Prognostic impact of Fas-associated death domain, a key component in death receptor signaling, is dependent on the presence of lymph node metastasis in head and neck squamous cell carcinoma

Cancer Biology and Therapy

Volumn 14, Issue 4, 2013, Pages 365-369

  Fan, Songqing ^a,b   Müller, Susan ^a   Chen, Zhuo Georgia ^a   Pan, Lin ^a   Tighiouart, Mourad ^a   Shin, Dong M ^a   Khuri, Fadlo R ^a   Sun, Shi Yong ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Caspase 8; Death receptor 5; FADD; Head and neck cancer; Immunohistochemistry

Indexed keywords

CASPASE 8; DEATH RECEPTOR 5; FAS ASSOCIATED DEATH DOMAIN PROTEIN;

APOPTOSIS; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; PRIMARY TUMOR; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UNIVARIATE ANALYSIS;

CASPASE-8; DEATH RECEPTOR 5; FADD; HEAD AND NECK CANCER; IMMUNOHISTOCHEMISTRY;

CARCINOMA, SQUAMOUS CELL; CASPASE 8; DISEASE-FREE SURVIVAL; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; PROGNOSIS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION;

EID: 84875830093     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.23636     Document Type: Article

References (12)

1. Seiwert TY, Cohen EE. State-of-the-art management of locally advanced head and neck cancer. Br J Cancer 2005; 92:1341-8; PMID:15846296; http://dx.doi.org/10.1038/sj.bjc.6602510.
2. Yang A, Wilson NS, Ashkenazi A. Proapoptotic DR4 and DR5 signaling in cancer cells: Toward clinical translation. Curr Opin Cell Biol 2010; 22:837-44; PMID:20813513; http://dx.doi.org/10.1016/j. ceb.2010.08.001.
3. Gonzalvez F, Ashkenazi A. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 2010; 29:4752-65; PMID:20531300; http://dx.doi.org/10. 1038/onc.2010.221.
4. Tourneur L, Chiocchia G. FADD: A regulator of life and death. Trends Immunol 2010; 31:260-9; PMID:20576468; http://dx.doi.org/10.1016/j. it.2010.05.005.
5. Chen G, Bhojani MS, Heaford AC, Chang DC, Laxman B, Thomas DG, et al. Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas. Proc Natl Acad Sci U S A 2005; 102:12507-12; PMID:16109772; http://dx.doi.org/10.1073/pnas.0500397102.
6. Tomioka H, Morita K, Hasegawa S, Omura K. Gene expression analysis by cDNA microarray in oral squamous cell carcinoma. J Oral Pathol Med 2006; 35:206-11; PMID:16519767; http://dx.doi.org/10.1111/j.1600-0714.2006.00410.x.
7. Gibcus JH, Menkema L, Mastik MF, Hermsen MA, de Bock GH, van Velthuysen ML, et al. Amplicon mapping and expression profiling identify the Fasassociated death domain gene as a new driver in the 11q13.3 amplicon in laryngeal/pharyngeal cancer. Clin Cancer Res 2007; 13:6257-66; PMID:17975136; http://dx.doi.org/10.1158/1078-0432.CCR-07-1247.
8. Prapinjumrune C, Morita K, Kuribayashi Y, Hanabata Y, Shi Q, Nakajima Y, et al. DNA amplification and expression of FADD in oral squamous cell carcinoma. J Oral Pathol Med 2010; 39:525-32; PMID:20040024.
9. Elrod HA, Fan S, Muller S, Chen GZ, Pan L, Tighiouart M, et al. Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact. PLoS One 2010; 5:e12178; PMID:20808443; http://dx.doi.org/10.1371/journal.pone.0012178.
10. Sun SY. Understanding the Role of the Death Receptor 5/FADD/caspase-8 Death Signaling in Cancer Metastasis. Mol Cell Pharmacol 2011; 3:31-4; PMID:21461184.
11. Zhang X, Hunt JL, Landsittel DP, Muller S, Adler-Storthz K, Ferris RL, et al. Correlation of proteaseactivated receptor-1 with differentiation markers in squamous cell carcinoma of the head and neck and its implication in lymph node metastasis. Clin Cancer Res 2004; 10:8451-9; PMID:15625067; http://dx.doi.org/ 10.1158/1078-0432.CCR-04-0546.
12. Muller S, Su L, Tighiouart M, Saba N, Zhang H, Shin DM, et al. Distinctive E-cadherin and epidermal growth factor receptor expression in metastatic and nonmetastatic head and neck squamous cell carcinoma: Predictive and prognostic correlation. Cancer 2008; 113:97-107; PMID:18473353; http://dx.doi.org/10.1002/cncr.23557.