Glutamate transporter expression and function in a striatal neuronal model of Huntington's disease

Neurochemistry International

Volumn 62, Issue 7, 2013, Pages 973-981

  Petr, Geraldine T ^a,b   Bakradze, Ekaterina ^a   Frederick, Natalie M ^a   Wang, Jianlin ^a   Armsen, Wencke ^a,b   Aizenman, Elias ^c   Rosenberg, Paul A ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

EAAC1; Glutamate transporters; Huntington's disease; Na+ dependent glutamate uptake; STHdH cells

Indexed keywords

GLUTAMATE TRANSPORTER; GLUTAMIC ACID; POTASSIUM CHANNEL; PROTEIN EAAC1; PROTEIN GLT 1B; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; BRAIN NERVE CELL; CYTOPLASM; ENZYME ACTIVATION; HUNTINGTON CHOREA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STRIATE CORTEX;

AMINO ACID TRANSPORT SYSTEM X-AG; CELL LINE; CELLS, CULTURED; CORPUS STRIATUM; HUMANS; HUNTINGTON DISEASE; MUTATION; NEURONS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84875958901     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.02.026     Document Type: Article

References (54)

1. R.L. Albin, A.B. Young, J.B. Penney, B. Handelin, R. Balfour, K.D. Anderson, D.S. Markel, W.W. Tourtellotte, and A. Reiner Abnormalities of striatal projection neurons and N-methyl-d-aspartate receptors in presymptomatic Huntington's disease N. Engl. J. Med. 322 1990 1293 1298
2. K. Aoyama, S.W. Suh, A.M. Hamby, J. Liu, W.Y. Chan, Y. Chen, and R.A. Swanson Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse Nat. Neurosci. 9 2006 119 126
3. J.L. Arriza, S. Eliasof, M.P. Kavanaugh, and S.G. Amara Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance Proc. Natl. Acad. Sci. USA 94 1997 4155 4160
4. J.L. Arriza, W.A. Fairman, J.I. Wadiche, G.H. Murdoch, M.P. Kavanaugh, and S.G. Amara Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex J. Neurosci. 14 1994 5559 5569
5. B. Barbour, B.U. Keller, I. Llano, and A. Marty Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells Neuron 12 1994 1331 1343
6. S.E. Browne, and M.F. Beal The energetics of Huntington's disease Neurochem. Res. 29 2004 531 546
7. J.H. Cha Transcriptional dysregulation in Huntington's disease Trends Neurosci. 23 2000 387 392
8. W. Chen, C. Aoki, V. Mahadomrongkul, C.E. Gruber, G.J. Wang, R. Blitzblau, N. Irwin, and P.A. Rosenberg Expression of a variant form of the glutamate transporter GLT-1 in neuronal cultures and in neurons and astrocytes in the rat brain J. Neurosci. 22 2002 2142 2152
9. W. Chen, V. Mahadomrongkul, U.V. Berger, M. Bassan, T. DeSilva, K. Tanaka, N. Irwin, C. Aoki, and P.A. Rosenberg The glutamate transporter GLT-1a is expressed in excitatory axon terminals of mature hippocampal neurons J. Neurosci. 24 2004 1136 1148
10. E. Colin, E. Regulier, V. Perrin, A. Durr, A. Brice, P. Aebischer, N. Deglon, S. Humbert, and F. Saudou Akt is altered in an animal model of Huntington's disease and in patients Eur. J. Neurosci. 21 2005 1478 1488
11. F. Conti, S. DeBiasi, A. Minelli, J.D. Rothstein, and M. Melone EAAC1, a high-affinity glutamate tranporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex Cereb. Cortex 8 1998 108 116
12. J.T. Coyle, and R. Schwarcz Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea Nature 263 1976 244 246
13. L. Cui, H. Jeong, F. Borovecki, C.N. Parkhurst, N. Tanese, and D. Krainc Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration Cell 127 2006 59 69
14. T.M. DeSilva, A.Y. Kabakov, P.E. Goldhoff, J.J. Volpe, and P.A. Rosenberg Regulation of glutamate transport in developing rat oligodendrocytes J. Neurosci. 29 2009 7898 7908
15. M. DiFiglia Excitotoxic injury of the neostriatum: a model for Huntington's disease Trends Neurosci. 13 1990 286 289
16. +-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1) Mol. Pharmacol. 49 1996 465 473
17. R. Dringen Metabolism and functions of glutathione in brain Prog. Neurobiol. 62 2000 649 671
18. W. El-Kholy, P.E. Macdonald, J.H. Lin, J. Wang, J.M. Fox, P.E. Light, Q. Wang, R.G. Tsushima, and M.B. Wheeler The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism FASEB J. 17 2003 720 722
19. W.A. Fairman, R.J. Vandenberg, J.L. Arriza, M.P. Kavanaugh, and S.G. Amara An excitatory amino-acid transporter with properties of a ligand-gated chloride channel Nature 375 1995 599 603
20. M.M. Fan, and L.A. Raymond N-methyl-d-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease Prog. Neurobiol. 81 2007 272 293
21. D.N. Furness, Y. Dehnes, A.Q. Akhtar, D.J. Rossi, M. Hamann, N.J. Grutle, V. Gundersen, S. Holmseth, K.P. Lehre, K. Ullensvang, M. Wojewodzic, Y. Zhou, D. Attwell, and N.C. Danbolt A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2) Neuroscience 157 2008 80 94
22. 3H] glutamate transport in glial cultures J. Neurochem. 64 1995 2572 2580
23. L.R. Gauthier, B.C. Charrin, M. Borrell-Pages, J.P. Dompierre, H. Rangone, F.P. Cordelieres, J. De Mey, M.E. MacDonald, V. Lessmann, S. Humbert, and F. Saudou Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules Cell 118 2004 127 138
24. S. Gines, E. Ivanova, I.S. Seong, C.A. Saura, and M.E. MacDonald Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-d-aspartate receptor activation in Huntington's disease knock-in striatal cells J. Biol. Chem. 278 2003 50514 50522
25. M.I. Gonzalez, B.T. Susarla, K.M. Fournier, A.L. Sheldon, and M.B. Robinson Constitutive endocytosis and recycling of the neuronal glutamate transporter, excitatory amino acid carrier 1 J. Neurochem. 103 2007 1917 1931
26. S. Gunawardena, L.S. Her, R.G. Brusch, R.A. Laymon, I.R. Niesman, B. Gordesky-Gold, L. Sintasath, N.M. Bonini, and L.S. Goldstein Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila Neuron 40 2003 25 40
27. Y. He, W.G. Janssen, J.D. Rothstein, and J.H. Morrison Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus J. Comp. Neurol. 418 2000 255 269
28. K. Huang, M.H. Kang, C. Askew, R. Kang, S.S. Sanders, J. Wan, N.G. Davis, and M.R. Hayden Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease Neurobiol. Dis. 40 2010 207 215
29. Y. Kanai, and M.A. Hediger Primary structure and functional characterization of a high-affinity glutamate transporter Nature 360 1992 467 471
30. H. Katagiri, K. Tanaka, and T. Manabe Requirement of appropriate glutamate concentrations in the synaptic cleft for hippocampal LTP induction Eur. J. Neurosci. 14 2001 547 553
31. E. Krizman-Genda, M.I. Gonzalez, O. Zelenaia, and M.B. Robinson Evidence that Akt mediates platelet-derived growth factor-dependent increases in activity and surface expression of the neuronal glutamate transporter, EAAC1 Neuropharmacology 49 2005 872 882
32. X. Li, A. Valencia, E. Sapp, N. Masso, J. Alexander, P. Reeves, K.B. Kegel, N. Aronin, and M. Difiglia Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease J. Neurosci. 30 2010 4552 4561
33. M. Melone, M. Bellesi, and F. Conti Synaptic localization of GLT-1a in the rat somatic sensory cortex Glia 57 2009 108 117
34. T.S. Otis, G. Brasnjo, J.A. Dzubay, and M. Pratap Interactions between glutamate transporters and metabotropic glutamate receptors at excitatory synapses in the cerebellar cortex Neurochem. Int. 45 2004 537 544
35. E. Peacey, C.C. Miller, J. Dunlop, and M. Rattray The four major N- and C-terminal splice variants of the excitatory amino acid transporter GLT-1 form cell surface homomeric and heteromeric assemblies Mol. Pharmacol. 75 2009 1062 1073
36. G. Pines, N.C. Danbolt, M. Bjoras, Y. Zhang, A. Bendahan, L. Eide, H. Koepsell, J. Storm-Mathisen, E. Seeberg, and B.I. Kanner Cloning and expression of a rat brain l-glutamate transporter Nature 360 1992 464 467
37. W.J. Powers, T.O. Videen, J. Markham, L. McGee-Minnich, J.V. Antenor-Dorsey, T. Hershey, and J.S. Perlmutter Selective defect of in vivo glycolysis in early Huntington's disease striatum Proc. Natl. Acad. Sci. USA 104 2007 2945 2949
38. G. Powis, R. Bonjouklian, M.M. Berggren, A. Gallegos, R. Abraham, C. Ashendel, L. Zalkow, W.F. Matter, J. Dodge, and G. Grindey Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase Cancer Res. 54 1994 2419 2423
39. T. Rauen, M. Wiessner, R. Sullivan, A. Lee, and D.V. Pow A new GLT-1 splice variant: cloning and immunolocalization of GLT-1c in the mammalian retina and brain Neurochem. Int. 45 2004 1095 1106
40. J.D. Rothstein, L. Martin, A.I. Levey, M. Dykes-Hoberg, L. Jin, D. Wu, N. Nash, and R.W. Kuncl Localization of neuronal and glial glutamate transporters Neuron 13 1994 713 725
41. M. Scanziani, P.A. Salin, K.E. Vogt, R.C. Malenka, and R.A. Nicoll Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors Nature 385 1997 630 634
42. G. Shanker, J.W. Allen, L.A. Mutkus, and M. Aschner The uptake of cysteine in cultured primary astrocytes and neurons Brain Res. 902 2001 156 163
43. K. Shimamoto, B. Lebrun, Y. Yasuda-Kamatani, M. Sakaitani, Y. Shigeri, N. Yumoto, and T. Nakajima dl-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters Mol. Pharmacol. 53 1998 195 201
44. W. Stoffel, R. Korner, D. Wachtmann, and B.U. Keller Functional analysis of glutamate transporters in excitatory synaptic transmission of GLAST1 and GLAST1/EAAC1 deficient mice Brain Res. Mol. Brain Res. 128 2004 170 181
45. T. Storck, S. Schulte, K. Hofmann, and W. Stoffel Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain Proc. Natl. Acad. Sci. USA 89 1992 10955 10959
46. M. Takahashi, Y. Kovalchuk, and D. Attwell Pre- and postsynaptic determinants of EPSC waveform at cerebellar climbing fiber and parallel fiber to Purkinje cell synapses J. Neurosci. 15 1995 5693 5702
47. F. Trettel, D. Rigamonti, P. Hilditch-Maguire, V.C. Wheeler, A.H. Sharp, F. Persichetti, E. Cattaneo, and M.E. MacDonald Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells Hum. Mol. Genet. 9 2000 2799 2809
48. J. Velier, M. Kim, C. Schwarz, T.W. Kim, E. Sapp, K. Chase, N. Aronin, and M. DiFiglia Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways Exp. Neurol. 152 1998 34 40
49. C.J. Vlahos, W.F. Matter, K.Y. Hui, and R.F. Brown A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4- one (LY294002) J. Biol. Chem. 269 1994 5241 5248
50. G.J. Wang, H.J. Chung, J. Schnuer, K. Pratt, A.C. Zable, M.P. Kavanaugh, and P.A. Rosenberg High affinity glutamate transport in rat cortical neurons in culture Mol. Pharmacol. 53 1998 88 96
51. J.M. Wilson, I. Khabazian, D.V. Pow, U.K. Craig, and C.A. Shaw Decrease in glial glutamate transporter variants and excitatory amino acid receptor down-regulation in a murine model of ALS-PDC Neuromolecular Med. 3 2003 105 118
52. A. Wyttenbach, O. Sauvageot, J. Carmichael, C. Diaz-Latoud, A.P. Arrigo, and D.C. Rubinsztein Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin Hum. Mol. Genet. 11 2002 1137 1151
53. A.B. Young, J.T. Greenamyre, Z. Hollingsworth, R. Albin, C. D'Amato, I. Shoulson, and J.B. Penney NMDA receptor losses in putamen from patients with Huntington's disease Science 241 1988 981 983
54. N. Zerangue, and M.P. Kavanaugh Interaction of l-cysteine with a human excitatory amino acid transporter J. Physiol. 493 Pt 2 1996 419 423