Pifithrin-α, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the MyD88-independent pathway

International Immunopharmacology

Volumn 15, Issue 4, 2013, Pages 671-678

  Mendjargal, Adilsaikhan ^a   Odkhuu, Erdenezaya ^a   Koide, Naoki ^a   Nagata, Hiroshi ^a   Kurokawa, Tsuyoshi ^a   Nonami, Toshiaki ^a   Yokochi, Takashi ^a  

^a AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Interferon beta; Lipopolysaccharide (LPS); MyD88 independent pathway; Nitric oxide; p53 inhibitor; Pifithrin alpha

Indexed keywords

BETA INTERFERON; I KAPPA B; INTERFERON REGULATORY FACTOR 3; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PIFITHRIN ALPHA; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; GENE SILENCING; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TREATMENT DURATION;

ANIMALS; BENZOTHIAZOLES; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; DRUG-INDUCED LIVER INJURY; GENE SILENCING; INTERFERON-BETA; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TOLUENE; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84875964052     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.02.014     Document Type: Article

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