Lipoplexes versus nanoparticles: PDNA/siRNA delivery

Drug Delivery

Volumn 20, Issue 2, 2013, Pages 57-64

  Khurana, Bharat ^a   Goyal, Amit K ^a   Budhiraja, Abhishek ^a   Aora, Diasy ^a   Vyas, Suresh P ^b  

^a ISF COLLEGE OF PHARMACY   (India)

^b DR H S GOUR UNIVERSITY   (India)

Author keywords

Chitosan; Gene delivery; Liposomes; Nanoparticles; SiRNA

Indexed keywords

CHITOSAN; GREEN FLUORESCENT PROTEIN; LIPOPLEX; NANOPARTICLE; PLASMID DNA; SMALL INTERFERING RNA;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOTOXICITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGHT SCATTERING; PARTICLE SIZE; PRIORITY JOURNAL; REPORTER GENE; SURFACE CHARGE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

CELL SURVIVAL; CHITOSAN; DRUG CARRIERS; DRUG COMPOUNDING; FATTY ACIDS, MONOUNSATURATED; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; LIPOSOMES; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; PARTICLE SIZE; PHOSPHATIDYLETHANOLAMINES; QUATERNARY AMMONIUM COMPOUNDS; RNA, SMALL INTERFERING; SURFACE PROPERTIES; TRANSFECTION;

EID: 84875710486     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2012.752419     Document Type: Article

References (22)

1. Akhtar S, Benter IF. (2007). Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest 117:3623-32.
2. Bosher JM, Labouesse M. (2000). RNA interference: genetic wand and genetic watchdog. Nat Cell Biol 2:E31-6.
3. Cho YW, Kim J-D, Park K. (2003). Polycation gene delivery systems: escape from endosomes to cytosol. J Pharm Pharmacol 55:721-34.
4. Ciania L, Ristoria S, Salvatia A, et al. (2004). DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery: zeta potential measurements and electron spin resonance spectra. Biochim Biophys Acta 1664:70-9.
5. Dykxhoorn DM, Novina CD, Sharp PA. (2003). Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol 4:457-67.
6. Elbashir SM, Martinez J, Patkaniowska A, et al. (2001). Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J 20:6877-88.
7. Fire A, Xu S, Montgomery MK, et al. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806-11.
8. Hassani Z, Lemkine GF, Erbacher P, et al. (2005). Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels. J Gene Med 7:198-207.
9. Howard KA, Rahbek UL, Liu X, et al. (2006). RNA interference in vitro and in vivo using a chitosan/siRNA nanoparticle system. Mol Ther 14:476-84.
10. Janes KA, Calvo P, Alonso MJ. (2001). Polysaccharide colloidal particles as delivery systems for macromolecules. Adv Drug Del Rev 47:83-97.
11. Katas H, Alpar HO. (2006). Development and characterization of chitosan nanoparticles for siRNA delivery. J Control Rel 115:216-25.
12. Leung PK, Whittaker PA. (2005). RNA interference: from gene silencing to gene-specific therapeutics. Pharmacol Ther 107:222-39.
13. Li CX, Parker A, Menocal E, et al. (2006). Delivery of RNA interference. Cell Cycle 5:2103-9.
14. Martinez J, Patkaniowska A, Urlaub H, et al. (2002). Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110:563-74.
15. Milligan JF, Uhlenbeck OC. (1989). Synthesis of small RNAs using T7 RNA polymerase. Methods Enzymol 180:51-62.
16. Mislick KA, Baldeschwieler JD. (1996). Evidence for the role of proteoglycans in cation mediated gene transfer. Proc Natl Acad Sci USA 93:12349-54.
17. Nicolau C, Gregoriadis G. (1998). Demetrios Papahadjopoulos (1934-98). Nature 396:118.
18. Raoul C, Barker SD, Aebischer P. (2006). Viral-based modelling and correction of neurodegenerative diseases by RNA interference. Gene Ther 13:487-95.
19. Reddy LS, Sarojamma V, Ramakrishna V. (2006). RNAi in medicine: current and future perspectives. Biotech Mol Biol Rev 1:103-14.
20. Ruponen M, Honkakoski P, Rönkkö S, et al. (2003). Extracellular and intracellular barriers in non-viral gene delivery. J Control Rel 93: 213-17.
21. Ruponen M, Yla-Herttuala S, Urtti A. (1999). Interactions of polymeric and liposomal gene delivery systems with extracellular glycosami-noglycans: physicochemical and transfection studies. Biochim Biophys Acta 1415:331-41.
22. Yadav P, Rour D, Hughes JA. (2007). Evaluation of two cationic delivery systems for siRNA. Oligonucleotides 17:213-21.