Injectable thermogelling chitosan for the local delivery of bone morphogenetic protein

Journal of Materials Science: Materials in Medicine

Volumn 23, Issue 9, 2012, Pages 2141-2149

  McLaughlin, Shaun W ^a   Cui, Zhanwu ^b   Starnes, Trevor ^c   Laurencin, Cato T ^b,d   Kan, Ho Man ^b   Wu, Qian ^b   Nair, Lakshmi S ^b,d  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE ACTIVITY; BONE MORPHOGENETIC PROTEINS; ECTOPIC BONES; FIBROUS CAPSULE; FOREIGN BODY RESPONSE; HYDROGEN PHOSPHATES; IN-VITRO; IN-VIVO; LOCAL DELIVERY; MC3T3-E1; MICROCOMPUTED TOMOGRAPHY; NEUTROPHIL INFILTRATION; OSTEOBLAST CELLS; POST-IMPLANTATION; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 (RHBMP-2); RHBMP-2; THERMOGELLING; TISSUE RESPONSE;

AMMONIUM COMPOUNDS; BIOCOMPATIBILITY; COMPUTERIZED TOMOGRAPHY; HIERARCHICAL SYSTEMS; HYDROGEN; IMPLANTS (SURGICAL); PHOSPHATASES; TISSUE;

CHITOSAN;

ALKALINE PHOSPHATASE; CHITOSAN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CELL ENCAPSULATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG ACTIVITY; FOREIGN BODY; GEL; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROBIAL ACTIVITY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; RAT;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; CHITOSAN; CHO CELLS; CRICETINAE; CRICETULUS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GELS; HUMANS; INJECTIONS, INTRALESIONAL; MALE; MICE; PHASE TRANSITION; RATS; RATS, SPRAGUE-DAWLEY; TEMPERATURE;

EID: 84867099322     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-012-4677-4     Document Type: Article

References (32)

1. Cho JH, Kim SH, Park KD, Jung MC, Yang WI, Han SW, et al. Chondrogenic differentiation of human mesenchymal stem cells using a thermosensitive poly(N-isopropylacrylamide and water soluble chitosan co-polymer. Biomaterials. 2004;25:5743-51.
2. Bhattarai N, Ramay HR, Gunn J, Matsen FA, Zhang M. PEG grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release. J Controlled Release. 2005;103:609-24.
3. Chung H, Go D, Bae J, Jung I, Lee J, Park K. Synthesis and characterization of Pluronic grafted chitosan copolymer as a novel injectable biomaterial. Curr Appl Phys. 2005;5:485-8. (Pubitemid 40714979)
4. Nair LS, Laurencin CT. Biodegradable polymers as biomaterials. Prog Polym Sci. 2007;32:762-8.
5. Nair LS, Starnes T, Ko JW, Laurencin CT. Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications. Biomacromolecules. 2007;8:3779-85.
6. Nair LS, Laurencin CT, Tandon M. Injectable hydrogels as biomaterials. In: Basu B, Katti DS, Kumar A, editors, Advanced Materials. Weinheim: Wiley; 2009.
7. Takahashi Y, Yamamoto M, Tabata Y. Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-Tricalcium phosphate. Biomaterials. 2005;26:4856-65.
8. Wang EA, et al. Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci USA. 1990; 87:2220-4.
9. Burks M, Nair LS. Long term effects of bone morphogenic protein based treatments in humans. J Long Term Effects Med Implants. 2010;20:277-93.
10. Govender S, Csimma C, Genant HK, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002; 84-A: 2123-2134.
11. Shields LB, Raque GH, Glassman SD, Campbell M, Vitaz T, Harpring J, Shields CB. Adverse effects associated with highdose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine. 2006;31:542-7.
12. Facca S, Ferrand A, Mendoza-Palomares C, Perrin-Schmitt F, Netter P, Mainard D, Liverneaux P, Benkirane-Jessel N. Bone formation induced by growth factors embedded into the nanostructured particles. J Biomed Nanotechnol. 2011;7:482-5.
13. Crouzier T, Sailhan F, Becquart P, Guillot R, Logeart-Avramoglou D, Picart C. The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating. Biomaterials. 2011;32:7543-54.
14. Jeon O, Powell C, Solorio LD, Krebs MD, Alsberg E. Affinitybased growth factor delivery using biodegradable, photocrosslinked heparin-Alginate hydrogels. J Control Release. 2011 (in press).
15. Gu Y, Chen L, Yang HL, Luo ZP, Tang TS. Evaluation of an injectable silk fibroin enhanced calcium phosphate cement loaded with human recombinant bone morphogenetic protein-2 in ovine lumbar interbody fusion. J Biomed Mater Res. 2011;97A:177-85.
16. Stephan SJ, Tholpady SS, Gross B, Petrie-Aronin CE, Botchway EA, Nair LS, Ogle RC, Park SS. Injectable tissue-engineered bone repair of a rat calvarial defect. Laryngoscope. 2010;120: 895-901.
17. Haider ZS, Hamdy RC, Tabrizian M. Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: delivery systems for BMPs in orthopaedic and craniofacial tissue engineering. Biotechnol Lett. 2009;31:1825-35.
18. Azab AK, Doviner V, Orkin B, Kleinstern J, Srebnik M, Nissan A, Rubinstein A. Biocompatibility evaluation of cross-linked chitosan hydrogels after subcutaneous and intraperitoneal implantation in the rat. J Biomed Mater Res. 2007;83A:414-22.
19. Jeon O, et al. Long term delivery enhances in vivo osteogenic efficacy of bone morphogenetic protein-2 compared to short term delivery. Biochem Biophys Res Commun. 2008;369:774-80.
20. Bessa PC, et al. Silk fibroin microparticles as carriers for delivery of human recombinant bone morphogenetic protein-2: in vitro and in vivo bioactivity. Tissue Eng Part C. 2010;16(5):937-45.
21. Abarrategi A, Civantos A, Ramos V, Casado JVS, Lopez-Lacomba JL. Chitosan film as rhBMP-2 carrier: delivery properties for bone tissue application. Biomacromolecules. 2008;9:711-8. (Pubitemid 351298498)
22. Bush JR, Madhu V, Balian G, Laurencin CT, Nair LS. Thermosensitive chitosan as a matrix for the controlled delivery of biologically active molecules for accelerated bone repair. Proceedings of the AIChE meeting; 2007.
23. Lim SM, Song DK, Oh SH, Lee-Yoon DS, Bae EH, Lee JH. In vitro and in vivo degradation behavior of acetylated chitosan porous beads. J Biomater Sci. Polym Edn. 2008;19:453-66.
24. VandeVord PJ, Mathew HWT, DeSilva SP, Mayton L, Wu B, Wooley PH. Evaluation of the biocompatibility of a chitosan scaffold in mice. J Biomed Mater Res. 2002;59:585-90.
25. Simard P, Galarneau H, Marois S, Rusu D, Hoemann CD, Poubelle PE, El-Gabalawy H, Fernandes MJ. Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation: implications for cartilage repair. Arthr Res Ther. 2009;11:R74.
26. Shannon C, Thull R, von Recum A. Types I and III collagen in the tissue capsules of titanium and stainless-steel implants. J Biomed Mater Res. 1997;34:401-8. (Pubitemid 27097810)
27. Usami Y, Okamoto Y, Minami S, Matsuhashi A, Kumazawa NH, Tanioka S, Shigemasa Y. Migration of canine neutrophils to chitin and chitosan. J Vetenary Med Sci. 1993;55:739-42.
28. Kosaka T, Kaneko Y, Nakada Y, Matsuura M, Tanaka S. Effect of chitosan implanation on activation of canine macrophages and polymorphonuclear cells after surgical stress. J Vetenary Med Sci. 1996;58:963-7. (Pubitemid 126475265)
29. Hoemann CD, Chen G, Marchand C, Tran-Khanh N, Thibault M, Chevrier A, Sun J, Shive MS, Fernandes MJG, Poubelle PE, Centola M, El-Gabalawy H. Scaffold guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1 ? macrophages. Am J Sports Med. 2010;38:1845-56.
30. Hirano S, Tsuichida H, Nagao N. N-Acetylation in chitosan and the rate of its enzymatic hydrolysis. Biomaterials. 1989;10: 574-6.
31. Hosseinkhani H, Hosseinkhani M, Khademhosseini A, Kobayashi H. Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold. J Control Release. 2007;117:380-6. (Pubitemid 46216579)
32. Yang HS, La WG, Bhang SH, Jeon JY, Lee JH, Kim BS. Heparin-conjugatged fibrin as an injectable system for sustained delivery of bone morphogenetic protein-2. Tissue Eng Part A. 2010;16:1225-33.