Testing for departures from additivity in mixtures of perfluoroalkyl acids (PFAAs)

Toxicology

Volumn 306, Issue , 2013, Pages 169-175

  Carr, Caroline K ^a   Watkins, Andrew M ^b   Wolf, Cynthia J ^b   Abbott, Barbara D ^b   Lau, Christopher ^b   Gennings, Chris ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Biomonitoring; Mixtures; PFAAs

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; ORGANOFLUORINE DERIVATIVE; PERFLUOROALKYL ACID; PERFLUOROHEXANE SULFONATE; PERFLUOROOCTANESULFONIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL ANALYSIS; ENZYME ACTIVATION; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYNTHESIS;

EID: 84875820571     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.02.016     Document Type: Article

References (21)

1. Abbott B.D., Wolf C.J., Schmid J.E., Das K.P., Zehr R.D., Helfant L., Nakayama S., Lindstrom A.B., Strynar M.J., Lau C. Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha. Toxicol. Sci. 2007, 98(2):571-581.
2. Abbott, Wood C.R., Watkins A.M., Das K.P., Lau C.S. Peroxisome proliferator-activated receptors alpha, Beta, and gamma mRNA and protein expression in human fetal tissues. PPAR Res. 2010, 2010. Article ID 690907, 19 pages. 10.1155/2010/690907.
3. Abbott B.D., Wood C.R., Watkins A.M., Tatum-Gibbs K., Das K.P., Lau C. Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues. Reprod. Toxicol. 2012, 33:491-505.
4. Berenbaum M.C. The expected effect of a combination of agents: the general solution. J. Theor. Biol. 1985, 114:413-431.
5. Carr, C.K., Wolf, C.R., Abbott, B.D., Lau, C.S., Gennings, C. Determining a robust D-efficient design for testing for departures from additivity of PFAAs, submitted for publication.
6. Casey M., Gennings C., Carter J.H., Moser V.C., Simmons J.E. Detecting interaction(s) and assessing the impact of component subsets in a chemical mixture using fixed-ratio mixture ray designs. J. Agric. Biol. Environ. Stat. 2004, 9(3):339-361.
7. Kato K., Wong L.Y., Jia L.T., Kuklenyik Z., Calafat A.M. Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008. Environ. Sci. Technol. 2011, 45(19):8037-8045.
8. Kennedy G.L., Butenhoff J.L., Olsen G.W., O'Connor J.C., Seacat A.M., Perkins R.G., Biegel L.B., Murphy S.R., Farrar D.G. The toxicology of perfluorooctanoate. Crit. Rev. Toxicol. 2004, 34(4):351-384.
9. Klaunig J.E., Babich M.A., Baetcke K.P., Cook J.C., Corton J.C., David R.M., DeLuca J.G., Lai D.Y., McKee R.H., Peters J.M., Roberts R.A., Fenner-Crisp P.A. PPARalpha agonist-induced rodent tumors: modes of action and human relevance. Crit. Rev. Toxicol. 2003, 33(6):655-780.
10. Lau C., Anitole K., Hodes C., Lai D., Pfahles-Hutchens A., Seed J. Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol. Sci. 2007, 99(2):366-394.
11. Lau C. Perfluorinated compounds. Molecular, Clinical and Environmental Toxicology, vol. 3: Environmental Toxicology 2012, 47-86. Springer, Basel. A. Luch (Ed.).
12. Loewe S. The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 1953, 3:285-290.
13. Loewe S., Muischnek H. Effect of combinations: mathematical basis of problem. Arch Exp Pathol Pharmakol 1926, 114:313-326.
14. Rodea-Palomares I., Leganes F., Rosal R., Fernandez-Pinas F. Toxicological interactions of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) with selected pollutants. J. Hazard. Mater. 2012, 201-202:209-218.
15. Rosen M.B., Lee J.S., Ren H., Vallanat B., Liu J., Waalkes M.P., Abbott B.D., Lau C., Corton J.C. Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR. Toxicol. Sci. 2008, 103(1):46-56.
16. Rosen M.B., Schmid J.E., Das K.P., Wood C.R., Zehr R.D., Lau C. Gene expression profiling in the liver and lung of perfluorooctane sulfonate-exposed mouse fetuses: comparison to changes induced by exposure to perfluorooctanoic acid?. Reprod. Toxicol. 2009, 27(3-4):278-288.
17. Rosen M.B., Thibodeaux J.R., Wood C.R., Zehr R.D., Schmid J.E., Lau C. Gene expression profiling in the lung and liver of PFOA-exposed mouse fetuses?. Toxicology 2007, 239(1-2):15-33.
18. Wei Y., Shi X., Zhang H., Wang J., Zhou B., Dai J. Combined effects of polyfluorinated and perfluorinated compounds on primary cultured hepatocytes from rare minnow (Gobiocypris rarus) using toxicogenomic analysis. Aquat. Toxicol. 2009, 95(1):27-36.
19. Wolf C.J., Schmid J.E., Lau C., Abbott B.D. Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARalpha) by perfluoroalkyl acids (PFAAs): further investigation of C4-C12 compounds. Reprod. Toxicol. 2012, 33:546-551.
20. Wolf C.J., Takacs M.L., Schmid J.E., Lau C., Abbott B.D. Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths. Toxicol. Sci. 2008, 106(1):162-171.
21. Wolf C.J., Zehr R.D., Schmid J.E., Lau C., Abbott B.D. Developmental effects of perfluorononanoic acid in the mouse are dependent on peroxisome proliferator-activated receptor-alpha. PPAR Res. 2010, 2010. Article ID 282896, 11 pages. 10.1155/2010/282896.