The hydroxyl epimer of doxorubicin controls the rate of formation of cytotoxic anthracycline-DNA adducts

Cancer Chemotherapy and Pharmacology

Volumn 71, Issue 3, 2013, Pages 809-816

  Forrest, Robert A ^a   Swift, Lonnie P ^b   Evison, Benny J ^a   Rephaeli, Ada ^c   Nudelman, Abraham ^d   Phillips, Don R ^a   Cutts, Suzanne M ^a  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c TEL AVIV UNIVERSITY   (Israel)

^d BAR ILAN UNIVERSITY   (Israel)

Author keywords

DNA damage; Drug DNA adduct; Epirubicin; Formaldehyde; p53

Indexed keywords

ANTHRACYCLINE; DOXORUBICIN; EPIRUBICIN; PIVALOYLOXYMETHYL BUTYRATE; PROTEIN P53; ANTINEOPLASTIC ANTIBIOTIC; CARBOHYDRATE; COLORING AGENT; CROSS LINKING REAGENT; CYTOTOXIN; DRUG DERIVATIVE; FORMALDEHYDE; PROPIDIUM IODIDE; RHODAMINE; TETRAMETHYLRHODAMINE METHYL ESTER;

APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CELL FREE SYSTEM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COVALENT BOND; DNA ADDUCT; DNA CROSS LINKING; DRUG DNA BINDING; DRUG STRUCTURE; EPIMER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; CHEMISTRY; DRUG EFFECT; FEMALE; GENETIC TRANSCRIPTION; HYDROXYLATION; METABOLISM; TUMOR CELL LINE; WESTERN BLOTTING;

ANTHRACYCLINES; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CARBOHYDRATES; CELL LINE, TUMOR; COLORING AGENTS; CROSS-LINKING REAGENTS; CYTOTOXINS; DNA ADDUCTS; EPIRUBICIN; FEMALE; FORMALDEHYDE; HUMANS; HYDROXYLATION; PROPIDIUM; RHODAMINES; TRANSCRIPTION, GENETIC;

MLCS; MLOWN;

EID: 84875871379     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-012-2049-x     Document Type: Article

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