Proceedings of the 2012 National Toxicology Program Satellite Symposium

Toxicologic Pathology

Volumn 41, Issue 2, 2013, Pages 151-180

  Elmore, Susan A ^a   Berridge, Brian R ^b   Boyle, Michael C ^a   Cora, Michelle C ^a   Hoenerhoff, Mark J ^a   Kooistra, Linda ^c   Laast, Victoria A ^d   Morrison, James P ^c   Rao, Deepa ^e   Rinke, Matthias ^f   Yoshizawa, Katsuhiko ^g  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b GLAXOSMITHKLINE   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

^d Building No3   (China)

^e INTEGRATED LABORATORY SYSTEMS   (United States)

^f BAYER PHARMA AG   (Germany)

^g KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

adrenal cortex adenoma; atypical foci of altered hepatocytes; cardiac schwannoma; cardiomyopathy; cortical cystic degeneration; eosinophilic crystalline pneumonia; exencephaly; holoprosencephaly; intrahepatocytic erythrocytes; megaloblastic anemia; myocardial fibrosis; myocardial necrosis; neuroepithelial dysplasia; NTP Satellite Symposium; pancreatic ductal cell adenoma; pernicious anemia; Rathke's cleft; subendothelial hepatocytes

Indexed keywords

ADENOMA; ADRENAL CORTEX; ADRENAL CORTICAL LESION; CARDIOMYOPATHY; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; DYSPLASIA; EMBRYONIC NEUROEPITHELIAL DYSPLASIA; EOSINOPHILIC CRYSTALLINE PNEUMONIA; ERYTHROCYTE; EXENCEPHALY; FEMALE; HEART PAPILLARY MUSCLE; HOLOPROSENCEPHALY; LIVER CELL; MALE; MEGALOBLASTIC ANEMIA; MOUSE; NEURILEMOMA; NOMENCLATURE; NONHUMAN; PERNICIOUS ANEMIA; PNEUMONIA; PRIORITY JOURNAL; RAT; RATHKE CLEFT CYST; SCIENTIFIC LITERATURE; SYMPOSIUM; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; DIAGNOSTIC TECHNIQUES AND PROCEDURES; HUMANS; PATHOLOGY; TERMINOLOGY AS TOPIC; TOXICOLOGY;

MUS MUSCULUS;

EID: 84875708267     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312467102     Document Type: Conference Paper

References (75)

1. Adams E. T., Auerbach S., Blackshear P. E., Bradley A., Gruebbel M. M., Little P. B., Malarkey D., Maronpot R., McKay J. S., Miller R. A., Moore R. R., Morrison J. P., Nyska A., Ramot Y., Rao D., Suttie A., Wells M. Y., Willson G. A., Elmore S. A.. Proceedings of the 2010 National Toxicology Program satellite symposium. Toxicol Pathol. 2011 ; 39: 240-66
2. Alison R. H., Elwell M. R., Jokinen M. P., Dittrich K. L., Boorman G. A.. Morphology and classification of 96 primary cardiac neoplasms in Fischer 344 rats. Vet Pathol. 1987 ; 24: 488-94
3. Bach U., Hailey J. R., Hill G. D., Kaufmann W., Latimer K. S., Malarkey D. E., Maronpot R. M., Miller R. A., Moore R. R., Morrison J. P., Nolte T., Rinke M., Rittinghausen S., Suttie A. W., Travlos G. S., Vahle J. L., Willson G. A., Elmore S. A.. Proceedings of the 2009 National Toxicology Program satellite symposium. Toxicol Pathol. 2010 ; 38: 9-36
4. Bain B. J., Clark D. M., Lampert I. A., Wilkins B. S. Bone Marrow Pathology. Oxford, UK: Blackwell Sciences ; 2001 :
5. Balazs T., Payne B. J.. Myocardial papillary necrosis induced by hypotensive agents in dogs. Toxicol and Appl Pharmacol. 1971 ; 20: 442-45
6. Balazs T., Ohtake S., Cummings J. R., Noble J. F.. Ventricular extrasystoles induced by epinephrine, nicotine, ethanol, and vasopressin in dogs with myocardial lesions. Toxicol and Appl Pharmacol. 1969 ; 15: 189-205
7. Banizs B., Pike M. M., Millican C. L., Ferguson W. B., Komlosi P., Sheetz J., Bell P. D., Schwiebert E. M., Yoder B. K.. Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus. Development. 2005 ; 132: 5329-39
8. Berridge B. R., Pettit S., Walker D. B., Jaffe A. S., Schultze A. E., Herman E., Reagan W. J., Lipshultz S. E., Apple F. S., York M. J.. A translational approach to detecting drug-induced cardiac injury with cardiac troponins: Consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute. Am Heart J. 2009 ; 158: 21-29
9. Bills N. D., Koury M. J., Clifford A. J., Dessypris E. N.. Ineffective hematopoiesis in folate-deficient mice. Blood. 1992 ; 79: 2273-80
10. Brix A. E., Nyska A., Haseman J. K., Sells D. M., Jokinen M. P., Walker N. J.. Incidences of selected lesions in control female harlan sprague-dawley rats from two-year studies performed by the National Toxicology Program. Toxicol Pathol. 2005 ; 33: 477-83
11. Chang N. C., Hung S. I., Hwa K. Y., Kato I., Chen J. E., Liu C. H., Chang A. C.. A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin. J Biol Chem. 2001 ; 276: 17497-506
12. Clements P., Brady S., York M., Berridge B., Mikaelian I., Nicklaus R., Gandhi M., Roman I., Stamp C., Davies D., McGill P., Williams T., Pettit S., Walker D., Turton J., Bounous D., Dunn B., Hausner E., Herman E., Holt G., Lamb M., Louden C., Mylecraine L., MacGregor J., Reagan W., Roome N., Schultze E., Stoll R., Stonebrook M., Taggert P., Thudium D., Topper M., Wallace K.. Time course characterization of serum cardiac troponins, heart fatty acid-binding protein, and morphologic findings with isoproterenol-induced myocardial injury in the rat. Toxicol Pathol. 2010 ; 38: 703-14
13. Copp A. J., Greene N. D.. Genetics and development of neural tube defects. J Path. 2010 ; 220: 217-30
14. Daniel P. M., Prichard M. M. L.. Anterior pituitary necrosis: Infarction of the pars distalis produced experimentally in the rat. Exp Physiol. 1956 ; XLI: 215-29
15. Evans G. O. Animal Clinical Chemistry: A Practical Guide for Toxicologists and Biomadical Researchers. Boca Raton, FL: Taylor and Francis Group ; 2009 :
16. Feldmesser M., Kress Y., Casadevall A.. Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary cryptococcus neoformans infection. Infect Immun. 2001 ; 69: 2723-27
17. France M. P., Muir D.. An outbreak of pulmonary mycosis in respiratory burst-deficient (gp91(phox-/-))mice with concurrent acidophilic macrophage pneumonia. J Comp Pathol. 2000 ; 123: 190-94
18. Furukawa F., Sato H., Imaida K., Toyoda K., Imazawa T., Takahashi M., Hayashi Y.. Induction of pancreatic tumors in male Syrian golden hamsters by intraperitoneal N-methyl-N-nitrosourea injection. Pancreas. 1992 ; 7: 153-58
19. Geng X., Oliver G.. Pathogenesis of holoprosencephaly. J Clin Invest. 2009 ; 119: 1403-413
20. Goldfarb S., Pugh T. D., Koen H., He Y. Z.. Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy. Environ Health Perspect. 1983 ; 50: 149-61
21. goRENI. The standard reference for nomenclature and diagnostic criteria in toxicologic pathology. Accessed October 2012. http://www.goreni.org/.
22. Greaves P. Histopathology of Preclinical Toxicity Studies. Greaves P., ed. New York, NY: Academic Press ; 2007: 270-333.
23. Guo L., Johnson R. S., Schuh J. C.. Biochemical characterization of endogenously formed eosinophilic crystals in the lungs of mice. J Biol Chem. 2000 ; 275: 8032-37
24. Hamlin M. H., Banas D. A. Pathology of the Fischer Rat, Reference and Atlas. Boorman G. A. Eustis S. L. Elwell M R. Montgomery C. A. MacKenzie W. F., ed. San Diego, CA: Academic Press ; 1990: 501-18.
25. Han Y., Alvarez-Buylla A.. Role of primary cilia in brain development and cancer. Curr Opin Neurobiol. 2010 ; 20: 58-67
26. Hansen J. F., Ross P. E., Makovec G. T., Eustis S. L., Sigler R. E. Guides for Toxicologic Pathology. Washington, DC: ; 1995 :
27. Harada T., Enomoto A., Boorman G. A., Maronpot R. R. Pathology of the Mouse. Maronpot Robert R., ed. Vienna, IL: Cache River Press ; 1999: 119-83.
28. Harbord M., Novelli M., Canas B., Power D., Davis C., Godovac-Zimmermann J., Roes J., Segal A. W.. Ym1 is a neutrophil granule protein that crystallizes in p47phox-deficient mice. J Biol Chem. 2002 ; 277: 5468-75
29. Harris M. J., Juriloff D. M.. An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure. Birth Defects Res A Clin Mol Teratol. 2010 ; 8: 653-6
30. Hoenerhoff M. J., Starost M. F., Ward J. M.. Eosinophilic crystalline pneumonia as a major cause of death in 129S4/SvJae mice. Vet Pathol. 2006 ; 43: 682-88
31. Hornick J. L., Bundock E. A., Fletcher C. D.. Hybrid schwannoma/ perineurioma: Clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol. 2009 ; 33: 1554-561
32. Hosotani R., Ida J., Kogire M., Fujimoto K., Doi R., Imamura M.. Expression of pancreatic duodenal hoemobox-1 in pancreatic islet neogenesis after surgical wrapping in rats. Surgery. 2004 ; 135: 297-306
33. Hung S. I., Chang A. C., Kato I., Chang N. C.. Transient expression of Ym1, a heparin-binding lectin, during developmental hematopoiesis and inflammation. J Leukoc Biol. 2002 ; 72: 72-82
34. Irons R. D., Smith C. N., Stillman W. S., Shah R. S., Steinhagen W. H., Leiderman L. J.. Macrocytic-megaloblastic anemia in male B6C3F1 mice following chronic exposure to 1,3-butadiene. Toxicol Appl Pharmacol. 1986a ; 83: 95-100
35. Irons R. D., Smith C. N., Stillman W. S., Shah R. S., Steinhagen W. H., Leiderman L. J.. Macrocytic-megaloblastic anemia in male NIH Swiss mice following repeated exposure to 1,3-butadiene. Toxicol Appl Pharmacol. 1986b ; 85: 450-55
36. Kemi M., Matsumoto H., Nomura Y., Takahashi R.. Comparative histomorphology between Isoproterenol-induced early lesions and postmortem artifacts in the rat heart. Exp Anim. 1995 ; 44: 240-49
37. Koen H., Pugh T. D., Goldfarb S.. Centrilobular distribution of diethylnitrosamine-induced hepatocellular foci in the mouse. Lab Invest. 1983 ; 49: 78-81
38. Langford L. A., Porter S., Bunge R. P.. Immortalized rat Schwann cells produce tumours in vivo. J Neurocytol. 1988 ; 17: 521-29
39. Lansdown A. B., Grasso P.. Histological observations on a Rathke's cleft abnormality in a laboratory rat. J Comp Pathol. 1971 ; 81: 141-44
40. Liu Q., Cheng L. I., Yi L., Zhu N., Wood A., Changpriroa C. M., Ward J. M., Jackson S. H.. p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia. Am J Pathol. 2009 ; 174: 153-63
41. Louvi A., Grove E. A.. Cilia in the CNS: The quiet organelle claims center stage. Neuron. 2011 ; 69: 1046-60
42. Luginbühl H., Detweiler D. K.. Cardiovascular lesions in dogs. Ann NY Acad Sci. 1965 ; 127: 517-40
43. MacKenzie W. F., Boorman G. A. Pathology of the Fischer Rat - Reference and atlas. Boorman G. A. Eustis S. L. Elwell M. R. Montgomery C. A. MacKenzie W. F., ed. San Diego, CA: Academic Press ; 1990: 485-500.
44. Marchesi F., Monestiroli S. V., Capillo M., Gobbi A., Minucci S., Pelicci P. G., Scanziani E.. Eosinophilic crystals as a distinctive morphologic feature of a hyaline droplet nephropathy in a mouse model of acute myelogenous leukaemia. J Vet Med A Physiol Pathol Clin Med. 2003 ; 50: 103-107
45. McMartin D. N., Sahota P. S., Gunson D. E., Han Hsu H., Spaet R. H.. Neoplasms and related proliferative lesions in control sprague-dawley rats from carcinogenicity studies. Historical data and diagnostic considerations. Toxicol Pathol. 1992 ; 20: 212-25
46. Monis B., Valentich M. A., Urrutia R., Rivolta M.. Multicentric focal acinar cell hyperplasia and hepatocyte-like cell metaplasia are induced by nitrosomethylurea in rat pancreas. Int J Pancreatol. 1991 ; 8: 119-31
47. Murray A. B., Luz A.. Acidophilic macrophage pneumonia in laboratory mice. Vet Pathol. 1990 ; 27: 274-81
48. Nagatani M., Yamakawa S., Ando R., Edamoto H., Saito T., Tamura K.. Highly invasive intracranial malignant schwannoma in a rat. J Toxicol Pathol. 2009 ; 22: 139-42
49. Nathaniel D. R.. Paracrystalline arrays in atypical cristae and mitochondrial division. J Cell Sci. 1980 ; 42: 23-32
50. National Toxicology Program. (1999). Technical Report 469. Accessed October, 2012. http://ntp.niehs.nih.gov/ntp/htdocs/LT-rpts/tr469.pdf.
51. National Toxicology Program. (2011). Technical Report 570. AccessedOctober, 2012. http://ntp.niehs.nih.gov/ntp/htdocs/LT-rpts/TR570.pdf.
52. Nikitin A., Lennartz K., Pozharisski K. M., Rajewsky M. F.. Rat model of the human «Triton» tumor: direct genetic evidence for the myogenic differentiation capacity of schwannoma cells using the mutant neu gene as a cell lineage marker. Differentiation. 1991 ; 48: 33-42
53. Nio J., Fujimoto W., Konno A., Kon Y., Owhashi M., Iwanaga T.. Cellular expression of murine Ym1 and Ym2, chitinase family proteins, as revealed by in situ hybridization and immunohistochemistry. Histochem Cell Biol. 2004 ; 121: 473-82
54. Novilla M. N., Sandusky G. E., Hoover D. M., Ray S. E., Wightman K. A.. A retrospective survey of endocardial proliferative lesions in rats. Vet Pathol. 1991 ; 28: 156-65
55. Pollice L., Ricco R., Russo S., Maiorano E., Pagniello G., Delfino-Pesce V. Appl Pathol. 1988: 73-81.
56. Reddy J. K., Rao M. S.. Pancreatic adenocarcinoma in inbred guinea pigs induced by N-methyl-N-nitrosourea. Cancer Res. 1975 ; 35: 2269-77
57. Riley M. G. I., Boonnan G. A., McDonald M. M., Lognecker D., Solleveld H. A., Giles H. D. Guides for Toxicologic Pathology. Washington, DC: ; 1990 :
58. Sato H., Kawase S., Oku Y., Kamiya M., Ohbayashi M.. Acidophilic protein crystals in lungs and bile ducts of helminth-infected mice. Nihon Juigaku Zasshi. 1988 ; 50: 299-302
59. Scales S. J., de Sauvage F. J.. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009 ; 30: 303-12
60. Shultz L. D., Coman D. R., Bailey C. L., Beamer W. G., Sidman C. L. Am J Pathol. Pathology I., ed. 1984: 179-92.
61. Suski J., Lebiedzinska M., Machado N. G., Oliveira P. J., Pinton P., Duszynski J., Wieckowski M. R.. Mitochondrial tolerance to drugs and toxic agents in ageing and disease. Curr Drug Tar. 2011 ; 12: 827-49
62. Svoboda D. J., Manning R. T.. Chronic alcoholism with fatty metamorphosis of the liver. Mitochondrial alterations in hepatic cells. Am J Pathol. 1964 ; 44: 645-62
63. Takamoto M., Ovington K. S., Behm C. A., Sugane K., Young I. G., Matthaei K. I.. Eosinophilia, parasite burden and lung damage in Toxocara canis infection in C57Bl/6 mice genetically deficient in IL-5. Immunology. 1997 ; 90: 511-17
64. Teredesai A., Woehrmann T.. Endocardial schwannomas in the Wistar rat. J Vet Med A Physiol Pathol Clin Med. 2005 ; 52: 403-406
65. Thoolen B., Maronpot R. R., Harada T., Nyska A., Rousseaux C. R., Nolte T., Malarkey D. E., Kaufmann W., Kuettler K., Ulrich D., Nakae D., Gregson R., Vinlove M. P., Brix A. E., Singh B., Belpoggi F., Ward J. M.. Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicol Pathol. 2010 ; 38: 5S - 81S
66. Van Vleet J. F., Ferrans V. J., Herman E. Handbook of Toxicologic Pathology. 2002 ). Cardiovascular and Skeletal Muscle Systems. In Handbook of Toxicologic Pathology (HaschekW. M.RousseauxC. G.WalligM. A., Eds.), 2nd ed., pp. 363-456. Academic Press, New York, NY. Haschek W. M. Rousseaux C. G. Wallig M. A., ed. New York, NY: Academic Press ; 2002: 363-456.
67. Veland I. R., Awan A., Pederson L. B., Yoder B. K., Christensen S. T.. Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol. 2009 ; 111: 39-53
68. Waern I., Jia J., Pejler G., Zcharia E., Vlodavsky I., Li J. P., Wernersson S.. Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase. Mol Immunol. 2010 ; 47: 1467-75
69. Ward J. M.. Pulmonary pathology of the motheaten mouse. Veterinary pathology. 1978 ; 15: 170-78
70. Ward J. M., Yoon M., Anver M. R., Haines D. C., Kudo G., Gonzalez F. J., Kimura S.. Hyalinosis and Ym1/Ym2 gene expression in the stomach and respiratory tract of 129S4/SvJae and wild-type and CYP1A2-null B6, 129 mice. Am J Pathol. 2001 ; 158: 323-32
71. Watanabe Y. G.. The occurrence and developmental origin of epithelial cysts in the rat and mouse adenohypophysis. Arch Histol Cytol. 1991 ; 54: 511-18
72. Webb D. C., McKenzie A. N., Foster P. S.. Expression of the Ym2 lectin-binding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: identification of a novel allergy-associated protein. J Biol Chem. 2001 ; 276: 41969-76
73. Wickramasinghe S. N.. Diagnosis of megaloblastic anaemias. Blood Rev. 2006 ; 20: 299-318
74. Yaeger M. J., Mullin K., Ensley S. M., Ware W. A., Slavin R. E.. Myocardial toxicity in a group of Greyhounds administered ractopamine. Vet Path. 2012 ; 49: 569-73
75. Zhao J., Zhu H., Wong C. H., Leung K. Y., Wong W. S.. Increased lungkine and chitinase levels in allergic airway inflammation: a proteomics approach. Proteomics. 2005 ; 5: 2799-807