Oral administration of vitamin C and histidine attenuate cyclophosphamide-induced hemorrhagic cystitis in rats

Indian Journal of Pharmacology

Volumn 45, Issue 2, 2013, Pages 126-129

  Farshid, Amir Abbas ^a   Tamaddonfard, Esmaeal ^a   Ranjbar, Sepideh ^a  

^a URMIA UNIVERSITY   (Iran)

Author keywords

Cyclophosphamide; hemorrhagic cystitis; histidine; rats; vitamin C

Indexed keywords

ASCORBIC ACID; CYCLOPHOSPHAMIDE; HISTIDINE; MALONALDEHYDE;

ANIMAL EXPERIMENT; ARTICLE; BLADDER BLEEDING; BLADDER WALL; CELL INFILTRATION; HEMORRHAGIC CYSTITIS; LEUKOCYTE; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT;

CYCLOPHOSPHAMIDE; HEMORRHAGIC CYSTITIS; HISTIDINE; RATS; VITAMIN C;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ASCORBIC ACID; CYCLOPHOSPHAMIDE; CYSTITIS; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; HEMORRHAGE; HISTIDINE; MALE; MALONDIALDEHYDE; RATS; RATS, WISTAR; URINARY BLADDER; VITAMINS;

EID: 84875985361     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.108283     Document Type: Article

References (24)

1. Levine AL, Richie PJ. Urological complications of cyclophosphamide. J Urol 1989;141:1063-9
2. Sadir S, Deveci S, Korkmaz A, Oter S. Alpha tocopherol, beta carotene, and melatonin administration protects cyclophosphamide-induced oxidative damage to bladder tissue in rats. Cell Biochem Funct 2007;25:521-6
3. Eichel E, Scheidweiler K, Kost J, Shojaie J, Schwarz E, Messing E, et al. Assessment of murine bladder permeability with fluorescein: Validation with cyclophosphamide and protamine. Urology 2001;58:113-8
4. Li Y, Schellhorn HE. New developments and novel therapeutic perspectives for vitamin C. J Nutr 2007;137:2171-84
5. Mandl J, Szarka A, Banhegyi G. Vitamin C: Update on physiology and pharmacology. Br J Pharmacol 2009;157:1097-110
6. Ghosh S, Ghosh D, Chattopadhyay S, Debnath J. Effect of ascorbic acid supplementation on liver and kidneys toxicity in cyclophosphamide-Treated female albino rats. J Toxicol Sci 1999;24:141-4
7. Ray S, Sengupta C, Roy K. Evaluation of ascorbic acid as suppressor of cyclophosphamide induced lipid peroxidation using common laboratory markers. Acta Pol Pharm 2005;62:145-52
8. Gurbuz N, Ozkul A, Burgaz S. Effects of vitamin C and N-Acetylcysteine against cyclophosphamide-induced genotoxicity in exfoliated bladder cells of mice in vivo. J BUON 2009;14:647-52
9. Farshid AA, Tamaddonfard E, Yahyaee F. Effects of histidine and N-Acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats. Indian J Exp Biol 2010;48:1136-42
10. Farshid AA, Tamaddonfard E, Belasius MS, Hamzeh-Gooshchi N. Histopathological comparison of the effects of histidine and ketotifen in a rat model of colitis. Bull Vet Inst Pulawy 2009;53:795-800
11. Wade AM, Tucker HN. Antioxidant characteristics of L-histidine. J Nutr Biochem 1998;9:308-15
12. Lee YT, Hsu CC, Lin MH, Liu KS, Yin MC. Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation. Eur J Pharmacol 2005;513:145-50
13. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: The FRAP assay. Anal Biochem 1996;239:70-6
14. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by tiobarbituric acid reaction. Anal Biochem 1979;95:351-8
15. Korkmaz A, Topal T, Oter S. Pathophysiological aspects of cyclophosphamide and ifosfamaide induced hemorrhagic cystitis: Implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 2007;23:303-12
16. Yu BP. Cellular defense against damage from reactive oxygen species. Physiol Rev 1994;74:139-62
17. Rezvanfar MA, Farshid AA, Sadrkhanlou RA, Ahmadi A, Rezvanfar MA, Salehnia A, et al. Benefit of Satureja khuzestanica in subchronically rat model of cyclophosphamide-induced hemorrhagic cystitis. Exp Toxicol Pathol 2010;62:323-30
18. Motawi TM, Sadik NA, Refaat A. Cytoprotective effects of DL-Alpha lipoic acid or squalene on cyclophosphamide-induced oxidative injury: An experimental study on rat myocardium, testicles and urinary bladder. Food Chem Toxicol 2010;48:2326-36
19. Das UB, Mallick M, Debnath JM, Ghosh D. Protective effects of ascorbic acid on cyclophosphamide-induced testicular gametogenic and androgenic disorders in male rats. Asian J Androl 2002;4:201-7
20. El-Batch M, Ibrahim W, Said S. Effect of histidine on autotoxin activity in experimentally induced liver fibrosis. J Biochem Mol Toxicol 2011;25:143-50
21. Badary OA. L-histidinol, attenuates Fanconi syndrome induced by ifosfamide in rats. Exp Nephrol 1999;7:323-7
22. Liu WH, Liu TC, Yin MC. Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury. Food Chem Toxicol 2008;46:1503-9
23. Esrefoglu M, Gul M, Ates B, Batcioglu K, Selimoglu MA. Antioxidative effect of melatonin, ascorbic acid and N-Acetylcysteine on caerolein-induced pancreatitis and associated liver injury in rats. World J Gastroenterol 2006;14:259-64
24. Yu T, Bai J, Hu K, Wang Z. The effects of free radical scavenger and antioxidant on the increase in intracellular adriamycin accumulation induced by ultrasound. Ultrason Sonochem 2003;10:33-5