A paradigm shift from biophysical to neurobiological: The fading influence of claude bernard's ideas about general anesthesia

Anesthesiology

Volumn 118, Issue 4, 2013, Pages 984-985

  Forman, Stuart A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AWARENESS; BINDING SITE; COGNITION; CORRELATION ANALYSIS; GENE MUTATION; GENERAL ANESTHESIA; HUMAN; HYDROPHOBICITY; LETTER; LIPID BILAYER; MEDICAL LITERATURE; MINIMUM LUNG ALVEOLUS CONCENTRATION; MOLECULAR BIOLOGY; NEUROBIOLOGY; NEUTRON DIFFRACTION; PERCEPTION; PRIORITY JOURNAL; SCIENTIST; TRANSGENIC ANIMAL;

BIOMEDICAL RESEARCH; HUMANS;

EID: 84875896431     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3182860777     Document Type: Letter

References (12)

1. Perouansky M: The quest for a unified model of anesthetic action: A century in Claude Bernard's shadow. Anesthesiology 2012; 117:465-74
2. Ginosar Y, Binshtok AM: Mechanisms in anesthesia and analgesia: Convention, crisis, and the shoulders of giants. Anesthesiology 2012; 117:451-3
3. Popper K: Logik der Forschung: Zur Erkenntnistheorie Der Modernen Naturwissenschaft (the Logic of Scientific Rresearch). Tuebingen, Germany, Mohr Siebeck, 1935
4. Franks NP, Lieb WR: Where do general anaesthetics act? Nature 1978; 274:339-42
5. Stoelting RK, Longnecker DE, Eger EI 2nd: Minimum alveolar concentrations in man on awakening from methoxyflurane, halothane, ether and fluroxene anesthesia: MAC awake. Anesthesiology 1970; 33:5-9
6. G rasshoff C, Rudolph U, Antkowiak B: Molecular and systemic mechanisms of general anaesthesia: The 'multi-site and multiple mechanisms' concept. Curr Opin Anaesthesiol 2005; 18:386-91
7. Solt K, Forman SA: Correlating the clinical actions and molecular mechanisms of general anesthetics. Curr Opin Anaesthesiol 2007; 20:300-6
8. Mashour GA: Consciousness unbound: Toward a paradigm of general anesthesia. Anesthesiology 2004; 100:428-33
9. Alkire MT, Hudetz AG, Tononi G: Consciousness and anesthesia. Science 2008; 322:876-80
10. Brown EN, Purdon PL, Van Dort CJ: General anesthesia and altered states of arousal: A systems neuroscience analysis. Annu Rev Neurosci 2011; 34:601-28
11. Forman SA: Molecular approaches to improved general anesthetics. Anesthesiol Clin North America 2010; 28:761-71
12. Mashour GA, Orser BA, Avidan MS: Intraoperative awareness: From neurobiology to clinical practice. Anesthesiology 2011; 114:1218-33