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Volumn 4, Issue 2, 2013, Pages

Phosphorylation of signal transducer and activator of transcription 1 reduces bortezomib-mediated apoptosis in cancer cells

Author keywords

Bortezomib; Cisplatin; HSP70; JAK1; Ovarian cancer; STAT1

Indexed keywords

BORTEZOMIB; CISPLATIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; JANUS KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; STAT1 PROTEIN;

EID: 84875987607     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.38     Document Type: Article
Times cited : (23)

References (54)
  • 2
    • 44449107683 scopus 로고    scopus 로고
    • Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells
    • Baritaki S, Suzuki E, Umezawa K, Spandidos DA, Berenson J, Daniels TR et al. Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells. J Immunol 2008; 180: 6199-6210.
    • (2008) J Immunol , vol.180 , pp. 6199-6210
    • Baritaki, S.1    Suzuki, E.2    Umezawa, K.3    Spandidos, D.A.4    Berenson, J.5    Daniels, T.R.6
  • 3
    • 81855189631 scopus 로고    scopus 로고
    • Proteasome inhibitors suppress expression of NPM and ARF proteins
    • Pandit B, Gartel AL. Proteasome inhibitors suppress expression of NPM and ARF proteins. Cell Cycle 2011; 10: 3827-3829.
    • (2011) Cell Cycle , vol.10 , pp. 3827-3829
    • Pandit, B.1    Gartel, A.L.2
  • 5
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    • Beg AA, Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 1996; 274: 782-784.
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 6
    • 33644916110 scopus 로고    scopus 로고
    • Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
    • Berenson JR, Yang HH, Sadler K, Jarutirasarn SG, Vescio RA, Mapes R et al. Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. J Clin Oncol 2006; 24: 937-944.
    • (2006) J Clin Oncol , vol.24 , pp. 937-944
    • Berenson, J.R.1    Yang, H.H.2    Sadler, K.3    Jarutirasarn, S.G.4    Vescio, R.A.5    Mapes, R.6
  • 8
    • 1042301419 scopus 로고    scopus 로고
    • STAT1-induced apoptosis is mediated by caspases 2, 3, and 7
    • Sironi JJ, Ouchi T. STAT1-induced apoptosis is mediated by caspases 2, 3, and 7. J Biol Chem 2004; 279: 4066-4074.
    • (2004) J Biol Chem , vol.279 , pp. 4066-4074
    • Sironi, J.J.1    Ouchi, T.2
  • 9
    • 0037232131 scopus 로고    scopus 로고
    • Novel interferons
    • Vilcek J. Novel interferons. Nat Immunol 2003; 4: 8-9.
    • (2003) Nat Immunol , vol.4 , pp. 8-9
    • Vilcek, J.1
  • 10
    • 70450252001 scopus 로고    scopus 로고
    • Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis
    • Chang CW, Tsai WH, Chuang WJ, Lin YS, Wu JJ, Liu CC et al. Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis. J Biol Chem 2009; 284: 33195-33205.
    • (2009) J Biol Chem , vol.284 , pp. 33195-33205
    • Chang, C.W.1    Tsai, W.H.2    Chuang, W.J.3    Lin, Y.S.4    Wu, J.J.5    Liu, C.C.6
  • 12
    • 17444362227 scopus 로고    scopus 로고
    • Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells
    • Roberts D, Schick J, Conway S, Biade S, Laub PB, Stevenson JP et al. Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells. Br J Cancer 2005; 92: 1149-1158.
    • (2005) Br J Cancer , vol.92 , pp. 1149-1158
    • Roberts, D.1    Schick, J.2    Conway, S.3    Biade, S.4    Laub, P.B.5    Stevenson, J.P.6
  • 14
    • 0030054309 scopus 로고    scopus 로고
    • Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer
    • McGuire WP, Hoskins WJ, Brady MF, Kucera PR, Partridge EE, Look KY et al. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med 1996; 334: 1-6.
    • (1996) N Engl J Med , vol.334 , pp. 1-6
    • McGuire, W.P.1    Hoskins, W.J.2    Brady, M.F.3    Kucera, P.R.4    Partridge, E.E.5    Look, K.Y.6
  • 16
    • 33645731530 scopus 로고    scopus 로고
    • Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis
    • Bazzaro M, Lee MK, Zoso A, Stirling WL, Santillan A, Shih IM et al. Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis. Cancer Res 2006; 66: 3754-3763.
    • (2006) Cancer Res , vol.66 , pp. 3754-3763
    • Bazzaro, M.1    Lee, M.K.2    Zoso, A.3    Stirling, W.L.4    Santillan, A.5    Shih, I.M.6
  • 17
    • 24944526723 scopus 로고    scopus 로고
    • Phase i trial of bortezomib and carboplatin in recurrent ovarian or primary peritoneal cancer
    • Aghajanian C, Dizon DS, Sabbatini P, Raizer JJ, Dupont J, Spriggs DR. Phase I trial of bortezomib and carboplatin in recurrent ovarian or primary peritoneal cancer. J Clin Oncol 2005; 23: 5943-5949.
    • (2005) J Clin Oncol , vol.23 , pp. 5943-5949
    • Aghajanian, C.1    Dizon, D.S.2    Sabbatini, P.3    Raizer, J.J.4    Dupont, J.5    Spriggs, D.R.6
  • 18
    • 0033817518 scopus 로고    scopus 로고
    • Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341
    • Frankel A, Man S, Elliott P, Adams J, Kerbel RS. Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin Cancer Res 2000; 6: 3719-3728.
    • (2000) Clin Cancer Res , vol.6 , pp. 3719-3728
    • Frankel, A.1    Man, S.2    Elliott, P.3    Adams, J.4    Kerbel, R.S.5
  • 19
    • 70349754173 scopus 로고    scopus 로고
    • A phase II evaluation of bortezomib in the treatment of recurrent platinum-sensitive ovarian or primary peritoneal cancer: A Gynecologic Oncology Group study
    • Aghajanian C, Blessing JA, Darcy KM, Reid G, DeGeest K, Rubin SC et al. A phase II evaluation of bortezomib in the treatment of recurrent platinum-sensitive ovarian or primary peritoneal cancer: a Gynecologic Oncology Group study. Gynecol Oncol 2009; 115: 215-220.
    • (2009) Gynecol Oncol , vol.115 , pp. 215-220
    • Aghajanian, C.1    Blessing, J.A.2    Darcy, K.M.3    Reid, G.4    Degeest, K.5    Rubin, S.C.6
  • 20
    • 50349096803 scopus 로고    scopus 로고
    • Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis
    • Powers MV, Clarke PA, Workman P. Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell 2008; 14: 250-262.
    • (2008) Cancer Cell , vol.14 , pp. 250-262
    • Powers, M.V.1    Clarke, P.A.2    Workman, P.3
  • 22
    • 84875974343 scopus 로고    scopus 로고
    • ClinicalTrial.gov
    • ClinicalTrial.govhttp://clinicaltrials.gov/ct2/home 2012.
  • 24
    • 0032560475 scopus 로고    scopus 로고
    • Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice
    • Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, Old LJ et al. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci USA 1998; 95: 7556-7561.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7556-7561
    • Kaplan, D.H.1    Shankaran, V.2    Dighe, A.S.3    Stockert, E.4    Aguet, M.5    Old, L.J.6
  • 25
    • 0029863169 scopus 로고    scopus 로고
    • Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl
    • Carlesso N, Frank DA, Griffin JD. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med 1996; 183: 811-820.
    • (1996) J Exp Med , vol.183 , pp. 811-820
    • Carlesso, N.1    Frank, D.A.2    Griffin, J.D.3
  • 26
    • 0031436969 scopus 로고    scopus 로고
    • B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
    • Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. J Clin Invest 1997; 100: 3140-3148.
    • (1997) J Clin Invest , vol.100 , pp. 3140-3148
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 27
    • 84866381896 scopus 로고    scopus 로고
    • Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistance
    • Zimmerman MA, Rahman NT, Yang D, Lahat G, Lazar AJ, Pollock RE et al. Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistance. Cancer Res 2012; 72: 4724-4732.
    • (2012) Cancer Res , vol.72 , pp. 4724-4732
    • Zimmerman, M.A.1    Rahman, N.T.2    Yang, D.3    Lahat, G.4    Lazar, A.J.5    Pollock, R.E.6
  • 28
    • 84864271417 scopus 로고    scopus 로고
    • Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
    • Dimberg LY, Dimberg A, Ivarsson K, Fryknas M, Rickardson L, Tobin G et al. Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma. BMC Cancer 2012; 12: 318.
    • (2012) BMC Cancer , vol.12 , pp. 318
    • Dimberg, L.Y.1    Dimberg, A.2    Ivarsson, K.3    Fryknas, M.4    Rickardson, L.5    Tobin, G.6
  • 30
    • 33744959426 scopus 로고    scopus 로고
    • PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells
    • Yeung BH, Huang DC, Sinicrope FA. PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells. J Biol Chem 2006; 281: 11923-11932.
    • (2006) J Biol Chem , vol.281 , pp. 11923-11932
    • Yeung, B.H.1    Huang, D.C.2    Sinicrope, F.A.3
  • 32
  • 33
    • 70350011890 scopus 로고    scopus 로고
    • A novel defense mechanism that is activated on amyloid-beta insult to mediate cell survival: Role of SGK1-STAT1/STAT2 signaling
    • Hsu WL, Chiu TH, Tai DJ, Ma YL, Lee EH. A novel defense mechanism that is activated on amyloid-beta insult to mediate cell survival: role of SGK1-STAT1/STAT2 signaling. Cell Death Differ 2009; 16: 1515-1529.
    • (2009) Cell Death Differ , vol.16 , pp. 1515-1529
    • Hsu, W.L.1    Chiu, T.H.2    Tai, D.J.3    Ma, Y.L.4    Lee, E.H.5
  • 34
    • 35948943113 scopus 로고    scopus 로고
    • Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma
    • Voorhees PM, Chen Q, Kuhn DJ, Small GW, Hunsucker SA, Strader JS et al. Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma. Clin Cancer Res 2007; 13: 6469-6478.
    • (2007) Clin Cancer Res , vol.13 , pp. 6469-6478
    • Voorhees, P.M.1    Chen, Q.2    Kuhn, D.J.3    Small, G.W.4    Hunsucker, S.A.5    Strader, J.S.6
  • 35
    • 0033555548 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters
    • Stephanou A, Isenberg DA, Nakajima K, Latchman DS. Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters. J Biol Chem 1999; 274: 1723-1728.
    • (1999) J Biol Chem , vol.274 , pp. 1723-1728
    • Stephanou, A.1    Isenberg, D.A.2    Nakajima, K.3    Latchman, D.S.4
  • 36
    • 0035378665 scopus 로고    scopus 로고
    • Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway
    • Madamanchi NR, Li S, Patterson C, Runge MS. Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway. J Biol Chem 2001; 276: 18915-18924.
    • (2001) J Biol Chem , vol.276 , pp. 18915-18924
    • Madamanchi, N.R.1    Li, S.2    Patterson, C.3    Runge, M.S.4
  • 37
    • 12444266407 scopus 로고    scopus 로고
    • Apoptosis-resistant phenotype in HL-60-derived cells HCW-2 is related to changes in expression of stressinduced proteins that impact on redox status and mitochondrial metabolism
    • Salvioli S, Storci G, Pinti M, Quaglino D, Moretti L, Merlo-Pich M et al. Apoptosis-resistant phenotype in HL-60-derived cells HCW-2 is related to changes in expression of stressinduced proteins that impact on redox status and mitochondrial metabolism. Cell Death Differ 2003; 10: 163-174.
    • (2003) Cell Death Differ , vol.10 , pp. 163-174
    • Salvioli, S.1    Storci, G.2    Pinti, M.3    Quaglino, D.4    Moretti, L.5    Merlo-Pich, M.6
  • 39
    • 83555174315 scopus 로고    scopus 로고
    • The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells
    • Monaghan KA, Khong T, Burns CJ, Spencer A. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia 2011; 25: 1891-1899.
    • (2011) Leukemia , vol.25 , pp. 1891-1899
    • Monaghan, K.A.1    Khong, T.2    Burns, C.J.3    Spencer, A.4
  • 40
    • 77954605430 scopus 로고    scopus 로고
    • Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: Therapeutic implications
    • Pham LV, Tamayo AT, Li C, Bornmann W, Priebe W, Ford RJ. Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications. Mol Cancer Ther 2010; 9: 2026-2036.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2026-2036
    • Pham, L.V.1    Tamayo, A.T.2    Li, C.3    Bornmann, W.4    Priebe, W.5    Ford, R.J.6
  • 41
    • 53749102921 scopus 로고    scopus 로고
    • Blockage of interleukin-6 signaling with 6-amino-4-quinazoline synergistically induces the inhibitory effect of bortezomib in human U266 cells
    • Park J, Ahn KS, Bae EK, Kim BS, Kim BK, Lee YY et al. Blockage of interleukin-6 signaling with 6-amino-4-quinazoline synergistically induces the inhibitory effect of bortezomib in human U266 cells. Anticancer Drugs 2008; 19: 777-782.
    • (2008) Anticancer Drugs , vol.19 , pp. 777-782
    • Park, J.1    Ahn, K.S.2    Bae, E.K.3    Kim, B.S.4    Kim, B.K.5    Lee, Y.Y.6
  • 42
    • 29044439134 scopus 로고    scopus 로고
    • Constitutive activation of STAT proteins in the HDLM-2 and L540 Hodgkin lymphoma-derived cell lines supports cell survival
    • Cochet O, Frelin C, Peyron JF, Imbert V. Constitutive activation of STAT proteins in the HDLM-2 and L540 Hodgkin lymphoma-derived cell lines supports cell survival. Cell Signal 2006; 18: 449-455.
    • (2006) Cell Signal , vol.18 , pp. 449-455
    • Cochet, O.1    Frelin, C.2    Peyron, J.F.3    Imbert, V.4
  • 43
    • 80051653958 scopus 로고    scopus 로고
    • Modulation of cisplatin cytotoxicity due to its combination with bortezomib and the nature of its administration
    • Al-Eisawi Z, Beale P, Chan C, Yu JQ, Huq F. Modulation of cisplatin cytotoxicity due to its combination with bortezomib and the nature of its administration. Anticancer Res 2011; 31: 2757-2762.
    • (2011) Anticancer Res , vol.31 , pp. 2757-2762
    • Al-Eisawi, Z.1    Beale, P.2    Chan, C.3    Yu, J.Q.4    Huq, F.5
  • 44
    • 77149165728 scopus 로고    scopus 로고
    • Primary ovarian cancer cells are sensitive to the proaptotic effects of proteasome inhibitors
    • Pasquini L, Petronelli A, Petrucci E, Saulle E, Mariani G, Scambia G et al. Primary ovarian cancer cells are sensitive to the proaptotic effects of proteasome inhibitors. Int J Oncol 2010; 36: 707-713.
    • (2010) Int J Oncol , vol.36 , pp. 707-713
    • Pasquini, L.1    Petronelli, A.2    Petrucci, E.3    Saulle, E.4    Mariani, G.5    Scambia, G.6
  • 45
    • 33846013251 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa
    • Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H et al. Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. J Biol Chem 2006; 281: 31440-31447.
    • (2006) J Biol Chem , vol.281 , pp. 31440-31447
    • Fribley, A.M.1    Evenchik, B.2    Zeng, Q.3    Park, B.K.4    Guan, J.Y.5    Zhang, H.6
  • 46
    • 79959895071 scopus 로고    scopus 로고
    • HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer
    • Stronach EA, Alfraidi A, Rama N, Datler C, Studd JB, Agarwal R et al. HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer. Cancer Res 2011; 71: 4412-4422.
    • (2011) Cancer Res , vol.71 , pp. 4412-4422
    • Stronach, E.A.1    Alfraidi, A.2    Rama, N.3    Datler, C.4    Studd, J.B.5    Agarwal, R.6
  • 47
    • 59449105383 scopus 로고    scopus 로고
    • Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1
    • Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, Howell SB. Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. Clin Cancer Res 2009; 15: 553-560.
    • (2009) Clin Cancer Res , vol.15 , pp. 553-560
    • Jandial, D.D.1    Farshchi-Heydari, S.2    Larson, C.A.3    Elliott, G.I.4    Wrasidlo, W.J.5    Howell, S.B.6
  • 48
    • 78649273715 scopus 로고    scopus 로고
    • Stroke after treatment with bortezomib and dexamethasone in a Chinese patient with extramedullary relapse of multiple myeloma
    • Guo HF, Su HL, Mao JJ, Sun C, Wang J, Zhou X. Stroke after treatment with bortezomib and dexamethasone in a Chinese patient with extramedullary relapse of multiple myeloma. Int J Clin Pharmacol Ther 2010; 48: 776-778.
    • (2010) Int J Clin Pharmacol Ther , vol.48 , pp. 776-778
    • Guo, H.F.1    Su, H.L.2    Mao, J.J.3    Sun, C.4    Wang, J.5    Zhou, X.6
  • 49
    • 0032570594 scopus 로고    scopus 로고
    • Microtubuleinterfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways
    • Wang TH, Wang HS, Ichijo H, Giannakakou P, Foster JS, Fojo T et al. Microtubuleinterfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J Biol Chem 1998; 273: 4928-4936.
    • (1998) J Biol Chem , vol.273 , pp. 4928-4936
    • Wang, T.H.1    Wang, H.S.2    Ichijo, H.3    Giannakakou, P.4    Foster, J.S.5    Fojo, T.6
  • 50
    • 33749240743 scopus 로고    scopus 로고
    • Nucleophosmin/B23 regulates transcriptional activation of E2F1 via modulating the promoter binding of NF-kappaB, E2F1 and pRB
    • Lin CY, Liang YC, Yung BY. Nucleophosmin/B23 regulates transcriptional activation of E2F1 via modulating the promoter binding of NF-kappaB, E2F1 and pRB. Cell Signal 2006; 18: 2041-2048.
    • (2006) Cell Signal , vol.18 , pp. 2041-2048
    • Lin, C.Y.1    Liang, Y.C.2    Yung, B.Y.3
  • 51
    • 33748935161 scopus 로고    scopus 로고
    • Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells
    • Yeh CW, Huang SS, Lee RP, Yung BY. Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells. Mol Pharmacol 2006; 70: 1443-1453.
    • (2006) Mol Pharmacol , vol.70 , pp. 1443-1453
    • Yeh, C.W.1    Huang, S.S.2    Lee, R.P.3    Yung, B.Y.4
  • 52
    • 2442676752 scopus 로고    scopus 로고
    • Physiological and pathological responses to hypoxia
    • Michiels C. Physiological and pathological responses to hypoxia. Am J Pathol 2004; 164: 1875-1882.
    • (2004) Am J Pathol , vol.164 , pp. 1875-1882
    • Michiels, C.1
  • 53
    • 77949873402 scopus 로고    scopus 로고
    • Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma
    • Chao A, Tsai CL, Wei PC, Hsueh S, Chao AS, Wang CJ et al. Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma. Cancer Lett 2010; 291: 99-107.
    • (2010) Cancer Lett , vol.291 , pp. 99-107
    • Chao, A.1    Tsai, C.L.2    Wei, P.C.3    Hsueh, S.4    Chao, A.S.5    Wang, C.J.6
  • 54
    • 33646504879 scopus 로고    scopus 로고
    • Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression
    • Chao A, Wang TH, Lee YS, Hsueh S, Chao AS, Chang TC et al. Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression. Int J Cancer 2006; 119: 91-98.
    • (2006) Int J Cancer , vol.119 , pp. 91-98
    • Chao, A.1    Wang, T.H.2    Lee, Y.S.3    Hsueh, S.4    Chao, A.S.5    Chang, T.C.6


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