Expression of HIV transgene aggravates kidney injury in diabetic mice

Kidney International

Volumn 83, Issue 4, 2013, Pages 626-634

  Mallipattu, Sandeep K ^a   Liu, Ruijie ^a,b   Zhong, Yifei ^c   Chen, Ed Y ^a   D'Agati, Vivette ^d   Kaufman, Lewis ^a   Ma'Ayan, Avi ^a   Klotman, Paul E ^e   Chuang, Peter Y ^a   He, John C ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

diabetic nephropathy; glomerulopathy; HIV

Indexed keywords

SMAD3 PROTEIN; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; GENE EXPRESSION; GENETIC ANALYSIS; GLOMERULUS; HIV ASSOCIATED NEPHROPATHY; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENE; TRANSGENIC MOUSE; UPREGULATION;

EID: 84875716220     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.445     Document Type: Article

References (41)

1. Rao TK, Filippone EJ, Nicastri AD et al. Associated focal and segmental glomerulosclerosis in the acquired immunodeficiency syndrome. N Engl J Med 1984; 310: 669-673.
2. Gardenswartz MH, Lerner CW, Seligson GR et al. Renal disease in patients with AIDS: a clinicopathologic study. Clin Nephrol 1984; 21: 197-204.
3. Pardo V, Aldana M, Colton RM et al. Glomerular lesions in the acquired immunodeficiency syndrome. Ann Intern Med 1984; 101: 429-434.
4. Carbone L, D'Agati V, Cheng JT et al. Course and prognosis of human immunodeficiency virus-associated nephropathy. Am J Med 1989; 87: 389-395.
5. Cantor KP, Weiss SH, Goedert JJ et al. HTLV-I/II seroprevalence and HIV/HTLV coinfection among U.S. intravenous drug users. J Acquir Immune Defic Syndr 1991; 4: 460-467.
6. Gupta SK, Eustace JA, Winston JA et al. Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America. Clinical Infectious Diseases 2005; 40: 1559-1585.
7. Mallipattu SK, Wyatt CM, He JC. The new epidemiology of HIV-related kidney disease. J AIDS Clin Res 2012; S4: 001-006.
8. Berliner AR, Fine DM, Lucas GM et al. Observations on a cohort of HIVinfected patients undergoing native renal biopsy. Am J Nephrol 2008; 28: 478-486.
9. Ross MJ, Klotman PE, Winston JA. HIV-associated nephropathy: case study and review of the literature. AIDS Patient Care STDS 2000; 14: 637-645.
10. Fine DM, Perazella MA, Lucas GM et al. Kidney biopsy in HIV: beyond HIVassociated nephropathy. Am J Kidney Dis 2008; 51: 504-514.
11. Choi AI, Rodriguez RA, Bacchetti P et al. Racial differences in end-stage renal disease rates in HIV infection versus diabetes. J Am Soc Nephrol 2007; 18: 2968-2974.
12. Medapalli R, Parikh CR, Gordon K et al. Comorbid diabetes and the risk of progressive chronic kidney disease in HIV-infected adults: Data from the Veterans Aging Cohort Study. J Acquir Immune Defic Syndr 2012; 60: 393-399.
13. Dickie P, Felser J, Eckhaus M et al. HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. Virology 1991; 185: 109-119.
14. Fornoni A, Ijaz A, Tejada T et al. Role of inflammation in diabetic nephropathy. Curr Diabetes Rev 2008; 4: 10-17.
15. Martinka S, Bruggeman LA. Persistent NF-kappaB activation in renal epithelial cells in a mouse model of HIV-associated nephropathy. Am J Physiol Renal Physiol 2006; 290: F657-F665.
16. Brosius FC 3rd, Alpers CE, Bottinger EP et al. Mouse models of diabetic nephropathy. J Am Soc Nephrol 2009; 20: 2503-2512.
17. Zhong J, Zuo Y, Ma J et al. Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy. Kidney Int 2005; 68: 1048-1060.
18. Gharavi AG, Ahmad T, Wong RD et al. Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc Natl Acad Sci USA 2004; 101: 2488-2493.
19. Susztak K, Bottinger E, Novetsky A et al. Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease. Diabetes 2004; 53: 784-794.
20. Butkowski RJ, Wieslander J, Kleppel M et al. Basement membrane collagen in the kidney: regional localization of novel chains related to collagen IV. Kidney Int 1989; 35: 1195-1202.
21. He C, Esposito C, Phillips C et al. Dissociation of glomerular hypertrophy, cell proliferation, and glomerulosclerosis in mouse strains heterozygous for a mutation (Os) which induces a 50% reduction in nephron number. J Clin Invest 1996; 97: 1242-1249.
22. Yabuki A, Tanaka S, Matsumoto M et al. Morphometric study of gender differences with regard to age-related changes in the C57BL/6 mouse kidney. Exp Anim 2006; 55: 399-404.
23. Yang HC, Zuo Y, Fogo AB. Models of chronic kidney disease. Drug Discov Today Dis Models 2010; 7: 13-19.
24. Chen EY, Xu H, Gordonov S et al. Expression2Kinases: mRNA profiling linked to multiple upstream regulatory layers. Bioinformatics 2012; 28: 105-111.
25. Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med 2011; 62: 141-155.
26. Robertson KR, Smurzynski M, Parsons TD et al. The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS 2007; 21: 1915-1921.
27. Shikano M, Sobajima H, Yoshikawa H et al. Usefulness of a highly sensitive urinary and serum IL-6 assay in patients with diabetic nephropathy. Nephron 2000; 85: 81-85.
28. Niewczas MA, Gohda T, Skupien J et al. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol 2012; 23: 507-515.
29. Bruggeman LA, Dikman S, Meng C et al. Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression. J Clin Invest 1997; 100: 84-92.
30. Feng X, Lu TC, Chuang PY et al. Reduction of Stat3 activity attenuates HIV-induced kidney injury. J Am Soc Nephrol 2009; 20: 2138-2146.
31. Wu KK, Huan Y. Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharmacol 2008; Chapter 5: Unit 5 47; 5.47.1-5.47.14.
32. Sanden SK, Wiggins JE, Goyal M et al. Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms' tumor-1 protein used as a podocyte nuclear marker. J Am Soc Nephrol 2003; 14: 2484-2493.
33. Awazu M, Omori S, Ishikura K et al. The lack of cyclin kinase inhibitor p27(Kip1) ameliorates progression of diabetic nephropathy. J Am Soc Nephrol 2003; 14: 699-708.
34. Schiffer M, Mundel P, Shaw AS et al. A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis. J Biol Chem 2004; 279: 37004-37012.
35. Koop K, Eikmans M, Baelde HJ et al. Expression of podocyte-associated molecules in acquired human kidney diseases. J Am Soc Nephrol 2003; 14: 2063-2071.
36. Reiniger N, Lau K, McCalla D et al. Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse. Diabetes 2010; 59: 2043-2054.
37. Takemoto M, Asker N, Gerhardt H et al. A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol 2002; 161: 799-805.
38. Zuo Y, Matsusaka T, Zhong J et al. HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis. J Am Soc Nephrol 2006; 17: 2832-2843.
39. Pfaffl MW. A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 2001; 29: e45.
40. Potapova TA, Sivakumar S, Flynn JN et al. Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited. Mol Biol Cell 2011; 22: 1191-1206.
41. Gassmann M, Grenacher B, Rohde B et al. Quantifying Western blots: pitfalls of densitometry. Electrophoresis 2009; 30: 1845-1855.