Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapyand loxoprofen in rats

Journal of Physiology and Pharmacology

Volumn 64, Issue 1, 2013, Pages 65-75

  Amagase, K ^a   Yoshida, Y ^a   Hara, D ^a   Murakami, T ^a   Takeuchi, K ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Aspirin; Clopidogrel; Double antithrombotic therapy; Egualen; Gastric bleeding; Gastrointestinal damage; Ischemia reperfusion; Nonsteroidal antiinflammatory drugs; Stable azulene derivative

Indexed keywords

ACETYLSALICYLIC ACID; AZULETIL; CLOPIDOGREL; HEMOGLOBIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LOXOPROFEN; MESSENGER RNA; MYELOPEROXIDASE; OZAGREL; SERATRODAST; URETHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CLAMP; ARTICLE; CELIAC ARTERY; CONTROLLED STUDY; DRUG MECHANISM; ENTEROBACTERIACEAE; ENZYME ACTIVITY; INTESTINE INJURY; MALE; MUCUS SECRETION; NONHUMAN; PROPHYLAXIS; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; STOMACH HEMORRHAGE; STOMACH INJURY;

ANIMALS; ASPIRIN; AZULENES; BENZOQUINONES; GASTRIC MUCOSA; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL TRACT; HEPTANOIC ACIDS; MALE; MICE; MICE, INBRED C57BL; MUCUS; NITRIC OXIDE SYNTHASE TYPE II; PEPTIC ULCER; PEROXIDASE; PHENYLPROPIONATES; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SESQUITERPENES; TICLOPIDINE;

EID: 84875763491     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Okabe S, Takeuchi K, Mori Y, Furukawa O, Yamada Y. Effects of KT1-32 on gastric lesions and duodenal ulcers induced in rats. Nihon Yakurigaku Zasshi 1986; 88: 467-476.
2. Yano S, Horie S, Wakabayashi S, Mochizuki S, Tomiyama A, Watanabe K. Increasing effect of sodium 3-ethyl-7-isopropyl-1-azulenesulfonate 1/3 hydrate (KT1-32), a novel antiulcer agent, on gastric mucosal blood flow in anesthetized rats. Res Commun Chem Pathol Pharmacol 1990; 70: 253-256.
3. Mochizuki S, Matsumoto M, Wakabayashi S, Kosakai K, Tomiyama A, Kishimoto S. Therapeutic effect of egualen sodium (KT1-32), a new antiulcer agent, on chronic gastritis induced by sodium taurocholate in rats. J Gastroenterol 1996; 31: 785-792.
4. Miyoshi A, Okabe H, Miwa T, et al. Clinical evaluation of egualen sodium in the treatment of gastric ulcer: a multicenter double-blind comparative study with cetraxate hydrocholoride. Jpn Pharmacol Ther 1999; 27: 837-852.
5. Miyoshi A, Miwa T, Nakazawa S, Kajiyama G, Hayakawa A, Ogawa N. Combined therapy with egualen sodium and cimetidine for patients with gastric ulcer: clinical evaluation of initial treatment. A multicenter controlled study in comparison with cometidine alone. Jpn Pharmacol Ther 1999; 27: 853-868.
6. Rogers C, Brown A, Szabo S. Gastric mucosal protection by new aryl sulfhydryl drugs. Dig Dis Sci 1988; 33: 324-329.
7. Mochizuki S, Wakabayashi S, Tomiyama A, Satake N, Shibata S. Thromboxane A2 antagonistic action of a new anti-ulcer agent, azuletil sodium (KT1-32). Scan J Gastroenterol 1989; 24: 194-197.
8. Kotani T, Kobata A, Nakamura E, Amagase K, Takeuchi K. Roles of COX-2 and prostacyclin/IP receptors in mucosal defense against ischemia/reperfusion injury in mouse stomach. J Pharmacol Exp Ther 2006; 316: 547-555.
9. Takeuchi K, Kojima S, Abe N, Takayama S. Pathogenic importance of thromboxane A2 in ischemia/reperfusion-induced gastric injury in mice. (abstract). Gastroenterology 2011; 140 (5 Suppl. 1): S-314.1.
10. Hori Y, Katori M, Harada Y, Uchida Y, Tanaka K. Potentiation of bradykinin-induced nociceptive response by arachidonate metabolites in dogs. Jpn J Pharmacol 1986; 132: 47-52.
11. Camposo D, Cataldo MG, Paterna S, Bivona A, Barbarino C. Cytoprotective therapy of gastric ulcers: a controlled clinical evaluation of triletide versus carbenoxolone. Pharmatherapeutica 1985; 4: 166-170.
12. Dorsam RT, Kunapuli S P. Central role of the P2Y12 receptor in platelet activation. J Clin Invest 2004; 113: 340-345.
13. Izuhara C, Yamasaki K, Honda M, Nishio H, Takeuchi K. Aggravation by clopidogrel, an anti-platelet drug, of HCl/aspirin-induced gastric bleeding and lesions in rats: prophylactic effect of rebamipide. Jpn Pharmacol Ther 2010; 38: 333-345.
14. Izuhara C, Takayama S, Itayama M, Hoshin N, Yoshida Y, Takeuchi K. Animal model for evaluating gastric bleeding and ulcerogenic response induced by aspirin plus clopidogrel. In: Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract: Mechanism, Prevention and Treatment, L. Filaretova, K. Takeuchi K, (eds). Karger Publication 2012; pp. 87-96.
15. Hallas J, Dall M, Andries A, et al. Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study. Brit Med J 2006; 333: 726.
16. Uchiyama S, Yamazaki M, Nakamura T, et al: New modalities and aspects of antiplatelet therapy for stroke prevention. Cerebrovasc Dis 2006; 21(Suppl. 1): 7-16.
17. Goldstein JL, Eisen GM, Lewis B, Gralnek IM, Zlotnick S, Fort JG. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol 2005; 3: 133-141.
18. Maiden L, Thjodleifsson B, Theodors A, Gonzalez J, Bjarnason I. A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. Gastroenterology 2005; 128: 1172-1178.
19. Fujimori S, Seo T, Gudis K, et al. Prevention of nonsteroidal anti-inflammatory drug-induced small-intestinal injury by prostaglandin: a pilot randomized controlled trial evaluated by capsule endoscopy. Gastrointest Endosc 2009; 69: 1339-1346.
20. Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: assessment of inflammation in rat and hamster models. Gastroenterology 1984; 87: 1344-1350.
21. Holzer P, Pabst MA, Lippe IT. Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa. Gastroenterology 1986; 96: 1425-1433.
22. Amagase K, Ochi A, Sugihara T, Kato S, Takeuchi K. Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats. J Gastroenterol Hepatol 2010; 25: S111-S118.
23. Deitch EA, Ma L, Ma WJ, et al. Inhibition of endotoxin-induced bacterial translocation in mice. J Clin Invest 1989; 84: 36-42.
24. Takeuchi K, Yokota A, Taniguchi M, Takahira Y, Tanaka A. Factors involved in up-regulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal antiinflammatory drugs. Dig Dis Sci 2006; 51: 1250-1259.
25. Takeuchi K, Tanaka A, Kato S, Amagase K, Satoh H. Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage. Clinica Chimica Acta 2010; 411: 459-466.
26. Nakamori Y, Komatsu Y, Kotani T, Kojima S, Takeuchi K. Pathogenic importance of cysteinyl leukotrienes in development of gastric lesions induced by ischemia/reperfusion in mice. J Pharmacol Exp Ther 2010; 333: 91-98.
27. Kobata A, Kotani T, Komatsu Y, Amagase K, Kato S, Takeuchi K. Dual action of nitric oxide in the pathogenesis of ischemia/reperfusion-induced mucosal injury in mouse stomach. Digestion 2007; 75: 188-197.
28. Takayama S, Izuhara C, Yamada N, et al. A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion: prophylactic effects of antiulcer drugs. J Physiol Pharmacol 2012; 63: 41-52.
29. Dorsam RT, Kunapuli S P. Central role of the P2Y12 receptor in platelet activation. J Clin Invest 2004; 113: 340-345.
30. Ritchie W P. Acute gastric mucosal damage induced by bile salts, acid, and ischemia. Gastroenterology 1975; 68: 699-707.
31. Takeuchi K, Ueki S, Tanaka H. Endogenous prostaglandins in gastric alkaline response in the rat stomach after damage. Am J Physiol 1986; 250: G842-G849.
32. Bjarnason I, Zanelli G, Smith T, et al. Nonsteroidal anit-inflammatory drug-induced intestinal inflammation in humans. Gastroenterology 1987; 93: 480-489.
33. Laine L. GI risk and risk factors of NSAIDs. J Cardivasc Pharmacol 2006; 47(Suppl. 1): S60-S66.
34. Kameda N, Higuchi K, Shiba M, et al. A prospective, single-blind trial comparing wireless capsule endoscopy and double- balloon enteroscopy in patients with obscure gastrointestinal bleeding. J Gastroenterol 2008; 43: 434-440.
35. Takeuchi K, Miyazawa T, Tanaka A, Kato S, Kunikata T. Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats. Digestion 2002; 66: 30-41.
36. Zwolinska-Wcislo M, Krzysiek-Maczka G, Ptak-Belowska A, et al. Antibiotic treatment with ampicillin accelerates the healing of colonic damage impaired by aspirin and coxib in the experimental colitis: importance of intestinal bacteria, colonic microcirculation and proinflammatory cytokines. J Physiol Pharmacol 2011; 62: 357-368.
37. Boughton-Smith NK, Evans SM, Laszlo F, Whitle BJ, Moncada S. The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat. Br J Pharmacol 1993; 110: 1189-1195.
38. Kamei K, Kubo Y, Kato N, Hatazawa R, Amagase K, Takeuchi K. Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats. Dig Dis Sci 2008; 53: 2657-2666.
39. Amagase K, Ochi A, Kojo A, et al. Prophylactic effect of monosodium glutamate against NSAID-induced enteropathy. J Pharmacol Sci 2012; 118: 131-137.