Albrecht U, Sun ZS, Eichele G, Lee CC, (1997) A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell 91: 1055-1064.
19. Pazienza V, Vinciguerra M, Andriulli A, Mangia A, (2010) Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-{gamma} in Huh-7 cells. J Gen Virol 91: 1678-1686.
20. Arjona A, Sarkar DK, (2006) The circadian gene mPer2 regulates the daily rhythm of IFN-gamma. J Interferon Cytokine Res 26: 645-649.
21. Miyazaki K, Wakabayashi M, Chikahisa S, Sei H, Ishida N, (2007) PER2 controls circadian periods through nuclear localization in the suprachiasmatic nucleus. Genes Cells 12: 1225-1234.
22. Kim EY, Bae K, Ng FS, Glossop NR, Hardin PE, et al. (2002) Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity. Neuron 34: 69-81.
23. Schibler U, (2007) The daily timing of gene expression and physiology in mammals. Dialogues Clin Neurosci 9: 257-272.
24. Canaple L, Kakizawa T, Laudet V, (2003) The days and nights of cancer cells. Cancer Res 63: 7545-7552.
25. Zhu Y, Stevens RG, Leaderer D, Hoffman A, Holford T, et al. (2008) Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk. Breast Cancer Res Treat 107: 421-425.
26. Chu LW, Zhu Y, Yu K, Zheng T, Yu H, et al. (2008) Variants in circadian genes and prostate cancer risk: a population-based study in China. Prostate Cancer Prostatic Dis 11: 342-348.
27. Lin YM, Chang JH, Yeh KT, Yang MY, Liu TC, et al. (2008) Disturbance of circadian gene expression in hepatocellular carcinoma. Mol Carcinog 47: 925-933.
28. Chen P, Kakan X, Zhang J, (2010) Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride. FEBS Lett 584: 1597-1601.
29. Oshima T, Takenoshita S, Akaike M, Kunisaki C, Fujii S, et al. (2011) Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep 25: 1439-1446.
30. Chen P, Li C, Pang W, Zhao Y, Dong W, et al. (2009) The protective role of Per2 against carbon tetrachloride-induced hepatotoxicity. Am J Pathol 174: 63-70.
31. Narasimamurthy R, Hatori M, Nayak SK, Liu F, Panda S, et al. (2012) Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A 109: 12662-12667.
32. Chen R, Schirmer A, Lee Y, Lee H, Kumar V, et al. (2009) Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell 36: 417-430.
33. Keum SJ, Park SM, Park JH, Jung JH, Shin EJ, et al. (2012) The specific infectivity of hepatitis C virus changes through its life cycle. Virology 433: 462-470.
34. Jonas MM, (1996) Interferon-alpha for viral hepatitis. J Pediatr Gastroenterol Nutr 23: 93-106.
35. Kwon YC, Kang JI, Hwang SB, Ahn BY, (2012) The ribonuclease L-dependent antiviral roles of human 2′,5′-oligoadenylate synthetase family members against hepatitis C virus. FEBS Lett 587: 156-164.
36. Kang TH, Sancar A, (2009) Circadian regulation of DNA excision repair: implications for chrono-chemotherapy. Cell Cycle 8: 1665-1667.
37. Quera Salva MA, Hartley S, Barbot F, Alvarez JC, Lofaso F, et al. (2011) Circadian rhythms, melatonin and depression. Curr Pharm Des 17: 1459-1470.
38. Lange CM, Zeuzem S (2012) Perspectives and challenges of interferon-free therapy for chronic hepatitis C. J Hepatol Oct 24. doi:pii: S0168-8278(12)00818-5. 10.1016/j.jhep.2012.10.019. [Epub ahead of print].