Integrated microfluidic systems for molecular diagnostics: A universal electrode platform for rapid diagnosis of urinary tract infections

IEEE Nanotechnology Magazine

Volumn 7, Issue 1, 2013, Pages 31-37

  Sin, Mandy L Y ^a   Gau, Vincent ^b   Liao, Joseph ^c   Wong, P K ^a  

^a University of Arizona   (United States)

^b GeneFluidics Inc   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSTIC SYSTEMS; ELECTROCHEMICAL SENSING; INTEGRATED MICROFLUIDIC SYSTEMS; INTEGRATED PLATFORM; INTENSIVE RESEARCH; MICROFLUIDIC PLATFORMS; MOLECULAR DIAGNOSTICS; URINARY TRACT INFECTIONS;

ELECTROLYTIC ANALYSIS; HEALTH CARE; SELF ASSEMBLED MONOLAYERS;

MICROFLUIDICS;

EID: 84875724497     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1109/MNANO.2012.2237331     Document Type: Article

References (19)

1. M. L. Sin, J. Gao, J. C. Liao, and P. K. Wong, "System integration: A major step toward lab on a chip," J. Biol. Eng., vol. 5, p. 6, 2011.
2. R. Mariella, "Sample preparation: The weak link in microfluidics-based biodetection," Biomed. Microdevices, vol. 10, pp. 777-784, Dec. 2008.
3. G. Whitesides, "Solving problems," Lab Chip, vol. 10, pp. 2317-2318, 2010.
4. T. H. Wang and P. K. Wong, "Transforming microfluidics into laboratory automation," J. Assoc. Lab. Autom., vol. 15, pp. A15-A16, 2010.
5. P. K. Wong, T. H. Wang, J. H. Deval, and C. M. Ho, "Electrokinetics in micro devices for biotechnology applications," IEEE/ASME Trans. Mechatron., vol. 9, pp. 366-376, June 2004.
6. A. Ramos, H. Morgan, N. G. Green, and A. Castellanos, "AC electrokinetics: A review of forces in microelectrode structures," J. Phys. D, Appl. Phys., vol. 31, pp. 2338-2353, Sept. 1998.
7. J. Gao, M. L. Y. Sin, T. Liu, V. Gau, J. C. Liao, and P. K. Wong, "Hybrid electrokinetic manipulation in high-conductivity media," Lab Chip, vol. 11, no. 10, pp. 1770-1775, 2011.
8. S. Park, Y. Zhang, T. H. Wang, and S. Yang, "Continuous dielectrophoretic bacterial separation and concentration from physiological media of high conductivity," Lab Chip, vol. 11, pp. 2893-2900, 2011.
9. M. L. Sin, T. Liu, J. D. Pyne, V. Gau, J. C. Liao, and P. K. Wong, "In situ electrokinetic enhancement for self-assembled-monolayer-based electrochemical biosensing," Anal. Chem., vol. 84, pp. 2702-2707, Mar. 2012.
10. M. L. Y. Sin, V. Gau, J. C. Liao, and P. K. Wong, "Electrothermal f luid manipulation of high-conductivity samples for laboratory automation applications," J. Assoc. Lab. Autom., vol. 15, pp. 426-432, 2010.
11. A. Sonnenberg, J. Y. Marciniak, R. Krishnan, and M. J. Heller, "Dielectrophoretic isolation of DNA and nanoparticles from blood," Electrophoresis, vol. 33, pp. 2482-2490, Aug. 2012.
12. R. Mohan, K. E. Mach, M. Bercovici, Y. Pan, L. Dhulipala, P. K. Wong, and J. C. Liao, "Clinical validation of integrated nucleic acid and protein detection on an electrochemical biosensor array for urinary tract infection diagnosis," PLoS One, vol. 6, p. e26846, 2011.
13. K. E. Mach, R. Mohan, E. J. Baron, M. C. Shih, V. Gau, P. K. Wong, and J. C. Liao, "A biosensor platform for rapid antimicrobial susceptibility testing directly from clinical samples," J. Urol., vol. 185, pp. 148-153, Jan. 2011.
14. Y. Pan, G. A. Sonn, M. L. Sin, K. E. Mach, M. C. Shih, V. Gau, P. K. Wong, and J. C. Liao, "Electrochemical immunosensor detection of urinary lactoferrin in clinical samples for urinary tract infection diagnosis," Biosens. Bioelectron., vol. 26, pp. 649-654, Oct. 2010.
15. K. E. Mach, P. K. Wong, and J. C. Liao, "Biosensor diagnosis of urinary tract infections: A path to better treatment?," Trends Pharmacol. Sci., Mar. 2011.
16. K. E. Mach, C. B. Du, H. Phull, D. A. Haake, M. C. Shih, E. J. Baron, and J. C. Liao, "Multiplex pathogen identification for polymicrobial urinary tract infections using biosensor technology: A prospective clinical study," J. Urol., Oct. 2009.
17. C. T. Ho, R. Z. Lin, H. Y. Chang, and C. H. Liu, "Micromachined electrochemical T-switches for cell sorting applications," Lab Chip, vol. 5, pp. 1248-1258, 2005.
18. C. M. Cheng and C. H. Liu, "An electrolysisbubble-actuated micropump based on the roughness gradient design of hydrophobic surface," J. Microelectromech. Syst., vol. 16, pp. 1095-1105, Oct. 2007.
19. C. H. Liu, S. C. Chan, and C. R. Chen, "A bubble-activated micropump with high-frequency flow reversal," Sens. Actuators A, Phys., vol. 163, pp. 501-509, Oct. 2010.