Generation of a human bone marrow-derived mesenchymal stem cell line expressing and secreting high levels of bioactive α-melanocyte-stimulating hormone

Journal of Biochemistry

Volumn 153, Issue 4, 2013, Pages 371-379

  Zhong, Yuesi ^a   Xu, Jianliang ^a   Deng, Meihai ^a   Liu, Bo ^a   Zhang, Fucheng ^a   Yuan, Yuzhe ^b   Yang, Xuhui ^c   Xu, Ruiyun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b INSTITUTE OF BLOOD TRANSFUSION   (China)

^c Guangdong Women and Children's Hospital   (China)

Author keywords

melanocyte stimulating hormone; anti inflammation; human bone marrow derived mesenchymal stem cells; lentiviral vector

Indexed keywords

ALPHA INTERMEDIN; MELANIN;

ADIPOGENESIS; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; HORMONE RELEASE; HUMAN; HUMAN CELL; LENTIVIRUS INFECTION; MESENCHYMAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN STABILITY; STEM CELL EXPANSION;

ADRENOCORTICOTROPIC HORMONE; ALPHA-MSH; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; HALF-LIFE; HUMANS; LENTIVIRUS; MELANINS; MELANOMA, EXPERIMENTAL; MESENCHYMAL STROMAL CELLS; MICE; OSTEOGENESIS; PEPTIDE FRAGMENTS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

LENTIVIRUS;

EID: 84875749442     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvt003     Document Type: Article

References (41)

1. Lipton, J.M. and Catania, A. (1997) Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH. Immunol. Today 18, 140-145
2. Brzoska, T., Luger, T.A., Maaser, C., Abels, C., and Boohm, M. (2008) Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr. Rev. 29, 581-602
3. Getting, S.J. (2006) Targeting melanocortin receptors as potential novel therapeutics. Pharmacol. Ther. 111, 1-15
4. Houra, K., Turcic, P., Gabricevic, M., Weitner, T., Konjevoda, P., and Stambuk, N. (2011) Interaction of a-melanocortin and its pentapeptide antisense LVKAT: effects on hepatoprotection in male CBA mice. Molecules 16, 7331-7343
5. Seidah, N.G., Benjannet, S., Hamelin, J., Mamarbachi, A.M., Basak, A., Marcinkiewicz, J., Mbikay, M., Chretien, M., and Marcinkiewicz, M. (1999) The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1. Ann. NY Acad. Sci. 885, 57-74
6. Slominski, A., Wortsman, J., Luger, T., Paus, R., and Solomon, S. (2000) Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol. Rev. 80, 979-1020
7. Boohm, M., Luger, T.A., Tobin, D.J., and Garca-Borro n, J.C. (2006) Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J Invest. Dermatol. 126, 1966-1975
8. Hruby, V.J., Wilkes, B.C., Hadley, M.E., Al-Obeidi, F., Sawyer, T.K., Staples, D.J., DeVaux, A.E., Dym, O., and Castrucci, A.M.d.L. (1987) a-Melanotropin: the minimal active sequence in the frog skin bioassay. J. Med. Chem. 30, 2126-2130
9. Turcic, P., Bradamante, M., Houra, K., Stambuk, N., Kelava, T., Konjevoda, P., Kazazic, S., Vikici-Topic, D., and Pokric, B. (2009) Effects of a-melanocortin enantiomers on acetaminophen-induced hepatotoxicity in CBA mice. Molecules 14, 5017-5026
10. Blagaic, V., Houra, K., Turcic, P., Stambuk, N., Konjevoda, P., Boban-Blagaic, A., Kelava, T., Kos, M., Aralica, G., and Culo, F. (2010) The influence of a-, b-, and g-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Molecules 15, 1232-1241
11. Wang, C.H., Jawan, B., Lee, T.H., Hung, K.S., Chou, W.Y., Lu, C.N., Liu, J.K., and Chen, Y.J. (2004) Single injection of naked plasmid encoding alpha-melanocytestimulating hormone protects against thioacetamide-induced acute liver failure in mice. Biochem. Biophys. Res. Commun. 322, 153-161
12. Lee, D.J., Biros, D.J., and Taylor, A.W. (2009) Injection of an alpha-melanocyte stimulating hormone expression plasmid is effective in suppressing experimental autoimmune uveitis. Int. Immunopharmacol. 9, 1079-1086
13. Wang, C.H., Lee, T.H., Lu, C.N., Chou, W.Y., Hung, K.S., Concejero, A.M., and Jawan, B. (2006) Electroporative alpha-MSH gene transfer attenuates thioacetamide-induced murine hepatic fibrosis by MMP and TIMP modulation. Gene Ther. 13, 1000-1009
14. Vessillier, S., Adams, G., Montero-Melendez, T., Jones, R., Seed, M., Perretti, M., and Chernajovsky, Y. (2012) Molecular engineering of short half-life small peptides (VIP, aMSH and g3MSH) fused to latency-associated peptide results in improved anti-inflamatory therapeutics. Ann. Rheum. Dis. 71, 143-149
15. Catania, A., Gatti, S., Colombo, G., and Lipton, J.M. (2004) Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol. Rev. 56, 1-29
16. Hruby, V.J. (2001) Design in topographical space of peptide and peptidomimetic ligands that affect behavior. A chemist's glimpse at the mind-body problem. Acc. Chem. Res. 34, 389-397
17. Kaplamadzhiev, D.B., Hisha, H., Adachi, Y., Ikehara, S., Tonchev, A.B., Boneva, N.B., Pyko, I.V., Kikuchi, M., Nakaya, M., Wakayama, T., Iseki, S., and Yamashima, T. (2010) Bone marrow-derived stromal cells can express neuronal markers by DHA/GPR40 signaling. BioSci. Trends 4, 119-129
18. Deans, R.J. and Moseley, A.B. (2000) Mesenchymal stem cells: biology and potential clinical uses. Exp. Hematol. 28, 875-884
19. Jiang, Y., Jahagirdar, B.N., Reinhardt, R.L., Schwartz, R.E., Keene, C.D., Ortiz-Gonzalez, X.R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., Du, J., Aldrich, S., Lisberg, A., Low, W.C., Largaespada, D.A., and Verfaillie, C.M. (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418, 41-49
20. Ichiyanagi, T., Anabuki, K., Nishijima, Y., and Ono, H. (2010) Isolation of mesenchymal stem cells from bone marrow wastes of spinal fusion procedure (TLIF) for low back pain patients and preparation of bone dusts for transplantable autologous bone graft with a serum glue. BioSci. Trends 4, 110-118
21. Martin, D.R., Cox, N.R., Hathcock, T.L., Niemeyer, G.P., and Baker, H.J. (2002) Isolation and characterization of multipotential mesenchymal stem cells from feline bone marrow. Exp. Hematol. 30, 879-886
22. Maccario, R., Podestá , M., Moretta, A., Cometa, A., Comoli, P., Montagna, D., Daudt, L., Ibatici, A., Piaggio, G., Pozzi, S., Frassoni, F., and Locatelli, F. (2005) Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4\+ T-cell subsets expressing a regulatory/suppressive phenotype. Haematologica 90, 516-525
23. Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P.D., Matteucci, P., Grisanti, S., and Gianni, A.M. (2002) Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99, 3838-3843
24. Le Blanc, K., Tammik, L., Sundberg, B., Haynesworth, S.E., and Ringden, O. (2003) Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand. J. Immunol. 57, 11-20
25. Goldstein, R.H., Reagan, M.R., Anderson, K., Kaplan, D.L., and Rosenblatt, M. (2010) Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and promote bone metastasis. Cancer Res. 70, 10044-10050
26. Karnoub, A.E., Dash, A.B., Vo, A.P., Sullivan, A., Brooks, M.W., Bell, G.W., Richardson, A.L., Polyak, K., Tubo, R., and Weinberg, R.A. (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449, 557-563
27. Theise, N.D., Badve, S., Saxena, R., Henegariu, O., Sell, S., Crawford, J.M., and Krause, D.S. (2000) Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 31, 235-240
28. Terai, S., Sakaida, I., Yamamoto, N., Omori, K., Watanabe, T., Ohata, S., Katada, T., Miyamoto, K., Shinoda, K., Nishina, H., and Okita, K. (2003) An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes. J. Biochem. 134, 551-558
29. Hu, Y.L., Huang, B., Zhang, T.Y., Miao, P.H., Tang, G.P., Tabata, Y., and Gao, J.Q. (2012) Mesenchymal stem cells as a novel carrier for targeted delivery of gene in cancer therapy based on nonviral transfection. Mol. Pharm. 9, 2698-2709
30. Walker, N.G., Mistry, A.R., Smith, L.E., Eves, P.C., Tsaknakis, G., Forster, S., Watt, S.M., and Macneil, S. (2012) A chemically defined carrier for the delivery of human mesenchymal stem/stromal cells to skin wounds. Tissue Eng. Part C Methods 18, 143-155
31. Ahmed, A.U., Tyler, M.A., Thaci, B., Alexiades, N.G., Han, Y., Ulasov, I.V., and Lesniak, M.S. (2011) A comparative study of neural and mesenchymal stem cell-based carriers for oncolytic adenovirus in a model of malignant glioma. Mol. Pharm. 8, 1559-1572
32. Dai, L.J., Moniri, M.R., Zeng, Z.R., Zhou, J.X., Rayat, J., and Warnock, G.L. (2011) Potential implications of mesenchymal stem cells in cancer therapy. Cancer Lett. 305, 8-20
33. Azizi, S.A., Stokes, D., Augelli, B.J., DiGirolamo, C., and Prockop, D.J. (1998) Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts. Proc. Natl Acad. Sci. USA 95, 3908-3913
34. Zhong, Y.S., Lin, N., Deng, M.H., Zhang, F.C., Tang, Z.F., and Xu, R.Y. (2010) Deficient proliferation of bone marrow-derived mesenchymal stem cells in patients with chronic hepatitis B viral infections and cirrhosis of the liver. Dig. Dis. Sci. 55, 438-445
35. Yin, P., Luby, T.M., Chen, H., Etemad-Moghadam, B., Lee, D., Aziz, N., Ramstedt, U., and Hedley, M.L. (2003) Generation of expression constructs that secrete bioactive aMSH and their use in the treatment of experimental autoimmune encephalomyelitis. Gene Ther. 10, 348-355
36. Reagan, M.R. and Kaplan, D.L. (2011) Mesenchymal stem cell tumor-homing: detection methods in disease model systems. Stem Cells 29, 920-927
37. Loebinger, M.R., Eddaoudi, A., Davies, D., and Janes, S.M. (2009) Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer. Cancer Res. 69, 4134-4142
38. Hen, G., Yosefi, S., Shinder, D., Or, A., Mygdal, S., Condiotti, R., Galun, E., Bor, A., Sela-Donenfeld, D., and Friedman-Einat, M. (2012) Gene transfer to chicks using lentiviral vectors administered via the embryonic chorioallantoic membrane. PLoS One 7, e36531
39. Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F.C., Krause, D.S., Deans, R.J., Keating, A., Prockop, D.J., and Horwitz, E.M. (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315-317
40. Naldini, L., Blomer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F.H., Verma, I.M., and Trono, D. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272, 263-267
41. Luger, T.A., Scholzen, T., and Grabbe, S. (1997) The role of alpha-melanocytestimulating hormone in cutaneous biology. J. Invest. Dermatol. 2, 87-93