Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease

Behavioural Brain Research

Volumn 222, Issue 2, 2011, Pages 375-379

  Reilly, Thomas J ^a   Staff, Roger T ^b   Ahearn, Trevor S ^a   Bentham, Peter ^c   Wischik, Claude M ^d   Murray, Alison D ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ABERDEEN ROYAL INFIRMARY   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d TAURX THERAPEUTICS LTD   (United Kingdom)

Author keywords

Alzheimer disease; Obsessive compulsive disorder; SPECT; Technetium

Indexed keywords

ABERRANT MOTOR BEHAVIOR; AGED; ALZHEIMER DISEASE; ANXIETY; ARTICLE; BASAL GANGLION; BRAIN BLOOD FLOW; BRAIN DYSFUNCTION; BRAIN FUNCTION; BRAIN METABOLISM; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FRONTAL CORTEX; HUMAN; LEFT MEDIAL ORBITAL GYRUS; LEFT SUPERIOR ORBITAL GYRUS; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; ORBITAL CORTEX; PRIORITY JOURNAL; RIGHT MEDIAL ORBITAL GYRUS; RIGHT SUPERIOR ORBITAL GYRUS; SYMPTOM; TASK PERFORMANCE;

AGED; ALZHEIMER DISEASE; BASAL GANGLIA; CEREBROVASCULAR CIRCULATION; CLINICAL TRIALS, PHASE II AS TOPIC; FEMALE; FRONTAL LOBE; HUMANS; MALE; MOTOR ACTIVITY; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M EXAMETAZIME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 79955971265     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.04.003     Document Type: Article

References (44)

1. Steinberg M., Shao H., Zandi P., Lyketsos C., Welsh-Bohmer K., Norton M., et al. Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. Int J Geriatr Psychiatry 2008, 23:170-177.
2. Lyketsos C.G., Sheppard J.M., Steinberg M., Tschanz J.A., Norton M.C., Steffens D.C., et al. Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study. Int J Geriatr Psychiatry 2001, 16:1043-1053.
3. Ikeda M., Fukuhara R., Shigenobu K., Hokoishi K., Maki N., Nebu A., et al. Dementia associated mental and behavioural disturbances in elderly people in the community: findings from the first Nakayama study. J Neurol Neurosurg Psychiatry 2004, 75:146-148.
4. Lyketsos C., Lopez O., Jones B., Fitzpatrick A., Breitner J., DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA 2002, 288:1475-1483.
5. Cummings J.L., Mega M., Gray K., Rosenberg-Thompson S., Carusi D.A., Gornbein J. The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994, 44:2308-2314.
6. Tatsumi H., Nakaaki S., Torii K., Shinagawa Y., Watanabe N., Murata Y., et al. Neuropsychiatric symptoms predict change in quality of life of Alzheimer disease patients: a two-year follow-up study. Psychiatry Clin Neurosci 2009, 63:374-384.
7. Gauthier S., Cummings J., Ballard C., Brodaty H., Grossberg G., Robert P., et al. Management of behavioral problems in Alzheimer's disease. Int Psychogeriatr 2010, 22:346-372.
8. Bathgate D., Snowden J.S., Varma A., Blackshaw A., Neary D. Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia. Acta Neurol Scand 2001, 103:367-378.
9. Okura T., Plassman B., Steffens D., Llewellyn D., Potter G., Langa K. Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study. J Am Geriatr Soc 2010, 58:330-337.
10. Scarmeas N., Brandt J., Blacker D., Albert M., Hadjigeorgiou G., Dubois B., et al. Disruptive behavior as a predictor in Alzheimer disease. Arch Neurol 2007, 64:1755-1761.
11. Lopez O.L., Wisniewski S.R., Becker J.T., Boller F., DeKosky S.T. Psychiatric medication and abnormal behavior as predictors of progression in probable Alzheimer disease. Arch Neurol 1999, 56:1266-1272.
12. Harwood D.G., Barker W.W., Ownby R.L., Duara R. Relationship of behavioral and psychological symptoms to cognitive impairment and functional status in Alzheimer's disease. Int J Geriatr Psychiatry 2000, 15:393-400.
13. Piccininni M., Di Carlo A., Baldereschi M., Zaccara G., Inzitari D. Behavioral and psychological symptoms in Alzheimer's disease: frequency and relationship with duration and severity of the disease. Dement Geriatr Cogn Disord 2005, 19:276-281.
14. Matsumoto N., Ikeda M., Fukuhara R., Shinagawa S., Ishikawa T., Mori T., et al. Caregiver burden associated with behavioral and psychological symptoms of dementia in elderly people in the local community. Dement Geriatr Cogn Disord 2007, 23:219-224.
15. Rosen H., Allison S., Schauer G., Gorno-Tempini M., Weiner M., Miller B. Neuroanatomical correlates of behavioural disorders in dementia. Brain 2005, 128:2612-2625.
16. Mataix-Cols D., Wooderson S., Lawrence N., Brammer M., Speckens A., Phillips M. Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiatry 2004, 61:564-576.
17. Nagata T., Shinagawa S., Ochiai Y., Kada H., Kasahara H., Nukariya K., et al. Relationship of frontal lobe dysfunction and aberrant motor behaviors in patients with Alzheimer's disease. Int Psychogeriatr 2010, 22:463-469.
18. Huey E., Zahn R., Krueger F., Moll J., Kapogiannis D., Wassermann E., et al. A psychological and neuroanatomical model of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 2008, 20:390-408.
19. Alptekin K., Degirmenci B., Kivircik B., Durak H., Yemez B., Derebek E., et al. Tc-99m HMPAO brain perfusion SPECT in drug-free obsessive-compulsive patients without depression. Psychiatry Res 2001, 107:51-56.
20. Lacerda A.L.T., Dalgalarrondo P., Caetano D., Camargo E., Etchebehere E.C.S.C., Soares J. Elevated thalamic and prefrontal regional cerebral blood flow in obsessive-compulsive disorder: a SPECT study. Psychiatry Res 2003, 123:125-134.
21. Rubin R.T., Villanueva-Meyer J., Ananth J., Trajmar P.G., Mena I. Regional xenon 133 cerebral blood flow and cerebral technetium 99m HMPAO uptake in unmedicated patients with obsessive-compulsive disorder and matched normal control subjects. Determination by high-resolution single-photon emission computed tomography. Arch Gen Psychiatry 1992, 49:695-702.
22. Lucey J.V., Costa D.C., Adshead G., Deahl M., Busatto G., Gacinovic S., et al. Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). Br J Psychiatry 1997, 171:346-350.
23. Machlin S.R., Harris G.J., Pearlson G.D., Hoehn-Saric R., Jeffery P., Camargo E.E. Elevated medial-frontal cerebral blood flow in obsessive-compulsive patients: a SPECT study. Am J Psychiatry 1991, 148:1240-1242.
24. Busatto G.F., Buchpiguel C.A., Zamignani D.R., Garrido G.E., Glabus M.F., Rosario-Campos M.C., et al. Regional cerebral blood flow abnormalities in early-onset obsessive-compulsive disorder: an exploratory SPECT study. J Am Acad Child Adolesc Psychiatry 2001, 40:347-354.
25. Crespo-Facorro B., Cabranes J.A., López-Ibor Alcocer M.I., Pay B., Prez C.F., Encinas M., et al. Regional cerebral blood flow in obsessive-compulsive patients with and without a chronic tic disorder. A SPECT study. Eur Arch Psychiatry Clin Neurosci 1999, 249:156-161.
26. Baxter L.R., Phelps M.E., Mazziotta J.C., Guze B.H., Schwartz J.M., Selin C.E. Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Arch Gen Psychiatry 1987, 44:211-218.
27. Swedo S.E., Schapiro M.B., Grady C.L., Cheslow D.L., Leonard H.L., Kumar A., et al. Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Arch Gen Psychiatry 1989, 46:518-523.
28. Perani D., Colombo C., Bressi S., Bonfanti A., Grassi F., Scarone S., et al. [18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment. Br J Psychiatry 1995, 166:244-250.
29. Sawle G.V., Hymas N.F., Lees A.J., Frackowiak R.S. Obsessional slowness. Functional studies with positron emission tomography. Brain 1991, 114:2191-2202.
30. Rauch S.L., Jenike M.A., Alpert N.M., Baer L., Breiter H.C., Savage C.R., et al. Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry 1994, 51:62-70.
31. Martinot J.L., Allilaire J.F., Mazoyer B.M., Hantouche E., Huret J.D., Legaut-Demare F., et al. Obsessive-compulsive disorder: a clinical, neuropsychological and positron emission tomography study. Acta Psychiatr Scand 1990, 82:233-242.
32. Whiteside S., Port J., Abramowitz J. A meta-analysis of functional neuroimaging in obsessive-compulsive disorder. Psychiatry Res 2004, 132:69-79.
33. Yamanishi T., Nakaaki S., Omori I., Hashimoto N., Shinagawa Y., Hongo J., et al. Changes after behavior therapy among responsive and nonresponsive patients with obsessive-compulsive disorder. Psychiatry Res 2009, 172:242-250.
34. Rotge J., Guehl D., Dilharreguy B., Cuny E., Tignol J., Bioulac B., et al. Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies. J Psychiatry Neurosci 2008, 33:405-412.
35. Bradley K.M., O'Sullivan V.T., Soper N.D.W., Nagy Z., King E.M., Smith A.D., et al. Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease. Brain 2002, 125:1772-1781.
36. Wischik C.M., Bentham P., Wischik D.J., Seng K.M. Tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks. Alzheimer's Association International Conference on Alzheimer's Disease 2008, [accepted abstract].
37. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 1994, American Psychiatric Press, Washington DC. 4th ed.
38. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
39. Cummings J.L. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology 1997, 48:S10-S16.
40. Rosen W.G., Mohs R.C., Davis K.L. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984, 141:1356-1364.
41. Tzourio-Mazoyer N., Landeau B., Papathanassiou D., Crivello F., Etard O., Delcroix N., et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002, 15:273-289.
42. Kringelbach M. The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci 2005, 6:691-702.
43. Williams G., Nestor P., Hodges J. Neural correlates of semantic and behavioural deficits in frontotemporal dementia. Neuroimage 2005, 24:1042-1051.
44. Du A.T., Jahng G.H., Hayasaka S., Kramer J.H., Rosen H.J., Gorno-Tempini M.L., et al. Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI. Neurology 2006, 67:1215-1220.