Recombinant thrombomodulin improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat LPS model

Thrombosis Research

Volumn 131, Issue 4, 2013, Pages 295-299

  Iba, Toshiaki ^a   Aihara, Koichiro ^a   Watanabe, Shin ^a   Yanagawa, Youichi ^a   Takemoto, Masaaki ^a   Yamada, Atsushi ^a   Yang, Daphne ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

activated leukocyte; anticoagulant therapy; high mobility group box 1; intravital microscope; microcirculation; severe sepsis

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; LIPOPOLYSACCHARIDE; RECOMBINANT THROMBOMODULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD FLOW; CELL DAMAGE; CELL INTERACTION; CIRCULATION; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; ENDOTHELIUM CELL; ENDOTOXEMIA; LEUKOCYTE; LEUKOCYTE ADHERENCE; MICROCIRCULATION; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL COMMUNICATION; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; HUMANS; LEUKOCYTES; LIPOPOLYSACCHARIDES; MICROCIRCULATION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; THROMBOMODULIN;

EID: 84875758117     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2012.11.025     Document Type: Article

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