The scientific drunk and the lamppost: Massive sequencing efforts in cancer discovery and treatment

Science Signaling

Volumn 6, Issue 269, 2013, Pages

  Yaffe, Michael B ^a,b  

^a AAAS   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE INHIBITOR; ANTINEOPLASTIC AGENT; B RAF KINASE INHIBITOR; BRCA1 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ISOCITRATE DEHYDROGENASE 1; MESSENGER RNA; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR INHIBITOR;

CANCER RESEARCH; CANCER THERAPY; DRUG EFFICACY; DRUG RESEARCH; FUNDING; GENE EXPRESSION PROFILING; GENE SEQUENCE; GENOME ANALYSIS; HUMAN; INFORMATION RETRIEVAL; PRIORITY JOURNAL; REVIEW; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; ANIMAL; ARTICLE; DNA SEQUENCE; GENETIC PREDISPOSITION; GENETICS; GENOMICS; METHODOLOGY; MOUSE; NEOPLASM; TRANSLATIONAL RESEARCH;

ANIMALS; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; HUMANS; MICE; NEOPLASMS; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84875750487     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003684     Document Type: Review

References (20)

1. Cancer Genome Atlas Research Network, Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
2. A. J. Levine, M. Oren, The first 30 years of p53: Growing ever more complex. Nat. Rev. Cancer 9, 749-758 (2009).
3. Cancer Genome Atlas Research Network, Integrated genomic analyses of ovarian carcinoma. Nature 474, 609-615 (2011).
4. Cancer Genome Atlas Network, Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
5. P. Laurent-Puig, H. Blons, P. H. Cugnenc, Sequence of molecular genetic events in colorectal tumorigenesis. Eur. J. Cancer Prev. 8 (suppl. 1), S39-S47 (1999).
6. Cancer Genome Atlas Research Network, Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519-525 (2012).
7. J. Baselga, Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer. Oncologist 16 (suppl. 1), 12-19 (2011).
8. N. Turner, A. Tutt, A. Ashworth, Hallmarks of 'BRCAness' in sporadic cancers. Nat. Rev. Cancer 4, 814-819 (2004).
9. P. J. O'Donovan, D. M. Livingston, BRCA1 and BRCA2: Breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis 31, 961-967 (2010).
10. J. H. Bielas, K. R. Loeb, B. P. Rubin, L. D. True, L. A. Loeb, Human cancers express a mutator phenotype. Proc. Natl. Acad. Sci. U.S.A. 103, 18238- 18242 (2006).
11. S. Negrini, V. G. Gorgoulis, T. D. Halazonetis, Genomic instability - An evolving hallmark of cancer. Nat. Rev. Mol. Cell Biol. 11, 220-228 (2010).
12. M. R. Stratton, Exploring the genomes of cancer cells: Progress and promise. Science 331, 1553- 1558 (2011).
13. C. Swanton, R. A. Burrell, P. A. Futreal, Breast cancer genome heterogeneity: A challenge to personalised medicine? Breast Cancer Res. 13, 104 (2011).
14. S. P. Treon, L. Xu, G. Yang, Y. Zhou, X. Liu, Y. Cao, P. Sheehy, R. J. Manning, C. J. Patterson, C. Tripsas, L. Arcaini, G. S. Pinkus, S. J. Rodig, A. R. Sohani, N. L. Harris, J. M. Laramie, D. A. Skifter, S. E. Lincoln, Z. R. Hunter, MYD88 L265P somatic mutation in Waldenström's macroglobulinemia. N. Engl. J. Med. 367, 826-833 (2012).
15. E. Tiacci, V. Trifonov, G. Schiavoni, A. Holmes, W. Kern, M. P. Martelli, A. Pucciarini, B. Bigerna, R. Pacini, V. A. Wells, P. Sportoletti, V. Pettirossi, R. Mannucci, O. Elliott, A. Liso, A. Ambrosetti, A. Pulsoni, F. Forconi, L. Trentin, G. Semenzato, G. Inghirami, M. Capponi, F. Di Raimondo, C. Patti, L. Arcaini, P. Musto, S. Pileri, C. Haferlach, S. Schnittger, G. Pizzolo, R. Foà, L. Farinelli, T. Haferlach, L. Pasqualucci, R. Rabadan, B. Falini, BRAF mutations in hairy-cell leukemia. N. Engl. J. Med. 364, 2305-2315 (2011).
16. D. W. Parsons, S. Jones, X. Zhang, J. C.-H. Lin, R. J. Leary, P. Angenendt, P. Mankoo, H. Carter, I.- M. Siu, G. L. Gallia, A. Olivi, R. McLendon, B. A. Rasheed, S. Keir, T. Nikolskaya, Y. Nikolsky, D. A. Busam, H. Tekleab, L. A. Diaz, Jr, J. Hartigan, D. R. Smith, R. L. Strausberg, S. K. N. Marie, S. M. O. Shinjo, H. Yan, G. J. Riggins, D. D. Bigner, R. Karchin, N. Papadopoulos, G. Parmigiani, B. Vogelstein, V. E. Velculescu, K. W. Kinzler, An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812 (2008).
17. H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix- Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, P. A. Futreal, Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
18. K. Rikova, A. Guo, Q. Zeng, A. Possemato, J. Yu, H. Haack, J. Nardone, K. Lee, C. Reeves, Y. Li, Y. Hu, Z. Tan, M. Stokes, L. Sullivan, J. Mitchell, R. Wetzel, J. Macneill, J. M. Ren, J. Yuan, C. E. Bakalarski, J. Villen, J. M. Kornhauser, B. Smith, D. Li, X. Zhou, S. P. Gygi, T.-L. Gu, R. D. Polakiewicz, J. Rush, M. J. Comb, Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-1203 (2007).
19. M. Soda, Y. L. Choi, M. Enomoto, S. Takada, Y. Yamashita, S. Ishikawa, S.-I. Fujiwara, H. Watanabe, K. Kurashina, H. Hatanaka, M. Bando, S. Ohno, Y. Ishikawa, H. Aburatani, T. Niki, Y. Sohara, Y. Sugiyama, H. Mano, Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448, 561-566 (2007).
20. J. T. Erler, R. Linding, Network-based drugs and biomarkers. J. Pathol. 220, 290-296 (2010).