The CMT4B disease-causing phosphatases Mtmr2 and Mtmr13 localize to the Schwann cell cytoplasm and endomembrane compartments, where they depend upon each other to achieve wild-type levels of protein expression

Human Molecular Genetics

Volumn 22, Issue 8, 2013, Pages 1493-1506

  Ng, Aubree A ^a   Logan, Anne M ^a,b   Schmidt, Eric J ^a   Robinson, Fred L ^a  

^a Department of Neurology   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MTMR13 PROTEIN; MTMR2 PROTEIN; MYELIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CHARCOT MARIE TOOTH TYPE 4B; CONTROLLED STUDY; CYTOPLASM; DEMYELINATION; ENDOSOME; ENZYME ACTIVATION; ENZYME SUBSTRATE; HEREDITARY MOTOR SENSORY NEUROPATHY; INTRACELLULAR SIGNALING; LYSOSOME; MALE; MOUSE; NERVE FIBER DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; SCHWANN CELL; SCIATIC NERVE; WILD TYPE;

ANIMALS; AXONS; CELL MEMBRANE; CHARCOT-MARIE-TOOTH DISEASE; CYTOPLASM; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; NERVE DEGENERATION; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN TYROSINE PHOSPHATASES, NON-RECEPTOR; SCHWANN CELLS; SCIATIC NERVE;

MUS;

EID: 84875788003     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds562     Document Type: Article

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