Poly(d-lactide)/poly(caprolactone) nanofiber-thermogelling chitosan gel composite scaffolds for osteochondral tissue regeneration in a rat model

Journal of Bioactive and Compatible Polymers

Volumn 28, Issue 2, 2013, Pages 115-125

  Cui, Zhanwu ^a   Wright, Lee D ^b   Guzzo, Rosa ^a   Freeman, Joseph W ^b,c   Drissi, Hicham ^a   Nair, Lakshmi S ^a,d  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

chitosan gel; Nanofiber; osteochondral defect; scaffold

Indexed keywords

BONE AND CARTILAGES; CHITOSAN COMPOSITES; CHITOSAN GEL; COMPOSITE SCAFFOLDS; ELECTROSPUN SCAFFOLDS; EXTRACELLULAR MATRICES; OSTEOCHONDRAL DEFECTS; OSTEOCHONDRAL TISSUES;

BONE; CARTILAGE; CHITOSAN; DEFECTS; NANOFIBERS; SCAFFOLDS; SINTERING; TISSUE; TISSUE REGENERATION;

SCAFFOLDS (BIOLOGY);

CHITOSAN; EOSIN; HEMATOXYLIN; MOLECULAR SCAFFOLD; NANOCOMPOSITE; NANOFIBER; POLYCAPROLACTONE; POLYLACTIDE; POROUS POLYMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE TISSUE; CARTILAGE; CONTROLLED STUDY; ELECTROSPINNING; HYDROGEL; IN VIVO STUDY; LEACHING; MALE; NONHUMAN; OSSIFICATION; RAT; TEMPERATURE SENSE; TISSUE REGENERATION;

RATTUS;

EID: 84875839734     PISSN: 08839115     EISSN: 15308030     Source Type: Journal    
DOI: 10.1177/0883911512472278     Document Type: Article

References (32)

1. Zaslav K, Cole B, Brewster R, et al. A prospective study of autologous chondrocyte implantation in patients with failed prior treatment for articular cartilage defect of the knee: results of the Study of the Treatment of Articular Repair (STAR) clinical trial. Am J Sports Med. 2009 ; 37: 42-55
2. Koç A, Emin N, Elçin AE, et al. In vitro osteogenic differentiation of rat mesenchymal stem cells in a microgravity bioreactor. J Bioact Compat Polym. 2008 ; 23: 244-261 (Pubitemid 351595237)
3. WangLZhaoLDetamoreMS. Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral tissue engineering. J Tissue Eng Regen Med2010. DOI: 10.1002/term.370, wileyonlinelibrary.com
4. Wright LD, Young RT, Andric T, et al. Fabrication and mechanical characterization of 3D electrospun scaffolds for tissue engineering. Biomed Mater. 2010 ; 5 :
5. Sherwooda JK, Riley SL, Palazzolo R, et al. A three-dimensional osteochondral composite scaffold for articular cartilage repair. Biomaterials. 2002 ; 23: 4739-4751 (Pubitemid 35291150)
6. Wang P, Gong P, Lin Y, et al. Nanofibrous electrospun barrier membrane promotes osteogenic differentiation of human mesenchymal stem cells. J Bioact Compat Polym. 2011 ; 26: 607-618
7. Erisken C, Kalyon DM, Wang H, et al. Osteochondral tissue formation through adipose-derived stromal cell differentiation on biomimetic polycaprolactone nanofibrous scaffolds with graded insulin and beta-glycerophosphate concentrations. Tissue Eng Part A. 2011 ; 17 (9 and 10). 1239-1252
8. Ragetly GR, Griffon DJ, Lee H, et al. Effect of chitosan scaffold microstructure on mesenchymal stem cell chondrogenesis. Acta Biomater. 2010 ; 6: 1430-1436
9. Frenkel SR, Toolan B, Menche D, et al. Chondrocyte transplantation using a collagen bilayer matrix for cartilage repair. J Bone Joint Surg Br. 1997 ; 79 (5). 831-836 (Pubitemid 27434509)
10. Wang Y, Kim U, Blasioli DJ, et al. In vitro cartilage tissue engineering with 3D porous aqueous-derived silk scaffolds and mesenchymal stem cells. Biomaterials. 2005 ; 26: 7082-7094 (Pubitemid 41095530)
11. Dai W, Kawazoe N, Lin X, et al. The influence of structural design of PLGA/collagen hybrid scaffolds in cartilage tissue engineering. Biomaterials. 2010 ; 31: 2141-2152
12. Tampieri A, Sandri M, Landi E, et al. Design of graded biomimetic osteochondral composite scaffolds. Biomaterials. 2008 ; 29: 3539-3546
13. Marquass B, Somerson JS, Hepp P, et al. A novel MSC-seeded triphasic construct for the repair of osteochondral defects. J Orthop Res. 2010 ; 28: 1586-1599
14. Kandel RA, Grynpas M, Pilliar R, et al. CIHR-Bioengineering of Skeletal Tissues Team. Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a sheep model. Biomaterials. 2006 ; 27: 4120-4131
15. Gotterbarm T, Richter W, Jung M, et al. An in vivo study of a growth-factor enhanced, cell free, two-layered collagen-tricalcium phosphate in deep osteochondral defects. Biomaterials. 2006 ; 27: 3387-3395
16. Cui W, Wang Q, Chen G, et al. Repair of articular cartilage defects with tissue-engineered osteochondral composites in pigs. J Biosci Bioeng. 2011 ; 111 (4). 493-500
17. Zhu C, Fan D, Ma X, et al. Effects of chitosan on properties of novel human-like collagen/chitosan hybrid vascular scaffold. J Bioact Compat Polym. 2009 ; 24: 560-576
18. Liu L, Xiong Z, Zhang R, et al. A novel osteochondral scaffold fabricated via multi-nozzle low temperature deposition manufacturing. J Bioact Compat Polym. 2009 ; 24: 18-30
19. Abarrategi A, Lópiz-Morales Y, Ramos V, Civantos A, López-Durán L, Marco F, López-Lacomba JL. Chitosan scaffolds for osteochondral tissue regeneration. J Biomed Mater Res Part A. 2010 ; 95A: 1132-1141
20. Hoemann CD, Hurtig M, Rossomacha E, et al. Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects. J Bone Joint Surg Am. 2005 ; 87: 2671-2686 (Pubitemid 41748291)
21. Hoemann CD, Sun J, Mckee MD, et al. Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects. Osteoarthritis Cartilage. 2007 ; 15: 78-89 (Pubitemid 46117917)
22. Senkou A, Simsek A, Sahin FI, et al. Interaction of cultured chondrocytes with chitosan scaffold. J Bioact Compat Polym. 2001 ; 16: 136-144 (Pubitemid 32588518)
23. Simard P, Galarneau H, Marois S, et al. Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation: implications for cartilage repair. Arthritis Res Ther. 2009 ; 11 (3). R74
24. Hoemann CD, Chen G, Marchand C, et al. Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages. Am J Sports Med. 2010 ; 38 (9). 1845-1856
25. Marchand C, Chen G, Tran-Khanh N, et al. Microdrilled cartilage defects treated with thrombin-solidified chitosan/blood implant regenerate a more hyaline, stable, and structurally integrated osteochondral unit compared to drilled controls. Tissue Eng Part A. 2012 ; 18 (5-6). 508-519
26. Chevrier A, Hoemann CD, Sun J, et al. Chitosan-glycerol phosphate/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects. Osteoarthritis Cartilage. 2007 ; 15 (3). 316-327
27. Park JS, Woo DG, Sun BK. In vitro and in vivo test of PEG/PCL based hydrogel scaffold for cell delivery applications. J Control Release. 2007 ; 124: 51-59 (Pubitemid 350103733)
28. Gong Y, He L, Zhou Q. Hydrogel filled polylactide porous scaffolds for cartilage tissue engineering. J Biomed Mater Res B Appl Biomater. 2007 ; 82: 192-204 (Pubitemid 47015369)
29. Wright LD, McKeon-Fischer KD, Nair LS, et al. Fabrication and mechanical characterization of 3-D electrospun scaffolds for tissue engineering. J Tissue Eng Regen Med. 2012 ;:
30. Wright LD, Andric T, Freeman JW. Utilizing NaCl to increase the porosity of electrospun materials. Mater Sci Eng. 2011 ; 31: 30-36
31. Nair LS, Sterns T, Ko J, et al. Development of Injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications. Biomacromolecules. 2007 ; 8 (12). 3779-3785
32. McLaughlin SW, Cui Z, Starnes T, et al. Injectable thermogelling chitosan for the local delivery of bone morphogenetic protein. J Mater Sci Mater Med. 2012 ; 9: 2141-2149