Autoantibody-induced internalization of nicotinic acetylcholine receptor α3 subunit exogenously expressed in human embryonic kidney cells

Journal of Neuroimmunology

Volumn 257, Issue 1-2, 2013, Pages 102-106

  Kobayashi, Shota ^a,b   Yokoyama, Shigeru ^c   Maruta, Takahiro ^d   Negami, Masako ^e   Muroyama, Akiko ^a   Mitsumoto, Yasuhide ^a   Iwasa, Kazuo ^c   Yamada, Masahito ^c   Yoshikawa, Hiroaki ^b,c  

^a HOKURIKU UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^d Kanazawa Nishi Hospital   (Japan)

^e Keiju Medical Center   (Japan)

Author keywords

Autoantibody; Nicotinic acetylcholine receptor 3 subunit; Receptor internalization

Indexed keywords

AUTOANTIBODY; CHOLINERGIC RECEPTOR; COMPLEMENTARY DNA; IMMUNOGLOBULIN G; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3 SUBUNIT; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3 SUBUNIT ANTIBODY; NICOTINIC ACETYLCHOLINE RECEPTOR BETA4 SUBUNIT; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ARTICLE; BIOACCUMULATION; BLOOD SAMPLING; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; EMBRYO; EMBRYO CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SYNAPTIC TRANSMISSION;

ANIMALS; AUTOANTIBODIES; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOCYTOSIS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; RATS; RECEPTORS, NICOTINIC;

EID: 84875804740     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.12.010     Document Type: Article

References (13)

1. Albuquerque E.X., Pereira E.F., Alkondon M., Rogers S.W. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol. Rev. 2009, 89:73-120.
2. Arancibia-Carcamo I.L., Fairfax B.P., Moss S.J., Kittler J.T. Studying the localization, surface stability and endocytosis of neurotransmitter receptors by antibody labeling and biotinylation approaches. Frontiers in Neuroscience 2006, CRC Press, Boca Raton, FL. J.T. Kittler, S.J. Moss (Eds.).
3. Flores C.M., DeCamp R.M., Kilo S., Rogers S.W., Hargreaves K.M. Neuronal nicotinic receptor expression in sensory neurons of the rat trigeminal ganglion: demonstration of alpha3beta4, a novel subtype in the mammalian nervous system. J. Neurosci. 1996, 16:7892-7901.
4. Genzen J.R., Van Cleve W., McGehee D.S. Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes. J. Neurophysiol. 2001, 86:1773-1782.
5. Klein C.M., Vernino S., Lennon V.A., Sandroni P., Fealey R.D., Benrud-Larson L., Sletten D., Low P.A. The spectrum of autoimmune autonomic neuropathies. Ann. Neurol. 2003, 53:752-758.
6. Lennon V.A., Ermilov L.G., Szurszewski J.H., Vernino S. Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease. J. Clin. Invest. 2003, 111:907-913.
7. McKeon A., Lennon V.A., Lachance D.H., Fealey R.D., Pittock S.J. Ganglionic acetylcholine receptor autoantibody: oncological, neurological, and serological accompaniments. Arch. Neurol. 2009, 66:735-741.
8. Mizushima S., Nagata S. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 1990, 18:5322.
9. Skok V.I. Nicotinic acetylcholine receptors in autonomic ganglia. Auton. Neurosci. 2002, 97:1-11.
10. Vernino S., Adamski J., Kryzer T.J., Fealey R.D., Lennon V.A. Neuronal nicotinic ACh receptor antibody in subacute autonomic neuropathy and cancer-related syndromes. Neurology 1998, 50:1806-1813.
11. Vernino S., Ermilov L.G., Sha L., Szurszewski J.H., Low P.A., Lennon V.A. Passive transfer of autoimmune autonomic neuropathy to mice. J. Neurosci. 2004, 24:7037-7042.
12. Vernino S., Lindstrom J., Hopkins S., Wang Z., Low P.A. Characterization of ganglionic acetylcholine receptor autoantibodies. J. Neuroimmunol. 2008, 197:63-69.
13. Wang Z., Low P.A., Jordan J., Freeman R., Gibbons C.H., Schroeder C., Sandroni P., Vernino S. Autoimmune autonomic ganglionopathy: IgG effects on ganglionic acetylcholine receptor current. Neurology 2007, 68:1917-1921.