Region-specific causal mechanism in the effects of ammonia on cerebral glucose metabolism in the rat brain

Journal of Neural Transmission

Volumn 120, Issue 3, 2013, Pages 375-382

  Maruoka, Nobuyuki ^a   Murata, Tetsuhito ^a   Omata, Naoto ^a   Mitsuya, Hironori ^a   Kiyono, Yasushi ^a   Okazawa, Hidehiko ^a   Wada, Yuji ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

18F 2 fluoro 2 deoxy d glucose; Ammonia; Brain slice; Glucose metabolism; Hepatic encephalopathy; N methyl d aspartate

Indexed keywords

AMMONIA; CYCLIC GMP; DIZOCILPINE; FLUORODEOXYGLUCOSE F 18;

AEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN CORTEX; BRAIN METABOLISM; BRAIN MITOCHONDRION; CEREBELLUM; CEREBRAL GLUCOSE METABOLISM; COLORIMETRY; CONTROLLED STUDY; CORPUS STRIATUM; GLUCOSE METABOLISM; GLYCOLYSIS; MALE; METABOLIC RATE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMMONIA; ANIMALS; AUTORADIOGRAPHY; CEREBELLUM; CEREBRAL CORTEX; CORPUS STRIATUM; GLUCOSE; MALE; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84875738355     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0906-8     Document Type: Article

References (43)

1. Aggarwal S, Kramer D, Yonas H, Obrist W, Kang Y, Martin M, Policare R (1994) Cerebral hemodynamic and metabolic changes in fulminant hepatic failure: a retrospective study. Hepatology 19:80-87 (Pubitemid 24020475)
2. Aggarwal S, Obrist W, Yonas H, Kramer D, Kang Y, Scott V, Planinsic R (2005) Cerebral hemodynamic and metabolic profiles in fulminant hepatic failure: relationship to outcome. Liver Transpl 11:1353-1360 (Pubitemid 43071584)
3. Cauli O, López-Larrubia P, Rodrigues TB, Cerdán S, Felipo V (2007) Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors. J Neurochem 103:1334-1343 (Pubitemid 47631826)
4. Cooper AJ, Plum F (1987) Biochemistry and physiology of brain ammonia. Physiol Rev 67:440-519 (Pubitemid 17063608)
5. Felipo V, Butterworth RF (2002) Mitochondrial dysfunction in acute hyperammonemia. Neurochem Int 40:487-491 (Pubitemid 34159149)
6. Ferrendelli JA, Kinscherf DA, Chang MM (1973) Regulation of levels of guanosine cyclic 3′,5′-monophosphate in the central nervous system: effects of depolarizing agents. Mol Pharmacol 9:445-454
7. Förstermann U, Gorsky LD, Pollock JS, Schmidt HH, Heller M, Murad F (1990) Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain. Biochem Biophys Res Commun 168:727-732 (Pubitemid 20164603)
8. Gjedde A (1981) High- and low-affinity transport of d-glucose from blood to brain. J Neurochem 36:1463-1471 (Pubitemid 11070813)
9. Greenberg LH, Troyer E, Ferrendelli JA, Weiss B (1978) Enzymatic regulation of the concentration of cyclic GMP in mouse brain. Neuropharmacology 17:737-745 (Pubitemid 9013936)
10. 18F]-fluoro-2-deoxy-d-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med 27:235-238 (Pubitemid 17024868)
11. Hawkins RA, Miller AL, Nielsen RC, Veech RL (1973) The acute action of ammonia on rat brain metabolism in vivo. Biochem J 134:1001-1008
12. Hermenegildo C, Monfort P, Felipo V (2000) Activation of N-methyl-d-aspartate receptors in rat brain in vivo following acute ammonia intoxication: characterization by in vivo brain microdialysis. Hepatology 31:709-715 (Pubitemid 30118640)
13. Huang SC, Phelps ME, Hoffman EJ, Sideris K, Selin CJ, Kuhl DE (1980) Noninvasive determination of local cerebral metabolic rate of glucose in man. Am J Physiol 238:E69-E82
14. Izumi Y, Izumi M, Matsukawa M, Funatsu M, Zorumski CF (2005) Ammonia-mediated LTP inhibition: effects of NMDA receptor antagonists and l-carnitine. Neurobiol Dis 20:615-624 (Pubitemid 41476287)
15. James IM, MacDonell L, Xanalatos C (1972) The effect of acute portacaval shunting in dogs on cerebral and peripheral blood flow and metabolism. Clin Sci 42:769-774
16. Johansen ML, Bak LK, Schousboe A, Iversen P, Sørensen M, Keiding S, Vilstrup H, Gjedde A, Ott P, Waagepetersen HS (2007) The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes. Neurochem Int 50:1042-1051 (Pubitemid 46962815)
17. Klejman A, Wegrzynowicz M, Szatmari EM, Mioduszewska B, Hetman M, Albrecht J (2005) Mechanisms of ammonia-induced cell death in rat cortical neurons: roles of NMDA receptors and glutathione. Neurochem Int 47:51-57 (Pubitemid 40848692)
18. +, K(+)-ATPase. J Neurochem 63:2172-2178 (Pubitemid 24369992)
19. Lai JC, Cooper AJ (1986) Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors. J Neurochem 47:1376-1386 (Pubitemid 17174649)
20. Lowry OH, Passonneau JV (1966) Kinetic evidence for multiple binding sites on phosphofructokinase. J Biol Chem 241:2268-2279
21. +, K(+)-ATPase that results in its activation in cerebellar neurons in culture. J Neurochem 66:99-104
22. 2+ of NMDA responses in spinal cord neurones. Nature 309:261-263 (Pubitemid 14139936)
23. McCandless DW, Schenker S (1981) Effect of acute ammonia intoxication on energy stores in the cerebral reticular activating system. Exp Brain Res 44:325-330 (Pubitemid 12227650)
24. McKhann GM, Tower DB (1961) Ammonia toxicity and cerebral oxidative metabolism. Am J Physiol 200:420-424
25. Mousseau DD, Butterworth RF (1994) Current theories on the pathogenesis of hepatic encephalopathy. Proc Soc Exp Biol Med 206:329-344 (Pubitemid 24270091)
26. Murata T, Omata N, Fujibayashi Y, Waki A, Sadato N, Yoshida S, Yano R, Yoshimoto M, Yonekura Y (1999) Dynamic changes in glucose metabolism of living rat brain slices induced by hypoxia and neurotoxic chemical-loading revealed by positron autoradiography. J Neural Transm 106:1075-1087 (Pubitemid 30009206)
27. Norenberg MD, Huo Z, Neary JT, Roig-Cantesano A (1997) The glial glutamate transporter in hyperammonemia and hepatic encephalopathy: relation to energy metabolism and glutamatergic neurotransmission. Glia 21:124-133 (Pubitemid 27389648)
28. Omata N, Murata T, Fujibayashi Y, Waki A, Sadato N, Yoshimoto M, Wada Y, Yonekura Y (2000) Hypoxic but not ischemic neurotoxicity of free radicals revealed by dynamic changes in glucose metabolism of fresh rat brain slices on positron autoradiography. J Cereb Blood Flow Metab 20:350-358 (Pubitemid 30108454)
29. Ouchi Y, Fukuyama H, Matsuzaki S, Ogawa M, Kimura J, Tsukada H, Kakiuchi T, Kosugi T, Nishiyama S (1996) Compartment analysis of cerebral glucose metabolism and in vitro glucose-metabolizing enzyme activities in the rat brain. Brain Res 706:267-272 (Pubitemid 26046725)
30. Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1-7 (Pubitemid 13129630)
31. Raiteri M, Maura G, Barzizza A (1991) Activation of presynaptic 5-hydroxytryptamine1-like receptors on glutamatergic terminals inhibits N-methyl-d-aspartate-induced cyclic GMP production in rat cerebellar slices. J Pharmacol Exp Ther 257:1184-1188
32. 3H]arginine uptake in brain following portacaval anastomosis. J Neurochem 65:677-678
33. Rao KV, Mawal YR, Qureshi IA (1997) Progressive decrease of cerebral cytochrome c oxidase activity in sparse-fur mice: role of acetyl-l-carnitine in restoring the ammonia-induced cerebral energy depletion. Neurosci Lett 224:83-86 (Pubitemid 27122176)
34. Ratnakumari L, Qureshi IA, Butterworth RF (1992) Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice. Biochem Biophys Res Commun 184:746-751
35. Ratnakumari L, Qureshi IA, Butterworth RF (1994) Regional amino acid neurotransmitter changes in brains of spf/Y mice with congenital ornithine transcarbamylase deficiency. Metab Brain Dis 9:43-51 (Pubitemid 24172386)
36. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897-916 (Pubitemid 8098854)
37. Steiner AL, Ferrendelli JA, Kipnis DM (1972) Radioimmunoassay for cyclic nucleotides. 3. Effect of ischemia, changes during development and regional distribution of adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in mouse brain. J Biol Chem 247:1121-1124
38. Sugden PH, Newsholme EA (1975) The effects of ammonium, inorganic phosphate and potassium ions on the activity of phosphofructokinases from muscle and nervous tissues of vertebrates and invertebrates. Biochem J 150:113-122
39. Wejksza K, Rzeski W, Turski WA, Hilgier W, Dybel A, Albrecht J (2006) Ammonia at pathophysiologically relevant concentrations activates kynurenic acid synthesis in cultured astrocytes and neurons. Neurotoxicology 27:619-622 (Pubitemid 43867778)
40. Wendon JA, Harrison PM, Keays R, Williams R (1994) Cerebral blood flow and metabolism in fulminant liver failure. Hepatology 19:1407-1413 (Pubitemid 24166461)
41. Wood PL (1991) Pharmacology of the second messenger, cyclic guanosine 3′,5′-monophosphate, in the cerebellum. Pharmacol Rev 43:1-25
42. Zhou BG, Norenberg MD (1999) Ammonia downregulates GLAST mRNA glutamate transporter in rat astrocyte cultures. Neurosci Lett 276:145-148 (Pubitemid 29535352)
43. Zwingmann C (2007) The anaplerotic flux and ammonia detoxification in hepatic encephalopathy. Metab Brain Dis 22:235-249 (Pubitemid 47624321)